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Protein

Cyclin-dependent kinase 4 inhibitor B

Gene

Cdkn2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity).By similarity

GO - Biological processi

  • aging Source: RGD
  • cell cycle Source: UniProtKB-KW
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • liver development Source: RGD
  • negative regulation of cell cycle G1/S phase transition Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of glial cell proliferation Source: RGD
  • positive regulation of epithelial cell differentiation Source: RGD
  • response to cytokine Source: RGD
  • response to organic cyclic compound Source: RGD

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor B
Alternative name(s):
p14-INK4b
p15-INK4b
Gene namesi
Name:Cdkn2b
Synonyms:Ink4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2324 Cdkn2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000048081 – 130Cyclin-dependent kinase 4 inhibitor BAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP55272
PRIDEiP55272

Expressioni

Tissue specificityi

Expression abundant in lung, less abundant in testis, barely detectable in liver, and not detectable in neonatal kidney, adult kidney, brain, heart, or spleen.

Gene expression databases

GenevisibleiP55272 RN

Interactioni

Subunit structurei

Heterodimer of CDKN2B with CDK4 or CDK6.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008898

Structurei

3D structure databases

ProteinModelPortaliP55272
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 34ANK 1Add BLAST30
Repeati38 – 66ANK 2Add BLAST29
Repeati71 – 100ANK 3Add BLAST30
Repeati104 – 130ANK 4Add BLAST27

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiP55272
KOiK04685
OrthoDBiEOG091G0WSF
PhylomeDBiP55272
TreeFamiTF352389

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Long (identifier: P55272-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS
60 70 80 90 100
AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV
110 120 130
CDAWGRLPVD LAEEQGHRDI ARYLHAATGD
Length:130
Mass (Da):13,749
Last modified:October 1, 1996 - v1
Checksum:iAC45B21FA69FAD92
GO
Isoform Short (identifier: P55272-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Note: No experimental confirmation available.
Show »
Length:85
Mass (Da):9,174
Checksum:i18B7A5B6D45C86EC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0187021 – 45Missing in isoform Short. CuratedAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79760 mRNA Translation: AAB35360.1
AF474978 mRNA Translation: AAL76340.1
AF474979 mRNA Translation: AAL76341.1
S77734 Genomic DNA No translation available.
RefSeqiNP_570825.1, NM_130812.3 [P55272-1]
UniGeneiRn.105626

Genome annotation databases

GeneIDi25164
KEGGirno:25164
UCSCiRGD:2324 rat [P55272-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiCDN2B_RAT
AccessioniPrimary (citable) accession number: P55272
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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