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Protein

Cyclin-dependent kinase 4 inhibitor B

Gene

Cdkn2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559585 Oncogene Induced Senescence
R-MMU-69231 Cyclin D associated events in G1

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor B
Alternative name(s):
p14-INK4b
p15-INK4b
Gene namesi
Name:Cdkn2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104737 Cdkn2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441851 – 130Cyclin-dependent kinase 4 inhibitor BAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP55271
PaxDbiP55271
PeptideAtlasiP55271
PRIDEiP55271

PTM databases

iPTMnetiP55271
PhosphoSitePlusiP55271

Expressioni

Tissue specificityi

Expressed ubiquitously.

Inductioni

By TGF-beta.

Gene expression databases

BgeeiENSMUSG00000073802 Expressed in 193 organ(s), highest expression level in small intestine
ExpressionAtlasiP55271 baseline and differential
GenevisibleiP55271 MM

Interactioni

Subunit structurei

Heterodimer of CDKN2B with CDK4 or CDK6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60249N
IntActiP55271, 1 interactor
STRINGi10090.ENSMUSP00000095595

Structurei

Secondary structure

1130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55271
SMRiP55271
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55271

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 34ANK 1Add BLAST30
Repeati38 – 66ANK 2Add BLAST29
Repeati71 – 100ANK 3Add BLAST30
Repeati104 – 130ANK 4Add BLAST27

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiP55271
KOiK04685
OMAiRDEDKGM
OrthoDBiEOG091G0WSF
PhylomeDBiP55271
TreeFamiTF352389

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

P55271-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGGSSDAGL ATAAARGQVE TVRQLLEAGA DPNALNRFGR RPIQVMMMGS
60 70 80 90 100
AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLVV LHRAGARLDV
110 120 130
CDAWGRLPVD LAEEQGHRDI ARYLHAATGD
Length:130
Mass (Da):13,789
Last modified:October 1, 1996 - v1
Checksum:i7AAD60FF552BCFF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66085, U66084 Genomic DNA Translation: AAB39833.1
BC002010 mRNA Translation: AAH02010.1
CCDSiCCDS18351.1
RefSeqiNP_031696.1, NM_007670.4
UniGeneiMm.423094

Genome annotation databases

EnsembliENSMUST00000097981; ENSMUSP00000095595; ENSMUSG00000073802
GeneIDi12579
KEGGimmu:12579
UCSCiuc008tok.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66085, U66084 Genomic DNA Translation: AAB39833.1
BC002010 mRNA Translation: AAH02010.1
CCDSiCCDS18351.1
RefSeqiNP_031696.1, NM_007670.4
UniGeneiMm.423094

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9SNMR-A1-130[»]
ProteinModelPortaliP55271
SMRiP55271
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60249N
IntActiP55271, 1 interactor
STRINGi10090.ENSMUSP00000095595

PTM databases

iPTMnetiP55271
PhosphoSitePlusiP55271

Proteomic databases

EPDiP55271
PaxDbiP55271
PeptideAtlasiP55271
PRIDEiP55271

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097981; ENSMUSP00000095595; ENSMUSG00000073802
GeneIDi12579
KEGGimmu:12579
UCSCiuc008tok.2 mouse

Organism-specific databases

CTDi1030
MGIiMGI:104737 Cdkn2b

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiP55271
KOiK04685
OMAiRDEDKGM
OrthoDBiEOG091G0WSF
PhylomeDBiP55271
TreeFamiTF352389

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559585 Oncogene Induced Senescence
R-MMU-69231 Cyclin D associated events in G1

Miscellaneous databases

EvolutionaryTraceiP55271
PROiPR:P55271
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073802 Expressed in 193 organ(s), highest expression level in small intestine
ExpressionAtlasiP55271 baseline and differential
GenevisibleiP55271 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2B_MOUSE
AccessioniPrimary (citable) accession number: P55271
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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