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Entry version 185 (10 Apr 2019)
Sequence version 2 (21 Aug 2007)
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Protein

Laminin subunit beta-2

Gene

LAMB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8957275 Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

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SIGNORi
P55268

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit beta-2
Alternative name(s):
Laminin B1s chain
Laminin-11 subunit beta
Laminin-14 subunit beta
Laminin-15 subunit beta
Laminin-3 subunit beta
Laminin-4 subunit beta
Laminin-7 subunit beta
Laminin-9 subunit beta
S-laminin subunit beta
Short name:
S-LAM beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMB2
Synonyms:LAMS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000172037.13

Human Gene Nomenclature Database

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HGNCi
HGNC:6487 LAMB2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
150325 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P55268

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pierson syndrome (PIERSS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome.
See also OMIM:609049
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031968246R → Q in PIERSS; without ocular abnormalities. 1 PublicationCorresponds to variant dbSNP:rs121912491EnsemblClinVar.1
Natural variantiVAR_031969246R → W in PIERSS. 1 PublicationCorresponds to variant dbSNP:rs121912488EnsemblClinVar.1
Natural variantiVAR_031970321C → R in PIERSS and NPHS5; with mild ocular abnormalities. 2 PublicationsCorresponds to variant dbSNP:rs121912492EnsemblClinVar.1
Natural variantiVAR_0319721380N → K in PIERSS and NPHS5; with mild ocular abnormalities; associated with F-1393. 2 PublicationsCorresponds to variant dbSNP:rs267607207EnsemblClinVar.1
Natural variantiVAR_0319731393L → F in PIERSS and NPHS5; with mild ocular abnormalities; associated with K-1380. 2 PublicationsCorresponds to variant dbSNP:rs267607208EnsemblClinVar.1
Nephrotic syndrome 5 with or without ocular abnormalities (NPHS5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS5 is characterized by very early onset of progressive renal failure. A subset of patients may develop mild ocular anomalies, such as myopia, nystagmus, and strabismus.
See also OMIM:614199
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066492147H → R in NPHS5. 1 PublicationCorresponds to variant dbSNP:rs387906644EnsemblClinVar.1
Natural variantiVAR_031970321C → R in PIERSS and NPHS5; with mild ocular abnormalities. 2 PublicationsCorresponds to variant dbSNP:rs121912492EnsemblClinVar.1
Natural variantiVAR_0319721380N → K in PIERSS and NPHS5; with mild ocular abnormalities; associated with F-1393. 2 PublicationsCorresponds to variant dbSNP:rs267607207EnsemblClinVar.1
Natural variantiVAR_0319731393L → F in PIERSS and NPHS5; with mild ocular abnormalities; associated with K-1380. 2 PublicationsCorresponds to variant dbSNP:rs267607208EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
3913

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
LAMB2

MalaCards human disease database

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MalaCardsi
LAMB2
MIMi609049 phenotype
614199 phenotype

Open Targets

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OpenTargetsi
ENSG00000172037

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
306507 LAMB2-related infantile-onset nephrotic syndrome
2670 Pierson syndrome
98915 Synaptic congenital myasthenic syndromes

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA164741827

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LAMB2

Domain mapping of disease mutations (DMDM)

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DMDMi
156630892

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001706833 – 1798Laminin subunit beta-2Add BLAST1766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi283 ↔ 292PROSITE-ProRule annotation
Disulfide bondi285 ↔ 310PROSITE-ProRule annotation
Disulfide bondi312 ↔ 321PROSITE-ProRule annotation
Disulfide bondi324 ↔ 344PROSITE-ProRule annotation
Disulfide bondi347 ↔ 356PROSITE-ProRule annotation
Disulfide bondi349 ↔ 374PROSITE-ProRule annotation
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi377 ↔ 386PROSITE-ProRule annotation
Disulfide bondi389 ↔ 407PROSITE-ProRule annotation
Disulfide bondi410 ↔ 423PROSITE-ProRule annotation
Disulfide bondi412 ↔ 438PROSITE-ProRule annotation
Disulfide bondi440 ↔ 449PROSITE-ProRule annotation
Disulfide bondi452 ↔ 467PROSITE-ProRule annotation
Disulfide bondi470 ↔ 484PROSITE-ProRule annotation
Disulfide bondi472 ↔ 491PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi505 ↔ 519PROSITE-ProRule annotation
Disulfide bondi522 ↔ 534PROSITE-ProRule annotation
Disulfide bondi524 ↔ 541PROSITE-ProRule annotation
Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
Disulfide bondi783 ↔ 795PROSITE-ProRule annotation
Disulfide bondi785 ↔ 802PROSITE-ProRule annotation
Disulfide bondi804 ↔ 813PROSITE-ProRule annotation
Disulfide bondi816 ↔ 828PROSITE-ProRule annotation
Disulfide bondi831 ↔ 843PROSITE-ProRule annotation
Disulfide bondi833 ↔ 850PROSITE-ProRule annotation
Disulfide bondi852 ↔ 861PROSITE-ProRule annotation
Disulfide bondi864 ↔ 874PROSITE-ProRule annotation
Disulfide bondi877 ↔ 886PROSITE-ProRule annotation
Disulfide bondi879 ↔ 893PROSITE-ProRule annotation
Disulfide bondi896 ↔ 905PROSITE-ProRule annotation
Disulfide bondi908 ↔ 924PROSITE-ProRule annotation
Disulfide bondi927 ↔ 943PROSITE-ProRule annotation
Disulfide bondi929 ↔ 954PROSITE-ProRule annotation
Disulfide bondi956 ↔ 965PROSITE-ProRule annotation
Disulfide bondi968 ↔ 983PROSITE-ProRule annotation
Disulfide bondi986 ↔ 1000PROSITE-ProRule annotation
Disulfide bondi988 ↔ 1007PROSITE-ProRule annotation
Disulfide bondi1010 ↔ 1019PROSITE-ProRule annotation
Disulfide bondi1022 ↔ 1035PROSITE-ProRule annotation
Disulfide bondi1038 ↔ 1058PROSITE-ProRule annotation
Disulfide bondi1040 ↔ 1065PROSITE-ProRule annotation
Disulfide bondi1067 ↔ 1076PROSITE-ProRule annotation
Disulfide bondi1079 ↔ 1092PROSITE-ProRule annotation
Glycosylationi1085N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1095 ↔ 1107PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1114PROSITE-ProRule annotation
Disulfide bondi1116 ↔ 1125PROSITE-ProRule annotation
Disulfide bondi1128 ↔ 1140PROSITE-ProRule annotation
Disulfide bondi1143 ↔ 1155PROSITE-ProRule annotation
Disulfide bondi1145 ↔ 1162PROSITE-ProRule annotation
Disulfide bondi1164 ↔ 1173PROSITE-ProRule annotation
Disulfide bondi1176 ↔ 1187PROSITE-ProRule annotation
Disulfide bondi1190InterchainCurated
Disulfide bondi1193InterchainCurated
Glycosylationi1249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1348N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1499N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1532Phosphoserine; by FAM20C1 Publication1
Disulfide bondi1797InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P55268

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P55268

MaxQB - The MaxQuant DataBase

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MaxQBi
P55268

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P55268

PeptideAtlas

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PeptideAtlasi
P55268

PRoteomics IDEntifications database

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PRIDEi
P55268

ProteomicsDB human proteome resource

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ProteomicsDBi
56831

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1443

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P55268

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55268

SwissPalm database of S-palmitoylation events

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SwissPalmi
P55268

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000172037 Expressed in 204 organ(s), highest expression level in apex of heart

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55268 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55268 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB000053
CAB078160
HPA001895
HPA050033

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-7 (laminin-321 or KS-laminin), laminin-9 (laminin-421), laminin-11 (laminin-521), laminin-14 (laminin-423) and laminin-15 (laminin-523).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110107, 41 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1772 Laminin-121 complex
CPX-1773 Laminin-221 complex
CPX-1776 Laminin-321 complex
CPX-1778 Laminin-421 complex
CPX-1780 Laminin-521 complex
CPX-1782 Laminin-423 complex
CPX-1783 Laminin-522 complex
CPX-1784 Laminin-523 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P55268

Database of interacting proteins

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DIPi
DIP-42106N

Protein interaction database and analysis system

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IntActi
P55268, 17 interactors

Molecular INTeraction database

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MINTi
P55268

STRING: functional protein association networks

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STRINGi
9606.ENSP00000388325

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P55268

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55268

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 282Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini283 – 346Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST64
Domaini347 – 409Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini410 – 469Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST60
Domaini470 – 521Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST52
Domaini522 – 552Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd BLAST31
Domaini561 – 777Laminin IV type BPROSITE-ProRule annotationAdd BLAST217
Domaini783 – 830Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini831 – 876Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST46
Domaini877 – 926Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST50
Domaini927 – 985Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST59
Domaini986 – 1037Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST52
Domaini1038 – 1094Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST57
Domaini1095 – 1142Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST48
Domaini1143 – 1189Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1190 – 1409Domain IIAdd BLAST220
Regioni1410 – 1442Domain alphaAdd BLAST33
Regioni1443 – 1798Domain IAdd BLAST356

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1253 – 1319Sequence analysisAdd BLAST67
Coiled coili1472 – 1526Sequence analysisAdd BLAST55
Coiled coili1577 – 1790Sequence analysisAdd BLAST214

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994 Eukaryota
ENOG410XPEG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007552

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052301

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P55268

KEGG Orthology (KO)

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KOi
K06243

Identification of Orthologs from Complete Genome Data

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OMAi
QIQIYNT

Database of Orthologous Groups

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OrthoDBi
655109at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P55268

TreeFam database of animal gene trees

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TreeFami
TF312903

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00181 EGF, 9 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 12 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P55268-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELTSRERGR GQPLPWELRL GLLLSVLAAT LAQAPAPDVP GCSRGSCYPA
60 70 80 90 100
TGDLLVGRAD RLTASSTCGL NGPQPYCIVS HLQDEKKCFL CDSRRPFSAR
110 120 130 140 150
DNPHSHRIQN VVTSFAPQRR AAWWQSENGI PAVTIQLDLE AEFHFTHLIM
160 170 180 190 200
TFKTFRPAAM LVERSADFGR TWHVYRYFSY DCGADFPGVP LAPPRHWDDV
210 220 230 240 250
VCESRYSEIE PSTEGEVIYR VLDPAIPIPD PYSSRIQNLL KITNLRVNLT
260 270 280 290 300
RLHTLGDNLL DPRREIREKY YYALYELVVR GNCFCYGHAS ECAPAPGAPA
310 320 330 340 350
HAEGMVHGAC ICKHNTRGLN CEQCQDFYRD LPWRPAEDGH SHACRKCECH
360 370 380 390 400
GHTHSCHFDM AVYLASGNVS GGVCDGCQHN TAGRHCELCR PFFYRDPTKD
410 420 430 440 450
LRDPAVCRSC DCDPMGSQDG GRCDSHDDPA LGLVSGQCRC KEHVVGTRCQ
460 470 480 490 500
QCRDGFFGLS ISDRLGCRRC QCNARGTVPG STPCDPNSGS CYCKRLVTGR
510 520 530 540 550
GCDRCLPGHW GLSHDLLGCR PCDCDVGGAL DPQCDEGTGQ CHCRQHMVGR
560 570 580 590 600
RCEQVQPGYF RPFLDHLIWE AEDTRGQVLD VVERLVTPGE TPSWTGSGFV
610 620 630 640 650
RLQEGQTLEF LVASVPKAMD YDLLLRLEPQ VPEQWAELEL IVQRPGPVPA
660 670 680 690 700
HSLCGHLVPK DDRIQGTLQP HARYLIFPNP VCLEPGISYK LHLKLVRTGG
710 720 730 740 750
SAQPETPYSG PGLLIDSLVL LPRVLVLEMF SGGDAAALER QATFERYQCH
760 770 780 790 800
EEGLVPSKTS PSEACAPLLI SLSTLIYNGA LPCQCNPQGS LSSECNPHGG
810 820 830 840 850
QCLCKPGVVG RRCDLCAPGY YGFGPTGCQA CQCSHEGALS SLCEKTSGQC
860 870 880 890 900
LCRTGAFGLR CDRCQRGQWG FPSCRPCVCN GHADECNTHT GACLGCRDHT
910 920 930 940 950
GGEHCERCIA GFHGDPRLPY GGQCRPCPCP EGPGSQRHFA TSCHQDEYSQ
960 970 980 990 1000
QIVCHCRAGY TGLRCEACAP GHFGDPSRPG GRCQLCECSG NIDPMDPDAC
1010 1020 1030 1040 1050
DPHTGQCLRC LHHTEGPHCA HCKPGFHGQA ARQSCHRCTC NLLGTNPQQC
1060 1070 1080 1090 1100
PSPDQCHCDP SSGQCPCLPN VQGPSCDRCA PNFWNLTSGH GCQPCACHPS
1110 1120 1130 1140 1150
RARGPTCNEF TGQCHCRAGF GGRTCSECQE LHWGDPGLQC HACDCDSRGI
1160 1170 1180 1190 1200
DTPQCHRFTG HCSCRPGVSG VRCDQCARGF SGIFPACHPC HACFGDWDRV
1210 1220 1230 1240 1250
VQDLAARTQR LEQRAQELQQ TGVLGAFESS FWHMQEKLGI VQGIVGARNT
1260 1270 1280 1290 1300
SAASTAQLVE ATEELRREIG EATEHLTQLE ADLTDVQDEN FNANHALSGL
1310 1320 1330 1340 1350
ERDRLALNLT LRQLDQHLDL LKHSNFLGAY DSIRHAHSQS AEAERRANTS
1360 1370 1380 1390 1400
ALAVPSPVSN SASARHRTEA LMDAQKEDFN SKHMANQRAL GKLSAHTHTL
1410 1420 1430 1440 1450
SLTDINELVC GAPGDAPCAT SPCGGAGCRD EDGQPRCGGL SCNGAAATAD
1460 1470 1480 1490 1500
LALGRARHTQ AELQRALAEG GSILSRVAET RRQASEAQQR AQAALDKANA
1510 1520 1530 1540 1550
SRGQVEQANQ ELQELIQSVK DFLNQEGADP DSIEMVATRV LELSIPASAE
1560 1570 1580 1590 1600
QIQHLAGAIA ERVRSLADVD AILARTVGDV RRAEQLLQDA RRARSWAEDE
1610 1620 1630 1640 1650
KQKAETVQAA LEEAQRAQGI AQGAIRGAVA DTRDTEQTLY QVQERMAGAE
1660 1670 1680 1690 1700
RALSSAGERA RQLDALLEAL KLKRAGNSLA ASTAEETAGS AQGRAQEAEQ
1710 1720 1730 1740 1750
LLRGPLGDQY QTVKALAERK AQGVLAAQAR AEQLRDEARD LLQAAQDKLQ
1760 1770 1780 1790
RLQELEGTYE ENERALESKA AQLDGLEARM RSVLQAINLQ VQIYNTCQ
Length:1,798
Mass (Da):195,981
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFB3531AD13E1486
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H520F5H520_HUMAN
Laminin subunit beta-2
LAMB2
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti914G → R in CAA92279 (PubMed:7698745).Curated1
Sequence conflicti1179G → A in AAB34682 (PubMed:7795887).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066492147H → R in NPHS5. 1 PublicationCorresponds to variant dbSNP:rs387906644EnsemblClinVar.1
Natural variantiVAR_031968246R → Q in PIERSS; without ocular abnormalities. 1 PublicationCorresponds to variant dbSNP:rs121912491EnsemblClinVar.1
Natural variantiVAR_031969246R → W in PIERSS. 1 PublicationCorresponds to variant dbSNP:rs121912488EnsemblClinVar.1
Natural variantiVAR_031970321C → R in PIERSS and NPHS5; with mild ocular abnormalities. 2 PublicationsCorresponds to variant dbSNP:rs121912492EnsemblClinVar.1
Natural variantiVAR_031971987E → K. Corresponds to variant dbSNP:rs34759087EnsemblClinVar.1
Natural variantiVAR_0319721380N → K in PIERSS and NPHS5; with mild ocular abnormalities; associated with F-1393. 2 PublicationsCorresponds to variant dbSNP:rs267607207EnsemblClinVar.1
Natural variantiVAR_0319731393L → F in PIERSS and NPHS5; with mild ocular abnormalities; associated with K-1380. 2 PublicationsCorresponds to variant dbSNP:rs267607208EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z68155, Z68156 Genomic DNA Translation: CAA92279.1
X79683 mRNA Translation: CAA56130.1
S77512 mRNA Translation: AAB34682.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2789.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55677
S53869

NCBI Reference Sequences

More...
RefSeqi
NP_002283.3, NM_002292.3
XP_005265184.1, XM_005265127.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.439726

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305544; ENSP00000307156; ENSG00000172037
ENST00000418109; ENSP00000388325; ENSG00000172037

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3913

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3913

UCSC genome browser

More...
UCSCi
uc003cwe.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68155, Z68156 Genomic DNA Translation: CAA92279.1
X79683 mRNA Translation: CAA56130.1
S77512 mRNA Translation: AAB34682.2
CCDSiCCDS2789.1
PIRiA55677
S53869
RefSeqiNP_002283.3, NM_002292.3
XP_005265184.1, XM_005265127.3
UniGeneiHs.439726

3D structure databases

ProteinModelPortaliP55268
SMRiP55268
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110107, 41 interactors
ComplexPortaliCPX-1772 Laminin-121 complex
CPX-1773 Laminin-221 complex
CPX-1776 Laminin-321 complex
CPX-1778 Laminin-421 complex
CPX-1780 Laminin-521 complex
CPX-1782 Laminin-423 complex
CPX-1783 Laminin-522 complex
CPX-1784 Laminin-523 complex
CORUMiP55268
DIPiDIP-42106N
IntActiP55268, 17 interactors
MINTiP55268
STRINGi9606.ENSP00000388325

Chemistry databases

ChEMBLiCHEMBL2364187

PTM databases

GlyConnecti1443
iPTMnetiP55268
PhosphoSitePlusiP55268
SwissPalmiP55268

Polymorphism and mutation databases

BioMutaiLAMB2
DMDMi156630892

Proteomic databases

EPDiP55268
jPOSTiP55268
MaxQBiP55268
PaxDbiP55268
PeptideAtlasiP55268
PRIDEiP55268
ProteomicsDBi56831

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3913
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305544; ENSP00000307156; ENSG00000172037
ENST00000418109; ENSP00000388325; ENSG00000172037
GeneIDi3913
KEGGihsa:3913
UCSCiuc003cwe.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3913
DisGeNETi3913
EuPathDBiHostDB:ENSG00000172037.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LAMB2
GeneReviewsiLAMB2
HGNCiHGNC:6487 LAMB2
HPAiCAB000053
CAB078160
HPA001895
HPA050033
MalaCardsiLAMB2
MIMi150325 gene
609049 phenotype
614199 phenotype
neXtProtiNX_P55268
OpenTargetsiENSG00000172037
Orphaneti306507 LAMB2-related infantile-onset nephrotic syndrome
2670 Pierson syndrome
98915 Synaptic congenital myasthenic syndromes
PharmGKBiPA164741827

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00940000156060
HOGENOMiHOG000007552
HOVERGENiHBG052301
InParanoidiP55268
KOiK06243
OMAiQIQIYNT
OrthoDBi655109at2759
PhylomeDBiP55268
TreeFamiTF312903

Enzyme and pathway databases

ReactomeiR-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP55268

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMB2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Laminin,_beta_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3913

Protein Ontology

More...
PROi
PR:P55268

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172037 Expressed in 204 organ(s), highest expression level in apex of heart
ExpressionAtlasiP55268 baseline and differential
GenevisibleiP55268 HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 9 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 12 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55268
Secondary accession number(s): Q16321
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 21, 2007
Last modified: April 10, 2019
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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