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UniProtKB - P55268 (LAMB2_HUMAN)

Entry version 194 (12 Aug 2020)
Sequence version 2 (21 Aug 2007)
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Protein

Laminin subunit beta-2

Gene

LAMB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P55268

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3000157, Laminin interactions
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-3000178, ECM proteoglycans
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8874081, MET activates PTK2 signaling
R-HSA-8957275, Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P55268

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit beta-2
Alternative name(s):
Laminin B1s chain
Laminin-11 subunit beta
Laminin-14 subunit beta
Laminin-15 subunit beta
Laminin-3 subunit beta
Laminin-4 subunit beta
Laminin-7 subunit beta
Laminin-9 subunit beta
S-laminin subunit beta
Short name:
S-LAM beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMB2
Synonyms:LAMS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000172037.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:6487, LAMB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		150325, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P55268

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pierson syndrome (PIERSS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031968246R → Q in PIERSS; without ocular abnormalities. 1 PublicationCorresponds to variant dbSNP:rs121912491EnsemblClinVar.1
Natural variantiVAR_031969246R → W in PIERSS. 1 PublicationCorresponds to variant dbSNP:rs121912488EnsemblClinVar.1
Natural variantiVAR_031970321C → R in PIERSS and NPHS5; with mild ocular abnormalities. 2 PublicationsCorresponds to variant dbSNP:rs121912492EnsemblClinVar.1
Natural variantiVAR_0319721380N → K in PIERSS and NPHS5; with mild ocular abnormalities; associated with F-1393. 2 PublicationsCorresponds to variant dbSNP:rs267607207EnsemblClinVar.1
Natural variantiVAR_0319731393L → F in PIERSS and NPHS5; with mild ocular abnormalities; associated with K-1380. 2 PublicationsCorresponds to variant dbSNP:rs267607208EnsemblClinVar.1
Nephrotic syndrome 5 with or without ocular abnormalities (NPHS5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS5 is characterized by very early onset of progressive renal failure. A subset of patients may develop mild ocular anomalies, such as myopia, nystagmus, and strabismus.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066492147H → R in NPHS5. 1 PublicationCorresponds to variant dbSNP:rs387906644EnsemblClinVar.1
Natural variantiVAR_031970321C → R in PIERSS and NPHS5; with mild ocular abnormalities. 2 PublicationsCorresponds to variant dbSNP:rs121912492EnsemblClinVar.1
Natural variantiVAR_0319721380N → K in PIERSS and NPHS5; with mild ocular abnormalities; associated with F-1393. 2 PublicationsCorresponds to variant dbSNP:rs267607207EnsemblClinVar.1
Natural variantiVAR_0319731393L → F in PIERSS and NPHS5; with mild ocular abnormalities; associated with K-1380. 2 PublicationsCorresponds to variant dbSNP:rs267607208EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		3913

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		LAMB2

MalaCards human disease database

More...MalaCardsi		LAMB2
MIMi609049, phenotype
614199, phenotype

Open Targets

More...OpenTargetsi		ENSG00000172037

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2670, Pierson syndrome
98915, Synaptic congenital myasthenic syndromes

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164741827

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P55268, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LAMB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		156630892

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001706833 – 1798Laminin subunit beta-2Add BLAST1766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi283 ↔ 292PROSITE-ProRule annotation
Disulfide bondi285 ↔ 310PROSITE-ProRule annotation
Disulfide bondi312 ↔ 321PROSITE-ProRule annotation
Disulfide bondi324 ↔ 344PROSITE-ProRule annotation
Disulfide bondi347 ↔ 356PROSITE-ProRule annotation
Disulfide bondi349 ↔ 374PROSITE-ProRule annotation
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi377 ↔ 386PROSITE-ProRule annotation
Disulfide bondi389 ↔ 407PROSITE-ProRule annotation
Disulfide bondi410 ↔ 423PROSITE-ProRule annotation
Disulfide bondi412 ↔ 438PROSITE-ProRule annotation
Disulfide bondi440 ↔ 449PROSITE-ProRule annotation
Disulfide bondi452 ↔ 467PROSITE-ProRule annotation
Disulfide bondi470 ↔ 484PROSITE-ProRule annotation
Disulfide bondi472 ↔ 491PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi505 ↔ 519PROSITE-ProRule annotation
Disulfide bondi522 ↔ 534PROSITE-ProRule annotation
Disulfide bondi524 ↔ 541PROSITE-ProRule annotation
Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
Disulfide bondi783 ↔ 795PROSITE-ProRule annotation
Disulfide bondi785 ↔ 802PROSITE-ProRule annotation
Disulfide bondi804 ↔ 813PROSITE-ProRule annotation
Disulfide bondi816 ↔ 828PROSITE-ProRule annotation
Disulfide bondi831 ↔ 843PROSITE-ProRule annotation
Disulfide bondi833 ↔ 850PROSITE-ProRule annotation
Disulfide bondi852 ↔ 861PROSITE-ProRule annotation
Disulfide bondi864 ↔ 874PROSITE-ProRule annotation
Disulfide bondi877 ↔ 886PROSITE-ProRule annotation
Disulfide bondi879 ↔ 893PROSITE-ProRule annotation
Disulfide bondi896 ↔ 905PROSITE-ProRule annotation
Disulfide bondi908 ↔ 924PROSITE-ProRule annotation
Disulfide bondi927 ↔ 943PROSITE-ProRule annotation
Disulfide bondi929 ↔ 954PROSITE-ProRule annotation
Disulfide bondi956 ↔ 965PROSITE-ProRule annotation
Disulfide bondi968 ↔ 983PROSITE-ProRule annotation
Disulfide bondi986 ↔ 1000PROSITE-ProRule annotation
Disulfide bondi988 ↔ 1007PROSITE-ProRule annotation
Disulfide bondi1010 ↔ 1019PROSITE-ProRule annotation
Disulfide bondi1022 ↔ 1035PROSITE-ProRule annotation
Disulfide bondi1038 ↔ 1058PROSITE-ProRule annotation
Disulfide bondi1040 ↔ 1065PROSITE-ProRule annotation
Disulfide bondi1067 ↔ 1076PROSITE-ProRule annotation
Disulfide bondi1079 ↔ 1092PROSITE-ProRule annotation
Glycosylationi1085N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1095 ↔ 1107PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1114PROSITE-ProRule annotation
Disulfide bondi1116 ↔ 1125PROSITE-ProRule annotation
Disulfide bondi1128 ↔ 1140PROSITE-ProRule annotation
Disulfide bondi1143 ↔ 1155PROSITE-ProRule annotation
Disulfide bondi1145 ↔ 1162PROSITE-ProRule annotation
Disulfide bondi1164 ↔ 1173PROSITE-ProRule annotation
Disulfide bondi1176 ↔ 1187PROSITE-ProRule annotation
Disulfide bondi1190InterchainCurated
Disulfide bondi1193InterchainCurated
Glycosylationi1249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1348N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1499N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1532Phosphoserine; by FAM20C1 Publication1
Disulfide bondi1797InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P55268

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P55268

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P55268

MaxQB - The MaxQuant DataBase

More...MaxQBi		P55268

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P55268

PeptideAtlas

More...PeptideAtlasi		P55268

PRoteomics IDEntifications database

More...PRIDEi		P55268

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56831

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1443, 4 N-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P55268, 8 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P55268

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P55268

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P55268

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172037, Expressed in apex of heart and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P55268, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P55268, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172037, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-7 (laminin-321 or KS-laminin), laminin-9 (laminin-421), laminin-11 (laminin-521), laminin-14 (laminin-423) and laminin-15 (laminin-523).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110107, 43 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1772, Laminin-121 complex
CPX-1773, Laminin-221 complex
CPX-1776, Laminin-321 complex
CPX-1778, Laminin-421 complex
CPX-1780, Laminin-521 complex
CPX-1782, Laminin-423 complex
CPX-1783, Laminin-522 complex
CPX-1784, Laminin-523 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P55268

Database of interacting proteins

More...DIPi		DIP-42106N

Protein interaction database and analysis system

More...IntActi		P55268, 38 interactors

Molecular INTeraction database

More...MINTi		P55268

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000388325

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P55268, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P55268

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 282Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini283 – 346Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST64
Domaini347 – 409Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini410 – 469Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST60
Domaini470 – 521Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST52
Domaini522 – 552Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd BLAST31
Domaini561 – 777Laminin IV type BPROSITE-ProRule annotationAdd BLAST217
Domaini783 – 830Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini831 – 876Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST46
Domaini877 – 926Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST50
Domaini927 – 985Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST59
Domaini986 – 1037Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST52
Domaini1038 – 1094Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST57
Domaini1095 – 1142Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST48
Domaini1143 – 1189Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1190 – 1409Domain IIAdd BLAST220
Regioni1410 – 1442Domain alphaAdd BLAST33
Regioni1443 – 1798Domain IAdd BLAST356

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1253 – 1319Sequence analysisAdd BLAST67
Coiled coili1472 – 1526Sequence analysisAdd BLAST55
Coiled coili1577 – 1790Sequence analysisAdd BLAST214

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0994, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001560_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P55268

KEGG Orthology (KO)

More...KOi		K06243

Identification of Orthologs from Complete Genome Data

More...OMAi		QCQPCEC

Database of Orthologous Groups

More...OrthoDBi		65841at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P55268

TreeFam database of animal gene trees

More...TreeFami		TF312903

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
IPR008211, Laminin_N
IPR038684, Laminin_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00053, Laminin_EGF, 13 hits
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 9 hits
SM00180, EGF_Lam, 13 hits
SM00136, LamNT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 10 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 12 hits
PS50027, EGF_LAM_2, 13 hits
PS51116, LAMININ_IVB, 1 hit
PS51117, LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P55268-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELTSRERGR GQPLPWELRL GLLLSVLAAT LAQAPAPDVP GCSRGSCYPA 
        60         70         80         90        100
TGDLLVGRAD RLTASSTCGL NGPQPYCIVS HLQDEKKCFL CDSRRPFSAR 
       110        120        130        140        150
DNPHSHRIQN VVTSFAPQRR AAWWQSENGI PAVTIQLDLE AEFHFTHLIM 
       160        170        180        190        200
TFKTFRPAAM LVERSADFGR TWHVYRYFSY DCGADFPGVP LAPPRHWDDV 
       210        220        230        240        250
VCESRYSEIE PSTEGEVIYR VLDPAIPIPD PYSSRIQNLL KITNLRVNLT 
       260        270        280        290        300
RLHTLGDNLL DPRREIREKY YYALYELVVR GNCFCYGHAS ECAPAPGAPA 
       310        320        330        340        350
HAEGMVHGAC ICKHNTRGLN CEQCQDFYRD LPWRPAEDGH SHACRKCECH 
       360        370        380        390        400
GHTHSCHFDM AVYLASGNVS GGVCDGCQHN TAGRHCELCR PFFYRDPTKD 
       410        420        430        440        450
LRDPAVCRSC DCDPMGSQDG GRCDSHDDPA LGLVSGQCRC KEHVVGTRCQ 
       460        470        480        490        500
QCRDGFFGLS ISDRLGCRRC QCNARGTVPG STPCDPNSGS CYCKRLVTGR 
       510        520        530        540        550
GCDRCLPGHW GLSHDLLGCR PCDCDVGGAL DPQCDEGTGQ CHCRQHMVGR 
       560        570        580        590        600
RCEQVQPGYF RPFLDHLIWE AEDTRGQVLD VVERLVTPGE TPSWTGSGFV 
       610        620        630        640        650
RLQEGQTLEF LVASVPKAMD YDLLLRLEPQ VPEQWAELEL IVQRPGPVPA 
       660        670        680        690        700
HSLCGHLVPK DDRIQGTLQP HARYLIFPNP VCLEPGISYK LHLKLVRTGG 
       710        720        730        740        750
SAQPETPYSG PGLLIDSLVL LPRVLVLEMF SGGDAAALER QATFERYQCH 
       760        770        780        790        800
EEGLVPSKTS PSEACAPLLI SLSTLIYNGA LPCQCNPQGS LSSECNPHGG 
       810        820        830        840        850
QCLCKPGVVG RRCDLCAPGY YGFGPTGCQA CQCSHEGALS SLCEKTSGQC 
       860        870        880        890        900
LCRTGAFGLR CDRCQRGQWG FPSCRPCVCN GHADECNTHT GACLGCRDHT 
       910        920        930        940        950
GGEHCERCIA GFHGDPRLPY GGQCRPCPCP EGPGSQRHFA TSCHQDEYSQ 
       960        970        980        990       1000
QIVCHCRAGY TGLRCEACAP GHFGDPSRPG GRCQLCECSG NIDPMDPDAC 
      1010       1020       1030       1040       1050
DPHTGQCLRC LHHTEGPHCA HCKPGFHGQA ARQSCHRCTC NLLGTNPQQC 
      1060       1070       1080       1090       1100
PSPDQCHCDP SSGQCPCLPN VQGPSCDRCA PNFWNLTSGH GCQPCACHPS 
      1110       1120       1130       1140       1150
RARGPTCNEF TGQCHCRAGF GGRTCSECQE LHWGDPGLQC HACDCDSRGI 
      1160       1170       1180       1190       1200
DTPQCHRFTG HCSCRPGVSG VRCDQCARGF SGIFPACHPC HACFGDWDRV 
      1210       1220       1230       1240       1250
VQDLAARTQR LEQRAQELQQ TGVLGAFESS FWHMQEKLGI VQGIVGARNT 
      1260       1270       1280       1290       1300
SAASTAQLVE ATEELRREIG EATEHLTQLE ADLTDVQDEN FNANHALSGL 
      1310       1320       1330       1340       1350
ERDRLALNLT LRQLDQHLDL LKHSNFLGAY DSIRHAHSQS AEAERRANTS 
      1360       1370       1380       1390       1400
ALAVPSPVSN SASARHRTEA LMDAQKEDFN SKHMANQRAL GKLSAHTHTL 
      1410       1420       1430       1440       1450
SLTDINELVC GAPGDAPCAT SPCGGAGCRD EDGQPRCGGL SCNGAAATAD 
      1460       1470       1480       1490       1500
LALGRARHTQ AELQRALAEG GSILSRVAET RRQASEAQQR AQAALDKANA 
      1510       1520       1530       1540       1550
SRGQVEQANQ ELQELIQSVK DFLNQEGADP DSIEMVATRV LELSIPASAE 
      1560       1570       1580       1590       1600
QIQHLAGAIA ERVRSLADVD AILARTVGDV RRAEQLLQDA RRARSWAEDE 
      1610       1620       1630       1640       1650
KQKAETVQAA LEEAQRAQGI AQGAIRGAVA DTRDTEQTLY QVQERMAGAE 
      1660       1670       1680       1690       1700
RALSSAGERA RQLDALLEAL KLKRAGNSLA ASTAEETAGS AQGRAQEAEQ 
      1710       1720       1730       1740       1750
LLRGPLGDQY QTVKALAERK AQGVLAAQAR AEQLRDEARD LLQAAQDKLQ 
      1760       1770       1780       1790 
RLQELEGTYE ENERALESKA AQLDGLEARM RSVLQAINLQ VQIYNTCQ
Length:1,798
Mass (Da):195,981
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFB3531AD13E1486
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H520F5H520_HUMAN
Laminin subunit beta-2
LAMB2
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti914G → R in CAA92279 (PubMed:7698745).Curated1
Sequence conflicti1179G → A in AAB34682 (PubMed:7795887).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066492147H → R in NPHS5. 1 PublicationCorresponds to variant dbSNP:rs387906644EnsemblClinVar.1
Natural variantiVAR_031968246R → Q in PIERSS; without ocular abnormalities. 1 PublicationCorresponds to variant dbSNP:rs121912491EnsemblClinVar.1
Natural variantiVAR_031969246R → W in PIERSS. 1 PublicationCorresponds to variant dbSNP:rs121912488EnsemblClinVar.1
Natural variantiVAR_031970321C → R in PIERSS and NPHS5; with mild ocular abnormalities. 2 PublicationsCorresponds to variant dbSNP:rs121912492EnsemblClinVar.1
Natural variantiVAR_031971987E → K. Corresponds to variant dbSNP:rs34759087EnsemblClinVar.1
Natural variantiVAR_0319721380N → K in PIERSS and NPHS5; with mild ocular abnormalities; associated with F-1393. 2 PublicationsCorresponds to variant dbSNP:rs267607207EnsemblClinVar.1
Natural variantiVAR_0319731393L → F in PIERSS and NPHS5; with mild ocular abnormalities; associated with K-1380. 2 PublicationsCorresponds to variant dbSNP:rs267607208EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z68155, Z68156 Genomic DNA Translation: CAA92279.1
X79683 mRNA Translation: CAA56130.1
S77512 mRNA Translation: AAB34682.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2789.1

Protein sequence database of the Protein Information Resource

More...PIRi		A55677
S53869

NCBI Reference Sequences

More...RefSeqi		NP_002283.3, NM_002292.3
XP_005265184.1, XM_005265127.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305544; ENSP00000307156; ENSG00000172037
ENST00000418109; ENSP00000388325; ENSG00000172037

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3913

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3913

UCSC genome browser

More...UCSCi		uc003cwe.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68155, Z68156 Genomic DNA Translation: CAA92279.1
X79683 mRNA Translation: CAA56130.1
S77512 mRNA Translation: AAB34682.2
CCDSiCCDS2789.1
PIRiA55677
S53869
RefSeqiNP_002283.3, NM_002292.3
XP_005265184.1, XM_005265127.3

3D structure databases

SMRiP55268
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110107, 43 interactors
ComplexPortaliCPX-1772, Laminin-121 complex
CPX-1773, Laminin-221 complex
CPX-1776, Laminin-321 complex
CPX-1778, Laminin-421 complex
CPX-1780, Laminin-521 complex
CPX-1782, Laminin-423 complex
CPX-1783, Laminin-522 complex
CPX-1784, Laminin-523 complex
CORUMiP55268
DIPiDIP-42106N
IntActiP55268, 38 interactors
MINTiP55268
STRINGi9606.ENSP00000388325

Chemistry databases

ChEMBLiCHEMBL2364187

PTM databases

GlyConnecti1443, 4 N-Linked glycans (4 sites)
GlyGeniP55268, 8 sites, 1 O-linked glycan (1 site)
iPTMnetiP55268
PhosphoSitePlusiP55268
SwissPalmiP55268

Polymorphism and mutation databases

BioMutaiLAMB2
DMDMi156630892

Proteomic databases

EPDiP55268
jPOSTiP55268
MassIVEiP55268
MaxQBiP55268
PaxDbiP55268
PeptideAtlasiP55268
PRIDEiP55268
ProteomicsDBi56831

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		995, 369 antibodies

The DNASU plasmid repository

More...DNASUi		3913

Genome annotation databases

EnsembliENST00000305544; ENSP00000307156; ENSG00000172037
ENST00000418109; ENSP00000388325; ENSG00000172037
GeneIDi3913
KEGGihsa:3913
UCSCiuc003cwe.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3913
DisGeNETi3913
EuPathDBiHostDB:ENSG00000172037.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		LAMB2
GeneReviewsiLAMB2
HGNCiHGNC:6487, LAMB2
HPAiENSG00000172037, Low tissue specificity
MalaCardsiLAMB2
MIMi150325, gene
609049, phenotype
614199, phenotype
neXtProtiNX_P55268
OpenTargetsiENSG00000172037
Orphaneti2670, Pierson syndrome
98915, Synaptic congenital myasthenic syndromes
PharmGKBiPA164741827

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0994, Eukaryota
GeneTreeiENSGT00940000156060
HOGENOMiCLU_001560_1_0_1
InParanoidiP55268
KOiK06243
OMAiQCQPCEC
OrthoDBi65841at2759
PhylomeDBiP55268
TreeFamiTF312903

Enzyme and pathway databases

PathwayCommonsiP55268
ReactomeiR-HSA-3000157, Laminin interactions
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-3000178, ECM proteoglycans
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8874081, MET activates PTK2 signaling
R-HSA-8957275, Post-translational protein phosphorylation
SIGNORiP55268

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3913, 5 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LAMB2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Laminin,_beta_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3913
PharosiP55268, Tbio

Protein Ontology

More...PROi		PR:P55268
RNActiP55268, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000172037, Expressed in apex of heart and 214 other tissues
ExpressionAtlasiP55268, baseline and differential
GenevisibleiP55268, HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
PfamiView protein in Pfam
PF00053, Laminin_EGF, 13 hits
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 9 hits
SM00180, EGF_Lam, 13 hits
SM00136, LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 10 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 12 hits
PS50027, EGF_LAM_2, 13 hits
PS51116, LAMININ_IVB, 1 hit
PS51117, LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55268
Secondary accession number(s): Q16321
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 21, 2007
Last modified: August 12, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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