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Entry version 145 (29 Sep 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Double-stranded RNA-specific adenosine deaminase

Gene

Adar

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi856ZincPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei858Proton donorPROSITE-ProRule annotation1
Metal bindingi912ZincPROSITE-ProRule annotation1
Metal bindingi982ZincPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Hydrolase, RNA-binding
Biological processAntiviral defense, Immunity, Innate immunity, mRNA processing, RNA-mediated gene silencing, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-75102, C6 deamination of adenosine
R-RNO-77042, Formation of editosomes by ADAR proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Double-stranded RNA-specific adenosine deaminase (EC:3.5.4.37)
Short name:
DRADA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adar
Synonyms:Dsrad
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
71099, Adar

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001717761 – 1175Double-stranded RNA-specific adenosine deaminaseAdd BLAST1175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30Asymmetric dimethylarginineBy similarity1
Modified residuei42Asymmetric dimethylarginineBy similarity1
Modified residuei228PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei431PhosphoserineBy similarity1
Modified residuei564PhosphoserineBy similarity1
Modified residuei579PhosphoserineBy similarity1
Modified residuei586PhosphoserineBy similarity1
Modified residuei754PhosphothreonineBy similarity1
Modified residuei760PhosphoserineBy similarity1
Modified residuei769PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1
Cross-linki821Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation reduces RNA-editing activity.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55266

PRoteomics IDEntifications database

More...
PRIDEi
P55266

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55266

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P55266

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Homodimerization is essential for its catalytic activity. Isoform 5 can form heterodimers with ADARB1/ADAR2.

Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. Binding to ILF3/NF90 up-regulates ILF3-mediated gene expression. Isoform 1 and isoform 5 (via DRBM 3 domain) interact with TNPO1. Isoform 5 (via DRBM domains) interacts with XPO5. Isoform 1 and isoform 5 can interact with EIF2AK2/PKR and UPF1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
249535, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000028181

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P55266

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini135 – 201Z-binding 1PROSITE-ProRule annotationAdd BLAST67
Domaini243 – 307Z-binding 2PROSITE-ProRule annotationAdd BLAST65
Domaini453 – 521DRBM 1PROSITE-ProRule annotationAdd BLAST69
Domaini564 – 632DRBM 2PROSITE-ProRule annotationAdd BLAST69
Domaini672 – 740DRBM 3PROSITE-ProRule annotationAdd BLAST69
Domaini832 – 1167A to I editasePROSITE-ProRule annotationAdd BLAST336

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni135 – 204Interaction with Z-DNABy similarityAdd BLAST70
Regioni207 – 239DisorderedSequence analysisAdd BLAST33
Regioni315 – 384DisorderedSequence analysisAdd BLAST70
Regioni524 – 561DisorderedSequence analysisAdd BLAST38
Regioni632 – 652DisorderedSequence analysisAdd BLAST21
Regioni662 – 671N-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signalBy similarity10
Regioni741 – 747C-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signalBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi319 – 362Polar residuesSequence analysisAdd BLAST44
Compositional biasi363 – 381Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi635 – 652Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first DRADA repeat binds Z-DNA.By similarity
The third dsRNA-binding domain (DRBM 3) contains an additional N-terminal alpha-helix that is part of a bi-partite nuclear localization signal, together with the sequence immediately C-terminal to DRBM 3. The presence of DRBM 3 is important to bring together the N-terminal and the C-terminal part of the bi-partite nuclear localization signal for import mediated by TNPO1. RNA binding interferes with nuclear import.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2777, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55266

Database of Orthologous Groups

More...
OrthoDBi
947117at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55266

Family and domain databases

Conserved Domains Database

More...
CDDi
cd19913, DSRM_DRADA_rpt1, 1 hit
cd19915, DSRM_DRADA_rpt3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002466, A_deamin
IPR044456, ADAR1_DSRM_1
IPR044457, ADAR1_DSRM_3
IPR014720, dsRBD_dom
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR042371, Z_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02137, A_deamin, 1 hit
PF00035, dsrm, 3 hits
PF02295, z-alpha, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00552, ADEAMc, 1 hit
SM00358, DSRM, 3 hits
SM00550, Zalpha, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50141, A_DEAMIN_EDITASE, 1 hit
PS50137, DS_RBD, 3 hits
PS50139, Z_BINDING, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P55266-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGFRGPTG VFPHQTQPCL DPSYEHSKWR YLQPRGSESY LRSFQLQQIE
60 70 80 90 100
FLKGRLPEAP LIGAQTQSLP PFLPGHWPRF PGPPAQGKQP EIWGFPRSVT
110 120 130 140 150
LRNQGFHIGP PLPPPHSRGP PWRGAEGLCS HFQELSISQN PEQKVLNRLE
160 170 180 190 200
ELGEGKATTA YALARELRTP KKDINRILYS LERKGKLHRG VGKPPLWSLV
210 220 230 240 250
PLSQACTQPP RAVNSDKEVP RGEPDLDSED GDPASDLEGP SELLDMAEIK
260 270 280 290 300
EKICDYLFNV SKSSALNLAK NIGLAKARDV NAVLIDLERQ GDVYREGATP
310 320 330 340 350
PIWYLTDKKR ERLQMKRSTH SGPAATPAAV SEATQSTSFP TCHPPQSGGS
360 370 380 390 400
SSMATSKRVE NGQEPVTKYE SRHEARPGPV RLRPHAYHNG PSRAGYVASE
410 420 430 440 450
NGPWATDDIP DNLNSIHTAP GEFRAIMEMP SFYSPTLPRC SPYKKLTECQ
460 470 480 490 500
LKNPVSGLLE YAQFTSQTCD FNLIEQSGPS HEPRFKFQVV INGREFPPAE
510 520 530 540 550
AGSKKVAKQD AAVKAMAILL REAKAKDSGQ PEELSNCPME EDPEKPAESQ
560 570 580 590 600
PPSSSATSLF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHDPKFQYCV
610 620 630 640 650
AVGAQTFPSV SAPSKKVAKQ MAAEEAMKAL QEEAANSADD QSGGANTDSL
660 670 680 690 700
DESVAPNKIR RIGELVRYLN TNPVGGLLEY ARSHGFAAEF KLIDQSGPPH
710 720 730 740 750
EPKFVYQAKV GGRWFPAVCA HSKKQGKQDA ADAALRVLIG ESEKAEQLGF
760 770 780 790 800
AEVTPVTGAS LRRTMLLLSR SPDAHPKTLP LTGSTFHDQI AMLSHRCFNA
810 820 830 840 850
LTNSFQPSLL GRKILAAIIM KRDPEDMGVV VSLGTGNRCV KGDSLSLKGE
860 870 880 890 900
TVNDCHAEII SRRGFIRFLY SELMKYNHHT AKNSIFELAR GGEKLQIKKT
910 920 930 940 950
VSFHLYISTA PCGDGAHFDK SCSDRAVEST ESRHYPVFEN PKQGKLRTKV
960 970 980 990 1000
ENGEGTIPVE SSDIVPTWDG IRLGERLRTM SCSDKILRWN VLGLQGALLT
1010 1020 1030 1040 1050
HFLQPVYLKS VTLGYLFSQG HLTRAICCRV TRDGNAFEDG LRYPFIVNHP
1060 1070 1080 1090 1100
KVGRVSVYDS KRQSGKTKET SVNWCLADGY DLEILDGTRG TVDGPGKELS
1110 1120 1130 1140 1150
RVSKKNIFLQ FKKLCSFRAR RDLLQLSYGE AKKAARDYDL AKNYFKKSLR
1160 1170
DMGYGNWISK PQEEKNFYLC PVPND
Length:1,175
Mass (Da):129,911
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5C7B5FFB771168C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V8T3G3V8T3_RAT
Adenosine deaminase, RNA-specific, ...
Adar rCG_62606
1,175Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18942 mRNA Translation: AAA65039.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I57549

NCBI Reference Sequences

More...
RefSeqi
NP_112268.1, NM_031006.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:81635

UCSC genome browser

More...
UCSCi
RGD:71099, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18942 mRNA Translation: AAA65039.1
PIRiI57549
RefSeqiNP_112268.1, NM_031006.1

3D structure databases

SMRiP55266
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi249535, 1 interactor
STRINGi10116.ENSRNOP00000028181

PTM databases

iPTMnetiP55266
PhosphoSitePlusiP55266

Proteomic databases

PaxDbiP55266
PRIDEiP55266

Genome annotation databases

GeneIDi81635
KEGGirno:81635
UCSCiRGD:71099, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
103
RGDi71099, Adar

Phylogenomic databases

eggNOGiKOG2777, Eukaryota
InParanoidiP55266
OrthoDBi947117at2759
PhylomeDBiP55266

Enzyme and pathway databases

ReactomeiR-RNO-75102, C6 deamination of adenosine
R-RNO-77042, Formation of editosomes by ADAR proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P55266

Family and domain databases

CDDicd19913, DSRM_DRADA_rpt1, 1 hit
cd19915, DSRM_DRADA_rpt3, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR002466, A_deamin
IPR044456, ADAR1_DSRM_1
IPR044457, ADAR1_DSRM_3
IPR014720, dsRBD_dom
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR042371, Z_dom
PfamiView protein in Pfam
PF02137, A_deamin, 1 hit
PF00035, dsrm, 3 hits
PF02295, z-alpha, 2 hits
SMARTiView protein in SMART
SM00552, ADEAMc, 1 hit
SM00358, DSRM, 3 hits
SM00550, Zalpha, 2 hits
SUPFAMiSSF46785, SSF46785, 2 hits
PROSITEiView protein in PROSITE
PS50141, A_DEAMIN_EDITASE, 1 hit
PS50137, DS_RBD, 3 hits
PS50139, Z_BINDING, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSRAD_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55266
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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