ADAR

Functionⁱ

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:7972084, PubMed:7565688, PubMed:12618436). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication.14 Publications

Caution

The N-terminus of isoform 4 has been derived from EST and genomic sequences.Curated

Catalytic activityⁱ

Adenine in double-stranded RNA + H₂O = hypoxanthine in double-stranded RNA + NH₃.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	910	ZincPROSITE-ProRule annotation	1
Active siteⁱ	912	Proton donorPROSITE-ProRule annotation	1
Metal bindingⁱ	966	ZincPROSITE-ProRule annotation	1
Metal bindingⁱ	1036	ZincPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
double-stranded RNA adenosine deaminase activity
Source: MGI
Inferred from direct assayⁱ
- 9020165
metal ion binding Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenosine to inosine editing
Source: UniProtKB
Inferred from direct assayⁱ
base conversion or substitution editing
Source: MGI
Inferred from direct assayⁱ
- 9020165
cellular response to virus Source: Ensembl
defense response to virus Source: UniProtKB-KW
definitive hemopoiesis Source: Ensembl
erythrocyte differentiation Source: Ensembl
hematopoietic progenitor cell differentiation Source: Ensembl
hematopoietic stem cell homeostasis Source: Ensembl
innate immune response
Source: UniProtKB
Traceable author statementⁱ
- 16475990
in utero embryonic development Source: Ensembl
miRNA loading onto RISC involved in gene silencing by miRNA
Source: MGI
Inferred from direct assayⁱ
- 23622242
mRNA processing Source: UniProtKB-KW
negative regulation of apoptotic process Source: Ensembl
negative regulation of protein kinase activity by regulation of protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19651874
negative regulation of RNA interference Source: Ensembl
negative regulation of type I interferon-mediated signaling pathway Source: Ensembl
negative regulation of viral genome replication Source: Ensembl
osteoblast differentiation Source: Ensembl
positive regulation of viral genome replication
Source: UniProtKB
Inferred from direct assayⁱ
- 19651874
pre-miRNA processing
Source: MGI
Inferred from direct assayⁱ
- 23622242
protein export from nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 19124606
protein import into nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 19124606
response to interferon-alpha
Source: UniProtKB
Inferred from direct assayⁱ
- 16475990
response to virus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15858013
somatic diversification of immune receptors via somatic mutation Source: Ensembl
type I interferon signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Hydrolase, RNA-binding
Biological process	Antiviral defense, Immunity, Innate immunity, mRNA processing, RNA-mediated gene silencing
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	3.5.4.37 2681
Reactomeⁱ	R-HSA-75102 C6 deamination of adenosine R-HSA-77042 Formation of editosomes by ADAR proteins R-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Double-stranded RNA-specific adenosine deaminase (EC:3.5.4.372 Publications) Short name: DRADA1 Publication Alternative name(s): 136 kDa double-stranded RNA-binding protein Short name: p136 Interferon-inducible protein 4 Short name: IFI-4 K88DSRBP
Gene namesⁱ	Name:ADAR Synonyms:ADAR1, DSRAD, G1P1, IFI4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160710.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:225 ADAR
MIMⁱ	146920 gene
neXtProtⁱ	NX_P55265

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Dyschromatosis symmetrica hereditaria (DSH)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant pigmentary genodermatosis characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the face and the dorsal parts of the hands and feet, that appear in infancy or early childhood.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017604	923	L → P in DSH. 1 PublicationCorresponds to variant dbSNP:rs28936680Ensembl.	1
Natural variantⁱVAR_021729	966	C → F in DSH. 1 Publication	1
Natural variantⁱVAR_026669	1155	R → W in DSH. 1 PublicationCorresponds to variant dbSNP:rs1044845711Ensembl.	1
Natural variantⁱVAR_017605	1165	F → S in DSH. 1 PublicationCorresponds to variant dbSNP:rs28936681Ensembl.	1

Aicardi-Goutieres syndrome 6 (AGS6)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069535	193	P → A in AGS6. 1 PublicationCorresponds to variant dbSNP:rs145588689EnsemblClinVar.	1
Natural variantⁱVAR_069536	870	A → T in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122893EnsemblClinVar.	1
Natural variantⁱVAR_069537	872	I → T in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122897EnsemblClinVar.	1
Natural variantⁱVAR_069538	892	R → H in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122892EnsemblClinVar.	1
Natural variantⁱVAR_069539	999	K → N in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122896EnsemblClinVar.	1
Natural variantⁱVAR_069540	1007	G → R in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122822EnsemblClinVar.	1
Natural variantⁱVAR_069541	1112	Y → F in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122895EnsemblClinVar.	1
Natural variantⁱVAR_069542	1113	D → H in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122894EnsemblClinVar.	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	418	K → R: Abolishes sumoylation. 1 Publication	1
Mutagenesisⁱ	708 – 801	Missing : Abolishes nuclear location. 1 PublicationAdd BLAST	94
Mutagenesisⁱ	708 – 710	MMP → AMA: Decreased nuclear and partially cytoplasmic location. 1 Publication	3
Mutagenesisⁱ	712 – 715	KVRK → AVAA: No effect on nuclear location. No effect on RNA binding. 1 Publication	4
Mutagenesisⁱ	716 – 724	Missing : Disrupts the bi-partite nuclear localization signal and abolishes nuclear location. 1 Publication	9
Mutagenesisⁱ	716	I → N: Disrupts the bi-partite nuclear localization signal and abolishes nuclear location; when associated with S-719 and N-723. 1 Publication	1
Mutagenesisⁱ	718	E → A: No effect on nuclear location; when associated with A-721 and A-724. 1 Publication	1
Mutagenesisⁱ	719	L → S: Disrupts the bi-partite nuclear localization signal and abolishes nuclear location; when associated with N-716 and N-723. 1 Publication	1
Mutagenesisⁱ	721	R → A: No effect on nuclear location; when associated with A-721 and A-724. 1 Publication	1
Mutagenesisⁱ	723	L → N: Disrupts the bi-partite nuclear localization signal and abolishes nuclear location; when associated with N-716 and S-719. 1 Publication	1
Mutagenesisⁱ	724	N → A: No effect on nuclear location; when associated with A-718 and A-721. 1 Publication	1
Mutagenesisⁱ	725 – 801	Missing : Disrupts nuclear localization signal. No effect on RNA binding. 1 PublicationAdd BLAST	77
Mutagenesisⁱ	777 – 778	KK → AA: Strongly impaired RNA binding. No effect on nuclear location. 1 Publication	2
Mutagenesisⁱ	801	R → A: Abolishes interaction with TNPO1, TNPO1-mediated nuclear import and nuclear location. 1 Publication	1

Keywords - Diseaseⁱ

Aicardi-Goutieres syndrome, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	103
MalaCards human disease database More...MalaCardsⁱ	ADAR
MIMⁱ	127400 phenotype 615010 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000160710
Orphanetⁱ	51 Aicardi-Goutieres syndrome 41 Dyschromatosis symmetrica hereditaria 225154 Familial infantile bilateral striatal necrosis
PharmGKBⁱ	PA24555

Polymorphism and mutation databases

BioMutaⁱ	ADAR
DMDMⁱ	313104303

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000171774	1 – 1226	Double-stranded RNA-specific adenosine deaminaseAdd BLAST		1226

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	26	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	285	PhosphoserineBy similarity	1
Cross-linkⁱ	384	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	408	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	418	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	418	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	418	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	481	PhosphoserineCombined sources	1
Cross-linkⁱ	580	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	601	PhosphothreonineCombined sources	1
Modified residueⁱ	603	PhosphothreonineCombined sources	1
Modified residueⁱ	614	PhosphoserineCombined sources	1
Modified residueⁱ	629	PhosphoserineCombined sources	1
Modified residueⁱ	636	PhosphoserineCombined sources	1
Modified residueⁱ	808	PhosphothreonineCombined sources	1
Modified residueⁱ	814	PhosphoserineCombined sources	1
Modified residueⁱ	823	PhosphoserineCombined sources	1
Modified residueⁱ	825	PhosphoserineCombined sources	1
Cross-linkⁱ	875	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Sumoylation reduces RNA-editing activity.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P55265
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P55265
PaxDbⁱ	P55265
PeptideAtlas More...PeptideAtlasⁱ	P55265
PRIDEⁱ	P55265
ProteomicsDBⁱ	56826 56827 [P55265-2] 56828 [P55265-3] 56829 [P55265-4] 56830 [P55265-5]

PTM databases

iPTMnetⁱ	P55265
PhosphoSitePlusⁱ	P55265
SwissPalmⁱ	P55265

Miscellaneous databases

PMAP-CutDBⁱ	P55265

PMAP-CutDBⁱ

P55265

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed, highest levels were found in brain and lung (PubMed:7972084). Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors.2 Publications

Inductionⁱ

Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000160710 Expressed in 237 organ(s), highest expression level in testis
CleanExⁱ	HS_ADAR
ExpressionAtlasⁱ	P55265 baseline and differential
Genevisibleⁱ	P55265 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB056157 HPA003890 HPA051519

HPAⁱ

CAB056157
HPA003890
HPA051519

Interactionⁱ

Subunit structureⁱ

Homodimer. Homodimerization is essential for its catalytic activity (PubMed:12618436). Isoform 5 can form heterodimers with ADARB1/ADAR2. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90 (PubMed:16055709). Binding to ILF3/NF90 up-regulates ILF3-mediated gene expression. Isoform 1 and isoform 5 (via DRBM 3 domain) interact with TNPO1 (PubMed:19124606, PubMed:24753571). Isoform 5 (via DRBM domains) interacts with XPO5 (PubMed:19124606). Isoform 1 and isoform 5 can interact with EIF2AK2/PKR and UPF1 (PubMed:17079286, PubMed:18362360).10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P14340	2	EBI-2462104,EBI-9825968	From Dengue virus type 2 (strain Thailand/NGS-C/1944).
	Q99IB8	3	EBI-2462104,EBI-6858501	From Hepatitis C virus genotype 2a (isolate JFH-1).
DICER1	Q9UPY3	8	EBI-6913210,EBI-395506
NS	P03496	8	EBI-2462104,EBI-2547442	From Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).
TARBP2	Q15633	3	EBI-6913210,EBI-978581
UPF1	Q92900	3	EBI-2462104,EBI-373471

Protein-protein interaction databases

BioGridⁱ	106617, 74 interactors
CORUMⁱ	P55265
Database of interacting proteins More...DIPⁱ	DIP-29310N
IntActⁱ	P55265, 55 interactors
Molecular INTeraction database More...MINTⁱ	P55265
STRINGⁱ	9606.ENSP00000357459

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	127 – 130	Combined sources	4
Helixⁱ	135 – 150	Combined sources	16
Beta strandⁱ	152 – 154	Combined sources	3
Helixⁱ	158 – 165	Combined sources	8
Helixⁱ	169 – 181	Combined sources	13
Beta strandⁱ	184 – 192	Combined sources	9
Beta strandⁱ	194 – 197	Combined sources	4
Helixⁱ	294 – 309	Combined sources	16
Helixⁱ	315 – 322	Combined sources	8
Helixⁱ	324 – 326	Combined sources	3
Helixⁱ	327 – 339	Combined sources	13
Beta strandⁱ	342 – 346	Combined sources	5
Beta strandⁱ	348 – 350	Combined sources	3
Beta strandⁱ	352 – 355	Combined sources	4
Helixⁱ	357 – 360	Combined sources	4
Turnⁱ	361 – 363	Combined sources	3
Helixⁱ	716 – 724	Combined sources	9
Helixⁱ	727 – 738	Combined sources	12
Beta strandⁱ	742 – 749	Combined sources	8
Beta strandⁱ	758 – 764	Combined sources	7
Beta strandⁱ	767 – 776	Combined sources	10
Helixⁱ	777 – 796	Combined sources	20

Show more details

3D structure databases

ProteinModelPortalⁱ	P55265
SMRⁱ	P55265
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P55265

EvolutionaryTraceⁱ

P55265

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	133 – 202	DRADA 1PROSITE-ProRule annotation3 PublicationsAdd BLAST	70
Repeatⁱ	293 – 360	DRADA 2PROSITE-ProRule annotationAdd BLAST	68
Domainⁱ	503 – 571	DRBM 1PROSITE-ProRule annotationAdd BLAST	69
Domainⁱ	614 – 682	DRBM 2PROSITE-ProRule annotationAdd BLAST	69
Domainⁱ	726 – 794	DRBM 3PROSITE-ProRule annotation1 PublicationAdd BLAST	69
Domainⁱ	886 – 1221	A to I editasePROSITE-ProRule annotationAdd BLAST	336

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	133 – 202	Interaction with Z-DNA3 PublicationsAdd BLAST	70
Regionⁱ	716 – 725	N-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal1 Publication	10
Regionⁱ	795 – 801	C-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal1 Publication	7

Domainⁱ

The first DRADA repeat binds Z-DNA.3 Publications

The third dsRNA-binding domain (DRBM 3) contains an additional N-terminal alpha-helix that is part of a bi-partite nuclear localization signal, together with the sequence immediately C-terminal to DRBM 3. The presence of DRBM 3 is important to bring together the N-terminal and the C-terminal part of the bi-partite nuclear localization signal for import mediated by TNPO1 (PubMed:24753571). RNA binding interferes with nuclear import (PubMed:19124606, PubMed:24753571).2 Publications

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG2777 Eukaryota ENOG410XT0Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074412
HOVERGENⁱ	HBG067087
InParanoidⁱ	P55265
KEGG Orthology (KO) More...KOⁱ	K12968
OMAⁱ	DPKFQYC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MZP
PhylomeDBⁱ	P55265
TreeFamⁱ	TF315806

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00048 DSRM, 3 hits
Gene3Dⁱ	1.10.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR002466 A_deamin IPR014720 dsRBD_dom IPR000607 dsRNA_A_deaminase IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02137 A_deamin, 1 hit PF00035 dsrm, 3 hits PF02295 z-alpha, 2 hits
SMARTⁱ	View protein in SMART SM00552 ADEAMc, 1 hit SM00358 DSRM, 3 hits SM00550 Zalpha, 2 hits
SUPFAMⁱ	SSF46785 SSF46785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50141 A_DEAMIN_EDITASE, 1 hit PS50139 DRADA_REPEAT, 2 hits PS50137 DS_RBD, 3 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: P55265-1) [UniParc]FASTA Add to basket

Also known as: ADAR-a, ADAR1L, p150

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ 
        60         70         80         90        100
LPEAPVIGKQ TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLR 
       110        120        130        140        150
SQGLQRGFQH PSPRGRSLPQ RGVDCLSSHF QELSIYQDQE QRILKFLEEL 
       160        170        180        190        200
GEGKATTAHD LSGKLGTPKK EINRVLYSLA KKGKLQKEAG TPPLWKIAVS 
       210        220        230        240        250
TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED LLEPFIAVSA 
       260        270        280        290        300
QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK 
       310        320        330        340        350
EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP 
       360        370        380        390        400
PIWHLTDKKR ERMQIKRNTN SVPETAPAAI PETKRNAEFL TCNIPTSNAS 
       410        420        430        440        450
NNMVTTEKVE NGQEPVIKLE NRQEARPEPA RLKPPVHYNG PSKAGYVDFE 
       460        470        480        490        500
NGQWATDDIP DDLNSIRAAP GEFRAIMEMP SFYSHGLPRC SPYKKLTECQ 
       510        520        530        540        550
LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV INGREFPPAE 
       560        570        580        590        600
AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ 
       610        620        630        640        650
TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV 
       660        670        680        690        700
AVGAQTFPSV SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQPEGMISE 
       710        720        730        740        750
SLDNLESMMP NKVRKIGELV RYLNTNPVGG LLEYARSHGF AAEFKLVDQS 
       760        770        780        790        800
GPPHEPKFVY QAKVGGRWFP AVCAHSKKQG KQEAADAALR VLIGENEKAE 
       810        820        830        840        850
RMGFTEVTPV TGASLRRTML LLSRSPEAQP KTLPLTGSTF HDQIAMLSHR 
       860        870        880        890        900
CFNTLTNSFQ PSLLGRKILA AIIMKKDSED MGVVVSLGTG NRCVKGDSLS 
       910        920        930        940        950
LKGETVNDCH AEIISRRGFI RFLYSELMKY NSQTAKDSIF EPAKGGEKLQ 
       960        970        980        990       1000
IKKTVSFHLY ISTAPCGDGA LFDKSCSDRA MESTESRHYP VFENPKQGKL 
      1010       1020       1030       1040       1050
RTKVENGEGT IPVESSDIVP TWDGIRLGER LRTMSCSDKI LRWNVLGLQG 
      1060       1070       1080       1090       1100
ALLTHFLQPI YLKSVTLGYL FSQGHLTRAI CCRVTRDGSA FEDGLRHPFI 
      1110       1120       1130       1140       1150
VNHPKVGRVS IYDSKRQSGK TKETSVNWCL ADGYDLEILD GTRGTVDGPR 
      1160       1170       1180       1190       1200
NELSRVSKKN IFLLFKKLCS FRYRRDLLRL SYGEAKKAAR DYETAKNYFK 
      1210       1220 
KGLKDMGYGN WISKPQEEKN FYLCPV

Note: Produced by alternative promoter usage.

Length:1,226

Mass (Da):136,066

Last modified:November 30, 2010 - v4

Checksum:ⁱ9CE095D6F9C1BC79

GO

Isoform 2 (identifier: P55265-2) [UniParc]FASTA Add to basket

Also known as: ADAR-b

The sequence of this isoform differs from the canonical sequence as follows:
807-832: Missing.

« Hide

        10         20         30         40         50
MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ 
        60         70         80         90        100
LPEAPVIGKQ TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLR 
       110        120        130        140        150
SQGLQRGFQH PSPRGRSLPQ RGVDCLSSHF QELSIYQDQE QRILKFLEEL 
       160        170        180        190        200
GEGKATTAHD LSGKLGTPKK EINRVLYSLA KKGKLQKEAG TPPLWKIAVS 
       210        220        230        240        250
TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED LLEPFIAVSA 
       260        270        280        290        300
QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK 
       310        320        330        340        350
EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP 
       360        370        380        390        400
PIWHLTDKKR ERMQIKRNTN SVPETAPAAI PETKRNAEFL TCNIPTSNAS 
       410        420        430        440        450
NNMVTTEKVE NGQEPVIKLE NRQEARPEPA RLKPPVHYNG PSKAGYVDFE 
       460        470        480        490        500
NGQWATDDIP DDLNSIRAAP GEFRAIMEMP SFYSHGLPRC SPYKKLTECQ 
       510        520        530        540        550
LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV INGREFPPAE 
       560        570        580        590        600
AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ 
       610        620        630        640        650
TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV 
       660        670        680        690        700
AVGAQTFPSV SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQPEGMISE 
       710        720        730        740        750
SLDNLESMMP NKVRKIGELV RYLNTNPVGG LLEYARSHGF AAEFKLVDQS 
       760        770        780        790        800
GPPHEPKFVY QAKVGGRWFP AVCAHSKKQG KQEAADAALR VLIGENEKAE 
       810        820        830        840        850
RMGFTELPLT GSTFHDQIAM LSHRCFNTLT NSFQPSLLGR KILAAIIMKK 
       860        870        880        890        900
DSEDMGVVVS LGTGNRCVKG DSLSLKGETV NDCHAEIISR RGFIRFLYSE 
       910        920        930        940        950
LMKYNSQTAK DSIFEPAKGG EKLQIKKTVS FHLYISTAPC GDGALFDKSC 
       960        970        980        990       1000
SDRAMESTES RHYPVFENPK QGKLRTKVEN GEGTIPVESS DIVPTWDGIR 
      1010       1020       1030       1040       1050
LGERLRTMSC SDKILRWNVL GLQGALLTHF LQPIYLKSVT LGYLFSQGHL 
      1060       1070       1080       1090       1100
TRAICCRVTR DGSAFEDGLR HPFIVNHPKV GRVSIYDSKR QSGKTKETSV 
      1110       1120       1130       1140       1150
NWCLADGYDL EILDGTRGTV DGPRNELSRV SKKNIFLLFK KLCSFRYRRD 
      1160       1170       1180       1190       1200
LLRLSYGEAK KAARDYETAK NYFKKGLKDM GYGNWISKPQ EEKNFYLCPV

Note: Produced by alternative splicing of isoform 1.

Show »

Length:1,200

Mass (Da):133,274

Checksum:ⁱ4CB1B306DAC584FC

GO

Isoform 3 (identifier: P55265-3) [UniParc]FASTA Add to basket

Also known as: ADAR-c

The sequence of this isoform differs from the canonical sequence as follows:
694-712: Missing.
807-832: Missing.

« Hide

        10         20         30         40         50
MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ 
        60         70         80         90        100
LPEAPVIGKQ TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLR 
       110        120        130        140        150
SQGLQRGFQH PSPRGRSLPQ RGVDCLSSHF QELSIYQDQE QRILKFLEEL 
       160        170        180        190        200
GEGKATTAHD LSGKLGTPKK EINRVLYSLA KKGKLQKEAG TPPLWKIAVS 
       210        220        230        240        250
TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED LLEPFIAVSA 
       260        270        280        290        300
QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK 
       310        320        330        340        350
EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP 
       360        370        380        390        400
PIWHLTDKKR ERMQIKRNTN SVPETAPAAI PETKRNAEFL TCNIPTSNAS 
       410        420        430        440        450
NNMVTTEKVE NGQEPVIKLE NRQEARPEPA RLKPPVHYNG PSKAGYVDFE 
       460        470        480        490        500
NGQWATDDIP DDLNSIRAAP GEFRAIMEMP SFYSHGLPRC SPYKKLTECQ 
       510        520        530        540        550
LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV INGREFPPAE 
       560        570        580        590        600
AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ 
       610        620        630        640        650
TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV 
       660        670        680        690        700
AVGAQTFPSV SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQVRKIGEL 
       710        720        730        740        750
VRYLNTNPVG GLLEYARSHG FAAEFKLVDQ SGPPHEPKFV YQAKVGGRWF 
       760        770        780        790        800
PAVCAHSKKQ GKQEAADAAL RVLIGENEKA ERMGFTELPL TGSTFHDQIA 
       810        820        830        840        850
MLSHRCFNTL TNSFQPSLLG RKILAAIIMK KDSEDMGVVV SLGTGNRCVK 
       860        870        880        890        900
GDSLSLKGET VNDCHAEIIS RRGFIRFLYS ELMKYNSQTA KDSIFEPAKG 
       910        920        930        940        950
GEKLQIKKTV SFHLYISTAP CGDGALFDKS CSDRAMESTE SRHYPVFENP 
       960        970        980        990       1000
KQGKLRTKVE NGEGTIPVES SDIVPTWDGI RLGERLRTMS CSDKILRWNV 
      1010       1020       1030       1040       1050
LGLQGALLTH FLQPIYLKSV TLGYLFSQGH LTRAICCRVT RDGSAFEDGL 
      1060       1070       1080       1090       1100
RHPFIVNHPK VGRVSIYDSK RQSGKTKETS VNWCLADGYD LEILDGTRGT 
      1110       1120       1130       1140       1150
VDGPRNELSR VSKKNIFLLF KKLCSFRYRR DLLRLSYGEA KKAARDYETA 
      1160       1170       1180 
KNYFKKGLKD MGYGNWISKP QEEKNFYLCP V

Note: Produced by alternative splicing of isoform 1.

Show »

Length:1,181

Mass (Da):131,170

Checksum:ⁱ9764C8AB27BE118E

GO

Isoform 4 (identifier: P55265-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-5: MNPRQ → MMSPICDQTIDSRLKVEKATWWGRVGGGSRPHWQPPGVRPCPEEVQDP

« Hide

        10         20         30         40         50
MMSPICDQTI DSRLKVEKAT WWGRVGGGSR PHWQPPGVRP CPEEVQDPGY 
        60         70         80         90        100
SLSGYYTHPF QGYEHRQLRY QQPGPGSSPS SFLLKQIEFL KGQLPEAPVI 
       110        120        130        140        150
GKQTPSLPPS LPGLRPRFPV LLASSTRGRQ VDIRGVPRGV HLRSQGLQRG 
       160        170        180        190        200
FQHPSPRGRS LPQRGVDCLS SHFQELSIYQ DQEQRILKFL EELGEGKATT 
       210        220        230        240        250
AHDLSGKLGT PKKEINRVLY SLAKKGKLQK EAGTPPLWKI AVSTQAWNQH 
       260        270        280        290        300
SGVVRPDGHS QGAPNSDPSL EPEDRNSTSV SEDLLEPFIA VSAQAWNQHS 
       310        320        330        340        350
GVVRPDSHSQ GSPNSDPGLE PEDSNSTSAL EDPLEFLDMA EIKEKICDYL 
       360        370        380        390        400
FNVSDSSALN LAKNIGLTKA RDINAVLIDM ERQGDVYRQG TTPPIWHLTD 
       410        420        430        440        450
KKRERMQIKR NTNSVPETAP AAIPETKRNA EFLTCNIPTS NASNNMVTTE 
       460        470        480        490        500
KVENGQEPVI KLENRQEARP EPARLKPPVH YNGPSKAGYV DFENGQWATD 
       510        520        530        540        550
DIPDDLNSIR AAPGEFRAIM EMPSFYSHGL PRCSPYKKLT ECQLKNPISG 
       560        570        580        590        600
LLEYAQFASQ TCEFNMIEQS GPPHEPRFKF QVVINGREFP PAEAGSKKVA 
       610        620        630        640        650
KQDAAMKAMT ILLEEAKAKD SGKSEESSHY STEKESEKTA ESQTPTPSAT 
       660        670        680        690        700
SFFSGKSPVT TLLECMHKLG NSCEFRLLSK EGPAHEPKFQ YCVAVGAQTF 
       710        720        730        740        750
PSVSAPSKKV AKQMAAEEAM KALHGEATNS MASDNQPEGM ISESLDNLES 
       760        770        780        790        800
MMPNKVRKIG ELVRYLNTNP VGGLLEYARS HGFAAEFKLV DQSGPPHEPK 
       810        820        830        840        850
FVYQAKVGGR WFPAVCAHSK KQGKQEAADA ALRVLIGENE KAERMGFTEV 
       860        870        880        890        900
TPVTGASLRR TMLLLSRSPE AQPKTLPLTG STFHDQIAML SHRCFNTLTN 
       910        920        930        940        950
SFQPSLLGRK ILAAIIMKKD SEDMGVVVSL GTGNRCVKGD SLSLKGETVN 
       960        970        980        990       1000
DCHAEIISRR GFIRFLYSEL MKYNSQTAKD SIFEPAKGGE KLQIKKTVSF 
      1010       1020       1030       1040       1050
HLYISTAPCG DGALFDKSCS DRAMESTESR HYPVFENPKQ GKLRTKVENG 
      1060       1070       1080       1090       1100
EGTIPVESSD IVPTWDGIRL GERLRTMSCS DKILRWNVLG LQGALLTHFL 
      1110       1120       1130       1140       1150
QPIYLKSVTL GYLFSQGHLT RAICCRVTRD GSAFEDGLRH PFIVNHPKVG 
      1160       1170       1180       1190       1200
RVSIYDSKRQ SGKTKETSVN WCLADGYDLE ILDGTRGTVD GPRNELSRVS 
      1210       1220       1230       1240       1250
KKNIFLLFKK LCSFRYRRDL LRLSYGEAKK AARDYETAKN YFKKGLKDMG 
      1260 
YGNWISKPQE EKNFYLCPV

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available. The N-terminus has been derived from EST and genomic sequences.Curated

Show »

Length:1,269

Mass (Da):140,838

Checksum:ⁱBB9B1DF19B8D3BC8

GO

Isoform 5 (identifier: P55265-5) [UniParc]FASTA Add to basket

Also known as: ADAR1S, p110

The sequence of this isoform differs from the canonical sequence as follows:
1-295: Missing.

« Hide

        10         20         30         40         50
MAEIKEKICD YLFNVSDSSA LNLAKNIGLT KARDINAVLI DMERQGDVYR 
        60         70         80         90        100
QGTTPPIWHL TDKKRERMQI KRNTNSVPET APAAIPETKR NAEFLTCNIP 
       110        120        130        140        150
TSNASNNMVT TEKVENGQEP VIKLENRQEA RPEPARLKPP VHYNGPSKAG 
       160        170        180        190        200
YVDFENGQWA TDDIPDDLNS IRAAPGEFRA IMEMPSFYSH GLPRCSPYKK 
       210        220        230        240        250
LTECQLKNPI SGLLEYAQFA SQTCEFNMIE QSGPPHEPRF KFQVVINGRE 
       260        270        280        290        300
FPPAEAGSKK VAKQDAAMKA MTILLEEAKA KDSGKSEESS HYSTEKESEK 
       310        320        330        340        350
TAESQTPTPS ATSFFSGKSP VTTLLECMHK LGNSCEFRLL SKEGPAHEPK 
       360        370        380        390        400
FQYCVAVGAQ TFPSVSAPSK KVAKQMAAEE AMKALHGEAT NSMASDNQPE 
       410        420        430        440        450
GMISESLDNL ESMMPNKVRK IGELVRYLNT NPVGGLLEYA RSHGFAAEFK 
       460        470        480        490        500
LVDQSGPPHE PKFVYQAKVG GRWFPAVCAH SKKQGKQEAA DAALRVLIGE 
       510        520        530        540        550
NEKAERMGFT EVTPVTGASL RRTMLLLSRS PEAQPKTLPL TGSTFHDQIA 
       560        570        580        590        600
MLSHRCFNTL TNSFQPSLLG RKILAAIIMK KDSEDMGVVV SLGTGNRCVK 
       610        620        630        640        650
GDSLSLKGET VNDCHAEIIS RRGFIRFLYS ELMKYNSQTA KDSIFEPAKG 
       660        670        680        690        700
GEKLQIKKTV SFHLYISTAP CGDGALFDKS CSDRAMESTE SRHYPVFENP 
       710        720        730        740        750
KQGKLRTKVE NGEGTIPVES SDIVPTWDGI RLGERLRTMS CSDKILRWNV 
       760        770        780        790        800
LGLQGALLTH FLQPIYLKSV TLGYLFSQGH LTRAICCRVT RDGSAFEDGL 
       810        820        830        840        850
RHPFIVNHPK VGRVSIYDSK RQSGKTKETS VNWCLADGYD LEILDGTRGT 
       860        870        880        890        900
VDGPRNELSR VSKKNIFLLF KKLCSFRYRR DLLRLSYGEA KKAARDYETA 
       910        920        930 
KNYFKKGLKD MGYGNWISKP QEEKNFYLCP V

Note: Produced by alternative promoter usage.

Show »

Length:931

Mass (Da):103,642

Checksum:ⁱ113B63CF165097FC

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	H0YCK3	H0YCK3_HUMAN		Double-stranded RNA-specific adenos... Double-stranded RNA-specific adenosine deaminase	ADAR	1,195	Annotation score:

Sequence cautionⁱ

The sequence CAE45853 differs from that shown. Reason: Erroneous termination at position 1227. Translated as stop.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	53	E → G in CAA55968 (Ref. 4) Curated	1
Sequence conflictⁱ	245	F → L in CAE45853 (PubMed:17974005).Curated	1
Sequence conflictⁱ	482	F → L in CAE45853 (PubMed:17974005).Curated	1
Sequence conflictⁱ	873	I → V in CAE45853 (PubMed:17974005).Curated	1
Sequence conflictⁱ	1093	D → G in CAE45853 (PubMed:17974005).Curated	1
Sequence conflictⁱ	1184	E → K in CAA55967 (Ref. 4) Curated	1
Sequence conflictⁱ	1184	E → K in CAA55968 (Ref. 4) Curated	1
Sequence conflictⁱ	1184	E → K in CAA67169 (Ref. 4) Curated	1
Sequence conflictⁱ	1184	E → K in CAA67170 (Ref. 4) Curated	1
Isoform 4 (identifier: P55265-4)
Sequence conflictⁱ	13	R → G in CAE45853 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048725	100	R → G6 PublicationsCorresponds to variant dbSNP:rs1466731Ensembl.	1
Natural variantⁱVAR_069535	193	P → A in AGS6. 1 PublicationCorresponds to variant dbSNP:rs145588689EnsemblClinVar.	1
Natural variantⁱVAR_017240	384	K → R4 PublicationsCorresponds to variant dbSNP:rs2229857EnsemblClinVar.	1
Natural variantⁱVAR_024407	587	Y → C. Corresponds to variant dbSNP:rs17843865EnsemblClinVar.	1
Natural variantⁱVAR_035805	806	E → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs144119808Ensembl.	1
Natural variantⁱVAR_069536	870	A → T in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122893EnsemblClinVar.	1
Natural variantⁱVAR_069537	872	I → T in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122897EnsemblClinVar.	1
Natural variantⁱVAR_069538	892	R → H in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122892EnsemblClinVar.	1
Natural variantⁱVAR_017604	923	L → P in DSH. 1 PublicationCorresponds to variant dbSNP:rs28936680Ensembl.	1
Natural variantⁱVAR_021729	966	C → F in DSH. 1 Publication	1
Natural variantⁱVAR_069539	999	K → N in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122896EnsemblClinVar.	1
Natural variantⁱVAR_069540	1007	G → R in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122822EnsemblClinVar.	1
Natural variantⁱVAR_069541	1112	Y → F in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122895EnsemblClinVar.	1
Natural variantⁱVAR_069542	1113	D → H in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122894EnsemblClinVar.	1
Natural variantⁱVAR_026669	1155	R → W in DSH. 1 PublicationCorresponds to variant dbSNP:rs1044845711Ensembl.	1
Natural variantⁱVAR_017605	1165	F → S in DSH. 1 PublicationCorresponds to variant dbSNP:rs28936681Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_019235	1 – 295	Missing in isoform 5. 1 PublicationAdd BLAST	295
Alternative sequenceⁱVSP_008872	1 – 5	MNPRQ → MMSPICDQTIDSRLKVEKAT WWGRVGGGSRPHWQPPGVRP CPEEVQDP in isoform 4. 1 Publication	5
Alternative sequenceⁱVSP_008873	694 – 712	Missing in isoform 3. CuratedAdd BLAST	19
Alternative sequenceⁱVSP_008874	807 – 832	Missing in isoform 2 and isoform 3. CuratedAdd BLAST	26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U10439 mRNA Translation: AAB06697.1 U75503 U75502 Genomic DNA Translation: AAB97116.1 U75503 U75502 Genomic DNA Translation: AAB97117.1 U75503 U75502 Genomic DNA Translation: AAB97118.1 U18121 mRNA Translation: AAC13782.1 X79448 mRNA Translation: CAA55967.1 X79449 mRNA Translation: CAA55968.1 X98559 mRNA Translation: CAA67169.1 X98559 mRNA Translation: CAA67170.1 BX538232 mRNA Translation: CAD98075.1 BX640741 mRNA Translation: CAE45853.1 Sequence problems. AL592078 Genomic DNA No translation available. AL606500 Genomic DNA No translation available. AL691488 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53183.1 CH471121 Genomic DNA Translation: EAW53187.1 BC038227 mRNA Translation: AAH38227.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1071.1 [P55265-1] CCDS30879.1 [P55265-5]
PIRⁱ	S65593
NCBI Reference Sequences More...RefSeqⁱ	NP_001020278.1, NM_001025107.2 [P55265-5] NP_001102.2, NM_001111.4 [P55265-1] NP_001180424.1, NM_001193495.1 [P55265-5] NP_056655.2, NM_015840.3 NP_056656.2, NM_015841.3 XP_006711174.1, XM_006711111.3 [P55265-5] XP_006711175.1, XM_006711112.2 [P55265-5] XP_006711176.1, XM_006711113.2 [P55265-5]
UniGeneⁱ	Hs.12341

Genome annotation databases

Ensemblⁱ	ENST00000368471; ENSP00000357456; ENSG00000160710 [P55265-5] ENST00000368474; ENSP00000357459; ENSG00000160710 [P55265-1]
GeneIDⁱ	103
KEGGⁱ	hsa:103
UCSC genome browser More...UCSCⁱ	uc001ffh.4 human [P55265-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P55265	Uncharacterized protein		MACMU		1269	UniRef90_P55265
Isoform 4 of Double-stranded RNA-specific adenosine deaminase		HUMAN		1269
Uncharacterized protein		MACFA		1268
Adenosine deaminase, RNA specific		RHIRO		1241
Adenosine deaminase, RNA specific		PAPAN		1232
+49
P55265-2	Double-stranded RNA-specific adenosine deaminase (Fragment)		HUMAN		1195	UniRef90_P55265-2
ADAR isoform 7 (Fragment)		PANTR		1195
ADAR isoform 4 (Fragment)		PONAB		1195
UPI0003ABB85D		MACFA		1242
UPI00045D9D0C		CHLSB		1209
+15
P55265-3	Isoform 2 of Double-stranded RNA-specific adenosine deaminase		HUMAN		1200	UniRef90_P55265-2
ADAR isoform 7 (Fragment)		PANTR		1195
ADAR isoform 4 (Fragment)		PONAB		1195
UPI0003ABB85D		MACFA		1242
UPI00045D9D0C		CHLSB		1209
+15

Protein	Similar proteins		Species	Score	Length	Source
P55265	Double-stranded RNA-specific adenosine deaminase		MOUSE		1178	UniRef50_P55265
Double-stranded RNA-specific adenosine deaminase		RAT		1175
Uncharacterized protein		MACMU		1269
Isoform 4 of Double-stranded RNA-specific adenosine deaminase		HUMAN		1269
Uncharacterized protein		MACFA		1268
+246
P55265-2	Double-stranded RNA-specific adenosine deaminase (Fragment)		HUMAN		1195	UniRef50_P55265-2
ADAR isoform 7 (Fragment)		PANTR		1195
ADAR isoform 4 (Fragment)		PONAB		1195
Double-stranded RNA-specific adenosine deaminase		MYOBR		1179
double-stranded RNA-specific adenosine deaminase isoform X3		NEOSC		1132
+44
P55265-3	Isoform 2 of Double-stranded RNA-specific adenosine deaminase		HUMAN		1200	UniRef50_P55265-2
ADAR isoform 7 (Fragment)		PANTR		1195
ADAR isoform 4 (Fragment)		PONAB		1195
Double-stranded RNA-specific adenosine deaminase		MYOBR		1179
double-stranded RNA-specific adenosine deaminase isoform X3		NEOSC		1132
+44

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U10439 mRNA Translation: AAB06697.1 U75503 U75502 Genomic DNA Translation: AAB97116.1 U75503 U75502 Genomic DNA Translation: AAB97117.1 U75503 U75502 Genomic DNA Translation: AAB97118.1 U18121 mRNA Translation: AAC13782.1 X79448 mRNA Translation: CAA55967.1 X79449 mRNA Translation: CAA55968.1 X98559 mRNA Translation: CAA67169.1 X98559 mRNA Translation: CAA67170.1 BX538232 mRNA Translation: CAD98075.1 BX640741 mRNA Translation: CAE45853.1 Sequence problems. AL592078 Genomic DNA No translation available. AL606500 Genomic DNA No translation available. AL691488 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53183.1 CH471121 Genomic DNA Translation: EAW53187.1 BC038227 mRNA Translation: AAH38227.1
CCDSⁱ	CCDS1071.1 [P55265-1] CCDS30879.1 [P55265-5]
PIRⁱ	S65593
RefSeqⁱ	NP_001020278.1, NM_001025107.2 [P55265-5] NP_001102.2, NM_001111.4 [P55265-1] NP_001180424.1, NM_001193495.1 [P55265-5] NP_056655.2, NM_015840.3 NP_056656.2, NM_015841.3 XP_006711174.1, XM_006711111.3 [P55265-5] XP_006711175.1, XM_006711112.2 [P55265-5] XP_006711176.1, XM_006711113.2 [P55265-5]
UniGeneⁱ	Hs.12341

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1QBJ	X-ray	2.10	A/B/C	133-209	[»]
	1QGP	NMR	-	A	125-200	[»]
	1XMK	X-ray	0.97	A	294-366	[»]
	2ACJ	X-ray	2.60	A/B/C/D	140-202	[»]
	2GXB	X-ray	2.25	A/B	140-202	[»]
	2L54	NMR	-	A	136-198	[»]
	2MDR	NMR	-	A	708-801	[»]
	3F21	X-ray	2.20	A/B/C	133-209	[»]
	3F22	X-ray	2.50	A/B/C	133-209	[»]
	3F23	X-ray	2.70	A/B/C	133-209	[»]
	3IRQ	X-ray	2.80	A/B/C/D	140-202	[»]
	3IRR	X-ray	2.65	A/B/C/D	140-202	[»]
ProteinModelPortalⁱ	P55265
SMRⁱ	P55265
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106617, 74 interactors
CORUMⁱ	P55265
DIPⁱ	DIP-29310N
IntActⁱ	P55265, 55 interactors
MINTⁱ	P55265
STRINGⁱ	9606.ENSP00000357459

PTM databases

iPTMnetⁱ	P55265
PhosphoSitePlusⁱ	P55265
SwissPalmⁱ	P55265

Polymorphism and mutation databases

BioMutaⁱ	ADAR
DMDMⁱ	313104303

Proteomic databases

EPDⁱ	P55265
MaxQBⁱ	P55265
PaxDbⁱ	P55265
PeptideAtlasⁱ	P55265
PRIDEⁱ	P55265
ProteomicsDBⁱ	56826 56827 [P55265-2] 56828 [P55265-3] 56829 [P55265-4] 56830 [P55265-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	103
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368471; ENSP00000357456; ENSG00000160710 [P55265-5] ENST00000368474; ENSP00000357459; ENSG00000160710 [P55265-1]
GeneIDⁱ	103
KEGGⁱ	hsa:103
UCSCⁱ	uc001ffh.4 human [P55265-1]

Organism-specific databases

CTDⁱ	103
DisGeNETⁱ	103
EuPathDBⁱ	HostDB:ENSG00000160710.15
GeneCardsⁱ	ADAR
HGNCⁱ	HGNC:225 ADAR
HPAⁱ	CAB056157 HPA003890 HPA051519
MalaCardsⁱ	ADAR
MIMⁱ	127400 phenotype 146920 gene 615010 phenotype
neXtProtⁱ	NX_P55265
OpenTargetsⁱ	ENSG00000160710
Orphanetⁱ	51 Aicardi-Goutieres syndrome 41 Dyschromatosis symmetrica hereditaria 225154 Familial infantile bilateral striatal necrosis
PharmGKBⁱ	PA24555
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2777 Eukaryota ENOG410XT0Z LUCA
GeneTreeⁱ	ENSGT00550000074412
HOVERGENⁱ	HBG067087
InParanoidⁱ	P55265
KOⁱ	K12968
OMAⁱ	DPKFQYC
OrthoDBⁱ	EOG091G0MZP
PhylomeDBⁱ	P55265
TreeFamⁱ	TF315806

Enzyme and pathway databases

BRENDAⁱ	3.5.4.37 2681
Reactomeⁱ	R-HSA-75102 C6 deamination of adenosine R-HSA-77042 Formation of editosomes by ADAR proteins R-HSA-909733 Interferon alpha/beta signaling

Miscellaneous databases

ChiTaRSⁱ	ADAR human
EvolutionaryTraceⁱ	P55265
GeneWikiⁱ	ADAR
GenomeRNAiⁱ	103
PMAP-CutDBⁱ	P55265
Protein Ontology More...PROⁱ	PR:P55265
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160710 Expressed in 237 organ(s), highest expression level in testis
CleanExⁱ	HS_ADAR
ExpressionAtlasⁱ	P55265 baseline and differential
Genevisibleⁱ	P55265 HS

Family and domain databases

CDDⁱ	cd00048 DSRM, 3 hits
Gene3Dⁱ	1.10.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR002466 A_deamin IPR014720 dsRBD_dom IPR000607 dsRNA_A_deaminase IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF02137 A_deamin, 1 hit PF00035 dsrm, 3 hits PF02295 z-alpha, 2 hits
SMARTⁱ	View protein in SMART SM00552 ADEAMc, 1 hit SM00358 DSRM, 3 hits SM00550 Zalpha, 2 hits
SUPFAMⁱ	SSF46785 SSF46785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50141 A_DEAMIN_EDITASE, 1 hit PS50139 DRADA_REPEAT, 2 hits PS50137 DS_RBD, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DSRAD_HUMAN
Accessionⁱ	P55265Primary (citable) accession number: P55265 Secondary accession number(s): B1AQQ9 Q9BYM4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 30, 2010
	Last modified:	September 12, 2018
	This is version 198 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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UniProtKB - P55265 (DSRAD_HUMAN)

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Double-stranded RNA-specific adenosine deaminase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

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Nucleus

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Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ