UniProtKB - P55265 (DSRAD_HUMAN)
Double-stranded RNA-specific adenosine deaminase
ADAR
Functioni
Caution
Catalytic activityi
- EC:3.5.4.373 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 910 | ZincPROSITE-ProRule annotation | 1 | |
Active sitei | 912 | Proton donorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 966 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 1036 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- double-stranded RNA adenosine deaminase activity Source: MGI
- double-stranded RNA binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- tRNA-specific adenosine deaminase activity Source: GO_Central
GO - Biological processi
- adenosine to inosine editing Source: UniProtKB
- base conversion or substitution editing Source: MGI
- cellular response to virus Source: Ensembl
- defense response to virus Source: UniProtKB-KW
- definitive hemopoiesis Source: Ensembl
- erythrocyte differentiation Source: Ensembl
- hematopoietic progenitor cell differentiation Source: Ensembl
- hematopoietic stem cell homeostasis Source: Ensembl
- innate immune response Source: UniProtKB
- miRNA loading onto RISC involved in gene silencing by miRNA Source: MGI
- mRNA processing Source: UniProtKB-KW
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProtKB
- negative regulation of RNA interference Source: Ensembl
- negative regulation of type I interferon-mediated signaling pathway Source: Ensembl
- osteoblast differentiation Source: Ensembl
- positive regulation of viral genome replication Source: UniProtKB
- pre-miRNA processing Source: MGI
- protein export from nucleus Source: UniProtKB
- protein import into nucleus Source: UniProtKB
- response to interferon-alpha Source: UniProtKB
- response to virus Source: UniProtKB
- RNA processing Source: GO_Central
- somatic diversification of immune receptors via somatic mutation Source: Ensembl
- type I interferon signaling pathway Source: Reactome
Keywordsi
Molecular function | DNA-binding, Hydrolase, RNA-binding |
Biological process | Antiviral defense, Immunity, Innate immunity, mRNA processing, RNA-mediated gene silencing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 3.5.4.37, 2681 |
PathwayCommonsi | P55265 |
Reactomei | R-HSA-75102, C6 deamination of adenosine R-HSA-77042, Formation of editosomes by ADAR proteins R-HSA-909733, Interferon alpha/beta signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Double-stranded RNA-specific adenosine deaminase (EC:3.5.4.372 Publications)Short name: DRADA1 Publication Alternative name(s): 136 kDa double-stranded RNA-binding protein Short name: p136 Interferon-inducible protein 4 Short name: IFI-4 K88DSRBP |
Gene namesi | Name:ADAR Synonyms:ADAR1, DSRAD, G1P1, IFI4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:225, ADAR |
MIMi | 146920, gene |
neXtProti | NX_P55265 |
VEuPathDBi | HostDB:ENSG00000160710.15 |
Subcellular locationi
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- supraspliceosomal complex Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Dyschromatosis symmetrica hereditaria (DSH)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017604 | 923 | L → P in DSH. 1 PublicationCorresponds to variant dbSNP:rs28936680EnsemblClinVar. | 1 | |
Natural variantiVAR_021729 | 966 | C → F in DSH. 1 Publication | 1 | |
Natural variantiVAR_026669 | 1155 | R → W in DSH. 1 PublicationCorresponds to variant dbSNP:rs1044845711Ensembl. | 1 | |
Natural variantiVAR_017605 | 1165 | F → S in DSH. 1 PublicationCorresponds to variant dbSNP:rs28936681EnsemblClinVar. | 1 |
Aicardi-Goutieres syndrome 6 (AGS6)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069535 | 193 | P → A in AGS6. 1 PublicationCorresponds to variant dbSNP:rs145588689EnsemblClinVar. | 1 | |
Natural variantiVAR_069536 | 870 | A → T in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122893EnsemblClinVar. | 1 | |
Natural variantiVAR_069537 | 872 | I → T in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122897EnsemblClinVar. | 1 | |
Natural variantiVAR_069538 | 892 | R → H in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122892EnsemblClinVar. | 1 | |
Natural variantiVAR_069539 | 999 | K → N in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122896EnsemblClinVar. | 1 | |
Natural variantiVAR_069540 | 1007 | G → R in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122822EnsemblClinVar. | 1 | |
Natural variantiVAR_069541 | 1112 | Y → F in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122895EnsemblClinVar. | 1 | |
Natural variantiVAR_069542 | 1113 | D → H in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122894EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 418 | K → R: Abolishes sumoylation. 1 Publication | 1 | |
Mutagenesisi | 708 – 801 | Missing : Abolishes nuclear location. 1 PublicationAdd BLAST | 94 | |
Mutagenesisi | 708 – 710 | MMP → AMA: Decreased nuclear and partially cytoplasmic location. 1 Publication | 3 | |
Mutagenesisi | 712 – 715 | KVRK → AVAA: No effect on nuclear location. No effect on RNA binding. 1 Publication | 4 | |
Mutagenesisi | 716 – 724 | Missing : Disrupts the bi-partite nuclear localization signal and abolishes nuclear location. 1 Publication | 9 | |
Mutagenesisi | 716 | I → N: Disrupts the bi-partite nuclear localization signal and abolishes nuclear location; when associated with S-719 and N-723. 1 Publication | 1 | |
Mutagenesisi | 718 | E → A: No effect on nuclear location; when associated with A-721 and A-724. 1 Publication | 1 | |
Mutagenesisi | 719 | L → S: Disrupts the bi-partite nuclear localization signal and abolishes nuclear location; when associated with N-716 and N-723. 1 Publication | 1 | |
Mutagenesisi | 721 | R → A: No effect on nuclear location; when associated with A-721 and A-724. 1 Publication | 1 | |
Mutagenesisi | 723 | L → N: Disrupts the bi-partite nuclear localization signal and abolishes nuclear location; when associated with N-716 and S-719. 1 Publication | 1 | |
Mutagenesisi | 724 | N → A: No effect on nuclear location; when associated with A-718 and A-721. 1 Publication | 1 | |
Mutagenesisi | 725 – 801 | Missing : Disrupts nuclear localization signal. No effect on RNA binding. 1 PublicationAdd BLAST | 77 | |
Mutagenesisi | 777 – 778 | KK → AA: Strongly impaired RNA binding. No effect on nuclear location. 1 Publication | 2 | |
Mutagenesisi | 801 | R → A: Abolishes interaction with TNPO1, TNPO1-mediated nuclear import and nuclear location. 1 Publication | 1 |
Keywords - Diseasei
Aicardi-Goutieres syndrome, Disease variantOrganism-specific databases
DisGeNETi | 103 |
GeneReviewsi | ADAR |
MalaCardsi | ADAR |
MIMi | 127400, phenotype 615010, phenotype |
OpenTargetsi | ENSG00000160710 |
Orphaneti | 51, Aicardi-Goutieres syndrome 41, Dyschromatosis symmetrica hereditaria 225154, Familial infantile bilateral striatal necrosis |
PharmGKBi | PA24555 |
Miscellaneous databases
Pharosi | P55265, Tbio |
Genetic variation databases
BioMutai | ADAR |
DMDMi | 313104303 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171774 | 1 – 1226 | Double-stranded RNA-specific adenosine deaminaseAdd BLAST | 1226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 26 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 285 | PhosphoserineBy similarity | 1 | |
Cross-linki | 384 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 408 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 418 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate | ||
Cross-linki | 418 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 418 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 481 | PhosphoserineCombined sources | 1 | |
Cross-linki | 580 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 601 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 603 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 614 | PhosphoserineCombined sources | 1 | |
Modified residuei | 629 | PhosphoserineCombined sources | 1 | |
Modified residuei | 636 | PhosphoserineCombined sources | 1 | |
Modified residuei | 808 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 814 | PhosphoserineCombined sources | 1 | |
Modified residuei | 823 | PhosphoserineCombined sources | 1 | |
Modified residuei | 825 | PhosphoserineCombined sources | 1 | |
Cross-linki | 875 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P55265 |
jPOSTi | P55265 |
MassIVEi | P55265 |
MaxQBi | P55265 |
PaxDbi | P55265 |
PeptideAtlasi | P55265 |
PRIDEi | P55265 |
ProteomicsDBi | 56826 [P55265-1] 56827 [P55265-2] 56828 [P55265-3] 56829 [P55265-4] 56830 [P55265-5] |
PTM databases
GlyGeni | P55265, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P55265 |
MetOSitei | P55265 |
PhosphoSitePlusi | P55265 |
SwissPalmi | P55265 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000160710, Expressed in testis and 248 other tissues |
ExpressionAtlasi | P55265, baseline and differential |
Genevisiblei | P55265, HS |
Organism-specific databases
HPAi | ENSG00000160710, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Homodimerization is essential for its catalytic activity (PubMed:12618436). Isoform 5 can form heterodimers with ADARB1/ADAR2.
Isoform 1 interacts with ILF2/NF45 and ILF3/NF90 (PubMed:16055709). Binding to ILF3/NF90 up-regulates ILF3-mediated gene expression. Isoform 1 and isoform 5 (via DRBM 3 domain) interact with TNPO1 (PubMed:19124606, PubMed:24753571). Isoform 5 (via DRBM domains) interacts with XPO5 (PubMed:19124606). Isoform 1 and isoform 5 can interact with EIF2AK2/PKR and UPF1 (PubMed:17079286, PubMed:18362360).
10 PublicationsBinary interactionsi
Hide detailsP55265
Isoform 1 [P55265-1]
With | #Exp. | IntAct |
---|---|---|
DICER1 [Q9UPY3] | 4 | EBI-6913056,EBI-395506 |
TARBP2 [Q15633] | 2 | EBI-6913056,EBI-978581 |
Isoform 5 [P55265-5]
With | #Exp. | IntAct |
---|---|---|
DICER1 [Q9UPY3] | 8 | EBI-6913210,EBI-395506 |
TARBP2 [Q15633] | 3 | EBI-6913210,EBI-978581 |
Protein-protein interaction databases
BioGRIDi | 106617, 125 interactors |
CORUMi | P55265 |
DIPi | DIP-29310N |
IntActi | P55265, 68 interactors |
MINTi | P55265 |
STRINGi | 9606.ENSP00000357459 |
Miscellaneous databases
RNActi | P55265, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P55265 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P55265 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 199 | Z-binding 1PROSITE-ProRule annotation3 PublicationsAdd BLAST | 67 | |
Domaini | 293 – 357 | Z-binding 2PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 503 – 571 | DRBM 1PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 614 – 682 | DRBM 2PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 726 – 794 | DRBM 3PROSITE-ProRule annotation1 PublicationAdd BLAST | 69 | |
Domaini | 886 – 1221 | A to I editasePROSITE-ProRule annotationAdd BLAST | 336 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 133 – 202 | Interaction with Z-DNA3 PublicationsAdd BLAST | 70 | |
Regioni | 716 – 725 | N-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal1 Publication | 10 | |
Regioni | 795 – 801 | C-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal1 Publication | 7 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2777, Eukaryota |
GeneTreei | ENSGT00940000157243 |
HOGENOMi | CLU_005382_0_0_1 |
InParanoidi | P55265 |
OMAi | KRERMQM |
OrthoDBi | 947117at2759 |
PhylomeDBi | P55265 |
TreeFami | TF315806 |
Family and domain databases
CDDi | cd19913, DSRM_DRADA_rpt1, 1 hit cd19915, DSRM_DRADA_rpt3, 1 hit |
Gene3Di | 1.10.10.10, 2 hits |
InterProi | View protein in InterPro IPR002466, A_deamin IPR044456, ADAR1_DSRM_1 IPR044457, ADAR1_DSRM_3 IPR014720, dsRBD_dom IPR000607, dsRNA_A_deaminase_rpt IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf IPR042371, Zalpha_dom |
Pfami | View protein in Pfam PF02137, A_deamin, 1 hit PF00035, dsrm, 3 hits PF02295, z-alpha, 2 hits |
SMARTi | View protein in SMART SM00552, ADEAMc, 1 hit SM00358, DSRM, 3 hits SM00550, Zalpha, 2 hits |
SUPFAMi | SSF46785, SSF46785, 2 hits |
PROSITEi | View protein in PROSITE PS50141, A_DEAMIN_EDITASE, 1 hit PS50137, DS_RBD, 3 hits PS50139, Z_BINDING, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ
60 70 80 90 100
LPEAPVIGKQ TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLR
110 120 130 140 150
SQGLQRGFQH PSPRGRSLPQ RGVDCLSSHF QELSIYQDQE QRILKFLEEL
160 170 180 190 200
GEGKATTAHD LSGKLGTPKK EINRVLYSLA KKGKLQKEAG TPPLWKIAVS
210 220 230 240 250
TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED LLEPFIAVSA
260 270 280 290 300
QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK
310 320 330 340 350
EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP
360 370 380 390 400
PIWHLTDKKR ERMQIKRNTN SVPETAPAAI PETKRNAEFL TCNIPTSNAS
410 420 430 440 450
NNMVTTEKVE NGQEPVIKLE NRQEARPEPA RLKPPVHYNG PSKAGYVDFE
460 470 480 490 500
NGQWATDDIP DDLNSIRAAP GEFRAIMEMP SFYSHGLPRC SPYKKLTECQ
510 520 530 540 550
LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV INGREFPPAE
560 570 580 590 600
AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ
610 620 630 640 650
TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV
660 670 680 690 700
AVGAQTFPSV SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQPEGMISE
710 720 730 740 750
SLDNLESMMP NKVRKIGELV RYLNTNPVGG LLEYARSHGF AAEFKLVDQS
760 770 780 790 800
GPPHEPKFVY QAKVGGRWFP AVCAHSKKQG KQEAADAALR VLIGENEKAE
810 820 830 840 850
RMGFTEVTPV TGASLRRTML LLSRSPEAQP KTLPLTGSTF HDQIAMLSHR
860 870 880 890 900
CFNTLTNSFQ PSLLGRKILA AIIMKKDSED MGVVVSLGTG NRCVKGDSLS
910 920 930 940 950
LKGETVNDCH AEIISRRGFI RFLYSELMKY NSQTAKDSIF EPAKGGEKLQ
960 970 980 990 1000
IKKTVSFHLY ISTAPCGDGA LFDKSCSDRA MESTESRHYP VFENPKQGKL
1010 1020 1030 1040 1050
RTKVENGEGT IPVESSDIVP TWDGIRLGER LRTMSCSDKI LRWNVLGLQG
1060 1070 1080 1090 1100
ALLTHFLQPI YLKSVTLGYL FSQGHLTRAI CCRVTRDGSA FEDGLRHPFI
1110 1120 1130 1140 1150
VNHPKVGRVS IYDSKRQSGK TKETSVNWCL ADGYDLEILD GTRGTVDGPR
1160 1170 1180 1190 1200
NELSRVSKKN IFLLFKKLCS FRYRRDLLRL SYGEAKKAAR DYETAKNYFK
1210 1220
KGLKDMGYGN WISKPQEEKN FYLCPV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IRQ9 | A0A3B3IRQ9_HUMAN | Double-stranded RNA-specific adenos... | ADAR | 1,158 | Annotation score: | ||
A0A3B3ITG9 | A0A3B3ITG9_HUMAN | Double-stranded RNA-specific adenos... | ADAR | 350 | Annotation score: | ||
A0A3B3ISX1 | A0A3B3ISX1_HUMAN | Double-stranded RNA-specific adenos... | ADAR | 707 | Annotation score: | ||
A0A3B3ISU1 | A0A3B3ISU1_HUMAN | Double-stranded RNA-specific adenos... | ADAR | 164 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 53 | E → G in CAA55968 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 245 | F → L in CAE45853 (PubMed:17974005).Curated | 1 | ||
Sequence conflicti | 482 | F → L in CAE45853 (PubMed:17974005).Curated | 1 | ||
Sequence conflicti | 873 | I → V in CAE45853 (PubMed:17974005).Curated | 1 | ||
Sequence conflicti | 1093 | D → G in CAE45853 (PubMed:17974005).Curated | 1 | ||
Sequence conflicti | 1184 | E → K in CAA55967 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 1184 | E → K in CAA55968 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 1184 | E → K in CAA67169 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 1184 | E → K in CAA67170 (Ref. 4) Curated | 1 | ||
Isoform 4 (identifier: P55265-4) | |||||
Sequence conflicti | 13 | R → G in CAE45853 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048725 | 100 | R → G6 PublicationsCorresponds to variant dbSNP:rs1466731EnsemblClinVar. | 1 | |
Natural variantiVAR_069535 | 193 | P → A in AGS6. 1 PublicationCorresponds to variant dbSNP:rs145588689EnsemblClinVar. | 1 | |
Natural variantiVAR_017240 | 384 | K → R4 PublicationsCorresponds to variant dbSNP:rs2229857EnsemblClinVar. | 1 | |
Natural variantiVAR_024407 | 587 | Y → C. Corresponds to variant dbSNP:rs17843865EnsemblClinVar. | 1 | |
Natural variantiVAR_035805 | 806 | E → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs144119808Ensembl. | 1 | |
Natural variantiVAR_069536 | 870 | A → T in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122893EnsemblClinVar. | 1 | |
Natural variantiVAR_069537 | 872 | I → T in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122897EnsemblClinVar. | 1 | |
Natural variantiVAR_069538 | 892 | R → H in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122892EnsemblClinVar. | 1 | |
Natural variantiVAR_017604 | 923 | L → P in DSH. 1 PublicationCorresponds to variant dbSNP:rs28936680EnsemblClinVar. | 1 | |
Natural variantiVAR_021729 | 966 | C → F in DSH. 1 Publication | 1 | |
Natural variantiVAR_069539 | 999 | K → N in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122896EnsemblClinVar. | 1 | |
Natural variantiVAR_069540 | 1007 | G → R in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122822EnsemblClinVar. | 1 | |
Natural variantiVAR_069541 | 1112 | Y → F in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122895EnsemblClinVar. | 1 | |
Natural variantiVAR_069542 | 1113 | D → H in AGS6. 1 PublicationCorresponds to variant dbSNP:rs398122894EnsemblClinVar. | 1 | |
Natural variantiVAR_026669 | 1155 | R → W in DSH. 1 PublicationCorresponds to variant dbSNP:rs1044845711Ensembl. | 1 | |
Natural variantiVAR_017605 | 1165 | F → S in DSH. 1 PublicationCorresponds to variant dbSNP:rs28936681EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019235 | 1 – 295 | Missing in isoform 5. 1 PublicationAdd BLAST | 295 | |
Alternative sequenceiVSP_008872 | 1 – 5 | MNPRQ → MMSPICDQTIDSRLKVEKAT WWGRVGGGSRPHWQPPGVRP CPEEVQDP in isoform 4. 1 Publication | 5 | |
Alternative sequenceiVSP_008873 | 694 – 712 | Missing in isoform 3. CuratedAdd BLAST | 19 | |
Alternative sequenceiVSP_008874 | 807 – 832 | Missing in isoform 2 and isoform 3. CuratedAdd BLAST | 26 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QBJ | X-ray | 2.10 | A/B/C | 133-209 | [»] | |
1QGP | NMR | - | A | 125-200 | [»] | |
1XMK | X-ray | 0.97 | A | 294-366 | [»] | |
2ACJ | X-ray | 2.60 | A/B/C/D | 140-202 | [»] | |
2GXB | X-ray | 2.25 | A/B | 140-202 | [»] | |
2L54 | NMR | - | A | 136-198 | [»] | |
2MDR | NMR | - | A | 708-801 | [»] | |
3F21 | X-ray | 2.20 | A/B/C | 133-209 | [»] | |
3F22 | X-ray | 2.50 | A/B/C | 133-209 | [»] | |
3F23 | X-ray | 2.70 | A/B/C | 133-209 | [»] | |
3IRQ | X-ray | 2.80 | A/B/C/D | 140-202 | [»] | |
3IRR | X-ray | 2.65 | A/B/C/D | 140-202 | [»] | |
5ZU1 | X-ray | 3.01 | A/B/C/D | 140-198 | [»] | |
5ZUO | X-ray | 2.90 | A/B/C/D | 140-202 | [»] | |
5ZUP | X-ray | 2.90 | A/B/C/D | 140-202 | [»] | |
7C0I | X-ray | 2.40 | A/B/C | 170-184 | [»] | |
SMRi | P55265 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106617, 125 interactors |
CORUMi | P55265 |
DIPi | DIP-29310N |
IntActi | P55265, 68 interactors |
MINTi | P55265 |
STRINGi | 9606.ENSP00000357459 |
PTM databases
GlyGeni | P55265, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P55265 |
MetOSitei | P55265 |
PhosphoSitePlusi | P55265 |
SwissPalmi | P55265 |
Genetic variation databases
BioMutai | ADAR |
DMDMi | 313104303 |
Proteomic databases
EPDi | P55265 |
jPOSTi | P55265 |
MassIVEi | P55265 |
MaxQBi | P55265 |
PaxDbi | P55265 |
PeptideAtlasi | P55265 |
PRIDEi | P55265 |
ProteomicsDBi | 56826 [P55265-1] 56827 [P55265-2] 56828 [P55265-3] 56829 [P55265-4] 56830 [P55265-5] |
Protocols and materials databases
Antibodypediai | 1280, 262 antibodies |
DNASUi | 103 |
Genome annotation databases
Organism-specific databases
CTDi | 103 |
DisGeNETi | 103 |
GeneCardsi | ADAR |
GeneReviewsi | ADAR |
HGNCi | HGNC:225, ADAR |
HPAi | ENSG00000160710, Low tissue specificity |
MalaCardsi | ADAR |
MIMi | 127400, phenotype 146920, gene 615010, phenotype |
neXtProti | NX_P55265 |
OpenTargetsi | ENSG00000160710 |
Orphaneti | 51, Aicardi-Goutieres syndrome 41, Dyschromatosis symmetrica hereditaria 225154, Familial infantile bilateral striatal necrosis |
PharmGKBi | PA24555 |
VEuPathDBi | HostDB:ENSG00000160710.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2777, Eukaryota |
GeneTreei | ENSGT00940000157243 |
HOGENOMi | CLU_005382_0_0_1 |
InParanoidi | P55265 |
OMAi | KRERMQM |
OrthoDBi | 947117at2759 |
PhylomeDBi | P55265 |
TreeFami | TF315806 |
Enzyme and pathway databases
BRENDAi | 3.5.4.37, 2681 |
PathwayCommonsi | P55265 |
Reactomei | R-HSA-75102, C6 deamination of adenosine R-HSA-77042, Formation of editosomes by ADAR proteins R-HSA-909733, Interferon alpha/beta signaling |
Miscellaneous databases
BioGRID-ORCSi | 103, 278 hits in 998 CRISPR screens |
ChiTaRSi | ADAR, human |
EvolutionaryTracei | P55265 |
GeneWikii | ADAR |
GenomeRNAii | 103 |
Pharosi | P55265, Tbio |
PROi | PR:P55265 |
RNActi | P55265, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160710, Expressed in testis and 248 other tissues |
ExpressionAtlasi | P55265, baseline and differential |
Genevisiblei | P55265, HS |
Family and domain databases
CDDi | cd19913, DSRM_DRADA_rpt1, 1 hit cd19915, DSRM_DRADA_rpt3, 1 hit |
Gene3Di | 1.10.10.10, 2 hits |
InterProi | View protein in InterPro IPR002466, A_deamin IPR044456, ADAR1_DSRM_1 IPR044457, ADAR1_DSRM_3 IPR014720, dsRBD_dom IPR000607, dsRNA_A_deaminase_rpt IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf IPR042371, Zalpha_dom |
Pfami | View protein in Pfam PF02137, A_deamin, 1 hit PF00035, dsrm, 3 hits PF02295, z-alpha, 2 hits |
SMARTi | View protein in SMART SM00552, ADEAMc, 1 hit SM00358, DSRM, 3 hits SM00550, Zalpha, 2 hits |
SUPFAMi | SSF46785, SSF46785, 2 hits |
PROSITEi | View protein in PROSITE PS50141, A_DEAMIN_EDITASE, 1 hit PS50137, DS_RBD, 3 hits PS50139, Z_BINDING, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DSRAD_HUMAN | |
Accessioni | P55265Primary (citable) accession number: P55265 Secondary accession number(s): B1AQQ9 Q9BYM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 218 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references