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Entry version 158 (11 Dec 2019)
Sequence version 3 (25 Nov 2008)
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Protein

Pancreatic secretory granule membrane major glycoprotein GP2

Gene

GP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pancreatic secretory granule membrane major glycoprotein GP2
Alternative name(s):
Pancreatic zymogen granule membrane protein GP-2
ZAP75
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169347.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4441 GP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602977 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55259

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2813

Open Targets

More...
OpenTargetsi
ENSG00000169347

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28822

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P55259 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274153

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004165729 – 512Pancreatic secretory granule membrane major glycoprotein GP2Add BLAST484
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000041658513 – 537Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi190 ↔ 200By similarity
Disulfide bondi194 ↔ 209By similarity
Disulfide bondi211 ↔ 241By similarity
Disulfide bondi229 ↔ 320By similarity
Disulfide bondi261 ↔ 284By similarity
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi401 ↔ 461PROSITE-ProRule annotationBy similarity
Disulfide bondi422 ↔ 477By similarity
Disulfide bondi466 ↔ 473By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi512GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P55259

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P55259

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55259

PeptideAtlas

More...
PeptideAtlasi
P55259

PRoteomics IDEntifications database

More...
PRIDEi
P55259

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56819 [P55259-1]
56820 [P55259-2]
56821 [P55259-3]
56822 [P55259-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1593

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55259

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P55259

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Pancreatic secretory (zymogen) granule.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169347 Expressed in 118 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P55259 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P55259 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015739
HPA016668

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYCN.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109075, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P55259, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370767

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P55259 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P55259

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini186 – 230EGF-likeAdd BLAST45
Domaini228 – 484ZPPROSITE-ProRule annotationAdd BLAST257

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVSV Eukaryota
ENOG410YDU6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156038

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293303

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55259

KEGG Orthology (KO)

More...
KOi
K19899

Identification of Orthologs from Complete Genome Data

More...
OMAi
DQNYTSP

Database of Orthologous Groups

More...
OrthoDBi
665331at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55259

TreeFam database of animal gene trees

More...
TreeFami
TF330284

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00100 Zona_pellucida, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00023 ZPELLUCIDA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00241 ZP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55259-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHLMERMVG SGLLWLALVS CILTQASAVQ RGYGNPIEAS SYGLDLDCGA
60 70 80 90 100
PGTPEAHVCF DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG
110 120 130 140 150
VRMSETCVQV HRCQTDAPMW LNGTHPALGD GITNHTACAH WSGNCCFWKT
160 170 180 190 200
EVLVKACPGG YHVYRLEGTP WCNLRYCTVP RDPSTVEDKC EKACRPEEEC
210 220 230 240 250
LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK CLLGGLGLGE
260 270 280 290 300
EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT
310 320 330 340 350
LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE
360 370 380 390 400
FIVRMALFQD QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN
410 420 430 440 450
CYATPTEDKA DLVKYFIIRN SCSNQRDSTI HVEENGQSSE SRFSVQMFMF
460 470 480 490 500
AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS QVRSEVPAID LARVLDLGPI
510 520 530
TRRGAQSPGV MNGTPSTAGF LVAWPMVLLT VLLAWLF
Length:537
Mass (Da):59,480
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A6B6A0FC64F50B8
GO
Isoform Beta (identifier: P55259-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-178: Missing.

Show »
Length:390
Mass (Da):43,392
Checksum:i1C8EB6F39DD5CAA9
GO
Isoform Alpha (identifier: P55259-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-181: Missing.

Show »
Length:534
Mass (Da):59,128
Checksum:iA2A5F8C612E1FB02
GO
Isoform 2 (identifier: P55259-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-180: Missing.

Show »
Length:387
Mass (Da):43,039
Checksum:i5EFE625C031A3A42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3I2I3L3I2_HUMAN
Pancreatic secretory granule membra...
GP2
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2Z7I3L2Z7_HUMAN
Pancreatic secretory granule membra...
GP2
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L486I3L486_HUMAN
Pancreatic secretory granule membra...
GP2
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L324I3L324_HUMAN
Pancreatic secretory granule membra...
GP2
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4Y3I3L4Y3_HUMAN
Pancreatic secretory granule membra...
GP2
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB19240 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti189K → KK in BAA07400 (Ref. 5) Curated1
Sequence conflicti243L → Q in BAA07400 (Ref. 5) Curated1
Sequence conflicti248L → F in BAA07400 (Ref. 5) Curated1
Sequence conflicti505A → G in BAA07400 (Ref. 5) Curated1
Sequence conflicti535 – 537WLF → LAV in BAA07400 (Ref. 5) Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03574931 – 180Missing in isoform 2. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_00694832 – 178Missing in isoform Beta. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_035750179 – 181Missing in isoform Alpha. 2 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U36221 mRNA Translation: AAB19240.1 Different initiation.
AC106796 Genomic DNA No translation available.
CH471186 Genomic DNA Translation: EAW50311.1
AB035541 mRNA Translation: BAA88166.1
AB035542 mRNA Translation: BAA88167.1
D38225 mRNA Translation: BAA07400.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10582.2 [P55259-3]
CCDS42128.1 [P55259-1]
CCDS45432.1 [P55259-4]
CCDS45433.1 [P55259-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
G02091

NCBI Reference Sequences

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RefSeqi
NP_001007241.2, NM_001007240.2 [P55259-1]
NP_001493.2, NM_001502.3 [P55259-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302555; ENSP00000304044; ENSG00000169347 [P55259-3]
ENST00000341642; ENSP00000343861; ENSG00000169347 [P55259-4]
ENST00000381360; ENSP00000370765; ENSG00000169347 [P55259-2]
ENST00000381362; ENSP00000370767; ENSG00000169347 [P55259-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2813

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2813

UCSC genome browser

More...
UCSCi
uc002dgv.4 human [P55259-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36221 mRNA Translation: AAB19240.1 Different initiation.
AC106796 Genomic DNA No translation available.
CH471186 Genomic DNA Translation: EAW50311.1
AB035541 mRNA Translation: BAA88166.1
AB035542 mRNA Translation: BAA88167.1
D38225 mRNA Translation: BAA07400.1
CCDSiCCDS10582.2 [P55259-3]
CCDS42128.1 [P55259-1]
CCDS45432.1 [P55259-4]
CCDS45433.1 [P55259-2]
PIRiG02091
RefSeqiNP_001007241.2, NM_001007240.2 [P55259-1]
NP_001493.2, NM_001502.3 [P55259-3]

3D structure databases

SMRiP55259
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109075, 3 interactors
IntActiP55259, 3 interactors
STRINGi9606.ENSP00000370767

PTM databases

GlyConnecti1593
iPTMnetiP55259
PhosphoSitePlusiP55259

Polymorphism and mutation databases

BioMutaiGP2
DMDMi215274153

Proteomic databases

jPOSTiP55259
MassIVEiP55259
PaxDbiP55259
PeptideAtlasiP55259
PRIDEiP55259
ProteomicsDBi56819 [P55259-1]
56820 [P55259-2]
56821 [P55259-3]
56822 [P55259-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P55259

Genome annotation databases

EnsembliENST00000302555; ENSP00000304044; ENSG00000169347 [P55259-3]
ENST00000341642; ENSP00000343861; ENSG00000169347 [P55259-4]
ENST00000381360; ENSP00000370765; ENSG00000169347 [P55259-2]
ENST00000381362; ENSP00000370767; ENSG00000169347 [P55259-1]
GeneIDi2813
KEGGihsa:2813
UCSCiuc002dgv.4 human [P55259-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2813
DisGeNETi2813
EuPathDBiHostDB:ENSG00000169347.16

GeneCards: human genes, protein and diseases

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GeneCardsi
GP2
HGNCiHGNC:4441 GP2
HPAiHPA015739
HPA016668
MIMi602977 gene
neXtProtiNX_P55259
OpenTargetsiENSG00000169347
PharmGKBiPA28822

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IVSV Eukaryota
ENOG410YDU6 LUCA
GeneTreeiENSGT00940000156038
HOGENOMiHOG000293303
InParanoidiP55259
KOiK19899
OMAiDQNYTSP
OrthoDBi665331at2759
PhylomeDBiP55259
TreeFamiTF330284

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GP2_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2813
PharosiP55259 Tbio

Protein Ontology

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PROi
PR:P55259
RNActiP55259 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169347 Expressed in 118 organ(s), highest expression level in body of pancreas
ExpressionAtlasiP55259 baseline and differential
GenevisibleiP55259 HS

Family and domain databases

InterProiView protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55259
Secondary accession number(s): A6NFM9
, A6NJA8, Q13338, Q9UIF1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: December 11, 2019
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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