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Entry version 215 (07 Apr 2021)
Sequence version 2 (28 Nov 2002)
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Protein

Caspase-6

Gene

CASP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed:8663580, PubMed:32298652). During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:17401638, PubMed:8663580, PubMed:9463409). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (PubMed:10559921, PubMed:14657026). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses (PubMed:32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed:32298652).By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

During activation, the N-terminal prodomain is removed by cleavage at a TETD site. Concomitantly, double cleavage gives rise to a large 18-kDa and a small 11-kDa subunit. The two large and two small subunits then assemble to form the active CASP6 complex (PubMed:8663580). Intramolecular cleavage at Asp-193 is a prerequisite for CASP6 self-activation (PubMed:20890311). Phosphorylation at Ser-257 by steric hindrance leads to self-activation inhibition (PubMed:15273717, PubMed:22433863, PubMed:22483120).5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei121By similarity1
Active sitei1632 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.22.59, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P55212

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-111465, Apoptotic cleavage of cellular proteins
R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-352238, Breakdown of the nuclear lamina
R-HSA-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases

SIGNOR Signaling Network Open Resource

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SIGNORi
P55212

Protein family/group databases

MEROPS protease database

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MEROPSi
C14.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase-6 (EC:3.4.22.592 Publications)
Short name:
CASP-6
Alternative name(s):
Apoptotic protease Mch-2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASP6
Synonyms:MCH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1507, CASP6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601532, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P55212

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000138794.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi163C → A: Catalytically inactive active-site mutant. 2 Publications1
Mutagenesisi257S → A: Suppression of caspase-6 activation. 1 Publication1
Mutagenesisi257S → D: Prevents caspase-6 autoactivation. 1 Publication1
Mutagenesisi257S → E: Loss of self-activation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
839

Open Targets

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OpenTargetsi
ENSG00000138794

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26090

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P55212, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3308

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1622

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CASP6

Domain mapping of disease mutations (DMDM)

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DMDMi
26006981

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000046081 – 23Add BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000460924 – 179Caspase-6 subunit p18Add BLAST156
PropeptideiPRO_0000004610180 – 193Add BLAST14
ChainiPRO_0000004611194 – 293Caspase-6 subunit p11Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79PhosphoserineBy similarity1
Modified residuei257Phosphoserine; by NUAK12 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NUAK1; phosphorylation inhibits self-activation.2 Publications
Cleavages by caspase-8 and subsequently by caspase-3 generate the two active subunits.1 Publication

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P55212

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P55212

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P55212

MaxQB - The MaxQuant DataBase

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MaxQBi
P55212

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P55212

PeptideAtlas

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PeptideAtlasi
P55212

PRoteomics IDEntifications database

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PRIDEi
P55212

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56817 [P55212-1]
56818 [P55212-2]

2D gel databases

USC-OGP 2-DE database

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OGPi
P55212

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P55212, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P55212

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55212

SwissPalm database of S-palmitoylation events

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SwissPalmi
P55212

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138794, Expressed in rectum and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55212, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55212, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138794, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunits (PubMed:19694615, PubMed:20890311).

Interacts with BIRC6/bruce (PubMed:15200957).

Interacts with RIPK3 (PubMed:32298652).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P55212
With#Exp.IntAct
ACTL7B [Q9Y614]3EBI-718729,EBI-25835070
ADAL - isoform 2 [Q6DHV7-2]3EBI-718729,EBI-18899653
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-718729,EBI-10173507
AK8 [Q96MA6]3EBI-718729,EBI-8466265
AKR1C8P [Q5T2L2]3EBI-718729,EBI-22006248
ALKBH3 - isoform 2 [Q96Q83-2]3EBI-718729,EBI-9089544
AMDHD2 - isoform 2 [Q9Y303-2]3EBI-718729,EBI-12323557
ANKEF1 [Q9NU02]3EBI-718729,EBI-8464238
ANXA4 [Q6LES2]3EBI-718729,EBI-10250835
APOA4 [P06727]3EBI-718729,EBI-1222447
APOBEC4 [Q8WW27]3EBI-718729,EBI-25836284
ARL6IP4 - isoform 4 [Q66PJ3-4]3EBI-718729,EBI-5280499
ASCL4 [Q6XD76]3EBI-718729,EBI-10254793
ATF4 [P18848]3EBI-718729,EBI-492498
ATG10 [Q9H0Y0]3EBI-718729,EBI-1048913
BAAT [Q14032]3EBI-718729,EBI-8994378
BCAT1 - isoform 4 [P54687-4]3EBI-718729,EBI-25834445
BCHE [P06276]3EBI-718729,EBI-7936069
BRWD1 - isoform D [Q9NSI6-4]3EBI-718729,EBI-10693038
BTBD9 - isoform 2 [Q96Q07-2]3EBI-718729,EBI-22006737
C11orf54 - isoform 3 [Q9H0W9-3]3EBI-718729,EBI-12108466
C12orf4 [Q9NQ89]3EBI-718729,EBI-11090973
C1D [Q13901]3EBI-718729,EBI-3844053
C3orf36 [Q3SXR2]3EBI-718729,EBI-18036948
C4orf33 [Q8N1A6]3EBI-718729,EBI-10264911
CAPN2 [P17655]3EBI-718729,EBI-1028956
CAPN3 - isoform IV [P20807-4]3EBI-718729,EBI-11532021
CASP3 [P42574]2EBI-718729,EBI-524064
itself8EBI-718729,EBI-718729
CBWD3 [Q5JTY5]3EBI-718729,EBI-723434
CBX4 - isoform 2 [O00257-3]3EBI-718729,EBI-4392727
CCNC [P24863]3EBI-718729,EBI-395261
CD209 - isoform 10 [Q9NNX6-10]3EBI-718729,EBI-12300031
CDC23 [Q9UJX2]3EBI-718729,EBI-396137
CDKN2C [P42773]3EBI-718729,EBI-711290
CDS2 [O95674]3EBI-718729,EBI-3913685
CFAP100 - isoform 2 [Q494V2-2]3EBI-718729,EBI-11953200
CHMP7 [Q8WUX9]3EBI-718729,EBI-749253
CIAO2B [Q9Y3D0]3EBI-718729,EBI-744045
CIART [Q8N365]3EBI-718729,EBI-10265133
CITED1 [Q99966]3EBI-718729,EBI-2624951
CLTA - isoform Non-brain [P09496-2]3EBI-718729,EBI-4401010
CNST - isoform 3 [Q6PJW8-3]3EBI-718729,EBI-25836090
COA7 [Q96BR5]3EBI-718729,EBI-6269632
COL2A1 - isoform 1 [P02458-1]3EBI-718729,EBI-12375799
CRCT1 [Q9UGL9]3EBI-718729,EBI-713677
CROT - isoform 2 [Q9UKG9-2]3EBI-718729,EBI-25835363
CRYBB3 [P26998]3EBI-718729,EBI-1965681
CTNNB1 [P35222]3EBI-718729,EBI-491549
CYBRD1 [Q53TN4]3EBI-718729,EBI-8637742
DCAF7 [P61962]3EBI-718729,EBI-359808
DLX3 [O60479]3EBI-718729,EBI-3908248
DNAJA3 - isoform 3 [Q96EY1-3]3EBI-718729,EBI-11526226
DPF1 - isoform 2 [Q92782-2]3EBI-718729,EBI-23669343
DPYSL5 [Q9BPU6]3EBI-718729,EBI-724653
E2F8 [A0AVK6]3EBI-718729,EBI-7779316
EEF1DP3 [Q658K8]3EBI-718729,EBI-10248874
EIF3F [O00303]3EBI-718729,EBI-711990
EIF3I [Q13347]3EBI-718729,EBI-354047
ELL2 [O00472]3EBI-718729,EBI-395274
EML1 [O00423]3EBI-718729,EBI-751327
ESRP1 - isoform 3 [Q6NXG1-3]3EBI-718729,EBI-21567429
FAM135B - isoform 4 [Q49AJ0-4]3EBI-718729,EBI-25835236
FAM177A1 - isoform 2 [Q8N128-2]3EBI-718729,EBI-12201693
FAM9A [Q8IZU1]3EBI-718729,EBI-8468186
FGD5 [Q6ZNL6]3EBI-718729,EBI-7962481
FGF21 [Q9NSA1]3EBI-718729,EBI-3909329
GABPB1 - isoform 3 [Q06547-3]3EBI-718729,EBI-9088619
GLYR1 - isoform 4 [Q49A26-4]3EBI-718729,EBI-12143817
GNB4 [Q9HAV0]3EBI-718729,EBI-358539
H3-5 [Q6NXT2]3EBI-718729,EBI-2868501
HAUS8 [Q9BT25]3EBI-718729,EBI-2558143
HELLS - isoform 6 [Q9NRZ9-6]3EBI-718729,EBI-12003732
HSPBAP1 - isoform 2 [Q96EW2-2]3EBI-718729,EBI-25835621
HTT [P42858]15EBI-718729,EBI-466029
IQCF1 - isoform 2 [Q8N6M8-2]3EBI-718729,EBI-21771049
JADE3 [Q92613]3EBI-718729,EBI-10278909
JMJD7 [P0C870]3EBI-718729,EBI-9090173
JPT1 [Q9UK76]3EBI-718729,EBI-720411
KCTD17 [Q8N5Z5]3EBI-718729,EBI-743960
KLHDC4 - isoform 2 [Q8TBB5-2]3EBI-718729,EBI-21838933
KLHL3 [Q9UH77]3EBI-718729,EBI-8524663
KLHL36 - isoform 2 [Q8N4N3-2]3EBI-718729,EBI-10973851
KRBOX4 - isoform 3 [Q5JUW0-3]3EBI-718729,EBI-12893625
KRT222 [Q8N1A0]3EBI-718729,EBI-8473062
LAMP2 - isoform LAMP-2B [P13473-2]3EBI-718729,EBI-21591415
LGALS9C [Q6DKI2]3EBI-718729,EBI-9088829
LHX5 [Q9H2C1]3EBI-718729,EBI-25835523
LINC00518 [Q8N0U6]3EBI-718729,EBI-10264791
LIPT1 [Q9Y234]3EBI-718729,EBI-727376
LNX1 [Q8TBB1]3EBI-718729,EBI-739832
LONRF2 [Q1L5Z9]3EBI-718729,EBI-2510853
LOXL4 [Q96JB6]3EBI-718729,EBI-749562
LPAL2 [Q16609]3EBI-718729,EBI-10238012
LRRC56 [Q8IYG6]3EBI-718729,EBI-14752528
LYNX1 - isoform 2 [P0DP58-2]3EBI-718729,EBI-21916939
MAL2 [Q969L2]3EBI-718729,EBI-944295
MAOB [P27338]3EBI-718729,EBI-3911344
METTL15 - isoform 4 [A6NJ78-4]3EBI-718729,EBI-10174029
MIEF2 - isoform 3 [Q96C03-3]3EBI-718729,EBI-11988931
MINDY1 - isoform 3 [Q8N5J2-3]3EBI-718729,EBI-12382151
MLST8 [A0A0A0MR05]3EBI-718729,EBI-25835557
MPI - isoform 2 [P34949-2]3EBI-718729,EBI-21823432
MRI1 [Q9BV20]3EBI-718729,EBI-747381
MRM1 - isoform 2 [Q6IN84-2]3EBI-718729,EBI-25835707
MYBPHL [A2RUH7]3EBI-718729,EBI-9088235
MYC [P01106]3EBI-718729,EBI-447544
NAA60 [Q9H7X0]3EBI-718729,EBI-12260336
NAB2 - isoform 2 [Q15742-2]3EBI-718729,EBI-25834665
NAGK - isoform 2 [Q9UJ70-2]3EBI-718729,EBI-11526455
NPEPL1 - isoform 5 [Q8NDH3-5]3EBI-718729,EBI-12329915
NTAQ1 [Q96HA8]3EBI-718729,EBI-741158
NUDT1 - isoform p18 [P36639-4]3EBI-718729,EBI-25834643
NUP37 [Q8NFH4]3EBI-718729,EBI-2563158
NUP43 [Q8NFH3]3EBI-718729,EBI-1059321
NUP54 [Q7Z3B4]3EBI-718729,EBI-741048
ODF3L2 [Q3SX64]3EBI-718729,EBI-6660184
OGFOD2 - isoform 2 [Q6N063-2]3EBI-718729,EBI-22006224
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-718729,EBI-25830200
PAAT [Q9H8K7]3EBI-718729,EBI-714785
PCYT2 [Q99447]3EBI-718729,EBI-750317
PDE4A - isoform 4 [P27815-4]3EBI-718729,EBI-12080840
PER1 [O15534]3EBI-718729,EBI-2557276
PHF23 [Q9BUL5]3EBI-718729,EBI-722852
PITPNA [Q00169]3EBI-718729,EBI-1042490
PITPNB [P48739]3EBI-718729,EBI-1047143
PKIA [P61925]3EBI-718729,EBI-2682139
PLEKHG4 - isoform 2 [Q58EX7-2]3EBI-718729,EBI-21503705
PLIN3 [O60664]3EBI-718729,EBI-725795
POLA2 [Q14181]3EBI-718729,EBI-712752
POLR1D [P0DPB6]3EBI-718729,EBI-359498
POLR2I [P36954]3EBI-718729,EBI-395202
PPARA [Q07869]3EBI-718729,EBI-78615
PPP1R11 [O60927]3EBI-718729,EBI-1048104
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-718729,EBI-25835994
PRKAG1 [P54619]3EBI-718729,EBI-1181439
PROCA1 - isoform 2 [Q8NCQ7-2]3EBI-718729,EBI-25836043
PTGDS [P41222]3EBI-718729,EBI-948821
PTPN4 [P29074]3EBI-718729,EBI-710431
RAB2B - isoform 2 [Q8WUD1-2]3EBI-718729,EBI-25835884
RABGAP1L - isoform 9 [Q5R372-9]3EBI-718729,EBI-10699389
RANGRF - isoform 3 [Q9HD47-3]3EBI-718729,EBI-9089733
RBBP4 [Q09028]3EBI-718729,EBI-620823
RELA [Q04206]3EBI-718729,EBI-73886
RGR - isoform 3 [P47804-3]3EBI-718729,EBI-25834767
RHEB [Q15382]3EBI-718729,EBI-1055287
RING1 [Q06587]3EBI-718729,EBI-752313
RNF10 [Q8N5U6]3EBI-718729,EBI-714023
RPS4X [P62701]3EBI-718729,EBI-354303
RUSC1-AS1 [Q66K80]3EBI-718729,EBI-10248967
SATB1 [Q01826]2EBI-718729,EBI-743747
SCAMP1 [O15126]3EBI-718729,EBI-954338
SCP2 - isoform 3 [P22307-3]3EBI-718729,EBI-25834804
SDF4 [Q9BRK5]3EBI-718729,EBI-1389808
SEMA4G - isoform 3 [Q9NTN9-3]3EBI-718729,EBI-9089805
SERPINA3 [P01011]3EBI-718729,EBI-296557
SF3B3 [Q15393]3EBI-718729,EBI-346977
SH3GLB2 [Q9NR46]3EBI-718729,EBI-749607
SHCBP1L [Q9BZQ2]3EBI-718729,EBI-10818532
SHOX2 - isoform 3 [O60902-3]3EBI-718729,EBI-9092164
SMG6 [Q86US8]3EBI-718729,EBI-3232100
SNCA [P37840]3EBI-718729,EBI-985879
SNF8 [Q96H20]3EBI-718729,EBI-747719
SNW1 [Q13573]3EBI-718729,EBI-632715
SPATA12 [Q7Z6I5]3EBI-718729,EBI-10696971
SPATS1 [Q496A3]3EBI-718729,EBI-3923692
SPRY4 [Q9C004]3EBI-718729,EBI-354861
SPRYD7 - isoform 2 [Q5W111-2]3EBI-718729,EBI-12408727
SPSB1 [Q96BD6]3EBI-718729,EBI-2659201
SYMPK - isoform 2 [Q92797-2]3EBI-718729,EBI-21560407
SYNCRIP - isoform 4 [O60506-4]3EBI-718729,EBI-11123832
TCAP [O15273]3EBI-718729,EBI-954089
TEN1 [Q86WV5]3EBI-718729,EBI-2562799
TENT5B [Q96A09]3EBI-718729,EBI-752030
TERF1 - isoform 2 [P54274-2]3EBI-718729,EBI-711018
TGM1 [P22735]3EBI-718729,EBI-2562368
TGM5 [O43548]3EBI-718729,EBI-12027348
TIGAR [Q9NQ88]3EBI-718729,EBI-3920747
TMEFF2 - isoform 2 [Q9UIK5-2]3EBI-718729,EBI-25835153
tmp_locus_54 [Q53NU3]3EBI-718729,EBI-10242677
TP53 [P04637]3EBI-718729,EBI-366083
TP53BP1 [Q12888]3EBI-718729,EBI-396540
TRIM23 [P36406]3EBI-718729,EBI-740098
TRIM69 - isoform 2 [Q86WT6-2]3EBI-718729,EBI-11525489
TUBB2A [Q13885]3EBI-718729,EBI-711595
UBE2A [P49459]3EBI-718729,EBI-2339348
VPS54 - isoform 4 [Q9P1Q0-4]3EBI-718729,EBI-25835297
WBP1L [Q9NX94]3EBI-718729,EBI-10316321
WDR31 - isoform 2 [Q8NA23-2]3EBI-718729,EBI-25835937
WDR77 [Q9BQA1]3EBI-718729,EBI-1237307
WNT7A [O00755]3EBI-718729,EBI-727198
YIF1A [O95070]3EBI-718729,EBI-2799703
ZBTB14 [O43829]3EBI-718729,EBI-10176632
ZBTB8OS - isoform 2 [Q8IWT0-2]3EBI-718729,EBI-12956041
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-718729,EBI-14104088
ZNF248 [Q05CR2]3EBI-718729,EBI-25835471
ZNF333 - isoform 2 [Q96JL9-2]3EBI-718729,EBI-25835852
ZNF597 [Q96LX8]3EBI-718729,EBI-9091553
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-718729,EBI-18036029
A0A384MDV83EBI-718729,EBI-25834468
B7Z3E83EBI-718729,EBI-25831617
Q86V283EBI-718729,EBI-10259496

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107289, 28 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-971, Caspase-6 complex

Database of interacting proteins

More...
DIPi
DIP-44649N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P55212

Protein interaction database and analysis system

More...
IntActi
P55212, 213 interactors

Molecular INTeraction database

More...
MINTi
P55212

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265164

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P55212

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P55212, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1293
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P55212

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P55212

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3573, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155140

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036904_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55212

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHVYAYD

Database of Orthologous Groups

More...
OrthoDBi
984395at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55212

TreeFam database of animal gene trees

More...
TreeFami
TF102023

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00032, CASc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029030, Caspase-like_dom_sf
IPR037554, Caspase_6
IPR033139, Caspase_cys_AS
IPR016129, Caspase_his_AS
IPR002398, Pept_C14
IPR002138, Pept_C14_p10
IPR001309, Pept_C14_p20
IPR015917, Pept_C14A

The PANTHER Classification System

More...
PANTHERi
PTHR10454, PTHR10454, 1 hit
PTHR10454:SF206, PTHR10454:SF206, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00376, IL1BCENZYME

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00115, CASc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52129, SSF52129, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01122, CASPASE_CYS, 1 hit
PS01121, CASPASE_HIS, 1 hit
PS50207, CASPASE_P10, 1 hit
PS50208, CASPASE_P20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P55212-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSASGLRRG HPAGGEENMT ETDAFYKREM FDPAEKYKMD HRRRGIALIF
60 70 80 90 100
NHERFFWHLT LPERRGTCAD RDNLTRRFSD LGFEVKCFND LKAEELLLKI
110 120 130 140 150
HEVSTVSHAD ADCFVCVFLS HGEGNHIYAY DAKIEIQTLT GLFKGDKCHS
160 170 180 190 200
LVGKPKIFII QACRGNQHDV PVIPLDVVDN QTEKLDTNIT EVDAASVYTL
210 220 230 240 250
PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKYG SSLEFTELLT
260 270 280 290
LVNRKVSQRR VDFCKDPSAI GKKQVPCFAS MLTKKLHFFP KSN
Length:293
Mass (Da):33,310
Last modified:November 28, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0738AE4F9791EBD7
GO
Isoform Beta (identifier: P55212-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-102: Missing.

Show »
Length:204
Mass (Da):22,574
Checksum:i9DCC10C99F81D912
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHU3D6RHU3_HUMAN
Caspase-6
CASP6
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBM3D6RBM3_HUMAN
Caspase-6
CASP6
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66G → R in AAC50168 (PubMed:7796396).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02924235E → K. Corresponds to variant dbSNP:rs11574697Ensembl.1
Natural variantiVAR_016130109A → T. Corresponds to variant dbSNP:rs5030674Ensembl.1
Natural variantiVAR_020126182T → S1 PublicationCorresponds to variant dbSNP:rs5030593Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00080514 – 102Missing in isoform Beta. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U20536 mRNA Translation: AAC50168.1
U20537 mRNA Translation: AAC50169.1
AY254046 Genomic DNA Translation: AAO63494.1
BC000305 mRNA Translation: AAH00305.1
BC004460 mRNA Translation: AAH04460.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3684.1 [P55212-1]
CCDS3685.1 [P55212-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001217.2, NM_001226.3 [P55212-1]
NP_116787.1, NM_032992.2 [P55212-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265164; ENSP00000265164; ENSG00000138794 [P55212-1]
ENST00000352981; ENSP00000285333; ENSG00000138794 [P55212-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
839

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:839

UCSC genome browser

More...
UCSCi
uc003hzn.2, human [P55212-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20536 mRNA Translation: AAC50168.1
U20537 mRNA Translation: AAC50169.1
AY254046 Genomic DNA Translation: AAO63494.1
BC000305 mRNA Translation: AAH00305.1
BC004460 mRNA Translation: AAH04460.1
CCDSiCCDS3684.1 [P55212-1]
CCDS3685.1 [P55212-2]
RefSeqiNP_001217.2, NM_001226.3 [P55212-1]
NP_116787.1, NM_032992.2 [P55212-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MI9model-A34-175[»]
B198-290[»]
2WDPX-ray1.95A/B/C/D1-293[»]
3K7EX-ray3.00A/B/C/D24-293[»]
3NKFX-ray2.90A/B/C/D24-293[»]
3NR2X-ray2.90A/B24-293[»]
3OD5X-ray1.60A/B24-293[»]
3P45X-ray2.53A/C/E/G/I/K/M/O1-179[»]
B/D/F/H/J/L/N/P193-293[»]
3P4UX-ray1.90A/C23-179[»]
B/D193-293[»]
3QNWX-ray2.65A/C/E/G24-179[»]
B/D/F/H194-293[»]
3S70X-ray1.62A/C24-293[»]
3S8EX-ray2.88A/B/C/D/E/F/G/H24-293[»]
3V6LX-ray2.20A/B21-293[»]
3V6MX-ray2.69A/B/C/D/F/G/I/J24-293[»]
4EJFX-ray2.65A/B/C/D24-293[»]
4FXOX-ray2.85A/B/C/D1-293[»]
4HVAX-ray2.07A/B24-293[»]
4IYRX-ray2.70A/B1-293[»]
4N5DX-ray2.06A/B24-293[»]
4N6GX-ray2.14A/B24-293[»]
4N7JX-ray1.67A/B24-293[»]
4N7MX-ray2.12A/B24-293[»]
4NBKX-ray1.94A/B24-293[»]
4NBLX-ray1.76A/B24-293[»]
4NBNX-ray1.75A/B24-293[»]
6DEUX-ray2.80A/B2-293[»]
6DEVX-ray2.35A/B/C/D2-293[»]
SMRiP55212
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107289, 28 interactors
ComplexPortaliCPX-971, Caspase-6 complex
DIPiDIP-44649N
ELMiP55212
IntActiP55212, 213 interactors
MINTiP55212
STRINGi9606.ENSP00000265164

Chemistry databases

BindingDBiP55212
ChEMBLiCHEMBL3308
GuidetoPHARMACOLOGYi1622

Protein family/group databases

MEROPSiC14.005

PTM databases

GlyGeniP55212, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP55212
PhosphoSitePlusiP55212
SwissPalmiP55212

Genetic variation databases

BioMutaiCASP6
DMDMi26006981

2D gel databases

OGPiP55212

Proteomic databases

EPDiP55212
jPOSTiP55212
MassIVEiP55212
MaxQBiP55212
PaxDbiP55212
PeptideAtlasiP55212
PRIDEiP55212
ProteomicsDBi56817 [P55212-1]
56818 [P55212-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1733, 1126 antibodies

The DNASU plasmid repository

More...
DNASUi
839

Genome annotation databases

EnsembliENST00000265164; ENSP00000265164; ENSG00000138794 [P55212-1]
ENST00000352981; ENSP00000285333; ENSG00000138794 [P55212-2]
GeneIDi839
KEGGihsa:839
UCSCiuc003hzn.2, human [P55212-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
839
DisGeNETi839

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CASP6
HGNCiHGNC:1507, CASP6
HPAiENSG00000138794, Tissue enhanced (intestine)
MIMi601532, gene
neXtProtiNX_P55212
OpenTargetsiENSG00000138794
PharmGKBiPA26090
VEuPathDBiHostDB:ENSG00000138794.9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3573, Eukaryota
GeneTreeiENSGT00940000155140
HOGENOMiCLU_036904_2_2_1
InParanoidiP55212
OMAiDHVYAYD
OrthoDBi984395at2759
PhylomeDBiP55212
TreeFamiTF102023

Enzyme and pathway databases

BRENDAi3.4.22.59, 2681
PathwayCommonsiP55212
ReactomeiR-HSA-111465, Apoptotic cleavage of cellular proteins
R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-352238, Breakdown of the nuclear lamina
R-HSA-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases
SIGNORiP55212

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
839, 5 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CASP6, human
EvolutionaryTraceiP55212

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Caspase_6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
839
PharosiP55212, Tchem

Protein Ontology

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PROi
PR:P55212
RNActiP55212, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000138794, Expressed in rectum and 211 other tissues
ExpressionAtlasiP55212, baseline and differential
GenevisibleiP55212, HS

Family and domain databases

CDDicd00032, CASc, 1 hit
InterProiView protein in InterPro
IPR029030, Caspase-like_dom_sf
IPR037554, Caspase_6
IPR033139, Caspase_cys_AS
IPR016129, Caspase_his_AS
IPR002398, Pept_C14
IPR002138, Pept_C14_p10
IPR001309, Pept_C14_p20
IPR015917, Pept_C14A
PANTHERiPTHR10454, PTHR10454, 1 hit
PTHR10454:SF206, PTHR10454:SF206, 1 hit
PRINTSiPR00376, IL1BCENZYME
SMARTiView protein in SMART
SM00115, CASc, 1 hit
SUPFAMiSSF52129, SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122, CASPASE_CYS, 1 hit
PS01121, CASPASE_HIS, 1 hit
PS50207, CASPASE_P10, 1 hit
PS50208, CASPASE_P20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55212
Secondary accession number(s): Q9BQE7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 28, 2002
Last modified: April 7, 2021
This is version 215 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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