UniProtKB - P55210 (CASP7_HUMAN)
Caspase-7
CASP7
Functioni
Catalytic activityi
- Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-. EC:3.4.22.60
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 144 | By similarity | 1 | |
Active sitei | 186 | 1 Publication | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: CAFA
- cysteine-type peptidase activity Source: ProtInc
- peptidase activity Source: BHF-UCL
GO - Biological processi
- apoptotic process Source: UniProtKB
- cellular response to staurosporine Source: CAFA
- execution phase of apoptosis Source: GO_Central
- proteolysis Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Apoptosis |
Enzyme and pathway databases
BRENDAi | 3.4.22.60, 2681 |
PathwayCommonsi | P55210 |
Reactomei | R-HSA-111459, Activation of caspases through apoptosome-mediated cleavage R-HSA-111463, SMAC (DIABLO) binds to IAPs R-HSA-111464, SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-111469, SMAC, XIAP-regulated apoptotic response R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins |
SIGNORi | P55210 |
Protein family/group databases
MEROPSi | C14.004 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase-7 (EC:3.4.22.60)Short name: CASP-7 Alternative name(s): Apoptotic protease Mch-3 CMH-1 ICE-like apoptotic protease 3 Short name: ICE-LAP3 Cleaved into the following 2 chains: |
Gene namesi | Name:CASP7 Synonyms:MCH3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1508, CASP7 |
MIMi | 601761, gene |
neXtProti | NX_P55210 |
VEuPathDBi | HostDB:ENSG00000165806.19 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 186 | C → A: No apoptotic activity. Loss of autocatalytic cleavage. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 840 |
OpenTargetsi | ENSG00000165806 |
PharmGKBi | PA26091 |
Miscellaneous databases
Pharosi | P55210, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3468 |
DrugBanki | DB05408, Emricasan DB03384, Fica DB06255, Incadronic acid |
DrugCentrali | P55210 |
GuidetoPHARMACOLOGYi | 1623 |
Genetic variation databases
BioMutai | CASP7 |
DMDMi | 1730092 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
PropeptideiPRO_0000004616 | 2 – 23 | N-terminally processedAdd BLAST | 22 | |
ChainiPRO_0000004617 | 24 – 198 | Caspase-7 subunit p20Add BLAST | 175 | |
PropeptideiPRO_0000004618 | 199 – 206 | 8 | ||
ChainiPRO_0000004619 | 207 – 303 | Caspase-7 subunit p11Add BLAST | 97 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 37 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, ZymogenProteomic databases
EPDi | P55210 |
jPOSTi | P55210 |
MassIVEi | P55210 |
MaxQBi | P55210 |
PaxDbi | P55210 |
PeptideAtlasi | P55210 |
PRIDEi | P55210 |
ProteomicsDBi | 56811 [P55210-1] 56812 [P55210-2] 56813 [P55210-3] |
PTM databases
iPTMneti | P55210 |
PhosphoSitePlusi | P55210 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000165806, Expressed in colonic mucosa and 224 other tissues |
ExpressionAtlasi | P55210, baseline and differential |
Genevisiblei | P55210, HS |
Organism-specific databases
HPAi | ENSG00000165806, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP55210
Protein-protein interaction databases
BioGRIDi | 107290, 53 interactors |
ComplexPortali | CPX-2862, Caspase-7 complex |
DIPi | DIP-29973N |
ELMi | P55210 |
IntActi | P55210, 25 interactors |
MINTi | P55210 |
STRINGi | 9606.ENSP00000358327 |
Chemistry databases
BindingDBi | P55210 |
Miscellaneous databases
RNActi | P55210, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P55210 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P55210 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00940000153232 |
HOGENOMi | CLU_1098210_0_0_1 |
InParanoidi | P55210 |
OrthoDBi | 984395at2759 |
PhylomeDBi | P55210 |
TreeFami | TF102023 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR015471, Casp3/7 IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit PTHR10454:SF31, PTHR10454:SF31, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit |
SUPFAMi | SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT
60 70 80 90 100
TRDRVPTYQY NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC
110 120 130 140 150
FRSLGFDVIV YNDCSCAKMQ DLLKKASEED HTNAACFACI LLSHGEENVI
160 170 180 190 200
YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL FFIQACRGTE LDDGIQADSG
210 220 230 240 250
PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRSPGRGSW FVQALCSILE
260 270 280 290 300
EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP HFHEKKQIPC VVSMLTKELY
FSQ
The sequence of this isoform differs from the canonical sequence as follows:
149-303: VIYGKDGVTP...MLTKELYFSQ → MESCSVTQAG...TWKSCRSSPG
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRL7 | A0A0A0MRL7_HUMAN | Caspase-7 | CASP7 | 388 | Annotation score: | ||
Q5SVL2 | Q5SVL2_HUMAN | Caspase-7 | CASP7 | 222 | Annotation score: | ||
A0A5F9ZHZ6 | A0A5F9ZHZ6_HUMAN | Caspase-7 | CASP7 | 302 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 194 | G → A in AAC50346 (PubMed:8576161).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048617 | 4 | D → E2 PublicationsCorresponds to variant dbSNP:rs11555408Ensembl. | 1 | |
Natural variantiVAR_048618 | 255 | D → E. Corresponds to variant dbSNP:rs2227310Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045325 | 1 – 36 | MADDQ…VPSLF → MQRGLFSDGDT in isoform 4. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_000806 | 1 | M → MDCVGWPPGRKWHLEKNTSC GGSSGICASYVTQM in isoform Alpha'. 3 Publications | 1 | |
Alternative sequenceiVSP_000807 | 149 – 303 | VIYGK…LYFSQ → MESCSVTQAGVQRRDLGRLQ PPPPRLAEGPSLMMASRPTR GPSMTQMLILDTRSQWKLTS SSPIPRFQAITRGGAQEEAP GLCKPSAPSWRSTEKTWKSC RSSPG in isoform Beta. 1 PublicationAdd BLAST | 155 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F1J | X-ray | 2.35 | A/B | 2-303 | [»] | |
1GQF | X-ray | 2.90 | A/B | 47-303 | [»] | |
1I4O | X-ray | 2.40 | A/B | 24-303 | [»] | |
1I51 | X-ray | 2.45 | A/C | 51-198 | [»] | |
B/D | 199-303 | [»] | ||||
1K86 | X-ray | 2.60 | A/B | 51-303 | [»] | |
1K88 | X-ray | 2.70 | A/B | 51-303 | [»] | |
1KMC | X-ray | 2.90 | A/B | 1-303 | [»] | |
1MIA | model | - | A | 57-193 | [»] | |
B | 211-303 | [»] | ||||
1SHJ | X-ray | 2.80 | A/B | 50-303 | [»] | |
1SHL | X-ray | 3.00 | A/B | 57-303 | [»] | |
2QL5 | X-ray | 2.34 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
2QL7 | X-ray | 2.40 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
2QL9 | X-ray | 2.14 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
2QLB | X-ray | 2.25 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
2QLF | X-ray | 2.80 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
2QLJ | X-ray | 2.60 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
3EDR | X-ray | 2.45 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
3H1P | X-ray | 2.61 | A/B | 50-303 | [»] | |
3IBC | X-ray | 2.75 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
3IBF | X-ray | 2.50 | A/C | 24-196 | [»] | |
B/D | 207-303 | [»] | ||||
3R5K | X-ray | 2.86 | A/B | 1-303 | [»] | |
4FDL | X-ray | 2.80 | A/B | 2-303 | [»] | |
4FEA | X-ray | 3.79 | A/B | 57-303 | [»] | |
4HQ0 | X-ray | 3.00 | A/B | 47-303 | [»] | |
4HQR | X-ray | 3.00 | A/B | 47-303 | [»] | |
4JB8 | X-ray | 1.70 | A | 24-198 | [»] | |
B | 207-303 | [»] | ||||
4JJ8 | X-ray | 2.94 | A/B | 57-303 | [»] | |
4JR1 | X-ray | 2.15 | A/B | 57-303 | [»] | |
4JR2 | X-ray | 1.65 | A/B | 57-303 | [»] | |
4LSZ | X-ray | 2.26 | A/C | 24-198 | [»] | |
B/D | 207-303 | [»] | ||||
4ZVO | X-ray | 2.85 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
4ZVP | X-ray | 2.50 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
4ZVQ | X-ray | 2.50 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
4ZVR | X-ray | 2.30 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
4ZVS | X-ray | 2.50 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
4ZVT | X-ray | 2.85 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
4ZVU | X-ray | 2.60 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
5IC6 | X-ray | 2.70 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
5K20 | X-ray | 2.20 | A/C | 1-198 | [»] | |
B/D | 199-303 | [»] | ||||
5V6U | X-ray | 2.80 | A/B | 1-303 | [»] | |
5V6Z | X-ray | 2.60 | A/B | 1-303 | [»] | |
SMRi | P55210 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107290, 53 interactors |
ComplexPortali | CPX-2862, Caspase-7 complex |
DIPi | DIP-29973N |
ELMi | P55210 |
IntActi | P55210, 25 interactors |
MINTi | P55210 |
STRINGi | 9606.ENSP00000358327 |
Chemistry databases
BindingDBi | P55210 |
ChEMBLi | CHEMBL3468 |
DrugBanki | DB05408, Emricasan DB03384, Fica DB06255, Incadronic acid |
DrugCentrali | P55210 |
GuidetoPHARMACOLOGYi | 1623 |
Protein family/group databases
MEROPSi | C14.004 |
PTM databases
iPTMneti | P55210 |
PhosphoSitePlusi | P55210 |
Genetic variation databases
BioMutai | CASP7 |
DMDMi | 1730092 |
Proteomic databases
EPDi | P55210 |
jPOSTi | P55210 |
MassIVEi | P55210 |
MaxQBi | P55210 |
PaxDbi | P55210 |
PeptideAtlasi | P55210 |
PRIDEi | P55210 |
ProteomicsDBi | 56811 [P55210-1] 56812 [P55210-2] 56813 [P55210-3] |
Protocols and materials databases
Antibodypediai | 18528, 1028 antibodies |
DNASUi | 840 |
Genome annotation databases
Organism-specific databases
CTDi | 840 |
DisGeNETi | 840 |
GeneCardsi | CASP7 |
HGNCi | HGNC:1508, CASP7 |
HPAi | ENSG00000165806, Tissue enhanced (intestine) |
MIMi | 601761, gene |
neXtProti | NX_P55210 |
OpenTargetsi | ENSG00000165806 |
PharmGKBi | PA26091 |
VEuPathDBi | HostDB:ENSG00000165806.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00940000153232 |
HOGENOMi | CLU_1098210_0_0_1 |
InParanoidi | P55210 |
OrthoDBi | 984395at2759 |
PhylomeDBi | P55210 |
TreeFami | TF102023 |
Enzyme and pathway databases
BRENDAi | 3.4.22.60, 2681 |
PathwayCommonsi | P55210 |
Reactomei | R-HSA-111459, Activation of caspases through apoptosome-mediated cleavage R-HSA-111463, SMAC (DIABLO) binds to IAPs R-HSA-111464, SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-111469, SMAC, XIAP-regulated apoptotic response R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins |
SIGNORi | P55210 |
Miscellaneous databases
BioGRID-ORCSi | 840, 3 hits in 880 CRISPR screens |
ChiTaRSi | CASP7, human |
EvolutionaryTracei | P55210 |
GeneWikii | Caspase_7 |
GenomeRNAii | 840 |
Pharosi | P55210, Tchem |
PROi | PR:P55210 |
RNActi | P55210, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165806, Expressed in colonic mucosa and 224 other tissues |
ExpressionAtlasi | P55210, baseline and differential |
Genevisiblei | P55210, HS |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR015471, Casp3/7 IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit PTHR10454:SF31, PTHR10454:SF31, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit |
SUPFAMi | SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CASP7_HUMAN | |
Accessioni | P55210Primary (citable) accession number: P55210 Secondary accession number(s): B4DQU7 Q96BA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 214 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families