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UniProtKB - P55210 (CASP7_HUMAN)

Entry version 214 (10 Feb 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Caspase-7

Gene

CASP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-. EC:3.4.22.60

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by isatin sulfonamides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei144By similarity1
Active sitei1861 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.22.60, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P55210

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-111459, Activation of caspases through apoptosome-mediated cleavage
R-HSA-111463, SMAC (DIABLO) binds to IAPs
R-HSA-111464, SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
R-HSA-111465, Apoptotic cleavage of cellular proteins
R-HSA-111469, SMAC, XIAP-regulated apoptotic response
R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins

SIGNOR Signaling Network Open Resource

More...SIGNORi		P55210

Protein family/group databases

MEROPS protease database

More...MEROPSi		C14.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase-7 (EC:3.4.22.60)
Short name:
CASP-7
Alternative name(s):
Apoptotic protease Mch-3
CMH-1
ICE-like apoptotic protease 3
Short name:
ICE-LAP3
Cleaved into the following 2 chains:
Caspase-7 subunit p20
Caspase-7 subunit p11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASP7
Synonyms:MCH3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1508, CASP7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601761, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P55210

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165806.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi186C → A: No apoptotic activity. Loss of autocatalytic cleavage. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		840

Open Targets

More...OpenTargetsi		ENSG00000165806

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26091

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P55210, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3468

Drug and drug target database

More...DrugBanki		DB05408, Emricasan
DB03384, Fica
DB06255, Incadronic acid

DrugCentral

More...DrugCentrali		P55210

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1623

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CASP7

Domain mapping of disease mutations (DMDM)

More...DMDMi		1730092

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000046162 – 23N-terminally processedAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000461724 – 198Caspase-7 subunit p20Add BLAST175
PropeptideiPRO_0000004618199 – 2068
ChainiPRO_0000004619207 – 303Caspase-7 subunit p11Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei37PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P55210

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P55210

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P55210

MaxQB - The MaxQuant DataBase

More...MaxQBi		P55210

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P55210

PeptideAtlas

More...PeptideAtlasi		P55210

PRoteomics IDEntifications database

More...PRIDEi		P55210

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56811 [P55210-1]
56812 [P55210-2]
56813 [P55210-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P55210

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P55210

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165806, Expressed in colonic mucosa and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P55210, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P55210, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165806, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.

Interacts with BIRC6/bruce.

Interacts with ATXN3 (short isoform 1) (PubMed:30455355).

Interacts with HSPA5 (PubMed:26045166).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107290, 53 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2862, Caspase-7 complex

Database of interacting proteins

More...DIPi		DIP-29973N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P55210

Protein interaction database and analysis system

More...IntActi		P55210, 25 interactors

Molecular INTeraction database

More...MINTi		P55210

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358327

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P55210

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P55210, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P55210

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P55210

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3573, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153232

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1098210_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P55210

Database of Orthologous Groups

More...OrthoDBi		984395at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P55210

TreeFam database of animal gene trees

More...TreeFami		TF102023

Family and domain databases

Conserved Domains Database

More...CDDi		cd00032, CASc, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015471, Casp3/7
IPR029030, Caspase-like_dom_sf
IPR033139, Caspase_cys_AS
IPR016129, Caspase_his_AS
IPR002398, Pept_C14
IPR002138, Pept_C14_p10
IPR001309, Pept_C14_p20
IPR015917, Pept_C14A

The PANTHER Classification System

More...PANTHERi		PTHR10454, PTHR10454, 1 hit
PTHR10454:SF31, PTHR10454:SF31, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00376, IL1BCENZYME

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00115, CASc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52129, SSF52129, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01122, CASPASE_CYS, 1 hit
PS01121, CASPASE_HIS, 1 hit
PS50207, CASPASE_P10, 1 hit
PS50208, CASPASE_P20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P55210-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT 
        60         70         80         90        100
TRDRVPTYQY NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC 
       110        120        130        140        150
FRSLGFDVIV YNDCSCAKMQ DLLKKASEED HTNAACFACI LLSHGEENVI 
       160        170        180        190        200
YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL FFIQACRGTE LDDGIQADSG 
       210        220        230        240        250
PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRSPGRGSW FVQALCSILE 
       260        270        280        290        300
EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP HFHEKKQIPC VVSMLTKELY 

FSQ
Length:303
Mass (Da):34,277
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD373EE54A232CA4
GO
Isoform Beta (identifier: P55210-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-303: VIYGKDGVTP...MLTKELYFSQ → MESCSVTQAG...TWKSCRSSPG

Note: Lacks enzymatic activity.Curated
Show »
Length:253
Mass (Da):28,030
Checksum:i514964EF3F6229E1
GO
Isoform Alpha' (identifier: P55210-3) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQM

Note: What we call isoform Alpha' is also known as Beta.1 Publication
Show »
Length:336
Mass (Da):37,815
Checksum:i34EEFF8AF5C318A2
GO
Isoform 4 (identifier: P55210-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLF → MQRGLFSDGDT

Show »
Length:278
Mass (Da):31,614
Checksum:iFAF2707D22D9CDE3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRL7A0A0A0MRL7_HUMAN
Caspase-7
CASP7
388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SVL2Q5SVL2_HUMAN
Caspase-7
CASP7
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHZ6A0A5F9ZHZ6_HUMAN
Caspase-7
CASP7
302Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti194G → A in AAC50346 (PubMed:8576161).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0486174D → E2 PublicationsCorresponds to variant dbSNP:rs11555408Ensembl.1
Natural variantiVAR_048618255D → E. Corresponds to variant dbSNP:rs2227310Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0453251 – 36MADDQ…VPSLF → MQRGLFSDGDT in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0008061M → MDCVGWPPGRKWHLEKNTSC GGSSGICASYVTQM in isoform Alpha'. 3 Publications1
Alternative sequenceiVSP_000807149 – 303VIYGK…LYFSQ → MESCSVTQAGVQRRDLGRLQ PPPPRLAEGPSLMMASRPTR GPSMTQMLILDTRSQWKLTS SSPIPRFQAITRGGAQEEAP GLCKPSAPSWRSTEKTWKSC RSSPG in isoform Beta. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U37448 mRNA Translation: AAC50303.1
U37449 mRNA Translation: AAC50304.1
U39613 mRNA Translation: AAC50346.1
U40281 mRNA Translation: AAC50352.1
U67319 mRNA Translation: AAC51152.1
U67320 mRNA Translation: AAC51153.1
U67206 mRNA Translation: AAF21460.1
BT006683 mRNA Translation: AAP35329.1
AB451281 mRNA Translation: BAG70095.1
AB451413 mRNA Translation: BAG70227.1
AK298964 mRNA Translation: BAG61059.1
AL592546 Genomic DNA No translation available.
AL627395 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49494.1
CH471066 Genomic DNA Translation: EAW49495.1
CH471066 Genomic DNA Translation: EAW49498.1
CH471066 Genomic DNA Translation: EAW49496.1
CH471066 Genomic DNA Translation: EAW49497.1
BC015799 mRNA Translation: AAH15799.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58096.1 [P55210-4]
CCDS7580.1 [P55210-3]
CCDS7581.1 [P55210-1]
CCDS7582.1 [P55210-2]

NCBI Reference Sequences

More...RefSeqi		NP_001218.1, NM_001227.4 [P55210-1]
NP_001253985.1, NM_001267056.1 [P55210-1]
NP_001253986.1, NM_001267057.1
NP_001253987.1, NM_001267058.1 [P55210-4]
NP_001307840.1, NM_001320911.1
NP_203124.1, NM_033338.5 [P55210-3]
NP_203125.1, NM_033339.4 [P55210-1]
NP_203126.1, NM_033340.3 [P55210-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000345633; ENSP00000298701; ENSG00000165806 [P55210-1]
ENST00000369315; ENSP00000358321; ENSG00000165806 [P55210-1]
ENST00000369318; ENSP00000358324; ENSG00000165806 [P55210-1]
ENST00000369331; ENSP00000358337; ENSG00000165806 [P55210-2]
ENST00000452490; ENSP00000398107; ENSG00000165806 [P55210-4]
ENST00000614447; ENSP00000478285; ENSG00000165806 [P55210-2]
ENST00000621345; ENSP00000480584; ENSG00000165806 [P55210-1]
ENST00000621607; ENSP00000478999; ENSG00000165806 [P55210-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:840

UCSC genome browser

More...UCSCi		uc001lam.5, human [P55210-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37448 mRNA Translation: AAC50303.1
U37449 mRNA Translation: AAC50304.1
U39613 mRNA Translation: AAC50346.1
U40281 mRNA Translation: AAC50352.1
U67319 mRNA Translation: AAC51152.1
U67320 mRNA Translation: AAC51153.1
U67206 mRNA Translation: AAF21460.1
BT006683 mRNA Translation: AAP35329.1
AB451281 mRNA Translation: BAG70095.1
AB451413 mRNA Translation: BAG70227.1
AK298964 mRNA Translation: BAG61059.1
AL592546 Genomic DNA No translation available.
AL627395 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49494.1
CH471066 Genomic DNA Translation: EAW49495.1
CH471066 Genomic DNA Translation: EAW49498.1
CH471066 Genomic DNA Translation: EAW49496.1
CH471066 Genomic DNA Translation: EAW49497.1
BC015799 mRNA Translation: AAH15799.1
CCDSiCCDS58096.1 [P55210-4]
CCDS7580.1 [P55210-3]
CCDS7581.1 [P55210-1]
CCDS7582.1 [P55210-2]
RefSeqiNP_001218.1, NM_001227.4 [P55210-1]
NP_001253985.1, NM_001267056.1 [P55210-1]
NP_001253986.1, NM_001267057.1
NP_001253987.1, NM_001267058.1 [P55210-4]
NP_001307840.1, NM_001320911.1
NP_203124.1, NM_033338.5 [P55210-3]
NP_203125.1, NM_033339.4 [P55210-1]
NP_203126.1, NM_033340.3 [P55210-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F1JX-ray2.35A/B2-303[»]
1GQFX-ray2.90A/B47-303[»]
1I4OX-ray2.40A/B24-303[»]
1I51X-ray2.45A/C51-198[»]
B/D199-303[»]
1K86X-ray2.60A/B51-303[»]
1K88X-ray2.70A/B51-303[»]
1KMCX-ray2.90A/B1-303[»]
1MIAmodel-A57-193[»]
B211-303[»]
1SHJX-ray2.80A/B50-303[»]
1SHLX-ray3.00A/B57-303[»]
2QL5X-ray2.34A/C24-196[»]
B/D207-303[»]
2QL7X-ray2.40A/C24-196[»]
B/D207-303[»]
2QL9X-ray2.14A/C24-196[»]
B/D207-303[»]
2QLBX-ray2.25A/C24-196[»]
B/D207-303[»]
2QLFX-ray2.80A/C24-196[»]
B/D207-303[»]
2QLJX-ray2.60A/C24-196[»]
B/D207-303[»]
3EDRX-ray2.45A/C24-196[»]
B/D207-303[»]
3H1PX-ray2.61A/B50-303[»]
3IBCX-ray2.75A/C24-196[»]
B/D207-303[»]
3IBFX-ray2.50A/C24-196[»]
B/D207-303[»]
3R5KX-ray2.86A/B1-303[»]
4FDLX-ray2.80A/B2-303[»]
4FEAX-ray3.79A/B57-303[»]
4HQ0X-ray3.00A/B47-303[»]
4HQRX-ray3.00A/B47-303[»]
4JB8X-ray1.70A24-198[»]
B207-303[»]
4JJ8X-ray2.94A/B57-303[»]
4JR1X-ray2.15A/B57-303[»]
4JR2X-ray1.65A/B57-303[»]
4LSZX-ray2.26A/C24-198[»]
B/D207-303[»]
4ZVOX-ray2.85A/C1-198[»]
B/D199-303[»]
4ZVPX-ray2.50A/C1-198[»]
B/D199-303[»]
4ZVQX-ray2.50A/C1-198[»]
B/D199-303[»]
4ZVRX-ray2.30A/C1-198[»]
B/D199-303[»]
4ZVSX-ray2.50A/C1-198[»]
B/D199-303[»]
4ZVTX-ray2.85A/C1-198[»]
B/D199-303[»]
4ZVUX-ray2.60A/C1-198[»]
B/D199-303[»]
5IC6X-ray2.70A/C1-198[»]
B/D199-303[»]
5K20X-ray2.20A/C1-198[»]
B/D199-303[»]
5V6UX-ray2.80A/B1-303[»]
5V6ZX-ray2.60A/B1-303[»]
SMRiP55210
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107290, 53 interactors
ComplexPortaliCPX-2862, Caspase-7 complex
DIPiDIP-29973N
ELMiP55210
IntActiP55210, 25 interactors
MINTiP55210
STRINGi9606.ENSP00000358327

Chemistry databases

BindingDBiP55210
ChEMBLiCHEMBL3468
DrugBankiDB05408, Emricasan
DB03384, Fica
DB06255, Incadronic acid
DrugCentraliP55210
GuidetoPHARMACOLOGYi1623

Protein family/group databases

MEROPSiC14.004

PTM databases

iPTMnetiP55210
PhosphoSitePlusiP55210

Genetic variation databases

BioMutaiCASP7
DMDMi1730092

Proteomic databases

EPDiP55210
jPOSTiP55210
MassIVEiP55210
MaxQBiP55210
PaxDbiP55210
PeptideAtlasiP55210
PRIDEiP55210
ProteomicsDBi56811 [P55210-1]
56812 [P55210-2]
56813 [P55210-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18528, 1028 antibodies

The DNASU plasmid repository

More...DNASUi		840

Genome annotation databases

EnsembliENST00000345633; ENSP00000298701; ENSG00000165806 [P55210-1]
ENST00000369315; ENSP00000358321; ENSG00000165806 [P55210-1]
ENST00000369318; ENSP00000358324; ENSG00000165806 [P55210-1]
ENST00000369331; ENSP00000358337; ENSG00000165806 [P55210-2]
ENST00000452490; ENSP00000398107; ENSG00000165806 [P55210-4]
ENST00000614447; ENSP00000478285; ENSG00000165806 [P55210-2]
ENST00000621345; ENSP00000480584; ENSG00000165806 [P55210-1]
ENST00000621607; ENSP00000478999; ENSG00000165806 [P55210-3]
GeneIDi840
KEGGihsa:840
UCSCiuc001lam.5, human [P55210-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		840
DisGeNETi840

GeneCards: human genes, protein and diseases

More...GeneCardsi		CASP7
HGNCiHGNC:1508, CASP7
HPAiENSG00000165806, Tissue enhanced (intestine)
MIMi601761, gene
neXtProtiNX_P55210
OpenTargetsiENSG00000165806
PharmGKBiPA26091
VEuPathDBiHostDB:ENSG00000165806.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3573, Eukaryota
GeneTreeiENSGT00940000153232
HOGENOMiCLU_1098210_0_0_1
InParanoidiP55210
OrthoDBi984395at2759
PhylomeDBiP55210
TreeFamiTF102023

Enzyme and pathway databases

BRENDAi3.4.22.60, 2681
PathwayCommonsiP55210
ReactomeiR-HSA-111459, Activation of caspases through apoptosome-mediated cleavage
R-HSA-111463, SMAC (DIABLO) binds to IAPs
R-HSA-111464, SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
R-HSA-111465, Apoptotic cleavage of cellular proteins
R-HSA-111469, SMAC, XIAP-regulated apoptotic response
R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins
SIGNORiP55210

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		840, 3 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CASP7, human
EvolutionaryTraceiP55210

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Caspase_7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		840
PharosiP55210, Tchem

Protein Ontology

More...PROi		PR:P55210
RNActiP55210, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165806, Expressed in colonic mucosa and 224 other tissues
ExpressionAtlasiP55210, baseline and differential
GenevisibleiP55210, HS

Family and domain databases

CDDicd00032, CASc, 1 hit
InterProiView protein in InterPro
IPR015471, Casp3/7
IPR029030, Caspase-like_dom_sf
IPR033139, Caspase_cys_AS
IPR016129, Caspase_his_AS
IPR002398, Pept_C14
IPR002138, Pept_C14_p10
IPR001309, Pept_C14_p20
IPR015917, Pept_C14A
PANTHERiPTHR10454, PTHR10454, 1 hit
PTHR10454:SF31, PTHR10454:SF31, 1 hit
PRINTSiPR00376, IL1BCENZYME
SMARTiView protein in SMART
SM00115, CASc, 1 hit
SUPFAMiSSF52129, SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122, CASPASE_CYS, 1 hit
PS01121, CASPASE_HIS, 1 hit
PS50207, CASPASE_P10, 1 hit
PS50208, CASPASE_P20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASP7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55210
Secondary accession number(s): B4DQU7
, B5BU45, D3DRB8, Q13364, Q53YD5, Q5SVL0, Q5SVL3, Q96BA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 10, 2021
This is version 214 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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