CASP7

Functionⁱ

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

Catalytic activityⁱ

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-.

Activity regulationⁱ

Inhibited by isatin sulfonamides.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	144	By similarity		1
Active siteⁱ	186			1

GO - Molecular functionⁱ

cysteine-type endopeptidase activity Source: Reactome
cysteine-type endopeptidase activity involved in apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cysteine-type endopeptidase activity involved in execution phase of apoptosis
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22253444
cysteine-type peptidase activity
Source: ProtInc
Traceable author statementⁱ
- 8567622
peptidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19740745

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17464193
cellular response to staurosporine
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22253444
execution phase of apoptosis Source: Reactome
proteolysis
Source: UniProtKB
Inferred from direct assayⁱ
- 12888622

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease
Biological process	Apoptosis

Enzyme and pathway databases

BRENDAⁱ	3.4.22.60 2681
Reactomeⁱ	R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage R-HSA-111463 SMAC binds to IAPs R-HSA-111464 SMAC-mediated dissociation of IAP:caspase complexes R-HSA-111465 Apoptotic cleavage of cellular proteins R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
SIGNORⁱ	P55210

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C14.004

MEROPSⁱ

C14.004

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Caspase-7 (EC:3.4.22.60) Short name: CASP-7 Alternative name(s): Apoptotic protease Mch-3 CMH-1 ICE-like apoptotic protease 3 Short name: ICE-LAP3 Cleaved into the following 2 chains: Caspase-7 subunit p20 Caspase-7 subunit p11
Gene namesⁱ	Name:CASP7 Synonyms:MCH3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165806.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1508 CASP7
MIMⁱ	601761 gene
neXtProtⁱ	NX_P55210

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	186	C → A: No apoptotic activity.		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	840
Open Targets More...OpenTargetsⁱ	ENSG00000165806
PharmGKBⁱ	PA26091

Chemistry databases

ChEMBLⁱ	CHEMBL3468
Drug and drug target database More...DrugBankⁱ	DB03384 Fica DB05408 IDN-6556
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1623

Polymorphism and mutation databases

BioMutaⁱ	CASP7
DMDMⁱ	1730092

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		RemovedCombined sources
PropeptideⁱPRO_0000004616	2 – 23	N-terminally processedAdd BLAST	22
ChainⁱPRO_0000004617	24 – 198	Caspase-7 subunit p20Add BLAST	175
PropeptideⁱPRO_0000004618	199 – 206		8
ChainⁱPRO_0000004619	207 – 303	Caspase-7 subunit p11Add BLAST	97

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1
Modified residueⁱ	37	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Zymogen

Proteomic databases

EPDⁱ	P55210
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P55210
PaxDbⁱ	P55210
PeptideAtlas More...PeptideAtlasⁱ	P55210
PRIDEⁱ	P55210
ProteomicsDBⁱ	56811 56812 [P55210-2] 56813 [P55210-3]

PTM databases

iPTMnetⁱ	P55210
PhosphoSitePlusⁱ	P55210

Miscellaneous databases

PMAP-CutDBⁱ	P55210

PMAP-CutDBⁱ

P55210

Expressionⁱ

Tissue specificityⁱ

Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

Gene expression databases

Bgeeⁱ	ENSG00000165806 Expressed in 211 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_CASP7
ExpressionAtlasⁱ	P55210 baseline and differential
Genevisibleⁱ	P55210 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025563

HPAⁱ

CAB025563

Interactionⁱ

Subunit structureⁱ

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BIRC2	Q13490	2	EBI-523958,EBI-514538
NIF3L1	Q9GZT8	4	EBI-523958,EBI-740897
PAK2	Q13177	6	EBI-523958,EBI-1045887
SAT1	P21673	5	EBI-523958,EBI-711613
SMPD1	P17405	6	EBI-523958,EBI-7095800
XIAP	P98170	2	EBI-523958,EBI-517127

Protein-protein interaction databases

BioGridⁱ	107290, 47 interactors
Database of interacting proteins More...DIPⁱ	DIP-29973N
ELMⁱ	P55210
IntActⁱ	P55210, 18 interactors
Molecular INTeraction database More...MINTⁱ	P55210
STRINGⁱ	9606.ENSP00000358327

Chemistry databases

BindingDBⁱ

P55210

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	56 – 58	Combined sources	3
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	68 – 74	Combined sources	7
Helixⁱ	80 – 82	Combined sources	3
Helixⁱ	90 – 104	Combined sources	15
Beta strandⁱ	106 – 113	Combined sources	8
Helixⁱ	116 – 127	Combined sources	12
Helixⁱ	131 – 133	Combined sources	3
Beta strandⁱ	137 – 143	Combined sources	7
Beta strandⁱ	149 – 152	Combined sources	4
Beta strandⁱ	155 – 158	Combined sources	4
Helixⁱ	159 – 163	Combined sources	5
Helixⁱ	164 – 166	Combined sources	3
Turnⁱ	168 – 170	Combined sources	3
Helixⁱ	172 – 174	Combined sources	3
Beta strandⁱ	179 – 185	Combined sources	7
Beta strandⁱ	188 – 190	Combined sources	3
Turnⁱ	209 – 211	Combined sources	3
Turnⁱ	215 – 218	Combined sources	4
Beta strandⁱ	219 – 225	Combined sources	7
Beta strandⁱ	227 – 229	Combined sources	3
Beta strandⁱ	232 – 234	Combined sources	3
Turnⁱ	235 – 237	Combined sources	3
Helixⁱ	240 – 252	Combined sources	13
Turnⁱ	253 – 255	Combined sources	3
Helixⁱ	258 – 272	Combined sources	15
Turnⁱ	276 – 278	Combined sources	3
Helixⁱ	280 – 282	Combined sources	3
Beta strandⁱ	290 – 293	Combined sources	4
Beta strandⁱ	296 – 298	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P55210
SMRⁱ	P55210
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P55210

EvolutionaryTraceⁱ

P55210

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3573 Eukaryota ENOG410ZQIE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912
HOVERGENⁱ	HBG050802
InParanoidⁱ	P55210
KEGG Orthology (KO) More...KOⁱ	K04397
PhylomeDBⁱ	P55210
TreeFamⁱ	TF102023

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032 CASc, 1 hit
InterProⁱ	View protein in InterPro IPR015471 Casp3/7 IPR029030 Caspase-like_dom_sf IPR033139 Caspase_cys_AS IPR016129 Caspase_his_AS IPR002398 Pept_C14 IPR002138 Pept_C14_p10 IPR001309 Pept_C14_p20 IPR015917 Pept_C14A
PANTHERⁱ	PTHR10454 PTHR10454, 1 hit PTHR10454:SF31 PTHR10454:SF31, 1 hit
PRINTSⁱ	PR00376 IL1BCENZYME
SMARTⁱ	View protein in SMART SM00115 CASc, 1 hit
SUPFAMⁱ	SSF52129 SSF52129, 1 hit
PROSITEⁱ	View protein in PROSITE PS01122 CASPASE_CYS, 1 hit PS01121 CASPASE_HIS, 1 hit PS50207 CASPASE_P10, 1 hit PS50208 CASPASE_P20, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform Alpha (identifier: P55210-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT 
        60         70         80         90        100
TRDRVPTYQY NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC 
       110        120        130        140        150
FRSLGFDVIV YNDCSCAKMQ DLLKKASEED HTNAACFACI LLSHGEENVI 
       160        170        180        190        200
YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL FFIQACRGTE LDDGIQADSG 
       210        220        230        240        250
PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRSPGRGSW FVQALCSILE 
       260        270        280        290        300
EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP HFHEKKQIPC VVSMLTKELY 

FSQ

Length:303

Mass (Da):34,277

Last modified:October 1, 1996 - v1

Checksum:ⁱCD373EE54A232CA4

GO

Isoform Beta (identifier: P55210-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
149-303: VIYGKDGVTP...MLTKELYFSQ → MESCSVTQAG...TWKSCRSSPG

« Hide

        10         20         30         40         50
MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT 
        60         70         80         90        100
TRDRVPTYQY NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC 
       110        120        130        140        150
FRSLGFDVIV YNDCSCAKMQ DLLKKASEED HTNAACFACI LLSHGEENME 
       160        170        180        190        200
SCSVTQAGVQ RRDLGRLQPP PPRLAEGPSL MMASRPTRGP SMTQMLILDT 
       210        220        230        240        250
RSQWKLTSSS PIPRFQAITR GGAQEEAPGL CKPSAPSWRS TEKTWKSCRS 

SPG

Note: Lacks enzymatic activity.

Show »

Length:253

Mass (Da):28,030

Checksum:ⁱ514964EF3F6229E1

GO

Isoform Alpha' (identifier: P55210-3) [UniParc]FASTA Add to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQM

« Hide

        10         20         30         40         50
MDCVGWPPGR KWHLEKNTSC GGSSGICASY VTQMADDQGC IEEQGVEDSA 
        60         70         80         90        100
NEDSVDAKPD RSSFVPSLFS KKKKNVTMRS IKTTRDRVPT YQYNMNFEKL 
       110        120        130        140        150
GKCIIINNKN FDKVTGMGVR NGTDKDAEAL FKCFRSLGFD VIVYNDCSCA 
       160        170        180        190        200
KMQDLLKKAS EEDHTNAACF ACILLSHGEE NVIYGKDGVT PIKDLTAHFR 
       210        220        230        240        250
GDRCKTLLEK PKLFFIQACR GTELDDGIQA DSGPINDTDA NPRYKIPVEA 
       260        270        280        290        300
DFLFAYSTVP GYYSWRSPGR GSWFVQALCS ILEEHGKDLE IMQILTRVND 
       310        320        330 
RVARHFESQS DDPHFHEKKQ IPCVVSMLTK ELYFSQ

Note: What we call isoform Alpha' is also known as Beta.1 Publication

Show »

Length:336

Mass (Da):37,815

Checksum:ⁱ34EEFF8AF5C318A2

GO

Isoform 4 (identifier: P55210-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-36: MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLF → MQRGLFSDGDT

« Hide

        10         20         30         40         50
MQRGLFSDGD TSKKKKNVTM RSIKTTRDRV PTYQYNMNFE KLGKCIIINN 
        60         70         80         90        100
KNFDKVTGMG VRNGTDKDAE ALFKCFRSLG FDVIVYNDCS CAKMQDLLKK 
       110        120        130        140        150
ASEEDHTNAA CFACILLSHG EENVIYGKDG VTPIKDLTAH FRGDRCKTLL 
       160        170        180        190        200
EKPKLFFIQA CRGTELDDGI QADSGPINDT DANPRYKIPV EADFLFAYST 
       210        220        230        240        250
VPGYYSWRSP GRGSWFVQAL CSILEEHGKD LEIMQILTRV NDRVARHFES 
       260        270 
QSDDPHFHEK KQIPCVVSML TKELYFSQ

Show »

Length:278

Mass (Da):31,614

Checksum:ⁱFAF2707D22D9CDE3

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MRL7	A0A0A0MRL7_HUMAN	Caspase-7 Caspase-7	CASP7	388	Annotation score:
Q5SVL2	Q5SVL2_HUMAN	Caspase-7 Caspase-7	CASP7	222	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	194	G → A in AAC50346 (PubMed:8576161).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048617	4	D → E2 PublicationsCorresponds to variant dbSNP:rs11555408Ensembl.		1
Natural variantⁱVAR_048618	255	D → E. Corresponds to variant dbSNP:rs2227310Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045325	1 – 36	MADDQ…VPSLF → MQRGLFSDGDT in isoform 4. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_000806	1	M → MDCVGWPPGRKWHLEKNTSC GGSSGICASYVTQM in isoform Alpha'. 3 Publications	1
Alternative sequenceⁱVSP_000807	149 – 303	VIYGK…LYFSQ → MESCSVTQAGVQRRDLGRLQ PPPPRLAEGPSLMMASRPTR GPSMTQMLILDTRSQWKLTS SSPIPRFQAITRGGAQEEAP GLCKPSAPSWRSTEKTWKSC RSSPG in isoform Beta. 1 PublicationAdd BLAST	155

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U37448 mRNA Translation: AAC50303.1 U37449 mRNA Translation: AAC50304.1 U39613 mRNA Translation: AAC50346.1 U40281 mRNA Translation: AAC50352.1 U67319 mRNA Translation: AAC51152.1 U67320 mRNA Translation: AAC51153.1 U67206 mRNA Translation: AAF21460.1 BT006683 mRNA Translation: AAP35329.1 AB451281 mRNA Translation: BAG70095.1 AB451413 mRNA Translation: BAG70227.1 AK298964 mRNA Translation: BAG61059.1 AL592546 Genomic DNA No translation available. AL627395 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49494.1 CH471066 Genomic DNA Translation: EAW49495.1 CH471066 Genomic DNA Translation: EAW49498.1 CH471066 Genomic DNA Translation: EAW49496.1 CH471066 Genomic DNA Translation: EAW49497.1 BC015799 mRNA Translation: AAH15799.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58096.1 [P55210-4] CCDS7580.1 [P55210-3] CCDS7581.1 [P55210-1] CCDS7582.1 [P55210-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001218.1, NM_001227.4 [P55210-1] NP_001253985.1, NM_001267056.1 [P55210-1] NP_001253986.1, NM_001267057.1 NP_001253987.1, NM_001267058.1 [P55210-4] NP_001307840.1, NM_001320911.1 NP_203124.1, NM_033338.5 [P55210-3] NP_203125.1, NM_033339.4 [P55210-1] NP_203126.1, NM_033340.3 [P55210-2]
UniGeneⁱ	Hs.9216

Genome annotation databases

Ensemblⁱ	ENST00000345633; ENSP00000298701; ENSG00000165806 [P55210-1] ENST00000369315; ENSP00000358321; ENSG00000165806 [P55210-1] ENST00000369318; ENSP00000358324; ENSG00000165806 [P55210-1] ENST00000369331; ENSP00000358337; ENSG00000165806 [P55210-2] ENST00000452490; ENSP00000398107; ENSG00000165806 [P55210-4] ENST00000614447; ENSP00000478285; ENSG00000165806 [P55210-2] ENST00000621345; ENSP00000480584; ENSG00000165806 [P55210-1] ENST00000621607; ENSP00000478999; ENSG00000165806 [P55210-3]
GeneIDⁱ	840
KEGGⁱ	hsa:840
UCSC genome browser More...UCSCⁱ	uc001lam.5 human [P55210-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P55210	Isoform Alpha' of Caspase-7		HUMAN		336	UniRef100_P55210
UPI00001130E2		HUMAN		280

Protein	Similar proteins		Species	Score	Length	Source
P55210	Isoform Alpha' of Caspase-7		HUMAN		336	UniRef90_P55210
Uncharacterized protein		COLAP		337
Uncharacterized protein		RHIBE		336
Uncharacterized protein		RHIRO		336
Caspase 7		GORGO		336
+23
P55210-2	CASP7 isoform 2		PANTR		253	UniRef90_P55210-2
Uncharacterized protein		PANPA		253
P55210-4	CASP7 isoform 3		PANTR		278	UniRef90_P55210-4
Uncharacterized protein		PANPA		278
Caspase 7		GORGO		278
Uncharacterized protein		MACMU		278
Uncharacterized protein		MACFA		278
+13

Protein	Similar proteins		Species	Score	Length	Source
P55210	Caspase-3		RAT		277	UniRef50_P55213
Caspase-7		MOUSE		303
Caspase-7		MESAU		303
Caspase-3		FELCA		277
Caspase-3		CANLF		277
+525
P55210-2	CASP7 isoform 2		PANTR		253	UniRef50_P55210-2
Uncharacterized protein		PANPA		253
Caspase 7		GORGO		253
Uncharacterized protein		RHIRO		253
Uncharacterized protein		NOMLE		253
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U37448 mRNA Translation: AAC50303.1 U37449 mRNA Translation: AAC50304.1 U39613 mRNA Translation: AAC50346.1 U40281 mRNA Translation: AAC50352.1 U67319 mRNA Translation: AAC51152.1 U67320 mRNA Translation: AAC51153.1 U67206 mRNA Translation: AAF21460.1 BT006683 mRNA Translation: AAP35329.1 AB451281 mRNA Translation: BAG70095.1 AB451413 mRNA Translation: BAG70227.1 AK298964 mRNA Translation: BAG61059.1 AL592546 Genomic DNA No translation available. AL627395 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49494.1 CH471066 Genomic DNA Translation: EAW49495.1 CH471066 Genomic DNA Translation: EAW49498.1 CH471066 Genomic DNA Translation: EAW49496.1 CH471066 Genomic DNA Translation: EAW49497.1 BC015799 mRNA Translation: AAH15799.1
CCDSⁱ	CCDS58096.1 [P55210-4] CCDS7580.1 [P55210-3] CCDS7581.1 [P55210-1] CCDS7582.1 [P55210-2]
RefSeqⁱ	NP_001218.1, NM_001227.4 [P55210-1] NP_001253985.1, NM_001267056.1 [P55210-1] NP_001253986.1, NM_001267057.1 NP_001253987.1, NM_001267058.1 [P55210-4] NP_001307840.1, NM_001320911.1 NP_203124.1, NM_033338.5 [P55210-3] NP_203125.1, NM_033339.4 [P55210-1] NP_203126.1, NM_033340.3 [P55210-2]
UniGeneⁱ	Hs.9216

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1F1J	X-ray	2.35	A/B	2-303	[»]
	1GQF	X-ray	2.90	A/B	47-303	[»]
	1I4O	X-ray	2.40	A/B	24-303	[»]
	1I51	X-ray	2.45	A/C	51-198	[»]
				B/D	199-303	[»]
	1K86	X-ray	2.60	A/B	51-303	[»]
	1K88	X-ray	2.70	A/B	51-303	[»]
	1KMC	X-ray	2.90	A/B	1-303	[»]
	1MIA	model	-	A	57-193	[»]
				B	211-303	[»]
	1SHJ	X-ray	2.80	A/B	50-303	[»]
	1SHL	X-ray	3.00	A/B	57-303	[»]
	2QL5	X-ray	2.34	A/C	24-196	[»]
				B/D	207-303	[»]
	2QL7	X-ray	2.40	A/C	24-196	[»]
				B/D	207-303	[»]
	2QL9	X-ray	2.14	A/C	24-196	[»]
				B/D	207-303	[»]
	2QLB	X-ray	2.25	A/C	24-196	[»]
				B/D	207-303	[»]
	2QLF	X-ray	2.80	A/C	24-196	[»]
				B/D	207-303	[»]
	2QLJ	X-ray	2.60	A/C	24-196	[»]
				B/D	207-303	[»]
	3EDR	X-ray	2.45	A/C	24-196	[»]
				B/D	207-303	[»]
	3H1P	X-ray	2.61	A/B	50-303	[»]
	3IBC	X-ray	2.75	A/C	24-196	[»]
				B/D	207-303	[»]
	3IBF	X-ray	2.50	A/C	24-196	[»]
				B/D	207-303	[»]
	3R5K	X-ray	2.86	A/B	1-303	[»]
	4FDL	X-ray	2.80	A/B	2-303	[»]
	4FEA	X-ray	3.79	A/B	57-303	[»]
	4HQ0	X-ray	3.00	A/B	47-303	[»]
	4HQR	X-ray	3.00	A/B	47-303	[»]
	4JB8	X-ray	1.70	A	24-198	[»]
				B	207-303	[»]
	4JJ8	X-ray	2.94	A/B	57-303	[»]
	4JR1	X-ray	2.15	A/B	57-303	[»]
	4JR2	X-ray	1.65	A/B	57-303	[»]
	4LSZ	X-ray	2.26	A/C	24-198	[»]
				B/D	207-303	[»]
	4ZVO	X-ray	2.85	A/C	1-198	[»]
				B/D	199-303	[»]
	4ZVP	X-ray	2.50	A/C	1-198	[»]
				B/D	199-303	[»]
	4ZVQ	X-ray	2.50	A/C	1-198	[»]
				B/D	199-303	[»]
	4ZVR	X-ray	2.30	A/C	1-198	[»]
				B/D	199-303	[»]
	4ZVS	X-ray	2.50	A/C	1-198	[»]
				B/D	199-303	[»]
	4ZVT	X-ray	2.85	A/C	1-198	[»]
				B/D	199-303	[»]
	4ZVU	X-ray	2.60	A/C	1-198	[»]
				B/D	199-303	[»]
	5IC6	X-ray	2.70	A/C	1-198	[»]
				B/D	199-303	[»]
	5K20	X-ray	2.20	A/C	1-198	[»]
				B/D	199-303	[»]
	5V6U	X-ray	2.80	A/B	1-303	[»]
	5V6Z	X-ray	2.60	A/B	1-303	[»]
ProteinModelPortalⁱ	P55210
SMRⁱ	P55210
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107290, 47 interactors
DIPⁱ	DIP-29973N
ELMⁱ	P55210
IntActⁱ	P55210, 18 interactors
MINTⁱ	P55210
STRINGⁱ	9606.ENSP00000358327

Chemistry databases

BindingDBⁱ	P55210
ChEMBLⁱ	CHEMBL3468
DrugBankⁱ	DB03384 Fica DB05408 IDN-6556
GuidetoPHARMACOLOGYⁱ	1623

Protein family/group databases

MEROPSⁱ	C14.004

MEROPSⁱ

C14.004

PTM databases

iPTMnetⁱ	P55210
PhosphoSitePlusⁱ	P55210

Polymorphism and mutation databases

BioMutaⁱ	CASP7
DMDMⁱ	1730092

Proteomic databases

EPDⁱ	P55210
MaxQBⁱ	P55210
PaxDbⁱ	P55210
PeptideAtlasⁱ	P55210
PRIDEⁱ	P55210
ProteomicsDBⁱ	56811 56812 [P55210-2] 56813 [P55210-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	840
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000345633; ENSP00000298701; ENSG00000165806 [P55210-1] ENST00000369315; ENSP00000358321; ENSG00000165806 [P55210-1] ENST00000369318; ENSP00000358324; ENSG00000165806 [P55210-1] ENST00000369331; ENSP00000358337; ENSG00000165806 [P55210-2] ENST00000452490; ENSP00000398107; ENSG00000165806 [P55210-4] ENST00000614447; ENSP00000478285; ENSG00000165806 [P55210-2] ENST00000621345; ENSP00000480584; ENSG00000165806 [P55210-1] ENST00000621607; ENSP00000478999; ENSG00000165806 [P55210-3]
GeneIDⁱ	840
KEGGⁱ	hsa:840
UCSCⁱ	uc001lam.5 human [P55210-1]

Organism-specific databases

CTDⁱ	840
DisGeNETⁱ	840
EuPathDBⁱ	HostDB:ENSG00000165806.19
GeneCardsⁱ	CASP7
HGNCⁱ	HGNC:1508 CASP7
HPAⁱ	CAB025563
MIMⁱ	601761 gene
neXtProtⁱ	NX_P55210
OpenTargetsⁱ	ENSG00000165806
PharmGKBⁱ	PA26091
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3573 Eukaryota ENOG410ZQIE LUCA
GeneTreeⁱ	ENSGT00760000118912
HOVERGENⁱ	HBG050802
InParanoidⁱ	P55210
KOⁱ	K04397
PhylomeDBⁱ	P55210
TreeFamⁱ	TF102023

Enzyme and pathway databases

BRENDAⁱ	3.4.22.60 2681
Reactomeⁱ	R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage R-HSA-111463 SMAC binds to IAPs R-HSA-111464 SMAC-mediated dissociation of IAP:caspase complexes R-HSA-111465 Apoptotic cleavage of cellular proteins R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
SIGNORⁱ	P55210

Miscellaneous databases

ChiTaRSⁱ	CASP7 human
EvolutionaryTraceⁱ	P55210
GeneWikiⁱ	Caspase_7
GenomeRNAiⁱ	840
PMAP-CutDBⁱ	P55210
Protein Ontology More...PROⁱ	PR:P55210
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165806 Expressed in 211 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_CASP7
ExpressionAtlasⁱ	P55210 baseline and differential
Genevisibleⁱ	P55210 HS

Family and domain databases

CDDⁱ	cd00032 CASc, 1 hit
InterProⁱ	View protein in InterPro IPR015471 Casp3/7 IPR029030 Caspase-like_dom_sf IPR033139 Caspase_cys_AS IPR016129 Caspase_his_AS IPR002398 Pept_C14 IPR002138 Pept_C14_p10 IPR001309 Pept_C14_p20 IPR015917 Pept_C14A
PANTHERⁱ	PTHR10454 PTHR10454, 1 hit PTHR10454:SF31 PTHR10454:SF31, 1 hit
PRINTSⁱ	PR00376 IL1BCENZYME
SMARTⁱ	View protein in SMART SM00115 CASc, 1 hit
SUPFAMⁱ	SSF52129 SSF52129, 1 hit
PROSITEⁱ	View protein in PROSITE PS01122 CASPASE_CYS, 1 hit PS01121 CASPASE_HIS, 1 hit PS50207 CASPASE_P10, 1 hit PS50208 CASPASE_P20, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CASP7_HUMAN
Accessionⁱ	P55210Primary (citable) accession number: P55210 Secondary accession number(s): B4DQU7 Q96BA0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 198 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Peptidase families
Classification of peptidase families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - P55210 (CASP7_HUMAN)

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Caspase-7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

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Protocols and materials databases

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Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ