Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleosome assembly protein 1-like 1

Gene

NAP1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 1
Alternative name(s):
NAP-1-related protein
Short name:
hNRP
Gene namesi
Name:NAP1L1
Synonyms:NRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000187109.13
HGNCiHGNC:7637 NAP1L1
MIMi164060 gene
neXtProtiNX_P55209

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4673
OpenTargetsiENSG00000187109
PharmGKBiPA31439

Polymorphism and mutation databases

BioMutaiNAP1L1
DMDMi1709337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001856522 – 388Nucleosome assembly protein 1-like 1Add BLAST387
PropeptideiPRO_0000393943389 – 391Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei62PhosphothreonineCombined sources1
Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphoserineCombined sources1
Modified residuei116N6-acetyllysineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei388Cysteine methyl esterCurated1
Lipidationi388S-farnesyl cysteine1 Publication1
Isoform 3 (identifier: P55209-3)
Modified residuei1N-acetylmethionineCombined sources1

Post-translational modificationi

Monoglycylated on glutamate residues. Cannot be polyglycylated due to the absence of functional TTLL10 in human (By similarity).By similarityCurated
Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and monoglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP55209
MaxQBiP55209
PaxDbiP55209
PeptideAtlasiP55209
PRIDEiP55209
ProteomicsDBi56810

2D gel databases

OGPiP55209

PTM databases

iPTMnetiP55209
PhosphoSitePlusiP55209
SwissPalmiP55209

Miscellaneous databases

PMAP-CutDBiP55209

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000187109 Expressed in 238 organ(s), highest expression level in amniotic fluid
CleanExiHS_NAP1L1
ExpressionAtlasiP55209 baseline and differential
GenevisibleiP55209 HS

Organism-specific databases

HPAiHPA028861

Interactioni

Subunit structurei

Interacts with SETD1A.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi110754, 147 interactors
CORUMiP55209
IntActiP55209, 84 interactors
MINTiP55209
STRINGi9606.ENSP00000261182

Structurei

3D structure databases

ProteinModelPortaliP55209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi273 – 279Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 30Asp/Glu-rich (acidic)Add BLAST21
Compositional biasi129 – 145Asp/Glu-rich (acidic)Add BLAST17
Compositional biasi348 – 378Asp/Glu-rich (acidic)Add BLAST31

Domaini

The acidic domains are probably involved in the interaction with histones.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiP55209
KOiK11279
OMAiEMITERD
OrthoDBiEOG091G0HVV
PhylomeDBiP55209
TreeFamiTF314349

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55209-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADIDNKEQS ELDQDLDDVE EVEEEETGEE TKLKARQLTV QMMQNPQILA
60 70 80 90 100
ALQERLDGLV ETPTGYIESL PRVVKRRVNA LKNLQVKCAQ IEAKFYEEVH
110 120 130 140 150
DLERKYAVLY QPLFDKRFEI INAIYEPTEE ECEWKPDEED EISEELKEKA
160 170 180 190 200
KIEDEKKDEE KEDPKGIPEF WLTVFKNVDL LSDMVQEHDE PILKHLKDIK
210 220 230 240 250
VKFSDAGQPM SFVLEFHFEP NEYFTNEVLT KTYRMRSEPD DSDPFSFDGP
260 270 280 290 300
EIMGCTGCQI DWKKGKNVTL KTIKKKQKHK GRGTVRTVTK TVSNDSFFNF
310 320 330 340 350
FAPPEVPESG DLDDDAEAIL AADFEIGHFL RERIIPRSVL YFTGEAIEDD
360 370 380 390
DDDYDEEGEE ADEEGEEEGD EENDPDYDPK KDQNPAECKQ Q
Length:391
Mass (Da):45,374
Last modified:October 1, 1996 - v1
Checksum:iE5B2EAA4EAE551D2
GO
Isoform 2 (identifier: P55209-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-391: EGEEEGDEENDPDYDPKKDQNPAECKQQ → VMFTK

Note: No experimental confirmation available.
Show »
Length:368
Mass (Da):42,762
Checksum:i2EBD999BBE889411
GO
Isoform 3 (identifier: P55209-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     117-143: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:323
Mass (Da):37,345
Checksum:iA9296FEC84E2B260
GO

Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W543F8W543_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
328Annotation score:
F5H4R6F5H4R6_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
383Annotation score:
B7Z9C2B7Z9C2_HUMAN
cDNA FLJ58569, highly similar to Nu...
NAP1L1
349Annotation score:
F8W118F8W118_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
209Annotation score:
F8VY35F8VY35_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
264Annotation score:
H0YHC3H0YHC3_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
198Annotation score:
H0YH88H0YH88_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
177Annotation score:
F8W020F8W020_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
207Annotation score:
F8W0J6F8W0J6_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
379Annotation score:
F8VV59F8VV59_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L1
327Annotation score:
There are more potential isoformsShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0573571 – 41Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_057358117 – 143Missing in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_053909364 – 391EGEEE…ECKQQ → VMFTK in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86667 mRNA Translation: AAC37544.1
BT007023 mRNA Translation: AAP35669.1
AK055020 mRNA Translation: BAG51450.1
AK122670 mRNA Translation: BAG53656.1
AL162068 mRNA Translation: CAB82405.1
AC011611 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97318.1
BC002387 mRNA Translation: AAH02387.1
CCDSiCCDS9013.1 [P55209-1]
PIRiS40510
RefSeqiNP_001294853.1, NM_001307924.2
NP_001317160.1, NM_001330231.1 [P55209-1]
NP_001317161.1, NM_001330232.1
NP_004528.1, NM_004537.6 [P55209-1]
NP_631946.1, NM_139207.4 [P55209-1]
XP_011536695.1, XM_011538393.2 [P55209-1]
XP_016874827.1, XM_017019338.1 [P55209-1]
UniGeneiHs.524599
Hs.695185

Genome annotation databases

EnsembliENST00000261182; ENSP00000261182; ENSG00000187109 [P55209-1]
ENST00000393263; ENSP00000376947; ENSG00000187109 [P55209-1]
ENST00000431879; ENSP00000409795; ENSG00000187109 [P55209-3]
ENST00000549596; ENSP00000447793; ENSG00000187109 [P55209-2]
ENST00000618691; ENSP00000477538; ENSG00000187109 [P55209-1]
GeneIDi4673
KEGGihsa:4673
UCSCiuc001sxw.3 human [P55209-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86667 mRNA Translation: AAC37544.1
BT007023 mRNA Translation: AAP35669.1
AK055020 mRNA Translation: BAG51450.1
AK122670 mRNA Translation: BAG53656.1
AL162068 mRNA Translation: CAB82405.1
AC011611 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97318.1
BC002387 mRNA Translation: AAH02387.1
CCDSiCCDS9013.1 [P55209-1]
PIRiS40510
RefSeqiNP_001294853.1, NM_001307924.2
NP_001317160.1, NM_001330231.1 [P55209-1]
NP_001317161.1, NM_001330232.1
NP_004528.1, NM_004537.6 [P55209-1]
NP_631946.1, NM_139207.4 [P55209-1]
XP_011536695.1, XM_011538393.2 [P55209-1]
XP_016874827.1, XM_017019338.1 [P55209-1]
UniGeneiHs.524599
Hs.695185

3D structure databases

ProteinModelPortaliP55209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110754, 147 interactors
CORUMiP55209
IntActiP55209, 84 interactors
MINTiP55209
STRINGi9606.ENSP00000261182

PTM databases

iPTMnetiP55209
PhosphoSitePlusiP55209
SwissPalmiP55209

Polymorphism and mutation databases

BioMutaiNAP1L1
DMDMi1709337

2D gel databases

OGPiP55209

Proteomic databases

EPDiP55209
MaxQBiP55209
PaxDbiP55209
PeptideAtlasiP55209
PRIDEiP55209
ProteomicsDBi56810

Protocols and materials databases

DNASUi4673
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261182; ENSP00000261182; ENSG00000187109 [P55209-1]
ENST00000393263; ENSP00000376947; ENSG00000187109 [P55209-1]
ENST00000431879; ENSP00000409795; ENSG00000187109 [P55209-3]
ENST00000549596; ENSP00000447793; ENSG00000187109 [P55209-2]
ENST00000618691; ENSP00000477538; ENSG00000187109 [P55209-1]
GeneIDi4673
KEGGihsa:4673
UCSCiuc001sxw.3 human [P55209-1]

Organism-specific databases

CTDi4673
DisGeNETi4673
EuPathDBiHostDB:ENSG00000187109.13
GeneCardsiNAP1L1
HGNCiHGNC:7637 NAP1L1
HPAiHPA028861
MIMi164060 gene
neXtProtiNX_P55209
OpenTargetsiENSG00000187109
PharmGKBiPA31439
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiP55209
KOiK11279
OMAiEMITERD
OrthoDBiEOG091G0HVV
PhylomeDBiP55209
TreeFamiTF314349

Miscellaneous databases

ChiTaRSiNAP1L1 human
GeneWikiiNAP1L1
GenomeRNAii4673
PMAP-CutDBiP55209
PROiPR:P55209
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187109 Expressed in 238 organ(s), highest expression level in amniotic fluid
CleanExiHS_NAP1L1
ExpressionAtlasiP55209 baseline and differential
GenevisibleiP55209 HS

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNP1L1_HUMAN
AccessioniPrimary (citable) accession number: P55209
Secondary accession number(s): B3KNT8, B3KV44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again