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Protein

Peregrin

Gene

BRPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:27939640). Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri21 – 47C2H2-typePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri273 – 323PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri327 – 360C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri384 – 448PHD-type 2PROSITE-ProRule annotationAdd BLAST65

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • histone H3 acetylation Source: UniProtKB
  • histone H3-K23 acetylation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of signal transduction by p53 class mediator Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PeregrinCurated
Alternative name(s):
Bromodomain and PHD finger-containing protein 1Imported
Protein Br1401 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRPF1Imported
Synonyms:BR1401 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156983.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14255 BRPF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602410 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55201

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder with dysmorphic facies and ptosis (IDDDFP)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development, intellectual disability, delayed language, and facial dysmorphisms, most notably ptosis. Additional features may include poor growth, hypotonia, and seizures.
See also OMIM:617333
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07807635 – 1214Missing in IDDDFP. 1 PublicationAdd BLAST1180
Natural variantiVAR_078077370P → S in IDDDFP; decreased histone H3-K23 acetylation; changed cytoplasmic localization; no effect on expression and assembly of the MOZ/MORF complex. 1 PublicationCorresponds to variant dbSNP:rs1057519509Ensembl.1
Natural variantiVAR_078078389C → R in IDDDFP. 1 PublicationCorresponds to variant dbSNP:rs1057519515Ensembl.1
Natural variantiVAR_078079455 – 1214Missing in IDDDFP; decreased histone H3-K23 acetylation; increased localization to the nucleus; decreased expression and assembly of the MOZ/MORF complex. 1 PublicationAdd BLAST760
Natural variantiVAR_078080833 – 1214Missing in IDDDFP; no effect on histone H3-K23 acetylation; increased aggregation in the cytoplasm; no effect on expression and assembly of the MOZ/MORF complex. 1 PublicationAdd BLAST382
Natural variantiVAR_078081988 – 1214Missing in IDDDFP. 1 PublicationAdd BLAST227
Natural variantiVAR_0780821100 – 1214Missing in IDDDFP; no effect on histone H3-K23 acetylation; no effect on expression and assembly of the MOZ/MORF complex. 1 PublicationAdd BLAST115

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7862

MalaCards human disease database

More...
MalaCardsi
BRPF1
MIMi617333 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000156983

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25424

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3132741

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2730

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRPF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241271

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111871 – 1214PeregrinAdd BLAST1214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei120PhosphoserineCombined sources1
Modified residuei147N6-acetyllysineBy similarity1
Modified residuei238PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1
Modified residuei580N6-acetyllysineBy similarity1
Modified residuei858PhosphothreonineBy similarity1
Modified residuei860PhosphoserineCombined sources1
Modified residuei917PhosphoserineBy similarity1
Modified residuei922PhosphoserineBy similarity1
Modified residuei926PhosphoserineBy similarity1
Modified residuei1076PhosphoserineCombined sources1
Modified residuei1187PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated by KAT6A.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P55201

MaxQB - The MaxQuant DataBase

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MaxQBi
P55201

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55201

PeptideAtlas

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PeptideAtlasi
P55201

PRoteomics IDEntifications database

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PRIDEi
P55201

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56806
56807 [P55201-2]
56808 [P55201-3]
56809 [P55201-4]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P55201-2 [P55201-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P55201

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55201

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156983 Expressed in 211 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_BRPF1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55201 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55201 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA003359

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (PubMed:16387653, PubMed:18794358, PubMed:27939640). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20400950, PubMed:21720545). May interact with KAT7 (PubMed:27939640).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113614, 26 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-727 MOZ1 histone acetyltransferase complex
CPX-738 MORF1 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P55201

Database of interacting proteins

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DIPi
DIP-59001N

Protein interaction database and analysis system

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IntActi
P55201, 26 interactors

Molecular INTeraction database

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MINTi
P55201

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373340

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P55201

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P55201

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55201

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P55201

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini645 – 715BromoPROSITE-ProRule annotationAdd BLAST71
Domaini1085 – 1168PWWPPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni59 – 222Interaction with KAT6A and KAT6B1 PublicationAdd BLAST164
Regioni501 – 821Interaction with MEAF6 and ING51 PublicationAdd BLAST321
Regioni543 – 1079Required for RUNX1 and RUNX2 transcriptional activationAdd BLAST537

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 47C2H2-typePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri273 – 323PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri327 – 360C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri384 – 448PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0955 Eukaryota
COG5141 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157794

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000705

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004895

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P55201

KEGG Orthology (KO)

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KOi
K11348

Identification of Orthologs from Complete Genome Data

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OMAi
WQWLPAN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00VK

Database for complete collections of gene phylogenies

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PhylomeDBi
P55201

TreeFam database of animal gene trees

More...
TreeFami
TF316118

Family and domain databases

Conserved Domains Database

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CDDi
cd05839 BR140_related, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR013087 Znf_C2H2_type
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55201-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP
60 70 80 90 100
PPPQQTPLRK HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE
110 120 130 140 150
VDLHGRVHRI SIFDNLDVVS EDEEAPEEAP ENGSNKENTE TPAATPKSGK
160 170 180 190 200
HKNKEKRKDS NHHHHHNVSA STTPKLPEVV YRELEQDTPD APPRPTSYYR
210 220 230 240 250
YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI PQEIFEYLMD
260 270 280 290 300
RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV
310 320 330 340 350
HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH
360 370 380 390 400
VVCALWIPEV CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC
410 420 430 440 450
HKANCYTAFH VTCAQQAGLY MKMEPVRETG ANGTSFSVRK TAYCDIHTPP
460 470 480 490 500
GSARRLPALS HSEGEEDEDE EEDEGKGWSS EKVKKAKAKS RIKMKKARKI
510 520 530 540 550
LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL HSYWTLKRQS
560 570 580 590 600
RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER
610 620 630 640 650
ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG
660 670 680 690 700
NIFSEPVPLS EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI
710 720 730 740 750
VSNCLKYNAK DTIFYRAAVR LREQGGAVLR QARRQAEKMG IDFETGMHIP
760 770 780 790 800
HSLAGDEATH HTEDAAEEER LVLLENQKHL PVEEQLKLLL ERLDEVNASK
810 820 830 840 850
QSVGRSRRAK MIKKEMTALR RKLAHQRETG RDGPERHGPS SRGSLTPHPA
860 870 880 890 900
ACDKDGQTDS AAEESSSQET SKGLGPNMSS TPAHEVGRRT SVLFSKKNPK
910 920 930 940 950
TAGPPKRPGR PPKNRESQMT PSHGGSPVGP PQLPIMSSLR QRKRGRSPRP
960 970 980 990 1000
SSSSDSDSDK STEDPPMDLP ANGFSGGNQP VKKSFLVYRN DCSLPRSSSD
1010 1020 1030 1040 1050
SESSSSSSSS AASDRTSTTP SKQGRGKPSF SRGTFPEDSS EDTSGTENEA
1060 1070 1080 1090 1100
YSVGTGRGVG HSMVRKSLGR GAGWLSEDED SPLDALDLVW AKCRGYPSYP
1110 1120 1130 1140 1150
ALIIDPKMPR EGMFHHGVPI PVPPLEVLKL GEQMTQEARE HLYLVLFFDN
1160 1170 1180 1190 1200
KRTWQWLPRT KLVPLGVNQD LDKEKMLEGR KSNIRKSVQI AYHRALQHRS
1210
KVQGEQSSET SDSD
Length:1,214
Mass (Da):137,499
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i618F359F21F4CBF7
GO
Isoform 2 (identifier: P55201-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-660: S → SEVTELD

Show »
Length:1,220
Mass (Da):138,185
Checksum:iA4ECE0FC3638BCE5
GO
Isoform 3 (identifier: P55201-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-765: Missing.

Note: No experimental confirmation available.
Show »
Length:1,213
Mass (Da):137,428
Checksum:iC92CF66AB4788CB6
GO
Isoform 4 (identifier: P55201-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     873-967: Missing.

Note: No experimental confirmation available.
Show »
Length:1,119
Mass (Da):127,363
Checksum:i1DD0F0BFDF1AFDCC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JHC0C9JHC0_HUMAN
Peregrin
BRPF1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDK5C9JDK5_HUMAN
Peregrin
BRPF1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5F → L in BAG57257 (PubMed:14702039).Curated1
Sequence conflicti299A → E in AAB02119 (PubMed:7906940).Curated1
Sequence conflicti306G → D in BAG57257 (PubMed:14702039).Curated1
Sequence conflicti341K → R in BAG57257 (PubMed:14702039).Curated1
Sequence conflicti729L → V in AAB02119 (PubMed:7906940).Curated1
Sequence conflicti1035F → S in BAG57257 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07807635 – 1214Missing in IDDDFP. 1 PublicationAdd BLAST1180
Natural variantiVAR_078077370P → S in IDDDFP; decreased histone H3-K23 acetylation; changed cytoplasmic localization; no effect on expression and assembly of the MOZ/MORF complex. 1 PublicationCorresponds to variant dbSNP:rs1057519509Ensembl.1
Natural variantiVAR_078078389C → R in IDDDFP. 1 PublicationCorresponds to variant dbSNP:rs1057519515Ensembl.1
Natural variantiVAR_078079455 – 1214Missing in IDDDFP; decreased histone H3-K23 acetylation; increased localization to the nucleus; decreased expression and assembly of the MOZ/MORF complex. 1 PublicationAdd BLAST760
Natural variantiVAR_078080833 – 1214Missing in IDDDFP; no effect on histone H3-K23 acetylation; increased aggregation in the cytoplasm; no effect on expression and assembly of the MOZ/MORF complex. 1 PublicationAdd BLAST382
Natural variantiVAR_078081988 – 1214Missing in IDDDFP. 1 PublicationAdd BLAST227
Natural variantiVAR_0780821100 – 1214Missing in IDDDFP; no effect on histone H3-K23 acetylation; no effect on expression and assembly of the MOZ/MORF complex. 1 PublicationAdd BLAST115
Natural variantiVAR_0282321117G → E. Corresponds to variant dbSNP:rs1042294Ensembl.1
Natural variantiVAR_0484301193H → Q. Corresponds to variant dbSNP:rs36081837Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037955660S → SEVTELD in isoform 2. 1 Publication1
Alternative sequenceiVSP_037956765Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_037957873 – 967Missing in isoform 4. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M91585 mRNA Translation: AAB02119.1
AF176815 Genomic DNA Translation: AAF19605.1
AK293865 mRNA Translation: BAG57257.1
AL713696 mRNA Translation: CAD28495.1
AC022382 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW63976.1
BC053851 mRNA Translation: AAH53851.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2575.1 [P55201-1]
CCDS33692.1 [P55201-2]
CCDS82729.1 [P55201-4]
CCDS82730.1 [P55201-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC2069

NCBI Reference Sequences

More...
RefSeqi
NP_001003694.1, NM_001003694.1 [P55201-2]
NP_001305978.1, NM_001319049.1 [P55201-4]
NP_001305979.1, NM_001319050.1 [P55201-3]
NP_004625.2, NM_004634.2 [P55201-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1004

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383829; ENSP00000373340; ENSG00000156983 [P55201-2]
ENST00000424362; ENSP00000398863; ENSG00000156983 [P55201-3]
ENST00000433861; ENSP00000402485; ENSG00000156983 [P55201-4]
ENST00000457855; ENSP00000410210; ENSG00000156983 [P55201-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7862

UCSC genome browser

More...
UCSCi
uc003bsf.4 human [P55201-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91585 mRNA Translation: AAB02119.1
AF176815 Genomic DNA Translation: AAF19605.1
AK293865 mRNA Translation: BAG57257.1
AL713696 mRNA Translation: CAD28495.1
AC022382 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW63976.1
BC053851 mRNA Translation: AAH53851.1
CCDSiCCDS2575.1 [P55201-1]
CCDS33692.1 [P55201-2]
CCDS82729.1 [P55201-4]
CCDS82730.1 [P55201-3]
PIRiJC2069
RefSeqiNP_001003694.1, NM_001003694.1 [P55201-2]
NP_001305978.1, NM_001319049.1 [P55201-4]
NP_001305979.1, NM_001319050.1 [P55201-3]
NP_004625.2, NM_004634.2 [P55201-1]
UniGeneiHs.1004

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9ENMR-A633-740[»]
2RS9NMR-B633-740[»]
2X35X-ray2.00A1076-1205[»]
2X4WX-ray1.50A1076-1205[»]
2X4XX-ray1.85A/C/E/G1076-1205[»]
2X4YX-ray1.70A/C/E/G/I/K/M/O1076-1205[»]
3L42X-ray1.30A1079-1207[»]
3MO8X-ray1.69A1079-1207[»]
4LC2X-ray1.65A626-740[»]
4QYDX-ray1.94A629-742[»]
4QYLX-ray1.80A/B/C/D629-742[»]
4UYEX-ray1.65A/B622-738[»]
5C6SX-ray1.30A1079-1207[»]
5C7NX-ray1.75A626-740[»]
5C85X-ray1.70A626-740[»]
5C87X-ray1.55A626-740[»]
5C89X-ray1.65A627-740[»]
5D7XX-ray1.35A626-740[»]
5DY7X-ray1.69A626-740[»]
5DYAX-ray1.65A626-740[»]
5DYCX-ray1.65A626-740[»]
5E3DX-ray1.71A626-740[»]
5E3GX-ray1.65A626-740[»]
5EM3X-ray1.40A626-740[»]
5EPRX-ray1.65A626-740[»]
5EPSX-ray1.47A627-740[»]
5EQ1X-ray1.55A626-740[»]
5ERCX-ray2.05A274-450[»]
5ETBX-ray1.33A626-740[»]
5ETDX-ray1.40A626-740[»]
5EV9X-ray1.45A626-740[»]
5EVAX-ray1.45A626-740[»]
5EWCX-ray1.75A626-740[»]
5EWDX-ray1.58A626-740[»]
5EWHX-ray1.63A626-740[»]
5EWVX-ray1.67A626-740[»]
5EWWX-ray1.73A626-740[»]
5FFVX-ray1.30A/B626-740[»]
5FFWX-ray1.50A/B626-740[»]
5FFYX-ray1.55A626-740[»]
5FG4X-ray1.65A626-740[»]
5FG5X-ray1.50A/B626-740[»]
5G4RX-ray1.96A/B/C/D622-738[»]
5G4SX-ray1.60A624-738[»]
5MWGX-ray1.50A/B626-740[»]
5MWHX-ray1.65A/B626-740[»]
5MWZX-ray1.25A626-740[»]
5MYGX-ray2.30A/B/C/D626-740[»]
5O4SX-ray1.75A/B626-740[»]
5O4TX-ray1.50A626-740[»]
5O55X-ray1.45A626-740[»]
5O5AX-ray1.60A626-740[»]
5O5FX-ray1.30A626-740[»]
5O5HX-ray1.85A626-740[»]
5OV8X-ray1.80A/B626-740[»]
5OWAX-ray1.95A/B/C/D626-740[»]
5OWBX-ray1.65A626-740[»]
5OWEX-ray1.70A626-740[»]
5T4UX-ray1.50A627-740[»]
5T4VX-ray1.65A627-740[»]
6EKQX-ray1.65A/B626-740[»]
ProteinModelPortaliP55201
SMRiP55201
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113614, 26 interactors
ComplexPortaliCPX-727 MOZ1 histone acetyltransferase complex
CPX-738 MORF1 histone acetyltransferase complex
CORUMiP55201
DIPiDIP-59001N
IntActiP55201, 26 interactors
MINTiP55201
STRINGi9606.ENSP00000373340

Chemistry databases

BindingDBiP55201
ChEMBLiCHEMBL3132741
GuidetoPHARMACOLOGYi2730

PTM databases

iPTMnetiP55201
PhosphoSitePlusiP55201

Polymorphism and mutation databases

BioMutaiBRPF1
DMDMi116241271

Proteomic databases

EPDiP55201
MaxQBiP55201
PaxDbiP55201
PeptideAtlasiP55201
PRIDEiP55201
ProteomicsDBi56806
56807 [P55201-2]
56808 [P55201-3]
56809 [P55201-4]
TopDownProteomicsiP55201-2 [P55201-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383829; ENSP00000373340; ENSG00000156983 [P55201-2]
ENST00000424362; ENSP00000398863; ENSG00000156983 [P55201-3]
ENST00000433861; ENSP00000402485; ENSG00000156983 [P55201-4]
ENST00000457855; ENSP00000410210; ENSG00000156983 [P55201-1]
GeneIDi7862
KEGGihsa:7862
UCSCiuc003bsf.4 human [P55201-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7862
DisGeNETi7862
EuPathDBiHostDB:ENSG00000156983.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BRPF1
HGNCiHGNC:14255 BRPF1
HPAiHPA003359
MalaCardsiBRPF1
MIMi602410 gene
617333 phenotype
neXtProtiNX_P55201
OpenTargetsiENSG00000156983
PharmGKBiPA25424

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0955 Eukaryota
COG5141 LUCA
GeneTreeiENSGT00940000157794
HOGENOMiHOG000000705
HOVERGENiHBG004895
InParanoidiP55201
KOiK11348
OMAiWQWLPAN
OrthoDBiEOG091G00VK
PhylomeDBiP55201
TreeFamiTF316118

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BRPF1 human
EvolutionaryTraceiP55201

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7862

Protein Ontology

More...
PROi
PR:P55201

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156983 Expressed in 211 organ(s), highest expression level in oocyte
CleanExiHS_BRPF1
ExpressionAtlasiP55201 baseline and differential
GenevisibleiP55201 HS

Family and domain databases

CDDicd05839 BR140_related, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR013087 Znf_C2H2_type
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRPF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55201
Secondary accession number(s): B4DEZ6
, Q7Z6E0, Q8TCM6, Q9UHI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: December 5, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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