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UniProtKB - P55198 (AF17_HUMAN)

Entry version 172 (25 May 2022)
Sequence version 3 (28 Mar 2018)
Previous versions | rss
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Protein

Protein AF-17

Gene

MLLT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei551KMT2A/MLL1 fusion point (in acute myeloid leukemia patient)1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri5 – 57PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri62 – 95C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri118 – 181PHD-type 2PROSITE-ProRule annotationAdd BLAST64

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P55198

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P55198

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein AF-17
Alternative name(s):
ALL1-fused gene from chromosome 17 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLLT6
Synonyms:AF17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7138, MLLT6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600328, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P55198

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000275023

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		4302

MalaCards human disease database

More...MalaCardsi		MLLT6

Open Targets

More...OpenTargetsi		ENSG00000275023

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30854

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P55198, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MLLT6

Domain mapping of disease mutations (DMDM)

More...DMDMi		215273929

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002159371 – 1093Protein AF-17Add BLAST1093

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei451PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P55198

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P55198

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P55198

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P55198

PeptideAtlas

More...PeptideAtlasi		P55198

PRoteomics IDEntifications database

More...PRIDEi		P55198

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56804

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P55198, 18 sites, 2 O-linked glycans (18 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P55198

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P55198

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P55198, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000275023, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with histone H3; interaction is necessary for MLLT6 binding to nucleosomes; interaction is inhibited by histone H3 'Lys-27' methylations (H3K27me1, H3K27me2 and H3K27me3).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110448, 83 interactors

Protein interaction database and analysis system

More...IntActi		P55198, 51 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000479910

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P55198, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P55198

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P55198

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni185 – 500DisorderedSequence analysisAdd BLAST316
Regioni729 – 764Leucine-zipperAdd BLAST36
Regioni775 – 871DisorderedSequence analysisAdd BLAST97
Regioni1060 – 1093DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi228 – 242Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi270 – 288Polar residuesSequence analysisAdd BLAST19
Compositional biasi289 – 304Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi316 – 357Polar residuesSequence analysisAdd BLAST42
Compositional biasi374 – 388Pro residuesSequence analysisAdd BLAST15
Compositional biasi406 – 420Polar residuesSequence analysisAdd BLAST15
Compositional biasi785 – 836Polar residuesSequence analysisAdd BLAST52
Compositional biasi850 – 864Pro residuesSequence analysisAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 57PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri62 – 95C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri118 – 181PHD-type 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0956, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158572

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P55198

Identification of Orthologs from Complete Genome Data

More...OMAi		YQMIQQV

Database of Orthologous Groups

More...OrthoDBi		327785at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P55198

TreeFam database of animal gene trees

More...TreeFami		TF316118

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034732, EPHD
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51805, EPHD, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P55198-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEMVGGCCV CSDERGWAEN PLVYCDGHAC SVAVHQACYG IVQVPTGPWF 
        60         70         80         90        100
CRKCESQERA ARVRCELCPH KDGALKRTDN GGWAHVVCAL YIPEVQFANV 
       110        120        130        140        150
LTMEPIVLQY VPHDRFNKTC YICEEQGRES KAASGACMTC NRHGCRQAFH 
       160        170        180        190        200
VTCAQMAGLL CEEEVLEVDN VKYCGYCKYH FSKMKTSRHS SGGGGGGAGG 
       210        220        230        240        250
GGGSMGGGGS GFISGRRSRS ASPSTQQEKH PTHHERGQKK SRKDKERLKQ 
       260        270        280        290        300
KHKKRPESPP SILTPPVVPT ADKVSSSASS SSHHEASTQE TSESSRESKG 
       310        320        330        340        350
KKSSSHSLSH KGKKLSSGKG VSSFTSASSS SSSSSSSSGG PFQPAVSSLQ 
       360        370        380        390        400
SSPDFSAFPK LEQPEEDKYS KPTAPAPSAP PSPSAPEPPK ADLFEQKVVF 
       410        420        430        440        450
SGFGPIMRFS TTTSSSGRAR APSPGDYKSP HVTGSGASAG THKRMPALSA 
       460        470        480        490        500
TPVPADETPE TGLKEKKHKA SKRSRHGPGR PKGSRNKEGT GGPAAPSLPS 
       510        520        530        540        550
AQLAGFTATA ASPFSGGSLV SSGLGGLSSR TFGPSGSLPS LSLESPLLGA 
       560        570        580        590        600
GIYTSNKDPI SHSGGMLRAV CSTPLSSSLL GPPGTSALPR LSRSPFTSTL 
       610        620        630        640        650
PSSSASISTT QVFSLAGSTF SLPSTHIFGT PMGAVNPLLS QAESSHTEPD 
       660        670        680        690        700
LEDCSFRCRG TSPQESLSSM SPISSLPALF DQTASAPCGG GQLDPAAPGT 
       710        720        730        740        750
TNMEQLLEKQ GDGEAGVNIV EMLKALHALQ KENQRLQEQI LSLTAKKERL 
       760        770        780        790        800
QILNVQLSVP FPALPAALPA ANGPVPGPYG LPPQAGSSDS LSTSKSPPGK 
       810        820        830        840        850
SSLGLDNSLS TSSEDPHSGC PSRSSSSLSF HSTPPPLPLL QQSPATLPLA 
       860        870        880        890        900
LPGAPAPLPP QPQNGLGRAP GAAGLGAMPM AEGLLGGLAG SGGLPLNGLL 
       910        920        930        940        950
GGLNGAAAPN PASLSQAGGA PTLQLPGCLN SLTEQQRHLL QQQEQQLQQL 
       960        970        980        990       1000
QQLLASPQLT PEHQTVVYQM IQQIQQKREL QRLQMAGGSQ LPMASLLAGS 
      1010       1020       1030       1040       1050
STPLLSAGTP GLLPTASAPP LLPAGALVAP SLGNNTSLMA AAAAAAAVAA 
      1060       1070       1080       1090 
AGGPPVLTAQ TNPFLSLSGA EGSGGGPKGG TADKGASANQ EKG
Length:1,093
Mass (Da):112,048
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC55F0801D9A0A5C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P2C6Q6P2C6_HUMAN
MLLT6 protein
MLLT6
325Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVY1A0A087WVY1_HUMAN
Protein AF-17
MLLT6
302Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07237 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15670 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126Q → T in AAA21145 (PubMed:8058765).Curated1
Sequence conflicti735R → W in BAD92870 (Ref. 3) Curated1
Sequence conflicti1065L → P in BAB15670 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08017033A → V. Corresponds to variant dbSNP:rs17855918Ensembl.1
Natural variantiVAR_022076198A → T. Corresponds to variant dbSNP:rs2241012Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U07932 mRNA Translation: AAA21145.1
AC006449 Genomic DNA No translation available.
AB209633 mRNA Translation: BAD92870.1
AK027133 mRNA Translation: BAB15670.1 Different initiation.
BC007237 mRNA Translation: AAH07237.1 Different initiation.
AL133659 mRNA Translation: CAB63772.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11327.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38533

NCBI Reference Sequences

More...RefSeqi		NP_005928.2, NM_005937.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000618876.2; ENSP00000477969.1; ENSG00000275851.4
ENST00000621332.5; ENSP00000479910.1; ENSG00000275023.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4302

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000621332.5; ENSP00000479910.1; NM_005937.4; NP_005928.2

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07932 mRNA Translation: AAA21145.1
AC006449 Genomic DNA No translation available.
AB209633 mRNA Translation: BAD92870.1
AK027133 mRNA Translation: BAB15670.1 Different initiation.
BC007237 mRNA Translation: AAH07237.1 Different initiation.
AL133659 mRNA Translation: CAB63772.2
CCDSiCCDS11327.1
PIRiI38533
RefSeqiNP_005928.2, NM_005937.3

3D structure databases

AlphaFoldDBiP55198
SMRiP55198
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110448, 83 interactors
IntActiP55198, 51 interactors
STRINGi9606.ENSP00000479910

PTM databases

GlyGeniP55198, 18 sites, 2 O-linked glycans (18 sites)
iPTMnetiP55198
PhosphoSitePlusiP55198

Genetic variation databases

BioMutaiMLLT6
DMDMi215273929

Proteomic databases

EPDiP55198
jPOSTiP55198
MassIVEiP55198
PaxDbiP55198
PeptideAtlasiP55198
PRIDEiP55198
ProteomicsDBi56804

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		73458, 110 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		4302

Genome annotation databases

EnsembliENST00000618876.2; ENSP00000477969.1; ENSG00000275851.4
ENST00000621332.5; ENSP00000479910.1; ENSG00000275023.5
GeneIDi4302
KEGGihsa:4302
MANE-SelectiENST00000621332.5; ENSP00000479910.1; NM_005937.4; NP_005928.2

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4302
DisGeNETi4302

GeneCards: human genes, protein and diseases

More...GeneCardsi		MLLT6
HGNCiHGNC:7138, MLLT6
HPAiENSG00000275023, Low tissue specificity
MalaCardsiMLLT6
MIMi600328, gene
neXtProtiNX_P55198
OpenTargetsiENSG00000275023
PharmGKBiPA30854
VEuPathDBiHostDB:ENSG00000275023

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0956, Eukaryota
GeneTreeiENSGT00940000158572
InParanoidiP55198
OMAiYQMIQQV
OrthoDBi327785at2759
PhylomeDBiP55198
TreeFamiTF316118

Enzyme and pathway databases

PathwayCommonsiP55198
SignaLinkiP55198

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4302, 30 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MLLT6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4302
PharosiP55198, Tdark

Protein Ontology

More...PROi		PR:P55198
RNActiP55198, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

ExpressionAtlasiP55198, baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732, EPHD
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249, PHD, 2 hits
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805, EPHD, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAF17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55198
Secondary accession number(s): Q59F28
, Q96IU3, Q9H5F6, Q9UF49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 28, 2018
Last modified: May 25, 2022
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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