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Entry version 159 (16 Oct 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Protein AF-17

Gene

MLLT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei551KMT2A/MLL1 fusion point (in acute myeloid leukemia patient)1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri5 – 57PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri62 – 95C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri118 – 181PHD-type 2PROSITE-ProRule annotationAdd BLAST64

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein AF-17
Alternative name(s):
ALL1-fused gene from chromosome 17 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLLT6
Synonyms:AF17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7138 MLLT6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600328 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55198

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
4302

Open Targets

More...
OpenTargetsi
ENSG00000275023

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30854

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P55198

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MLLT6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273929

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002159371 – 1093Protein AF-17Add BLAST1093

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei451PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P55198

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P55198

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P55198

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55198

PeptideAtlas

More...
PeptideAtlasi
P55198

PRoteomics IDEntifications database

More...
PRIDEi
P55198

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56804

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55198

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P55198

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55198 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004021

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with histone H3; interaction is necessary for MLLT6 binding to nucleosomes; interaction is inhibited by histone H3 'Lys-27' methylations (H3K27me1, H3K27me2 and H3K27me3).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110448, 51 interactors

Protein interaction database and analysis system

More...
IntActi
P55198, 42 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479910

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P55198

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni729 – 764Leucine-zipperAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi190 – 211Gly/Ser-richAdd BLAST22
Compositional biasi275 – 282Poly-Ser8
Compositional biasi326 – 338Poly-SerAdd BLAST13
Compositional biasi822 – 829Poly-Ser8
Compositional biasi834 – 862Pro-richAdd BLAST29
Compositional biasi935 – 984Gln-richAdd BLAST50
Compositional biasi1040 – 1051Poly-AlaAdd BLAST12
Compositional biasi1069 – 1080Gly-richAdd BLAST12

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 57PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri62 – 95C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri118 – 181PHD-type 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0956 Eukaryota
COG5141 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158572

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033831

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55198

KEGG Orthology (KO)

More...
KOi
K23588

Identification of Orthologs from Complete Genome Data

More...
OMAi
EKHPAHH

Database of Orthologous Groups

More...
OrthoDBi
327785at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55198

TreeFam database of animal gene trees

More...
TreeFami
TF316118

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P55198-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEMVGGCCV CSDERGWAEN PLVYCDGHAC SVAVHQACYG IVQVPTGPWF
60 70 80 90 100
CRKCESQERA ARVRCELCPH KDGALKRTDN GGWAHVVCAL YIPEVQFANV
110 120 130 140 150
LTMEPIVLQY VPHDRFNKTC YICEEQGRES KAASGACMTC NRHGCRQAFH
160 170 180 190 200
VTCAQMAGLL CEEEVLEVDN VKYCGYCKYH FSKMKTSRHS SGGGGGGAGG
210 220 230 240 250
GGGSMGGGGS GFISGRRSRS ASPSTQQEKH PTHHERGQKK SRKDKERLKQ
260 270 280 290 300
KHKKRPESPP SILTPPVVPT ADKVSSSASS SSHHEASTQE TSESSRESKG
310 320 330 340 350
KKSSSHSLSH KGKKLSSGKG VSSFTSASSS SSSSSSSSGG PFQPAVSSLQ
360 370 380 390 400
SSPDFSAFPK LEQPEEDKYS KPTAPAPSAP PSPSAPEPPK ADLFEQKVVF
410 420 430 440 450
SGFGPIMRFS TTTSSSGRAR APSPGDYKSP HVTGSGASAG THKRMPALSA
460 470 480 490 500
TPVPADETPE TGLKEKKHKA SKRSRHGPGR PKGSRNKEGT GGPAAPSLPS
510 520 530 540 550
AQLAGFTATA ASPFSGGSLV SSGLGGLSSR TFGPSGSLPS LSLESPLLGA
560 570 580 590 600
GIYTSNKDPI SHSGGMLRAV CSTPLSSSLL GPPGTSALPR LSRSPFTSTL
610 620 630 640 650
PSSSASISTT QVFSLAGSTF SLPSTHIFGT PMGAVNPLLS QAESSHTEPD
660 670 680 690 700
LEDCSFRCRG TSPQESLSSM SPISSLPALF DQTASAPCGG GQLDPAAPGT
710 720 730 740 750
TNMEQLLEKQ GDGEAGVNIV EMLKALHALQ KENQRLQEQI LSLTAKKERL
760 770 780 790 800
QILNVQLSVP FPALPAALPA ANGPVPGPYG LPPQAGSSDS LSTSKSPPGK
810 820 830 840 850
SSLGLDNSLS TSSEDPHSGC PSRSSSSLSF HSTPPPLPLL QQSPATLPLA
860 870 880 890 900
LPGAPAPLPP QPQNGLGRAP GAAGLGAMPM AEGLLGGLAG SGGLPLNGLL
910 920 930 940 950
GGLNGAAAPN PASLSQAGGA PTLQLPGCLN SLTEQQRHLL QQQEQQLQQL
960 970 980 990 1000
QQLLASPQLT PEHQTVVYQM IQQIQQKREL QRLQMAGGSQ LPMASLLAGS
1010 1020 1030 1040 1050
STPLLSAGTP GLLPTASAPP LLPAGALVAP SLGNNTSLMA AAAAAAAVAA
1060 1070 1080 1090
AGGPPVLTAQ TNPFLSLSGA EGSGGGPKGG TADKGASANQ EKG
Length:1,093
Mass (Da):112,048
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC55F0801D9A0A5C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P2C6Q6P2C6_HUMAN
MLLT6 protein
MLLT6
325Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVY1A0A087WVY1_HUMAN
Protein AF-17
MLLT6
302Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07237 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15670 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126Q → T in AAA21145 (PubMed:8058765).Curated1
Sequence conflicti735R → W in BAD92870 (Ref. 3) Curated1
Sequence conflicti1065L → P in BAB15670 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08017033A → V. Corresponds to variant dbSNP:rs17855918Ensembl.1
Natural variantiVAR_022076198A → T. Corresponds to variant dbSNP:rs2241012Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U07932 mRNA Translation: AAA21145.1
AC006449 Genomic DNA No translation available.
AB209633 mRNA Translation: BAD92870.1
AK027133 mRNA Translation: BAB15670.1 Different initiation.
BC007237 mRNA Translation: AAH07237.1 Different initiation.
AL133659 mRNA Translation: CAB63772.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11327.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38533

NCBI Reference Sequences

More...
RefSeqi
NP_005928.2, NM_005937.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000618876; ENSP00000477969; ENSG00000275851
ENST00000621332; ENSP00000479910; ENSG00000275023

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4302

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07932 mRNA Translation: AAA21145.1
AC006449 Genomic DNA No translation available.
AB209633 mRNA Translation: BAD92870.1
AK027133 mRNA Translation: BAB15670.1 Different initiation.
BC007237 mRNA Translation: AAH07237.1 Different initiation.
AL133659 mRNA Translation: CAB63772.2
CCDSiCCDS11327.1
PIRiI38533
RefSeqiNP_005928.2, NM_005937.3

3D structure databases

SMRiP55198
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110448, 51 interactors
IntActiP55198, 42 interactors
STRINGi9606.ENSP00000479910

PTM databases

iPTMnetiP55198
PhosphoSitePlusiP55198

Polymorphism and mutation databases

BioMutaiMLLT6
DMDMi215273929

Proteomic databases

EPDiP55198
jPOSTiP55198
MassIVEiP55198
PaxDbiP55198
PeptideAtlasiP55198
PRIDEiP55198
ProteomicsDBi56804

Genome annotation databases

EnsembliENST00000618876; ENSP00000477969; ENSG00000275851
ENST00000621332; ENSP00000479910; ENSG00000275023
GeneIDi4302
KEGGihsa:4302

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4302
DisGeNETi4302

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MLLT6
HGNCiHGNC:7138 MLLT6
HPAiHPA004021
MIMi600328 gene
neXtProtiNX_P55198
OpenTargetsiENSG00000275023
PharmGKBiPA30854

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0956 Eukaryota
COG5141 LUCA
GeneTreeiENSGT00940000158572
HOGENOMiHOG000033831
InParanoidiP55198
KOiK23588
OMAiEKHPAHH
OrthoDBi327785at2759
PhylomeDBiP55198
TreeFamiTF316118

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MLLT6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4302
PharosiP55198

Protein Ontology

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PROi
PR:P55198

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

ExpressionAtlasiP55198 baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAF17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55198
Secondary accession number(s): Q59F28
, Q96IU3, Q9H5F6, Q9UF49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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