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Entry version 175 (13 Nov 2019)
Sequence version 2 (24 Jul 2013)
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Protein

Protein AF-10

Gene

MLLT10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei266KMT2A/MLL1 fusion point (in acute myeloid leukemia patient B)1
Sitei627KMT2A/MLL1 fusion point (in acute myeloid leukemia patient C)1
Sitei664KMT2A/MLL1 fusion point (in acute myeloid leukemia patient A)1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri22 – 74PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri79 – 112C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri135 – 198PHD-type 2PROSITE-ProRule annotationAdd BLAST64

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P55197

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein AF-10Curated
Alternative name(s):
ALL1-fused gene from chromosome 10 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLLT10Imported
Synonyms:AF101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16063 MLLT10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602409 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55197

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.
A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi22I → A: Does not affect interaction with histone H3. 1 Publication1
Mutagenesisi80V → A: Does not affect interaction with histone H3. 1 Publication1
Mutagenesisi106A → V: Impairs interaction with histone H3. 1 Publication1
Mutagenesisi107L → A: Impairs interaction with histone H3. Reduces association to chromatin. Does not rescued histone H3 'Lys-79' dimethylation (H3K79me2) levels in MLLT10-depleted cells. Does not rescued DOT1L-target genes in MLLT10-depleted cells. 1 Publication1
Mutagenesisi109I → A: Impairs interaction with histone H3. 1 Publication1
Mutagenesisi114F → A: Impairs interaction with histone H3. 1 Publication1
Mutagenesisi120M → A: Impairs interaction with histone H3. 1 Publication1
Mutagenesisi179E → A: Impairs interaction with histone H3. 1 Publication1
Mutagenesisi190Y → A: Impairs interaction with histone H3. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
8028

MalaCards human disease database

More...
MalaCardsi
MLLT10

Open Targets

More...
OpenTargetsi
ENSG00000078403

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99861 Precursor T-cell acute lymphoblastic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30849

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P55197

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MLLT10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
527504034

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002159351 – 1068Protein AF-10Add BLAST1068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei217PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei436PhosphoserineCombined sources1
Modified residuei532PhosphoserineBy similarity1
Modified residuei684PhosphoserineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P55197

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P55197

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P55197

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55197

PeptideAtlas

More...
PeptideAtlasi
P55197

PRoteomics IDEntifications database

More...
PRIDEi
P55197

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3249
56802 [P55197-4]
56803 [P55197-2]
65583

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55197

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55197

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed abundantly in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000078403 Expressed in 209 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55197 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55197 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA005747

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

Interacts with FSTL3 isoform 2; the interaction enhances MLLT10 in vitro transcriptional activity and self-association.

Interacts with YEATS4.

Interacts with SS18.

Interacts with DOT1L; this interaction also occurs with the KMT2A/MLL1 fusion protein.

Interacts with histone H3; interaction is necessary for MLLT10 binding to nucleosomes; interaction is inhibited by histone H3 'Lys-27' methylations (H3K27me1, H3K27me2 and H3K27me3) amd acetylation; interaction stabilizes association of MLLT10 at chromatin; interaction is essential for histone H3 'Lys-79' dimethylation (H3K79me2) (PubMed:26439302).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P352224EBI-1104952,EBI-491549

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113723, 25 interactors

Database of interacting proteins

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DIPi
DIP-37633N

Protein interaction database and analysis system

More...
IntActi
P55197, 29 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000307411

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11068
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55197

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 287Self-associationAdd BLAST208
Regioni106 – 190Required for interaction with histone H31 PublicationAdd BLAST85
Regioni141 – 233Interaction with FSTL31 PublicationAdd BLAST93
Regioni311 – 674DNA-bindingAdd BLAST364
Regioni703 – 784Transactivation domain; required for DOT1L-bindingAdd BLAST82
Regioni750 – 778Leucine-zipperAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi229 – 240Glu/Lys-richAdd BLAST12

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 74PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri79 – 112C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri135 – 198PHD-type 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0956 Eukaryota
COG5141 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157711

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000033831

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P55197

KEGG Orthology (KO)

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KOi
K23588

Identification of Orthologs from Complete Genome Data

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OMAi
HNSGQRG

Database of Orthologous Groups

More...
OrthoDBi
327785at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55197

TreeFam database of animal gene trees

More...
TreeFami
TF316118

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00249 PHD, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: P55197-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSSDRPVSL EDEVSHSMKE MIGGCCVCSD ERGWAENPLV YCDGHGCSVA
60 70 80 90 100
VHQACYGIVQ VPTGPWFCRK CESQERAARV RCELCPHKDG ALKRTDNGGW
110 120 130 140 150
AHVVCALYIP EVQFANVSTM EPIVLQSVPH DRYNKTCYIC DEQGRESKAA
160 170 180 190 200
TGACMTCNKH GCRQAFHVTC AQFAGLLCEE EGNGADNVQY CGYCKYHFSK
210 220 230 240 250
LKKSKRGSNR SYDQSLSDSS SHSQDKHHEK EKKKYKEKDK HKQKHKKQPE
260 270 280 290 300
PSPALVPSLT VTTEKTYTST SNNSISGSLK RLEDTTARFT NANFQEVSAH
310 320 330 340 350
TSSGKDVSET RGSEGKGKKS SAHSSGQRGR KPGGGRNPGT TVSAASPFPQ
360 370 380 390 400
GSFSGTPGSV KSSSGSSVQS PQDFLSFTDS DLRNDSYSHS QQSSATKDVH
410 420 430 440 450
KGESGSQEGG VNSFSTLIGL PSTSAVTSQP KSFENSPGDL GNSSLPTAGY
460 470 480 490 500
KRAQTSGIEE ETVKEKKRKG NKQSKHGPGR PKGNKNQENV SHLSVSSASP
510 520 530 540 550
TSSVASAAGS ITSSSLQKSP TLLRNGSLQS LSVGSSPVGS EISMQYRHDG
560 570 580 590 600
ACPTTTFSEL LNAIHNGIYN SNDVAVSFPN VVSGSGSSTP VSSSHLPQQS
610 620 630 640 650
SGHLQQVGAL SPSAVSSAAP AVATTQANTL SGSSLSQAPS HMYGNRSNSS
660 670 680 690 700
MAALIAQSEN NQTDQDLGDN SRNLVGRGSS PRGSLSPRSP VSSLQIRYDQ
710 720 730 740 750
PGNSSLENLP PVAASIEQLL ERQWSEGQQF LLEQGTPSDI LGMLKSLHQL
760 770 780 790 800
QVENRRLEEQ IKNLTAKKER LQLLNAQLSV PFPTITANPS PSHQIHTFSA
810 820 830 840 850
QTAPTTDSLN SSKSPHIGNS FLPDNSLPVL NQDLTSSGQS TSSSSALSTP
860 870 880 890 900
PPAGQSPAQQ GSGVSGVQQV NGVTVGALAS GMQPVTSTIP AVSAVGGIIG
910 920 930 940 950
ALPGNQLAIN GIVGALNGVM QTPVTMSQNP TPLTHTTVPP NATHPMPATL
960 970 980 990 1000
TNSASGLGLL SDQQRQILIH QQQFQQLLNS QQLTPEQHQA FLYQLMQHHH
1010 1020 1030 1040 1050
QQHHQPELQQ LQIPGPTQIP INNLLAGTQA PPLHTATTNP FLTIHGDNAS
1060
QKVARLSDKT GPVAQEKS
Length:1,068
Mass (Da):113,320
Last modified:July 24, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C4D9B77F61BFEEE
GO
Isoform 1 (identifier: P55197-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     566-566: N → NDRGDSSTLTKQELKFI
     986-1011: EQHQAFLYQLMQHHHQQHHQPELQQL → VHRHPHFTQLPPTHFSPSMEIMQVRK
     1012-1068: Missing.

Show »
Length:1,027
Mass (Da):109,026
Checksum:i7C7C0059DDD46589
GO
Isoform 2 (identifier: P55197-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-126: RCELCPHKDG...VSTMEPIVLQ → AESRSVAQAK...GMQFLLVSLI
     127-1068: Missing.

Note: No experimental confirmation available.
Show »
Length:126
Mass (Da):13,851
Checksum:iB8E45EC6C2BA9FA8
GO
Isoform 3 (identifier: P55197-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-179: RCELCPHKDG...CAQFAGLLCE → MVCNSCWLAS...VIWRFKKERW
     180-1068: Missing.

Note: No experimental confirmation available.
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Length:179
Mass (Da):20,047
Checksum:iE522FE1E4B1ED346
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JT35Q5JT35_HUMAN
Protein AF-10
MLLT10
763Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5P4H0Y5P4_HUMAN
Protein AF-10
MLLT10
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5C4H0Y5C4_HUMAN
Protein AF-10
MLLT10
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0R2A0A494C0R2_HUMAN
Protein AF-10
MLLT10
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1P9A0A494C1P9_HUMAN
Protein AF-10
MLLT10
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C038A0A494C038_HUMAN
Protein AF-10
MLLT10
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C093A0A494C093_HUMAN
Protein AF-10
MLLT10
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC129946 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04455281 – 179RCELC…GLLCE → MVCNSCWLASSENVTPGYIE HHCACASPHPRCLVSNVPPV SGALMHCFWACLTTAAFFGP QSFTTCHMSFLVSRDILFYI YGFMPFISVVIWRFKKERW in isoform 3. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_04304481 – 126RCELC…PIVLQ → AESRSVAQAKVQWCDLSPLQ PLLPGFKRFSCLSLPNGMQF LLVSLI in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_043045127 – 1068Missing in isoform 2. 1 PublicationAdd BLAST942
Alternative sequenceiVSP_044553180 – 1068Missing in isoform 3. 1 PublicationAdd BLAST889
Alternative sequenceiVSP_047517566N → NDRGDSSTLTKQELKFI in isoform 1. 1 Publication1
Alternative sequenceiVSP_047518986 – 1011EQHQA…ELQQL → VHRHPHFTQLPPTHFSPSME IMQVRK in isoform 1. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_0475191012 – 1068Missing in isoform 1. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U13948 mRNA Translation: AAA79972.1
AY598745 mRNA Translation: AAT47519.1
AL161799 Genomic DNA No translation available.
AL358780 Genomic DNA No translation available.
AL359697 Genomic DNA No translation available.
AL357372 Genomic DNA No translation available.
BC080577 mRNA Translation: AAH80577.1
BC094844 mRNA No translation available.
BC129946 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS55706.1 [P55197-2]
CCDS55707.1 [P55197-3]
CCDS55708.1 [P55197-4]
CCDS7135.1 [P55197-1]

Protein sequence database of the Protein Information Resource

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PIRi
I38759

NCBI Reference Sequences

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RefSeqi
NP_001182555.1, NM_001195626.1 [P55197-4]
NP_001182556.1, NM_001195627.1 [P55197-2]
NP_001182557.1, NM_001195628.1 [P55197-3]
NP_001182559.1, NM_001195630.1 [P55197-3]
NP_001311225.1, NM_001324296.1 [P55197-3]
NP_004632.1, NM_004641.3 [P55197-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307729; ENSP00000307411; ENSG00000078403 [P55197-4]
ENST00000377059; ENSP00000366258; ENSG00000078403 [P55197-4]
ENST00000377072; ENSP00000366272; ENSG00000078403 [P55197-1]
ENST00000377091; ENSP00000366295; ENSG00000078403 [P55197-2]
ENST00000377100; ENSP00000366304; ENSG00000078403 [P55197-3]
ENST00000621220; ENSP00000484335; ENSG00000078403 [P55197-2]
ENST00000631589; ENSP00000488569; ENSG00000078403 [P55197-4]
ENST00000652497; ENSP00000498595; ENSG00000078403 [P55197-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8028

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8028

UCSC genome browser

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UCSCi
uc001iqq.3 human [P55197-4]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13948 mRNA Translation: AAA79972.1
AY598745 mRNA Translation: AAT47519.1
AL161799 Genomic DNA No translation available.
AL358780 Genomic DNA No translation available.
AL359697 Genomic DNA No translation available.
AL357372 Genomic DNA No translation available.
BC080577 mRNA Translation: AAH80577.1
BC094844 mRNA No translation available.
BC129946 mRNA No translation available.
CCDSiCCDS55706.1 [P55197-2]
CCDS55707.1 [P55197-3]
CCDS55708.1 [P55197-4]
CCDS7135.1 [P55197-1]
PIRiI38759
RefSeqiNP_001182555.1, NM_001195626.1 [P55197-4]
NP_001182556.1, NM_001195627.1 [P55197-2]
NP_001182557.1, NM_001195628.1 [P55197-3]
NP_001182559.1, NM_001195630.1 [P55197-3]
NP_001311225.1, NM_001324296.1 [P55197-3]
NP_004632.1, NM_004641.3 [P55197-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DAGX-ray1.60A1-208[»]
5DAHX-ray2.61A/B1-208[»]
6CKNX-ray2.49A/B704-779[»]
6CKOX-ray2.00A/B704-779[»]
6JN2X-ray3.60A699-782[»]
SMRiP55197
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi113723, 25 interactors
DIPiDIP-37633N
IntActiP55197, 29 interactors
STRINGi9606.ENSP00000307411

PTM databases

iPTMnetiP55197
PhosphoSitePlusiP55197

Polymorphism and mutation databases

BioMutaiMLLT10
DMDMi527504034

Proteomic databases

EPDiP55197
jPOSTiP55197
MassIVEiP55197
PaxDbiP55197
PeptideAtlasiP55197
PRIDEiP55197
ProteomicsDBi3249
56802 [P55197-4]
56803 [P55197-2]
65583

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8028

Genome annotation databases

EnsembliENST00000307729; ENSP00000307411; ENSG00000078403 [P55197-4]
ENST00000377059; ENSP00000366258; ENSG00000078403 [P55197-4]
ENST00000377072; ENSP00000366272; ENSG00000078403 [P55197-1]
ENST00000377091; ENSP00000366295; ENSG00000078403 [P55197-2]
ENST00000377100; ENSP00000366304; ENSG00000078403 [P55197-3]
ENST00000621220; ENSP00000484335; ENSG00000078403 [P55197-2]
ENST00000631589; ENSP00000488569; ENSG00000078403 [P55197-4]
ENST00000652497; ENSP00000498595; ENSG00000078403 [P55197-3]
GeneIDi8028
KEGGihsa:8028
UCSCiuc001iqq.3 human [P55197-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8028
DisGeNETi8028

GeneCards: human genes, protein and diseases

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GeneCardsi
MLLT10
HGNCiHGNC:16063 MLLT10
HPAiHPA005747
MalaCardsiMLLT10
MIMi602409 gene
neXtProtiNX_P55197
OpenTargetsiENSG00000078403
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA30849

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0956 Eukaryota
COG5141 LUCA
GeneTreeiENSGT00940000157711
HOGENOMiHOG000033831
InParanoidiP55197
KOiK23588
OMAiHNSGQRG
OrthoDBi327785at2759
PhylomeDBiP55197
TreeFamiTF316118

Enzyme and pathway databases

SIGNORiP55197

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MLLT10 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MLLT10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8028
PharosiP55197

Protein Ontology

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PROi
PR:P55197

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000078403 Expressed in 209 organ(s), highest expression level in testis
ExpressionAtlasiP55197 baseline and differential
GenevisibleiP55197 HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAF10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55197
Secondary accession number(s): B1ANA8
, Q5JT37, Q5VX90, Q66K63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 24, 2013
Last modified: November 13, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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