UniProtKB - P55196 (AFAD_HUMAN)
Afadin
AFDN
Functioni
GO - Molecular functioni
- actin filament binding Source: ARUK-UCL
- cadherin binding Source: BHF-UCL
- cell adhesion molecule binding Source: GO_Central
- protein C-terminus binding Source: ProtInc
- Ras GTPase binding Source: UniProtKB
GO - Biological processi
- adherens junction organization Source: Reactome
- bicellular tight junction assembly Source: ARUK-UCL
- cell adhesion Source: ProtInc
- cell-cell adhesion mediated by cadherin Source: ARUK-UCL
- cell-cell signaling Source: ProtInc
- establishment of endothelial intestinal barrier Source: UniProtKB
- establishment of protein localization to plasma membrane Source: ARUK-UCL
- negative regulation of cell migration Source: ARUK-UCL
- pore complex assembly Source: UniProtKB
- positive regulation of cell-cell adhesion Source: UniProtKB
- positive regulation of cell-cell adhesion mediated by cadherin Source: ARUK-UCL
- positive regulation of gene expression Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- regulation of protein localization Source: GO_Central
- signal transduction Source: ProtInc
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P55196 |
Reactomei | R-HSA-418990, Adherens junctions interactions [P55196-2] |
SignaLinki | P55196 |
SIGNORi | P55196 |
Names & Taxonomyi
Protein namesi | Recommended name: AfadinAlternative name(s): ALL1-fused gene from chromosome 6 protein Short name: Protein AF-6 Afadin adherens junction formation factorImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130396.20 |
HGNCi | HGNC:7137, AFDN |
MIMi | 159559, gene |
neXtProti | NX_P55196 |
Subcellular locationi
Other locations
- adherens junction 1 Publication
Note: Not found at cell-matrix AJs.By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- adherens junction Source: GO_Central
- cell junction Source: HPA
- cell-cell contact zone Source: ARUK-UCL
- cell-cell junction Source: ARUK-UCL
- pore complex Source: UniProtKB
- tight junction Source: ARUK-UCL
Keywords - Cellular componenti
Cell junctionPathology & Biotechi
Involvement in diseasei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 26 | Breakpoint for translocation to form KMT2A/MLL1-AFDN | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 4301 |
OpenTargetsi | ENSG00000130396 |
Miscellaneous databases
Pharosi | P55196, Tbio |
Chemistry databases
DrugBanki | DB08574, (5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one |
Polymorphism and mutation databases
BioMutai | AFDN |
DMDMi | 288558835 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215918 | 1 – 1824 | AfadinAdd BLAST | 1824 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 216 | PhosphoserineCombined sources | 1 | |
Modified residuei | 246 | PhosphoserineCombined sources | 1 | |
Modified residuei | 256 | PhosphoserineCombined sources | 1 | |
Modified residuei | 391 | PhosphoserineBy similarity | 1 | |
Modified residuei | 424 | PhosphoserineCombined sources | 1 | |
Modified residuei | 512 | PhosphoserineCombined sources | 1 | |
Modified residuei | 557 | PhosphoserineCombined sources | 1 | |
Modified residuei | 562 | PhosphoserineCombined sources | 1 | |
Modified residuei | 589 | PhosphoserineCombined sources | 1 | |
Modified residuei | 655 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1083 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1107 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1126 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1140 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1172 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1173 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1182 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1199 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1211 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1232 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1238 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1275 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1328 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1330 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1501 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1512 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1696 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1721 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1774 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1779 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1799 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1807 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P55196 |
jPOSTi | P55196 |
MassIVEi | P55196 |
PaxDbi | P55196 |
PeptideAtlasi | P55196 |
PRIDEi | P55196 |
ProteomicsDBi | 56796 [P55196-4] 56797 [P55196-1] 56798 [P55196-2] 56799 [P55196-3] 56800 [P55196-5] 56801 [P55196-6] |
PTM databases
iPTMneti | P55196 |
PhosphoSitePlusi | P55196 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130396, Expressed in oviduct epithelium and 216 other tissues |
ExpressionAtlasi | P55196, baseline and differential |
Genevisiblei | P55196, HS |
Organism-specific databases
HPAi | ENSG00000130396, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Interacts with F-actin, nectin and NECTIN3. Essential for the association of nectin and E-cadherin. Isoform 1/s-afadin does not interact with F-actin.
Interacts with ZO-1 and occludin, but probably in an indirect manner.
Interacts with RIT1 and RIT2 (By similarity).
Interacts with NRXN1 and BCR.
Interacts with ADAM10; the interaction locks ADAM10 at adherens junctions following ADAM10 recruitment to adherens junctions by TSPAN33 (PubMed:30463011).
By similarity3 PublicationsBinary interactionsi
Hide detailsP55196
With | #Exp. | IntAct |
---|---|---|
DBN1 [Q16643] | 4 | EBI-365875,EBI-351394 |
NECTIN2 [Q92692] | 2 | EBI-365875,EBI-718419 |
SRC [P12931] | 7 | EBI-365875,EBI-621482 |
GO - Molecular functioni
- actin filament binding Source: ARUK-UCL
- cadherin binding Source: BHF-UCL
- cell adhesion molecule binding Source: GO_Central
- protein C-terminus binding Source: ProtInc
- Ras GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110447, 114 interactors |
CORUMi | P55196 |
ELMi | P55196 |
IntActi | P55196, 44 interactors |
MINTi | P55196 |
STRINGi | 9606.ENSP00000375960 |
Miscellaneous databases
RNActi | P55196, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P55196 |
SMRi | P55196 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P55196 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 133 | Ras-associating 1PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 246 – 348 | Ras-associating 2PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 426 – 492 | FHAAdd BLAST | 67 | |
Domaini | 668 – 908 | DilutePROSITE-ProRule annotationAdd BLAST | 241 | |
Domaini | 1007 – 1093 | PDZPROSITE-ProRule annotationAdd BLAST | 87 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 146 – 185 | Sequence analysisAdd BLAST | 40 | |
Coiled coili | 1408 – 1448 | Sequence analysisAdd BLAST | 41 | |
Coiled coili | 1523 – 1667 | Sequence analysisAdd BLAST | 145 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 163 – 175 | Glu/Lys-richAdd BLAST | 13 | |
Compositional biasi | 1346 – 1392 | Pro-richAdd BLAST | 47 | |
Compositional biasi | 1578 – 1588 | Asp/Glu-rich (acidic)Add BLAST | 11 | |
Compositional biasi | 1678 – 1708 | Pro-richAdd BLAST | 31 |
Domaini
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1892, Eukaryota |
GeneTreei | ENSGT00940000155237 |
InParanoidi | P55196 |
OMAi | VTPRNID |
OrthoDBi | 23029at2759 |
PhylomeDBi | P55196 |
TreeFami | TF350731 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK
60 70 80 90 100
AAGNFATKCI RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG
110 120 130 140 150
ERRLDIDEKP LVVQLNWNKD DREGRFVLKN ENDAIPPKKA QSNGPEKQEK
160 170 180 190 200
EGVIQNFKRT LSKKEKKEKK KREKEALRQA SDKDDRPFQG EDVENSRLAA
210 220 230 240 250
EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS DGRPDSGGTL
260 270 280 290 300
RIYADSLKPN IPYKTILLST TDPADFAVAE ALEKYGLEKE NPKDYCIARV
310 320 330 340 350
MLPPGAQHSD EKGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDH
360 370 380 390 400
IPKKTKKHLE GKTPKGKERA DGSGYGSTLP PEKLPYLVEL SPGRRNHFAY
410 420 430 440 450
YNYHTYEDGS DSRDKPKLYR LQLSVTEVGT EKLDDNSIQL FGPGIQPHHC
460 470 480 490 500
DLTNMDGVVT VTPRSMDAET YVEGQRISET TMLQSGMKVQ FGASHVFKFV
510 520 530 540 550
DPSQDHALAK RSVDGGLMVK GPRHKPGIVQ ETTFDLGGDI HSGTALPTSK
560 570 580 590 600
STTRLDSDRV SSASSTAERG MVKPMIRVEQ QPDYRRQESR TQDASGPELI
610 620 630 640 650
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSNQY
660 670 680 690 700
RPDISPTERT HKVIAVVNKM VSMMEGVIQK QKNIAGALAF WMANASELLN
710 720 730 740 750
FIKQDRDLSR ITLDAQDVLA HLVQMAFKYL VHCLQSELNN YMPAFLDDPE
760 770 780 790 800
ENSLQRPKID DVLHTLTGAM SLLRRCRVNA ALTIQLFSQL FHFINMWLFN
810 820 830 840 850
RLVTDPDSGL CSHYWGAIIR QQLGHIEAWA EKQGLELAAD CHLSRIVQAT
860 870 880 890 900
TLLTMDKYAP DDIPNINSTC FKLNSLQLQA LLQNYHCAPD EPFIPTDLIE
910 920 930 940 950
NVVTVAENTA DELARSDGRE VQLEEDPDLQ LPFLLPEDGY SCDVVRNIPN
960 970 980 990 1000
GLQEFLDPLC QRGFCRLIPH TRSPGTWTIY FEGADYESHL LRENTELAQP
1010 1020 1030 1040 1050
LRKEPEIITV TLKKQNGMGL SIVAAKGAGQ DKLGIYVKSV VKGGAADVDG
1060 1070 1080 1090 1100
RLAAGDQLLS VDGRSLVGLS QERAAELMTR TSSVVTLEVA KQGAIYHGLA
1110 1120 1130 1140 1150
TLLNQPSPMM QRISDRRGSG KPRPKSEGFE LYNNSTQNGS PESPQLPWAE
1160 1170 1180 1190 1200
YSEPKKLPGD DRLMKNRADH RSSPNVANQP PSPGGKSAYA SGTTAKITSV
1210 1220 1230 1240 1250
STGNLCTEEQ TPPPRPEAYP IPTQTYTREY FTFPASKSQD RMAPPQNQWP
1260 1270 1280 1290 1300
NYEEKPHMHT DSNHSSIAIQ RVTRSQEELR EDKAYQLERH RIEAAMDRKS
1310 1320 1330 1340 1350
DSDMWINQSS SLDSSTSSQE HLNHSSKSVT PASTLTKSGP GRWKTPAAIP
1360 1370 1380 1390 1400
ATPVAVSQPI RTDLPPPPPP PPVHYAGDFD GMSMDLPLPP PPSANQIGLP
1410 1420 1430 1440 1450
SAQVAAAERR KREEHQRWYE KEKARLEEER ERKRREQERK LGQMRTQSLN
1460 1470 1480 1490 1500
PAPFSPLTAQ QMKPEKPSTL QRPQETVIRE LQPQQQPRTI ERRDLQYITV
1510 1520 1530 1540 1550
SKEELSSGDS LSPDPWKRDA KEKLEKQQQM HIVDMLSKEI QELQSKPDRS
1560 1570 1580 1590 1600
AEESDRLRKL MLEWQFQKRL QESKQKDEDD EEEEDDDVDT MLIMQRLEAE
1610 1620 1630 1640 1650
RRARLQDEER RRQQQLEEMR KREAEDRARQ EEERRRQEEE RTKRDAEEKR
1660 1670 1680 1690 1700
RQEEGYYSRL EAERRRQHDE AARRLLEPEA PGLCRPPLPR DYEPPSPSPA
1710 1720 1730 1740 1750
PGAPPPPPQR NASYLKTQVL SPDSLFTAKF VAYNEEEEEE DCSLAGPNSY
1760 1770 1780 1790 1800
PGSTGAAVGA HDACRDAKEK RSKSQDADSP GSSGAPENLT FKERQRLFSQ
1810 1820
GQDVSNKVKA SRKLTELENE LNTK
The sequence of this isoform differs from the canonical sequence as follows:
139-139: Missing.
393-407: Missing.
1605-1628: LQDEERRRQQQLEEMRKREAEDRA → VKGGVLWLCPSVVPILASACFPWG
1629-1824: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
139-139: Missing.
393-407: Missing.
1048-1048: Missing.
1747-1824: PNSYPGSTGA...TELENELNTK → QDKYSSTRKS...KRVTNQLSLS
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MQ02 | A8MQ02_HUMAN | Afadin | AFDN | 1,781 | Annotation score: | ||
J3KN01 | J3KN01_HUMAN | Afadin | AFDN | 1,831 | Annotation score: | ||
Q5TIG5 | Q5TIG5_HUMAN | Afadin | AFDN | 1,665 | Annotation score: | ||
H0Y7R8 | H0Y7R8_HUMAN | Afadin | AFDN | 389 | Annotation score: | ||
E9PFY5 | E9PFY5_HUMAN | Afadin | AFDN | 250 | Annotation score: | ||
F8W9I4 | F8W9I4_HUMAN | Afadin | AFDN | 247 | Annotation score: | ||
H0YA98 | H0YA98_HUMAN | Afadin | AFDN | 167 | Annotation score: | ||
H0Y8L4 | H0Y8L4_HUMAN | Afadin | AFDN | 313 | Annotation score: | ||
H0Y8U8 | H0Y8U8_HUMAN | Afadin | AFDN | 124 | Annotation score: | ||
H0Y948 | H0Y948_HUMAN | Afadin | AFDN | 191 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 374 | G → V in AAC50059 (PubMed:8242616).Curated | 1 | ||
Sequence conflicti | 1425 | R → P in AAC50059 (PubMed:8242616).Curated | 1 | ||
Isoform 1 (identifier: P55196-2) | |||||
Sequence conflicti | 1031 – 1032 | DV → D in AAC50059 (PubMed:8242616).Curated | 2 | ||
Sequence conflicti | 1031 – 1032 | DV → D in BAA32485 (PubMed:9679199).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038707 | 139 | Missing in isoform 1, isoform 2, isoform 3 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_038708 | 393 – 407 | Missing in isoform 1, isoform 2 and isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_038709 | 1048 | Missing in isoform 2 and isoform 3. Curated | 1 | |
Alternative sequenceiVSP_019257 | 1604 | R → RTAMPAISVLDL in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_000217 | 1605 – 1628 | LQDEE…AEDRA → VKGGVLWLCPSVVPILASAC FPWG in isoform 1. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_041197 | 1605 – 1606 | Missing in isoform 6. 1 Publication | 2 | |
Alternative sequenceiVSP_000218 | 1629 – 1824 | Missing in isoform 1. 1 PublicationAdd BLAST | 196 | |
Alternative sequenceiVSP_041198 | 1650 – 1653 | RRQE → VMVL in isoform 6. 1 Publication | 4 | |
Alternative sequenceiVSP_041199 | 1654 – 1824 | Missing in isoform 6. 1 PublicationAdd BLAST | 171 | |
Alternative sequenceiVSP_038710 | 1683 – 1746 | Missing in isoform 3. CuratedAdd BLAST | 64 | |
Alternative sequenceiVSP_038711 | 1747 – 1824 | PNSYP…ELNTK → QDKYSSTRKSHGDLLPAPLK PRPPPCQPRPASDGVFLSNS FQPPSAKANSTAHKKGQPLP PPKKSSSYHPSHCKGRGKRV TNQLSLS in isoform 2. CuratedAdd BLAST | 78 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02478 mRNA Translation: AAC50059.1 AB011399 Genomic DNA Translation: BAA32483.1 AB011399 Genomic DNA Translation: BAA32484.1 AB011399 Genomic DNA Translation: BAA32485.1 AL009178 Genomic DNA No translation available. AL049698 Genomic DNA No translation available. AL731868 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47482.1 AB209420 mRNA Translation: BAD92657.1 AL161973 mRNA Translation: CAB82312.1 Frameshift. |
CCDSi | CCDS47517.1 [P55196-6] CCDS75553.1 [P55196-3] |
PIRi | T47137 |
RefSeqi | NP_001035089.1, NM_001040000.2 [P55196-6] NP_001193937.1, NM_001207008.1 [P55196-3] NP_001278893.1, NM_001291964.1 XP_005267053.1, XM_005266996.3 |
Genome annotation databases
Ensembli | ENST00000392108; ENSP00000375956; ENSG00000130396 [P55196-6] ENST00000392112; ENSP00000375960; ENSG00000130396 [P55196-3] ENST00000400822; ENSP00000383623; ENSG00000130396 [P55196-5] ENST00000447894; ENSP00000404595; ENSG00000130396 [P55196-4] |
GeneIDi | 4301 |
KEGGi | hsa:4301 |
UCSCi | uc003qwc.3, human [P55196-4] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02478 mRNA Translation: AAC50059.1 AB011399 Genomic DNA Translation: BAA32483.1 AB011399 Genomic DNA Translation: BAA32484.1 AB011399 Genomic DNA Translation: BAA32485.1 AL009178 Genomic DNA No translation available. AL049698 Genomic DNA No translation available. AL731868 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47482.1 AB209420 mRNA Translation: BAD92657.1 AL161973 mRNA Translation: CAB82312.1 Frameshift. |
CCDSi | CCDS47517.1 [P55196-6] CCDS75553.1 [P55196-3] |
PIRi | T47137 |
RefSeqi | NP_001035089.1, NM_001040000.2 [P55196-6] NP_001193937.1, NM_001207008.1 [P55196-3] NP_001278893.1, NM_001291964.1 XP_005267053.1, XM_005266996.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T2M | NMR | - | A | 1003-1094 | [»] | |
1XZ9 | NMR | - | A | 1001-1096 | [»] | |
2AIN | NMR | - | A | 1003-1094 | [»] | |
2EXG | NMR | - | A | 1001-1096 | [»] | |
5A6C | X-ray | 2.90 | A/B | 1709-1746 | [»] | |
BMRBi | P55196 | |||||
SMRi | P55196 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110447, 114 interactors |
CORUMi | P55196 |
ELMi | P55196 |
IntActi | P55196, 44 interactors |
MINTi | P55196 |
STRINGi | 9606.ENSP00000375960 |
Chemistry databases
DrugBanki | DB08574, (5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one |
PTM databases
iPTMneti | P55196 |
PhosphoSitePlusi | P55196 |
Polymorphism and mutation databases
BioMutai | AFDN |
DMDMi | 288558835 |
Proteomic databases
EPDi | P55196 |
jPOSTi | P55196 |
MassIVEi | P55196 |
PaxDbi | P55196 |
PeptideAtlasi | P55196 |
PRIDEi | P55196 |
ProteomicsDBi | 56796 [P55196-4] 56797 [P55196-1] 56798 [P55196-2] 56799 [P55196-3] 56800 [P55196-5] 56801 [P55196-6] |
Protocols and materials databases
Antibodypediai | 4608, 260 antibodies |
DNASUi | 4301 |
Genome annotation databases
Ensembli | ENST00000392108; ENSP00000375956; ENSG00000130396 [P55196-6] ENST00000392112; ENSP00000375960; ENSG00000130396 [P55196-3] ENST00000400822; ENSP00000383623; ENSG00000130396 [P55196-5] ENST00000447894; ENSP00000404595; ENSG00000130396 [P55196-4] |
GeneIDi | 4301 |
KEGGi | hsa:4301 |
UCSCi | uc003qwc.3, human [P55196-4] |
Organism-specific databases
CTDi | 4301 |
DisGeNETi | 4301 |
EuPathDBi | HostDB:ENSG00000130396.20 |
GeneCardsi | AFDN |
HGNCi | HGNC:7137, AFDN |
HPAi | ENSG00000130396, Low tissue specificity |
MIMi | 159559, gene |
neXtProti | NX_P55196 |
OpenTargetsi | ENSG00000130396 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1892, Eukaryota |
GeneTreei | ENSGT00940000155237 |
InParanoidi | P55196 |
OMAi | VTPRNID |
OrthoDBi | 23029at2759 |
PhylomeDBi | P55196 |
TreeFami | TF350731 |
Enzyme and pathway databases
PathwayCommonsi | P55196 |
Reactomei | R-HSA-418990, Adherens junctions interactions [P55196-2] |
SignaLinki | P55196 |
SIGNORi | P55196 |
Miscellaneous databases
BioGRID-ORCSi | 4301, 22 hits in 851 CRISPR screens |
ChiTaRSi | AFDN, human |
EvolutionaryTracei | P55196 |
GeneWikii | MLLT4 |
GenomeRNAii | 4301 |
Pharosi | P55196, Tbio |
PROi | PR:P55196 |
RNActi | P55196, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130396, Expressed in oviduct epithelium and 216 other tissues |
ExpressionAtlasi | P55196, baseline and differential |
Genevisiblei | P55196, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AFAD_HUMAN | |
Accessioni | P55196Primary (citable) accession number: P55196 Secondary accession number(s): O75087 Q9NU92 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | February 9, 2010 | |
Last modified: | December 2, 2020 | |
This is version 213 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references