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Entry version 148 (29 Sep 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Membrane-associated protein Hem

Gene

Hem

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role during growth of the oocyte.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2029482, Regulation of actin dynamics for phagocytic cup formation
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-5663213, RHO GTPases Activate WASPs and WAVEs
R-DME-6798695, Neutrophil degranulation
R-DME-9013149, RAC1 GTPase cycle
R-DME-9013404, RAC2 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated protein Hem
Alternative name(s):
dHem-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hem
Synonyms:HEM2
ORF Names:CG5837
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011771, Hem

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0011771

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei989 – 1006HelicalSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002161761 – 1126Membrane-associated protein HemAdd BLAST1126

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55162

PRoteomics IDEntifications database

More...
PRIDEi
P55162

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55162

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed maternally in the oocyte and shows uniform expression during the first half of embryogenesis, but becomes restricted to the brain and the nervous system during late embryogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0011771, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P55162, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WAVE complex composed of Hem/Kette, Scar/Wave and Sra-1/Cyfip where it binds directly to the C-terminus of Sra-1.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
65698, 17 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2972, WAVE regulatory complex

Database of interacting proteins

More...
DIPi
DIP-18694N

Protein interaction database and analysis system

More...
IntActi
P55162, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0078162

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P55162

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HEM-1/HEM-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1917, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004450_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55162

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGMVMYN

Database of Orthologous Groups

More...
OrthoDBi
138196at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55162

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019137, Nck-associated_protein-1

The PANTHER Classification System

More...
PANTHERi
PTHR12093, PTHR12093, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09735, Nckap1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P55162-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPIFPNQQ KIAEKLIILN DRGLGILTRI YNIKKACGDT KSKPGFLSEK
60 70 80 90 100
SLESSIKFIV KRFPNIDVKG LNAIVNIKAE IIKSLSLYYH TFVDLLDFKD
110 120 130 140 150
NVCELLTTMD ACQIHLDITL NFELTKYYLD LVVTYVSLMI VLSRVEDRKA
160 170 180 190 200
VLGLYNAAYE LQNNQADTGF PRLGQMILDY EVPLKKLAEE FIPHQRLLTS
210 220 230 240 250
ALRSLTSIYA LRNLPADKWR EMQKLSLVGN PAILLKAVRT DTMSCEYISL
260 270 280 290 300
EAMDRWIIFG LLLNHQMLGQ YPEVNKIWLS ALESSWVVAL FRDEVLQIHQ
310 320 330 340 350
YIQATFDGIK GYSKRIGEVK EAYNTAVQKA ALMHRERRKF LRTALKELAL
360 370 380 390 400
IMTDQPGLLG PKAIFIFIGL CLARDEILWL LRHNDNPPLL KNKGKSNEDL
410 420 430 440 450
VDRQLPELLF HMEELRALVR KYSQVMQRYY VQYLSGFDAT DLNIRMQSLQ
460 470 480 490 500
MCPEDESIIF SSLYNTAAAL TVKQVEDNEL FYFRPFRLDW FRLQTYMSVG
510 520 530 540 550
KAALRIAEHA ELARLLDSMV FHTRVVDNLD EILVETSDLS IFCFYNKMFD
560 570 580 590 600
DQFHMCLEFP AQNRYIIAFP LICSHFQNCT HEMCPEERHH IRERSLSVVN
610 620 630 640 650
IFLEEMAKEA KNIITTICDE QCTMADALLP KHCAKILSVQ SARKKKDKSK
660 670 680 690 700
SKHFDDIRKP GDESYRKTRE DLTTMDKLHM ALTELCFAIN YCPTVNVWEF
710 720 730 740 750
AFAPREYLCQ NLEHRFSRDL VGMVMFNQET MEIAKPSELL ASVRAYMNVL
760 770 780 790 800
QTVENYVHID ITRVFNNCLL QQTQALDSHG EKTIAALYNT WYSEVLLRRV
810 820 830 840 850
SAGNIVFSIN QKAFVPISPE GWVPFNPQEF SDLNELRALA ELVGPYGIKT
860 870 880 890 900
LNETLMWHIA NQVQELKSLV STNKEVLITL RTSFDKPEVM KEQFKRLQDV
910 920 930 940 950
DRVLQRMTII GVIICFRNLV HEALVDVLDK RIPFLLSSVK DFQEHLPGGD
960 970 980 990 1000
QIRVASEMAS AAGLLCKVDP TLATTLKSKK PEFDEGEHLT ACLLMVFVAV
1010 1020 1030 1040 1050
SIPKLARNEN SFYRATIDGH SNNTHCMAAA INNIFGALFT ICGQSDMEDR
1060 1070 1080 1090 1100
MKEFLALASS SLLRLGQESD KEATRNRESI YLLLDEIVKQ SPFLTMDLLE
1110 1120
SCFPYVLIRN AYHGVYKQEQ ILGLAL
Length:1,126
Mass (Da):129,380
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i125FE7177AECC0E5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X80028 mRNA Translation: CAA56332.1
AE014296 Genomic DNA Translation: AAF51820.1
AY118579 mRNA Translation: AAM49948.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57832, S49208

NCBI Reference Sequences

More...
RefSeqi
NP_524214.1, NM_079490.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078510; FBpp0078162; FBgn0011771

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40462

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5837

UCSC genome browser

More...
UCSCi
CG5837-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80028 mRNA Translation: CAA56332.1
AE014296 Genomic DNA Translation: AAF51820.1
AY118579 mRNA Translation: AAM49948.1
PIRiS57832, S49208
RefSeqiNP_524214.1, NM_079490.4

3D structure databases

SMRiP55162
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65698, 17 interactors
ComplexPortaliCPX-2972, WAVE regulatory complex
DIPiDIP-18694N
IntActiP55162, 5 interactors
STRINGi7227.FBpp0078162

PTM databases

iPTMnetiP55162

Proteomic databases

PaxDbiP55162
PRIDEiP55162

Genome annotation databases

EnsemblMetazoaiFBtr0078510; FBpp0078162; FBgn0011771
GeneIDi40462
KEGGidme:Dmel_CG5837
UCSCiCG5837-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40462
FlyBaseiFBgn0011771, Hem
VEuPathDBiVectorBase:FBgn0011771

Phylogenomic databases

eggNOGiKOG1917, Eukaryota
GeneTreeiENSGT00390000016619
HOGENOMiCLU_004450_0_0_1
InParanoidiP55162
OMAiVGMVMYN
OrthoDBi138196at2759
PhylomeDBiP55162

Enzyme and pathway databases

ReactomeiR-DME-2029482, Regulation of actin dynamics for phagocytic cup formation
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-5663213, RHO GTPases Activate WASPs and WAVEs
R-DME-6798695, Neutrophil degranulation
R-DME-9013149, RAC1 GTPase cycle
R-DME-9013404, RAC2 GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
40462, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40462

Protein Ontology

More...
PROi
PR:P55162

Gene expression databases

BgeeiFBgn0011771, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues
GenevisibleiP55162, DM

Family and domain databases

InterProiView protein in InterPro
IPR019137, Nck-associated_protein-1
PANTHERiPTHR12093, PTHR12093, 1 hit
PfamiView protein in Pfam
PF09735, Nckap1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55162
Secondary accession number(s): Q540Y5, Q9VNU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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