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Protein

RTX-III toxin determinant A from serotype 8

Gene

apxIIIA

Organism
Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not have hemolytic activity but shows a strong cytotoxicity towards alveolar macrophages and neutrophils.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionToxin
Biological processCytolysis
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RTX-III toxin determinant A from serotype 8
Alternative name(s):
APX-IIIA
Cytolysin IIIA
Short name:
CLY-IIIA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:apxIIIA
Synonyms:clyIIIA, ptxA, rtxA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiActinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri715 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei248 – 265HelicalSequence analysisAdd BLAST18
Transmembranei275 – 334HelicalSequence analysisAdd BLAST60
Transmembranei372 – 418HelicalSequence analysisAdd BLAST47

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001962411 – 1052RTX-III toxin determinant A from serotype 8Add BLAST1052

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated by ApxIIIC. The toxin only becomes active when modified (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P55131

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P55131

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55131

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati744 – 761Hemolysin-type calcium-binding 1Add BLAST18
Repeati762 – 779Hemolysin-type calcium-binding 2Add BLAST18
Repeati780 – 797Hemolysin-type calcium-binding 3Add BLAST18
Repeati798 – 815Hemolysin-type calcium-binding 4Add BLAST18
Repeati826 – 843Hemolysin-type calcium-binding 5Add BLAST18
Repeati844 – 861Hemolysin-type calcium-binding 6Add BLAST18

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Gly-rich region is probably involved in binding calcium, which is required for target cell-binding or cytolytic activity.By similarity
The three transmembrane domains are believed to be involved in pore formation by the cytotoxin.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.150.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018511 Hemolysin-typ_Ca-bd_CS
IPR001343 Hemolysn_Ca-bd
IPR018504 RTX_N
IPR003995 RTX_toxin_determinant-A
IPR011049 Serralysin-like_metalloprot_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00353 HemolysinCabind, 3 hits
PF02382 RTX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01488 RTXTOXINA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51120 SSF51120, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00330 HEMOLYSIN_CALCIUM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P55131-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTWSSMLAD LKKRAEEAKR QAKKGYDVTK NGLQYGVSQA KLQALAAGKA
60 70 80 90 100
VQKYGNKLVL VIPKEYDGSV GNGFFDLVKA AEELGIQVKY VNRNELEVAH
110 120 130 140 150
KSLGTADQFL GLTERGLTLF APQLDQFLQK HSKISNVVGS STGDAVSKLA
160 170 180 190 200
KSQTIISGIQ SVLGTVLAGI NLNEAIISGG SELELAEAGV SLASELVSNI
210 220 230 240 250
AKGTTTIDAF TTQIQNFGKL VENAKGLGGV GRQLQNISGS ALSKTGLGLD
260 270 280 290 300
IISSLLSGVT ASFALANKNA STSTKVAAGF ELSNQVIGGI TKAVSSYILA
310 320 330 340 350
QRLAAGLSTT GPAAALIASS ISLAISPLAF LRVADNFNRS KEIGEFAERF
360 370 380 390 400
KKLGYDGDKL LSEFYHEAGT IDASITTIST ALSAIAAGTA AASAGALVGA
410 420 430 440 450
PITLLVTGIT GLISGILEFS KQPMLDHVAS KIGNKIDEWE KKYGKNYFEN
460 470 480 490 500
GYDARHKAFL EDSFSLLSSF NKQYETERAV LITQQRWDEY IGELAGITGK
510 520 530 540 550
GDKLSSGKAY VDYFQEGKLL EKKPDDFSKV VFDPTKGEID ISNSQTSTLL
560 570 580 590 600
KFVTPLLTPG TESRERTQTG KYEYITKLVV KGKDKWVVNG VKDKGAVYDY
610 620 630 640 650
TNLIQHAHIS SSVARGEEYR EVRLVSHLGN GNDKVFLAAG SAEIHAGEGH
660 670 680 690 700
DVVYYDKTDT GLLVIDGTKA TEQGRYSVTR ELSGATKILR EVIKNQKSAV
710 720 730 740 750
GKREETLEYR DYELTQSGNS NLKAHDELHS VEEIIGSNQR DEFKGSKFRD
760 770 780 790 800
IFHGADGDDL LNGNDGDDIL YGDKGNDELR GDNGNDQLYG GEGNDKLLGG
810 820 830 840 850
NGNNYLSGGD GNDELQVLGN GFNVLRGGKG DDKLYGSSGS DLLDGGEGND
860 870 880 890 900
YLEGGDGSDF YVYRSTSGNH TIYDQGKSSD LDKLYLSDFS FDRLLVEKVD
910 920 930 940 950
DNLVLRSNES SHNNGVLTIK DWFKEGNKYN HKIEQIVDKN GRKLTAENLG
960 970 980 990 1000
TYFKNAPKAD NLLNYATKED QNESNLSSLK TELSKIITNA GNFGVAKQGN
1010 1020 1030 1040 1050
TGINTAALNN EVNKIISSAN TFATSQLGGS GMGTLPSTNV NSMMLGNLAR

AA
Length:1,052
Mass (Da):112,810
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF83AFE25A6FD8758
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X80055 Genomic DNA Translation: CAA56358.1
X68815 Genomic DNA Translation: CAA48711.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B49219

NCBI Reference Sequences

More...
RefSeqi
WP_005620396.1, NZ_UIFY01000002.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80055 Genomic DNA Translation: CAA56358.1
X68815 Genomic DNA Translation: CAA48711.1
PIRiB49219
RefSeqiWP_005620396.1, NZ_UIFY01000002.1

3D structure databases

ProteinModelPortaliP55131
SMRiP55131
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP55131

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.150.10.10, 3 hits
InterProiView protein in InterPro
IPR018511 Hemolysin-typ_Ca-bd_CS
IPR001343 Hemolysn_Ca-bd
IPR018504 RTX_N
IPR003995 RTX_toxin_determinant-A
IPR011049 Serralysin-like_metalloprot_C
PfamiView protein in Pfam
PF00353 HemolysinCabind, 3 hits
PF02382 RTX, 1 hit
PRINTSiPR01488 RTXTOXINA
SUPFAMiSSF51120 SSF51120, 1 hit
PROSITEiView protein in PROSITE
PS00330 HEMOLYSIN_CALCIUM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTX32_ACTPL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55131
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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