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Protein

Leukotoxin translocation ATP-binding protein LktB

Gene

lktB

Organism
Pasteurella haemolytica-like sp. (strain 5943B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the ABC transporter complex LktBD involved in leukotoxin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).Curated

Caution

Leu-10 is present instead of the conserved Cys which is expected to be the active site residue of peptidase C39. Thus this protein is presumed to be without peptidase activity.Curated

Catalytic activityi

ATP + H2O + peptide(In) = ADP + phosphate + peptide(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi503 – 510ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotoxin translocation ATP-binding protein LktB (EC:3.6.3.43)
Gene namesi
Name:lktB
OrganismiPasteurella haemolytica-like sp. (strain 5943B)
Taxonomic identifieri53500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeMannheimia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei159 – 179HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei192 – 212HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei270 – 290HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei296 – 316HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei389 – 409HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923871 – 708Leukotoxin translocation ATP-binding protein LktBAdd BLAST708

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP55122
SMRiP55122
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 126Peptidase C39PROSITE-ProRule annotationAdd BLAST126
Domaini155 – 437ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST283
Domaini469 – 704ABC transporterPROSITE-ProRule annotationAdd BLAST236

Domaini

In LktB the peptidase C39 domain, the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR010132 ATPase_T1SS_HlyB
IPR027417 P-loop_NTPase
IPR005074 Peptidase_C39
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PF03412 Peptidase_C39, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR01846 type_I_sec_HlyB, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS50990 PEPTIDASE_C39, 1 hit

Sequencei

Sequence statusi: Complete.

P55122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVNHQSNDL GLVALKMLAQ YHNIPLNPEE IKHKFDIEGK GLTLTSWLLA
60 70 80 90 100
AKSLELKAKH IKKEISRLHL VNLPALVWQD NGKHFLLVKI DTDKKRYLTY
110 120 130 140 150
NLEQDAPKIL SQEEFESCYQ GKIILVTSRA SIVGQLAKFD FTWFIPAVIK
160 170 180 190 200
YRKIFLETLL VSIFLQIFAL ITPLFFQVVM DKVLVHRGFS TLNIITVALA
210 220 230 240 250
IVIIFEIVLS GLRTYIFAHS TSRIDVELGA RLFRHLLALP ISYFENRRVG
260 270 280 290 300
DTVARVRELD QIRNFLTGQA LTSVLDLLFS FIFFAVMWYY SPKLTLVILG
310 320 330 340 350
SLPCYILWSI FISPILRRRL DDKFARGADN QAFLVESVTA INMIKAMAVS
360 370 380 390 400
PQMTDTWDKQ LASYVSSSFR VTVLATIGQQ GVQLIQKTVM VINLWLGAHL
410 420 430 440 450
VISGDLSIGQ LIAFNMLSGQ VIAPVIRLAQ LWQDFTQVGI SVTRLGDVLN
460 470 480 490 500
SPTEQYQGKL SLPEIQGDIA FKNIRFRYKP DAPTILNNVN LEIKKGEVIG
510 520 530 540 550
IVGRSGSGKS TLTKLLQRFY IPENGQVLID GHDLALADPN WLRRQIGVVL
560 570 580 590 600
QDNVLLNRSI RENIALSEPG MSMERVIYAA KLAGAHDFIS DVREGYNTIV
610 620 630 640 650
GEQGAGLSGG QRQRIAIARA LVNNPKILIF DEATSALDYE SEHIIMQNMQ
660 670 680 690 700
KICQGRTVIL IAHRLSTVKN ADRIIVMEKG EIVEQGKHNE LLQNNNGLYS

YLHQLQLN
Length:708
Mass (Da):79,772
Last modified:October 1, 1996 - v1
Checksum:i7326D21411B5090A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12148 Genomic DNA Translation: AAA16445.1

Similar proteinsi

Entry informationi

Entry nameiLKTB_PASSP
AccessioniPrimary (citable) accession number: P55122
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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