lktB

Functionⁱ

Part of the ABC transporter complex LktBD involved in leukotoxin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).Curated

Caution

Leu-10 is present instead of the conserved Cys which is expected to be the active site residue of peptidase C39. Thus this protein is presumed to be without peptidase activity.Curated

Catalytic activityⁱ

ATP + H₂O + peptide(In) = ADP + phosphate + peptide(Out).

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	503 – 510	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
peptide-transporting ATPase activity Source: UniProtKB-EC
protein transporter activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein secretion by the type I secretion system Source: InterPro
proteolysis Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leukotoxin translocation ATP-binding protein LktB (EC:3.6.3.43)
Gene namesⁱ	Name:lktB
Organismⁱ	Pasteurella haemolytica-like sp. (strain 5943B)
Taxonomic identifierⁱ	53500 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Mannheimia

Subcellular locationⁱ

Cell inner membrane Curated; Multi-pass membrane protein Curated

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	159 – 179	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	192 – 212	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	270 – 290	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	296 – 316	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	389 – 409	HelicalPROSITE-ProRule annotationAdd BLAST	21

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell
type I protein secretion system complex Source: InterPro

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000092387	1 – 708	Leukotoxin translocation ATP-binding protein LktBAdd BLAST		708

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P55122
SMRⁱ	P55122
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 126	Peptidase C39PROSITE-ProRule annotationAdd BLAST	126
Domainⁱ	155 – 437	ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST	283
Domainⁱ	469 – 704	ABC transporterPROSITE-ProRule annotationAdd BLAST	236

Domainⁱ

In LktB the peptidase C39 domain, the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR010132 ATPase_T1SS_HlyB IPR027417 P-loop_NTPase IPR005074 Peptidase_C39
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 1 hit PF00005 ABC_tran, 1 hit PF03412 Peptidase_C39, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit
TIGRFAMsⁱ	TIGR01846 type_I_sec_HlyB, 1 hit
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit PS50990 PEPTIDASE_C39, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P55122-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVNHQSNDL GLVALKMLAQ YHNIPLNPEE IKHKFDIEGK GLTLTSWLLA 
        60         70         80         90        100
AKSLELKAKH IKKEISRLHL VNLPALVWQD NGKHFLLVKI DTDKKRYLTY 
       110        120        130        140        150
NLEQDAPKIL SQEEFESCYQ GKIILVTSRA SIVGQLAKFD FTWFIPAVIK 
       160        170        180        190        200
YRKIFLETLL VSIFLQIFAL ITPLFFQVVM DKVLVHRGFS TLNIITVALA 
       210        220        230        240        250
IVIIFEIVLS GLRTYIFAHS TSRIDVELGA RLFRHLLALP ISYFENRRVG 
       260        270        280        290        300
DTVARVRELD QIRNFLTGQA LTSVLDLLFS FIFFAVMWYY SPKLTLVILG 
       310        320        330        340        350
SLPCYILWSI FISPILRRRL DDKFARGADN QAFLVESVTA INMIKAMAVS 
       360        370        380        390        400
PQMTDTWDKQ LASYVSSSFR VTVLATIGQQ GVQLIQKTVM VINLWLGAHL 
       410        420        430        440        450
VISGDLSIGQ LIAFNMLSGQ VIAPVIRLAQ LWQDFTQVGI SVTRLGDVLN 
       460        470        480        490        500
SPTEQYQGKL SLPEIQGDIA FKNIRFRYKP DAPTILNNVN LEIKKGEVIG 
       510        520        530        540        550
IVGRSGSGKS TLTKLLQRFY IPENGQVLID GHDLALADPN WLRRQIGVVL 
       560        570        580        590        600
QDNVLLNRSI RENIALSEPG MSMERVIYAA KLAGAHDFIS DVREGYNTIV 
       610        620        630        640        650
GEQGAGLSGG QRQRIAIARA LVNNPKILIF DEATSALDYE SEHIIMQNMQ 
       660        670        680        690        700
KICQGRTVIL IAHRLSTVKN ADRIIVMEKG EIVEQGKHNE LLQNNNGLYS 

YLHQLQLN

Length:708

Mass (Da):79,772

Last modified:October 1, 1996 - v1

Checksum:ⁱ7326D21411B5090A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L12148 Genomic DNA Translation: AAA16445.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

L12148 Genomic DNA Translation: AAA16445.1

Protein	Similar proteins		Species	Score	Length
P55122	Leukotoxin translocation ATP-binding protein LktB		MANHA		708
Alpha-hemolysin translocation ATP-binding protein HlyB		Bibersteinia trehalosi USDA-ARS-USMARC-192		720
UPI000686814B		Mannheimia varigena		720
Type I secretion system permease/ATPase		Mannheimia haemolytica USDA-ARS-USMARC-184		720
Leukotoxin translocation ATP-binding protein lktB		Mannheimia haemolytica serotype A2 str. BOVINE		720
+23

Protein	Similar proteins		Species	Score	Length
P55122	Toxin RTX-III translocation ATP-binding protein		ACTPL		711
Type I secretion system permease/ATPase		Actinobacillus seminis		711
Exotoxin translocation ATP-binding protein PaxB		PASAE		711
Alpha-hemolysin translocation ATP-binding protein hlyB		Actinobacillus pleuropneumoniae serovar 4 str. M62		711
Toxin RTX-III translocation ATP-binding protein (RTX-III toxin determinant B)		ACTPJ		707
+440

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L12148 Genomic DNA Translation: AAA16445.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

L12148 Genomic DNA Translation: AAA16445.1

3D structure databases

ProteinModelPortalⁱ	P55122
SMRⁱ	P55122
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR010132 ATPase_T1SS_HlyB IPR027417 P-loop_NTPase IPR005074 Peptidase_C39
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 1 hit PF00005 ABC_tran, 1 hit PF03412 Peptidase_C39, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit
TIGRFAMsⁱ	TIGR01846 type_I_sec_HlyB, 1 hit
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit PS50990 PEPTIDASE_C39, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LKTB_PASSP
Accessionⁱ	P55122Primary (citable) accession number: P55122
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	October 25, 2017
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Documents

SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P55122 (LKTB_PASSP)

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Leukotoxin translocation ATP-binding protein LktB

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ