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Protein

Inhibin beta C chain

Gene

Inhbc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • hormone activity Source: UniProtKB-KW
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

ReactomeiR-MMU-209822 Glycoprotein hormones

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta C chain
Alternative name(s):
Activin beta-C chain
Gene namesi
Name:Inhbc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:105932 Inhbc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000003373219 – 236Sequence analysisAdd BLAST218
ChainiPRO_0000033733237 – 352Inhibin beta C chainAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi240 ↔ 248By similarity
Disulfide bondi247 ↔ 317By similarity
Disulfide bondi276 ↔ 349By similarity
Disulfide bondi280 ↔ 351By similarity
Disulfide bondi316InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP55104
PaxDbiP55104
PeptideAtlasiP55104
PRIDEiP55104

PTM databases

iPTMnetiP55104
PhosphoSitePlusiP55104

Expressioni

Tissue specificityi

Mainly expressed in the adult liver.

Gene expression databases

BgeeiENSMUSG00000025405 Expressed in 30 organ(s), highest expression level in liver
CleanExiMM_INHBC
GenevisibleiP55104 MM

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026472

Structurei

3D structure databases

ProteinModelPortaliP55104
SMRiP55104
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP55104
KOiK22688
OMAiYYDRDSN
OrthoDBiEOG091G09LW
PhylomeDBiP55104
TreeFamiTF351791

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001318 Inhibin_betaC
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PRINTSiPR00672 INHIBINBC
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55104-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSLLLALL FLTPTTVVNP KTEGPCPACW GAIFDLESQR ELLLDLAKKS
60 70 80 90 100
ILDKLHLSQR PILSRPVSRG ALKTALQRLR GPRRETLLEH DQRQEEYEII
110 120 130 140 150
SFADTDLSSI NQTRLEFHFS GRMASGMEVR QTRFMFFVQF PHNATQTMNI
160 170 180 190 200
RVLVLRPYDT NLTLTSQYVV QVNASGWYQL LLGPEAQAAC SQGHLTLELV
210 220 230 240 250
PESQVAHSSL ILGWFSHRPF VAAQVRVEGK HRVRRRGIDC QGASRMCCRQ
260 270 280 290 300
EFFVDFREIG WNDWIIQPEG YAMNFCTGQC PLHVAGMPGI SASFHTAVLN
310 320 330 340 350
LLKANAAAGT TGRGSCCVPT SRRPLSLLYY DRDSNIVKTD IPDMVVEACG

CS
Length:352
Mass (Da):39,401
Last modified:November 1, 1997 - v2
Checksum:i220812FD73717185
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243A → G in CAA62347 (PubMed:8838799).Curated1
Sequence conflicti243A → G in CAA62333 (PubMed:8838799).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90841, X90842 Genomic DNA Translation: CAA62347.1
X90819 mRNA Translation: CAA62333.1
U40773, U40772 Genomic DNA Translation: AAC52723.1
U95962 mRNA Translation: AAC53164.1
BC026140 mRNA Translation: AAH26140.1
CCDSiCCDS24240.1
PIRiJC5366
S70580
RefSeqiNP_034695.1, NM_010565.4
UniGeneiMm.2594

Genome annotation databases

EnsembliENSMUST00000026472; ENSMUSP00000026472; ENSMUSG00000025405
GeneIDi16325
KEGGimmu:16325
UCSCiuc007hjj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90841, X90842 Genomic DNA Translation: CAA62347.1
X90819 mRNA Translation: CAA62333.1
U40773, U40772 Genomic DNA Translation: AAC52723.1
U95962 mRNA Translation: AAC53164.1
BC026140 mRNA Translation: AAH26140.1
CCDSiCCDS24240.1
PIRiJC5366
S70580
RefSeqiNP_034695.1, NM_010565.4
UniGeneiMm.2594

3D structure databases

ProteinModelPortaliP55104
SMRiP55104
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026472

PTM databases

iPTMnetiP55104
PhosphoSitePlusiP55104

Proteomic databases

MaxQBiP55104
PaxDbiP55104
PeptideAtlasiP55104
PRIDEiP55104

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026472; ENSMUSP00000026472; ENSMUSG00000025405
GeneIDi16325
KEGGimmu:16325
UCSCiuc007hjj.2 mouse

Organism-specific databases

CTDi3626
MGIiMGI:105932 Inhbc

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP55104
KOiK22688
OMAiYYDRDSN
OrthoDBiEOG091G09LW
PhylomeDBiP55104
TreeFamiTF351791

Enzyme and pathway databases

ReactomeiR-MMU-209822 Glycoprotein hormones

Miscellaneous databases

PROiPR:P55104
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025405 Expressed in 30 organ(s), highest expression level in liver
CleanExiMM_INHBC
GenevisibleiP55104 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001318 Inhibin_betaC
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PRINTSiPR00672 INHIBINBC
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINHBC_MOUSE
AccessioniPrimary (citable) accession number: P55104
Secondary accession number(s): Q61452
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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