UniProtKB - P55103 (INHBC_HUMAN)
Inhibin beta C chain
INHBC
Functioni
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: ProtInc
GO - Biological processi
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- SMAD protein signal transduction Source: GO_Central
Keywordsi
Molecular function | Growth factor, Hormone |
Enzyme and pathway databases
PathwayCommonsi | P55103 |
Reactomei | R-HSA-209822, Glycoprotein hormones |
SignaLinki | P55103 |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibin beta C chainAlternative name(s): Activin beta-C chain |
Gene namesi | Name:INHBC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6068, INHBC |
MIMi | 601233, gene |
neXtProti | NX_P55103 |
VEuPathDBi | HostDB:ENSG00000175189 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: ProtInc
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3626 |
OpenTargetsi | ENSG00000175189 |
PharmGKBi | PA29879 |
Miscellaneous databases
Pharosi | P55103, Tbio |
Genetic variation databases
BioMutai | INHBC |
DMDMi | 1708438 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000033730 | 19 – 236 | Sequence analysisAdd BLAST | 218 | |
ChainiPRO_0000033731 | 237 – 352 | Inhibin beta C chainAdd BLAST | 116 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 143 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 240 ↔ 248 | By similarity | ||
Disulfide bondi | 247 ↔ 317 | By similarity | ||
Disulfide bondi | 276 ↔ 349 | By similarity | ||
Disulfide bondi | 280 ↔ 351 | By similarity | ||
Disulfide bondi | 316 | InterchainBy similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P55103 |
PaxDbi | P55103 |
PeptideAtlasi | P55103 |
PRIDEi | P55103 |
ProteomicsDBi | 56791 |
PTM databases
GlyGeni | P55103, 3 sites |
iPTMneti | P55103 |
PhosphoSitePlusi | P55103 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000175189, Expressed in liver and 41 other tissues |
Genevisiblei | P55103, HS |
Organism-specific databases
HPAi | ENSG00000175189, Tissue enriched (liver) |
Interactioni
Subunit structurei
Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: ProtInc
Protein-protein interaction databases
STRINGi | 9606.ENSP00000308716 |
Miscellaneous databases
RNActi | P55103, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000160065 |
HOGENOMi | CLU_020515_5_0_1 |
InParanoidi | P55103 |
OMAi | GLSTINQ |
OrthoDBi | 1385831at2759 |
PhylomeDBi | P55103 |
TreeFami | TF351791 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001318, Inhibin_betaC IPR001839, TGF-b_C IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
PRINTSi | PR00672, INHIBINBC |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS
60 70 80 90 100
ILDKLHLTQR PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS
110 120 130 140 150
FAETGLSTIN QTRLDFHFSS DRTAGDREVQ QASLMFFVQL PSNTTWTLKV
160 170 180 190 200
RVLVLGPHNT NLTLATQYLL EVDASGWHQL PLGPEAQAAC SQGHLTLELV
210 220 230 240 250
LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC QGGSRMCCRQ
260 270 280 290 300
EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN
310 320 330 340 350
LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG
CS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024230 | 322 | R → Q. Corresponds to variant dbSNP:rs2229357Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82540 mRNA Translation: CAA57890.1 CH471054 Genomic DNA Translation: EAW97011.1 BC130324 mRNA Translation: AAI30325.1 BC130326 mRNA Translation: AAI30327.1 |
CCDSi | CCDS8938.1 |
PIRi | JC2466 |
RefSeqi | NP_005529.1, NM_005538.3 |
Genome annotation databases
Ensembli | ENST00000309668; ENSP00000308716; ENSG00000175189 |
GeneIDi | 3626 |
KEGGi | hsa:3626 |
MANE-Selecti | ENST00000309668.3; ENSP00000308716.2; NM_005538.4; NP_005529.1 |
UCSCi | uc001snv.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82540 mRNA Translation: CAA57890.1 CH471054 Genomic DNA Translation: EAW97011.1 BC130324 mRNA Translation: AAI30325.1 BC130326 mRNA Translation: AAI30327.1 |
CCDSi | CCDS8938.1 |
PIRi | JC2466 |
RefSeqi | NP_005529.1, NM_005538.3 |
3D structure databases
SMRi | P55103 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000308716 |
PTM databases
GlyGeni | P55103, 3 sites |
iPTMneti | P55103 |
PhosphoSitePlusi | P55103 |
Genetic variation databases
BioMutai | INHBC |
DMDMi | 1708438 |
Proteomic databases
MassIVEi | P55103 |
PaxDbi | P55103 |
PeptideAtlasi | P55103 |
PRIDEi | P55103 |
ProteomicsDBi | 56791 |
Protocols and materials databases
Antibodypediai | 28599, 318 antibodies from 28 providers |
DNASUi | 3626 |
Genome annotation databases
Ensembli | ENST00000309668; ENSP00000308716; ENSG00000175189 |
GeneIDi | 3626 |
KEGGi | hsa:3626 |
MANE-Selecti | ENST00000309668.3; ENSP00000308716.2; NM_005538.4; NP_005529.1 |
UCSCi | uc001snv.3, human |
Organism-specific databases
CTDi | 3626 |
DisGeNETi | 3626 |
GeneCardsi | INHBC |
HGNCi | HGNC:6068, INHBC |
HPAi | ENSG00000175189, Tissue enriched (liver) |
MIMi | 601233, gene |
neXtProti | NX_P55103 |
OpenTargetsi | ENSG00000175189 |
PharmGKBi | PA29879 |
VEuPathDBi | HostDB:ENSG00000175189 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000160065 |
HOGENOMi | CLU_020515_5_0_1 |
InParanoidi | P55103 |
OMAi | GLSTINQ |
OrthoDBi | 1385831at2759 |
PhylomeDBi | P55103 |
TreeFami | TF351791 |
Enzyme and pathway databases
PathwayCommonsi | P55103 |
Reactomei | R-HSA-209822, Glycoprotein hormones |
SignaLinki | P55103 |
Miscellaneous databases
BioGRID-ORCSi | 3626, 13 hits in 1036 CRISPR screens |
GeneWikii | INHBC |
GenomeRNAii | 3626 |
Pharosi | P55103, Tbio |
PROi | PR:P55103 |
RNActi | P55103, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175189, Expressed in liver and 41 other tissues |
Genevisiblei | P55103, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001318, Inhibin_betaC IPR001839, TGF-b_C IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
PRINTSi | PR00672, INHIBINBC |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | INHBC_HUMAN | |
Accessioni | P55103Primary (citable) accession number: P55103 Secondary accession number(s): A1L3Y2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families