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Protein

Tachykinin-3

Gene

Tac3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-380095 Tachykinin receptors bind tachykinins
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-3
Alternative name(s):
Neurokinin B-like protein Zneurok1
Preprotachykinin-B
Short name:
PPT-B
Cleaved into the following chain:
Neurokinin-B
Short name:
NKB
Alternative name(s):
Neuromedin-K
Gene namesi
Name:Tac3
Synonyms:Nknb, Tac2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:98476 Tac2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003356821 – 79Add BLAST59
PeptideiPRO_000003356982 – 91Neurokinin-B10
PropeptideiPRO_000003357095 – 116Add BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55099
PRIDEiP55099

PTM databases

PhosphoSitePlusiP55099

Expressioni

Gene expression databases

BgeeiENSMUSG00000025400
CleanExiMM_TAC2
GenevisibleiP55099 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026466

Structurei

3D structure databases

SMRiP55099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QH Eukaryota
ENOG4111D7S LUCA
GeneTreeiENSGT00390000000335
HOGENOMiHOG000154597
HOVERGENiHBG016587
InParanoidiP55099
KOiK05240
OMAiAVCEESQ
OrthoDBiEOG091G0X8Y
PhylomeDBiP55099
TreeFamiTF337038

Family and domain databases

InterProiView protein in InterPro
IPR003635 Neurokinin-B/TAC3
IPR013055 Tachy_Neuro_lke_CS
PANTHERiPTHR15536 PTHR15536, 1 hit
PfamiView protein in Pfam
PF03823 Neurokinin_B, 1 hit
PIRSFiPIRSF001843 Neurokinin, 1 hit
PRINTSiPR01828 NEUROKININB
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSAMLFAAV LALSLAWTFG AVCEEPQGQG GRLSKDSDLY QLPPSLLRRL
60 70 80 90 100
YDSRPVSLEG LLKVLSKASV GPKETSLPQK RDMHDFFVGL MGKRNSQPDT
110
PTDVVEENTP SFGILK
Length:116
Mass (Da):12,737
Last modified:May 10, 2004 - v2
Checksum:iBD4C8B171C2213CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28G → E in BAA03316 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14423 mRNA Translation: BAA03316.1
AF186116 mRNA Translation: AAF01434.1
BC051476 mRNA Translation: AAH51476.1
CCDSiCCDS24248.1
PIRiI65342
RefSeqiNP_001186900.1, NM_001199971.1
NP_033338.2, NM_009312.2
UniGeneiMm.2374

Genome annotation databases

EnsembliENSMUST00000026466; ENSMUSP00000026466; ENSMUSG00000025400
ENSMUST00000179960; ENSMUSP00000136622; ENSMUSG00000025400
GeneIDi21334
KEGGimmu:21334
UCSCiuc007hkj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTKNK_MOUSE
AccessioniPrimary (citable) accession number: P55099
Secondary accession number(s): Q9QXS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 10, 2004
Last modified: June 20, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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