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UniProtKB - P55089 (UCN1_HUMAN)
Protein
Urocortin
Gene
UCN
Organism
Homo sapiens (Human)
Status
Functioni
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563).
Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563).
Plays a role in the establishment of normal hearing thresholds (By similarity).
Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).
By similarity1 PublicationMiscellaneous
Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.1 Publication
GO - Molecular functioni
- corticotropin-releasing hormone receptor 1 binding Source: Ensembl
- corticotropin-releasing hormone receptor 2 binding Source: Ensembl
- histone deacetylase inhibitor activity Source: Ensembl
- neuropeptide hormone activity Source: ProtInc
GO - Biological processi
- activation of protein kinase A activity Source: Ensembl
- aerobic respiration Source: Ensembl
- associative learning Source: Ensembl
- drinking behavior Source: Ensembl
- female pregnancy Source: Ensembl
- gastric emptying Source: Ensembl
- G protein-coupled receptor signaling pathway Source: ProtInc
- inflammatory response Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of appetite Source: Ensembl
- negative regulation of blood pressure Source: Ensembl
- negative regulation of cell size Source: Ensembl
- negative regulation of feeding behavior Source: GO_Central
- negative regulation of gastric acid secretion Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of hormone secretion Source: Ensembl
- negative regulation of necrotic cell death Source: Ensembl
- negative regulation of neuron death Source: Ensembl
- neuron projection development Source: Ensembl
- neuropeptide signaling pathway Source: Ensembl
- pancreatic juice secretion Source: Ensembl
- positive regulation of behavioral fear response Source: Ensembl
- positive regulation of calcium ion import Source: Ensembl
- positive regulation of cAMP-mediated signaling Source: Ensembl
- positive regulation of cardiac muscle contraction Source: Ensembl
- positive regulation of cell growth Source: Ensembl
- positive regulation of collagen biosynthetic process Source: Ensembl
- positive regulation of corticotropin secretion Source: UniProtKB
- positive regulation of DNA replication Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of translation Source: Ensembl
- positive regulation of vascular permeability Source: Ensembl
- regulation of synaptic transmission, glutamatergic Source: Ensembl
- response to auditory stimulus Source: Ensembl
- response to estradiol Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to oxidative stress Source: Ensembl
- response to pain Source: Ensembl
- sensory perception of sound Source: UniProtKB-KW
- social behavior Source: Ensembl
- startle response Source: Ensembl
- vasodilation Source: Ensembl
Keywordsi
Molecular function | Hormone |
Biological process | Hearing |
Enzyme and pathway databases
PathwayCommonsi | P55089 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin |
SignaLinki | P55089 |
SIGNORi | P55089 |
Names & Taxonomyi
Protein namesi | Recommended name: Urocortin |
Gene namesi | Name:UCN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12516, UCN |
MIMi | 600945, gene |
neXtProti | NX_P55089 |
VEuPathDBi | HostDB:ENSG00000163794 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Other locations
- axon terminus Source: Ensembl
- dendrite Source: Ensembl
- perikaryon Source: Ensembl
- varicosity Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 116 | R → A: Reduced affinity for CRHR1. 1 Publication | 1 | |
Mutagenesisi | 118 | I → A: Reduced affinity for CRHR2. 1 Publication | 1 | |
Mutagenesisi | 119 | F → A: Strongly reduced affinity for CRHR2. 1 Publication | 1 | |
Mutagenesisi | 122 | V → A: Reduced affinity for CRHR2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7349 |
OpenTargetsi | ENSG00000163794 |
PharmGKBi | PA37163 |
Miscellaneous databases
Pharosi | P55089, Tbio |
Genetic variation databases
BioMutai | UCN |
DMDMi | 1718059 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
PropeptideiPRO_0000006233 | 26 – 82 | Add BLAST | 57 | |
PeptideiPRO_0000006234 | 83 – 122 | UrocortinAdd BLAST | 40 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 122 | Valine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residuesProteomic databases
PaxDbi | P55089 |
PeptideAtlasi | P55089 |
PRIDEi | P55089 |
ProteomicsDBi | 56790 |
Expressioni
Tissue specificityi
Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).2 Publications
Gene expression databases
Bgeei | ENSG00000163794, Expressed in frontal cortex and 123 other tissues |
Genevisiblei | P55089, HS |
Organism-specific databases
HPAi | ENSG00000163794, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).
1 PublicationGO - Molecular functioni
- corticotropin-releasing hormone receptor 1 binding Source: Ensembl
- corticotropin-releasing hormone receptor 2 binding Source: Ensembl
- neuropeptide hormone activity Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 113196, 5 interactors |
IntActi | P55089, 2 interactors |
STRINGi | 9606.ENSP00000296099 |
Miscellaneous databases
RNActi | P55089, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P55089 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P55089 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 46 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S63E, Eukaryota |
GeneTreei | ENSGT00940000154473 |
HOGENOMi | CLU_138901_0_0_1 |
InParanoidi | P55089 |
OMAi | PGARNQG |
PhylomeDBi | P55089 |
TreeFami | TF332956 |
Family and domain databases
InterProi | View protein in InterPro IPR018446, Corticotropin-releasing_fac_CS IPR000187, CRF IPR003620, Urocortin_CRF |
PANTHERi | PTHR15035, PTHR15035, 1 hit |
Pfami | View protein in Pfam PF00473, CRF, 1 hit |
PRINTSi | PR01612, CRFFAMILY |
SMARTi | View protein in SMART SM00039, CRF, 1 hit |
PROSITEi | View protein in PROSITE PS00511, CRF, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P55089-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG
60 70 80 90 100
ARALLLLLAE RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL
110 120
ELARTQSQRE RAEQNRIIFD SVGK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038633 Genomic DNA Translation: AAC24204.1 CR542244 mRNA Translation: CAG47040.1 AC013413 Genomic DNA Translation: AAY24297.1 BC104470 mRNA Translation: AAI04471.1 BC104471 mRNA Translation: AAI04472.1 |
CCDSi | CCDS1747.1 |
RefSeqi | NP_003344.1, NM_003353.3 |
Genome annotation databases
Ensembli | ENST00000296099; ENSP00000296099; ENSG00000163794 |
GeneIDi | 7349 |
KEGGi | hsa:7349 |
MANE-Selecti | ENST00000296099.2; ENSP00000296099.2; NM_003353.4; NP_003344.1 |
UCSCi | uc002rjp.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038633 Genomic DNA Translation: AAC24204.1 CR542244 mRNA Translation: CAG47040.1 AC013413 Genomic DNA Translation: AAY24297.1 BC104470 mRNA Translation: AAI04471.1 BC104471 mRNA Translation: AAI04472.1 |
CCDSi | CCDS1747.1 |
RefSeqi | NP_003344.1, NM_003353.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RMF | NMR | - | A | 83-122 | [»] | |
3N96 | X-ray | 2.75 | E/F/G/H | 107-122 | [»] | |
6PB0 | electron microscopy | 3.00 | U | 83-122 | [»] | |
6PB1 | electron microscopy | 2.80 | U | 83-122 | [»] | |
SMRi | P55089 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113196, 5 interactors |
IntActi | P55089, 2 interactors |
STRINGi | 9606.ENSP00000296099 |
Genetic variation databases
BioMutai | UCN |
DMDMi | 1718059 |
Proteomic databases
PaxDbi | P55089 |
PeptideAtlasi | P55089 |
PRIDEi | P55089 |
ProteomicsDBi | 56790 |
Protocols and materials databases
Antibodypediai | 4400, 220 antibodies from 31 providers |
DNASUi | 7349 |
Genome annotation databases
Ensembli | ENST00000296099; ENSP00000296099; ENSG00000163794 |
GeneIDi | 7349 |
KEGGi | hsa:7349 |
MANE-Selecti | ENST00000296099.2; ENSP00000296099.2; NM_003353.4; NP_003344.1 |
UCSCi | uc002rjp.2, human |
Organism-specific databases
CTDi | 7349 |
DisGeNETi | 7349 |
GeneCardsi | UCN |
HGNCi | HGNC:12516, UCN |
HPAi | ENSG00000163794, Tissue enhanced (brain) |
MIMi | 600945, gene |
neXtProti | NX_P55089 |
OpenTargetsi | ENSG00000163794 |
PharmGKBi | PA37163 |
VEuPathDBi | HostDB:ENSG00000163794 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S63E, Eukaryota |
GeneTreei | ENSGT00940000154473 |
HOGENOMi | CLU_138901_0_0_1 |
InParanoidi | P55089 |
OMAi | PGARNQG |
PhylomeDBi | P55089 |
TreeFami | TF332956 |
Enzyme and pathway databases
PathwayCommonsi | P55089 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin |
SignaLinki | P55089 |
SIGNORi | P55089 |
Miscellaneous databases
BioGRID-ORCSi | 7349, 20 hits in 1034 CRISPR screens |
EvolutionaryTracei | P55089 |
GeneWikii | Urocortin |
GenomeRNAii | 7349 |
Pharosi | P55089, Tbio |
PROi | PR:P55089 |
RNActi | P55089, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163794, Expressed in frontal cortex and 123 other tissues |
Genevisiblei | P55089, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018446, Corticotropin-releasing_fac_CS IPR000187, CRF IPR003620, Urocortin_CRF |
PANTHERi | PTHR15035, PTHR15035, 1 hit |
Pfami | View protein in Pfam PF00473, CRF, 1 hit |
PRINTSi | PR01612, CRFFAMILY |
SMARTi | View protein in SMART SM00039, CRF, 1 hit |
PROSITEi | View protein in PROSITE PS00511, CRF, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UCN1_HUMAN | |
Accessioni | P55089Primary (citable) accession number: P55089 Secondary accession number(s): Q6FG64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families