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Protein

Urocortin

Gene

UCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).By similarity1 Publication

Miscellaneous

Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processHearing

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
SIGNORiP55089

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Gene namesi
Name:UCN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163794.6
HGNCiHGNC:12516 UCN
MIMi600945 gene
neXtProtiNX_P55089

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi116R → A: Reduced affinity for CRHR1. 1 Publication1
Mutagenesisi118I → A: Reduced affinity for CRHR2. 1 Publication1
Mutagenesisi119F → A: Strongly reduced affinity for CRHR2. 1 Publication1
Mutagenesisi122V → A: Reduced affinity for CRHR2. 1 Publication1

Organism-specific databases

DisGeNETi7349
OpenTargetsiENSG00000163794
PharmGKBiPA37163

Polymorphism and mutation databases

BioMutaiUCN
DMDMi1718059

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000623326 – 82Add BLAST57
PeptideiPRO_000000623483 – 122UrocortinAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122Valine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55089
PeptideAtlasiP55089
PRIDEiP55089
ProteomicsDBi56790

Expressioni

Tissue specificityi

Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).2 Publications

Gene expression databases

BgeeiENSG00000163794 Expressed in 103 organ(s), highest expression level in frontal cortex
CleanExiHS_UCN
GenevisibleiP55089 HS

Organism-specific databases

HPAiCAB010911

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113196, 4 interactors
STRINGi9606.ENSP00000296099

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55089
SMRiP55089
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55089

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8KZ Eukaryota
ENOG410Y0J4 LUCA
GeneTreeiENSGT00510000049284
HOGENOMiHOG000121779
HOVERGENiHBG036241
InParanoidiP55089
OMAiLRWSPGA
PhylomeDBiP55089
TreeFamiTF332956

Family and domain databases

InterProiView protein in InterPro
IPR018446 Corticotropin-releasing_fac_CS
IPR000187 CRF
IPR003620 Urocortin_CRF
PANTHERiPTHR15035 PTHR15035, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
PRINTSiPR01612 CRFFAMILY
SMARTiView protein in SMART
SM00039 CRF, 1 hit
PROSITEiView protein in PROSITE
PS00511 CRF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55089-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG
60 70 80 90 100
ARALLLLLAE RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL
110 120
ELARTQSQRE RAEQNRIIFD SVGK
Length:124
Mass (Da):13,458
Last modified:October 1, 1996 - v1
Checksum:i4F765DA75DDD4A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038633 Genomic DNA Translation: AAC24204.1
CR542244 mRNA Translation: CAG47040.1
AC013413 Genomic DNA Translation: AAY24297.1
BC104470 mRNA Translation: AAI04471.1
BC104471 mRNA Translation: AAI04472.1
CCDSiCCDS1747.1
RefSeqiNP_003344.1, NM_003353.3
UniGeneiHs.534363

Genome annotation databases

EnsembliENST00000296099; ENSP00000296099; ENSG00000163794
GeneIDi7349
KEGGihsa:7349
UCSCiuc002rjp.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038633 Genomic DNA Translation: AAC24204.1
CR542244 mRNA Translation: CAG47040.1
AC013413 Genomic DNA Translation: AAY24297.1
BC104470 mRNA Translation: AAI04471.1
BC104471 mRNA Translation: AAI04472.1
CCDSiCCDS1747.1
RefSeqiNP_003344.1, NM_003353.3
UniGeneiHs.534363

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMFNMR-A83-122[»]
3N96X-ray2.75E/F/G/H107-122[»]
ProteinModelPortaliP55089
SMRiP55089
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113196, 4 interactors
STRINGi9606.ENSP00000296099

Polymorphism and mutation databases

BioMutaiUCN
DMDMi1718059

Proteomic databases

PaxDbiP55089
PeptideAtlasiP55089
PRIDEiP55089
ProteomicsDBi56790

Protocols and materials databases

DNASUi7349
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296099; ENSP00000296099; ENSG00000163794
GeneIDi7349
KEGGihsa:7349
UCSCiuc002rjp.2 human

Organism-specific databases

CTDi7349
DisGeNETi7349
EuPathDBiHostDB:ENSG00000163794.6
GeneCardsiUCN
HGNCiHGNC:12516 UCN
HPAiCAB010911
MIMi600945 gene
neXtProtiNX_P55089
OpenTargetsiENSG00000163794
PharmGKBiPA37163
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8KZ Eukaryota
ENOG410Y0J4 LUCA
GeneTreeiENSGT00510000049284
HOGENOMiHOG000121779
HOVERGENiHBG036241
InParanoidiP55089
OMAiLRWSPGA
PhylomeDBiP55089
TreeFamiTF332956

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
SIGNORiP55089

Miscellaneous databases

EvolutionaryTraceiP55089
GeneWikiiUrocortin
GenomeRNAii7349
PROiPR:P55089
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163794 Expressed in 103 organ(s), highest expression level in frontal cortex
CleanExiHS_UCN
GenevisibleiP55089 HS

Family and domain databases

InterProiView protein in InterPro
IPR018446 Corticotropin-releasing_fac_CS
IPR000187 CRF
IPR003620 Urocortin_CRF
PANTHERiPTHR15035 PTHR15035, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
PRINTSiPR01612 CRFFAMILY
SMARTiView protein in SMART
SM00039 CRF, 1 hit
PROSITEiView protein in PROSITE
PS00511 CRF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUCN1_HUMAN
AccessioniPrimary (citable) accession number: P55089
Secondary accession number(s): Q6FG64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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