UCN

Functionⁱ

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563).

Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563).

Plays a role in the establishment of normal hearing thresholds (By similarity).

Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).

By similarity1 Publication

Miscellaneous

Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.1 Publication

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase A activity Source: Ensembl
aerobic respiration Source: Ensembl
associative learning Source: Ensembl
drinking behavior Source: Ensembl
female pregnancy Source: Ensembl
gastric emptying Source: Ensembl
G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- Ref.1
  "Cloning and characterization of human urocortin."
  Donaldson C.J., Sutton S.W., Perrin M.H., Corrigan A.Z., Lewis K.A., Rivier J.E., Vaughan J.M., Vale W.W.
  Endocrinology 137:2167-2170(1996) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
inflammatory response Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of appetite Source: Ensembl
negative regulation of blood pressure Source: Ensembl
negative regulation of cell size Source: Ensembl
negative regulation of feeding behavior
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
negative regulation of gastric acid secretion Source: Ensembl
negative regulation of gene expression Source: Ensembl
negative regulation of hormone secretion Source: Ensembl
negative regulation of necrotic cell death Source: Ensembl
negative regulation of neuron death Source: Ensembl
neuron projection development Source: Ensembl
neuropeptide signaling pathway Source: Ensembl
pancreatic juice secretion Source: Ensembl
positive regulation of behavioral fear response Source: Ensembl
positive regulation of calcium ion import Source: Ensembl
positive regulation of cAMP-mediated signaling Source: Ensembl
positive regulation of cardiac muscle contraction Source: Ensembl
positive regulation of cell growth Source: Ensembl
positive regulation of collagen biosynthetic process Source: Ensembl
positive regulation of corticotropin secretion
Source: UniProtKB
Inferred from direct assayⁱ
- "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."
  Hsu S.Y., Hsueh A.J.W.
  Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]
positive regulation of DNA replication Source: Ensembl
positive regulation of interleukin-6 production Source: Ensembl
positive regulation of peptidyl-serine phosphorylation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of translation Source: Ensembl
positive regulation of vascular permeability Source: Ensembl
regulation of synaptic transmission, glutamatergic Source: Ensembl
response to auditory stimulus Source: Ensembl
response to estradiol Source: Ensembl
response to glucocorticoid Source: Ensembl
response to oxidative stress Source: Ensembl
response to pain Source: Ensembl
sensory perception of sound Source: UniProtKB-KW
social behavior Source: Ensembl
startle response Source: Ensembl
vasodilation Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone
Biological process	Hearing

Enzyme and pathway databases

PathwayCommonsⁱ	P55089
Reactomeⁱ	R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin
SignaLinkⁱ	P55089
SIGNORⁱ	P55089

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Urocortin
Gene namesⁱ	Name:UCN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12516, UCN
MIMⁱ	600945, gene
neXtProtⁱ	NX_P55089
VEuPathDBⁱ	HostDB:ENSG00000163794

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	116	R → A: Reduced affinity for CRHR1. 1 Publication	1
Mutagenesisⁱ	118	I → A: Reduced affinity for CRHR2. 1 Publication	1
Mutagenesisⁱ	119	F → A: Strongly reduced affinity for CRHR2. 1 Publication	1
Mutagenesisⁱ	122	V → A: Reduced affinity for CRHR2. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7349
Open Targets More...OpenTargetsⁱ	ENSG00000163794
PharmGKBⁱ	PA37163

Miscellaneous databases

Pharosⁱ	P55089, Tbio

Pharosⁱ

P55089, Tbio

Genetic variation databases

BioMutaⁱ	UCN
DMDMⁱ	1718059

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST	25
PropeptideⁱPRO_0000006233	26 – 82	Add BLAST	57
PeptideⁱPRO_0000006234	83 – 122	UrocortinAdd BLAST	40

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	122	Valine amideBy similarity		1

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbⁱ	P55089
PeptideAtlas More...PeptideAtlasⁱ	P55089
PRIDEⁱ	P55089
ProteomicsDBⁱ	56790

Expressionⁱ

Tissue specificityⁱ

Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000163794, Expressed in frontal cortex and 123 other tissues
Genevisibleⁱ	P55089, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000163794, Tissue enhanced (brain)

HPAⁱ

ENSG00000163794, Tissue enhanced (brain)

Interactionⁱ

Subunit structureⁱ

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).

1 Publication

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	113196, 5 interactors
IntActⁱ	P55089, 2 interactors
STRINGⁱ	9606.ENSP00000296099

Miscellaneous databases

RNActⁱ	P55089, protein

RNActⁱ

P55089, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	108 – 121	Combined sources		14

Show more details

3D structure databases

AlphaFoldDBⁱ	P55089
SMRⁱ	P55089
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P55089

EvolutionaryTraceⁱ

P55089

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	23 – 46	DisorderedSequence analysisAdd BLAST		24

Sequence similaritiesⁱ

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG502S63E, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154473
HOGENOMⁱ	CLU_138901_0_0_1
InParanoidⁱ	P55089
OMAⁱ	PGARNQG
PhylomeDBⁱ	P55089
TreeFamⁱ	TF332956

Family and domain databases

InterProⁱ	View protein in InterPro IPR018446, Corticotropin-releasing_fac_CS IPR000187, CRF IPR003620, Urocortin_CRF
PANTHERⁱ	PTHR15035, PTHR15035, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00473, CRF, 1 hit
PRINTSⁱ	PR01612, CRFFAMILY
SMARTⁱ	View protein in SMART SM00039, CRF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00511, CRF, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P55089-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG 
        60         70         80         90        100
ARALLLLLAE RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL 
       110        120 
ELARTQSQRE RAEQNRIIFD SVGK

Length:124

Mass (Da):13,458

Last modified:October 1, 1996 - v1

Checksum:ⁱ4F765DA75DDD4A5E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF038633 Genomic DNA Translation: AAC24204.1 CR542244 mRNA Translation: CAG47040.1 AC013413 Genomic DNA Translation: AAY24297.1 BC104470 mRNA Translation: AAI04471.1 BC104471 mRNA Translation: AAI04472.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1747.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003344.1, NM_003353.3

Genome annotation databases

Ensemblⁱ	ENST00000296099.2; ENSP00000296099.2; ENSG00000163794.6
GeneIDⁱ	7349
KEGGⁱ	hsa:7349
MANE-Selectⁱ	ENST00000296099.2; ENSP00000296099.2; NM_003353.4; NP_003344.1
UCSC genome browser More...UCSCⁱ	uc002rjp.2, human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P55089	Urocortin		PONAB		134	UniRef90_P55089
UCN isoform 1		PANTR		124
Urocortin preproprotein		MACMU		124
Urocortin		GORGO		124
CRF domain-containing protein		CHLSB		124
+13

Protein	Similar proteins		Species	Score	Length	Source
P55089	Urocortin		RAT		122	UniRef50_P55090
Urocortin		SURSU		119
Urocortin		PANTA		124
Urocortin		RHIFE		127
Urocortin		PONAB		134
+50

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF038633 Genomic DNA Translation: AAC24204.1 CR542244 mRNA Translation: CAG47040.1 AC013413 Genomic DNA Translation: AAY24297.1 BC104470 mRNA Translation: AAI04471.1 BC104471 mRNA Translation: AAI04472.1
CCDSⁱ	CCDS1747.1
RefSeqⁱ	NP_003344.1, NM_003353.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2RMF	NMR	-	A	83-122	[»]
	3N96	X-ray	2.75	E/F/G/H	107-122	[»]
	6PB0	electron microscopy	3.00	U	83-122	[»]
	6PB1	electron microscopy	2.80	U	83-122	[»]
AlphaFoldDBⁱ	P55089
SMRⁱ	P55089
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	113196, 5 interactors
IntActⁱ	P55089, 2 interactors
STRINGⁱ	9606.ENSP00000296099

Genetic variation databases

BioMutaⁱ	UCN
DMDMⁱ	1718059

Proteomic databases

PaxDbⁱ	P55089
PeptideAtlasⁱ	P55089
PRIDEⁱ	P55089
ProteomicsDBⁱ	56790

Protocols and materials databases

Antibodypediaⁱ	4400, 220 antibodies from 31 providers
The DNASU plasmid repository More...DNASUⁱ	7349

Genome annotation databases

Ensemblⁱ	ENST00000296099.2; ENSP00000296099.2; ENSG00000163794.6
GeneIDⁱ	7349
KEGGⁱ	hsa:7349
MANE-Selectⁱ	ENST00000296099.2; ENSP00000296099.2; NM_003353.4; NP_003344.1
UCSCⁱ	uc002rjp.2, human

Organism-specific databases

CTDⁱ	7349
DisGeNETⁱ	7349
GeneCardsⁱ	UCN
HGNCⁱ	HGNC:12516, UCN
HPAⁱ	ENSG00000163794, Tissue enhanced (brain)
MIMⁱ	600945, gene
neXtProtⁱ	NX_P55089
OpenTargetsⁱ	ENSG00000163794
PharmGKBⁱ	PA37163
VEuPathDBⁱ	HostDB:ENSG00000163794
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502S63E, Eukaryota
GeneTreeⁱ	ENSGT00940000154473
HOGENOMⁱ	CLU_138901_0_0_1
InParanoidⁱ	P55089
OMAⁱ	PGARNQG
PhylomeDBⁱ	P55089
TreeFamⁱ	TF332956

Enzyme and pathway databases

PathwayCommonsⁱ	P55089
Reactomeⁱ	R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin
SignaLinkⁱ	P55089
SIGNORⁱ	P55089

Miscellaneous databases

BioGRID-ORCSⁱ	7349, 26 hits in 1068 CRISPR screens
EvolutionaryTraceⁱ	P55089
GeneWikiⁱ	Urocortin
GenomeRNAiⁱ	7349
Pharosⁱ	P55089, Tbio
Protein Ontology More...PROⁱ	PR:P55089
RNActⁱ	P55089, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163794, Expressed in frontal cortex and 123 other tissues
Genevisibleⁱ	P55089, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018446, Corticotropin-releasing_fac_CS IPR000187, CRF IPR003620, Urocortin_CRF
PANTHERⁱ	PTHR15035, PTHR15035, 1 hit
Pfamⁱ	View protein in Pfam PF00473, CRF, 1 hit
PRINTSⁱ	PR01612, CRFFAMILY
SMARTⁱ	View protein in SMART SM00039, CRF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00511, CRF, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UCN1_HUMAN
Accessionⁱ	P55089Primary (citable) accession number: P55089 Secondary accession number(s): Q6FG64
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	May 25, 2022
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniParc

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Annotation systems

Supporting data

UniProtKB - P55089 (UCN1_HUMAN)

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Urocortin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ