UniProtKB - P55085 (PAR2_HUMAN)
Protein
Proteinase-activated receptor 2
Gene
F2RL1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.26 Publications
Miscellaneous
Synthetic PAR agonist peptides (APs) that mimic the first six amino acids of the newly formed N-terminus activate the native, uncleaved receptor nonenzymatically by binding directly to the corresponding second extracellular loop to mediate signaling.
GO - Molecular functioni
- G-protein alpha-subunit binding Source: UniProtKB
- G-protein beta-subunit binding Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB
- signaling receptor activity Source: ProtInc
- signaling receptor binding Source: ProtInc
- thrombin-activated receptor activity Source: InterPro
GO - Biological processi
- blood coagulation Source: InterPro
- cell-cell junction maintenance Source: UniProtKB
- chemokine secretion Source: UniProtKB
- defense response to virus Source: UniProtKB
- establishment of endothelial barrier Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: UniProtKB
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- interferon-gamma production Source: UniProtKB
- interleukin-10 production Source: UniProtKB
- interleukin-1 beta production Source: UniProtKB
- leukocyte migration Source: UniProtKB
- leukocyte proliferation Source: UniProtKB
- mature conventional dendritic cell differentiation Source: UniProtKB
- negative regulation of chemokine secretion Source: UniProtKB
- negative regulation of JNK cascade Source: UniProtKB
- negative regulation of toll-like receptor 3 signaling pathway Source: UniProtKB
- negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
- neutrophil activation Source: UniProtKB
- positive regulation of actin filament depolymerization Source: UniProtKB
- positive regulation of blood vessel diameter Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of chemotaxis Source: UniProtKB
- positive regulation of cytokine production involved in immune response Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: GO_Central
- positive regulation of eosinophil degranulation Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of glomerular filtration Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of leukocyte chemotaxis Source: BHF-UCL
- positive regulation of neutrophil mediated killing of gram-negative bacterium Source: UniProtKB
- positive regulation of phagocytosis, engulfment Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of positive chemotaxis Source: BHF-UCL
- positive regulation of pseudopodium assembly Source: UniProtKB
- positive regulation of renin secretion into blood stream Source: UniProtKB
- positive regulation of Rho protein signal transduction Source: UniProtKB
- positive regulation of superoxide anion generation Source: UniProtKB
- positive regulation of toll-like receptor 2 signaling pathway Source: UniProtKB
- positive regulation of toll-like receptor 3 signaling pathway Source: UniProtKB
- positive regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of blood coagulation Source: BHF-UCL
- regulation of chemokine (C-X-C motif) ligand 2 production Source: UniProtKB
- regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- regulation of JNK cascade Source: UniProtKB
- T cell activation involved in immune response Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | P55085 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P55085 |
Protein family/group databases
TCDBi | 9.A.14.13.12, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Proteinase-activated receptor 2Short name: PAR-2 Alternative name(s): Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1 Cleaved into the following 2 chains: |
Gene namesi | Name:F2RL1 Synonyms:GPR11, PAR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164251.4 |
HGNCi | HGNC:3538, F2RL1 |
MIMi | 600933, gene |
neXtProti | NX_P55085 |
Subcellular locationi
Plasma membrane
Endosome
- early endosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: ProtInc
Plasma Membrane
- integral component of plasma membrane Source: BHF-UCL
- plasma membrane Source: UniProtKB
Other locations
- pseudopodium Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 37 – 71 | Extracellular1 PublicationAdd BLAST | 35 | |
Transmembranei | 72 – 101 | Helical; Name=11 PublicationAdd BLAST | 30 | |
Topological domaini | 102 – 108 | Cytoplasmic1 Publication | 7 | |
Transmembranei | 109 – 137 | Helical; Name=21 PublicationAdd BLAST | 29 | |
Topological domaini | 138 – 149 | Extracellular1 PublicationAdd BLAST | 12 | |
Transmembranei | 150 – 177 | Helical; Name=31 PublicationAdd BLAST | 28 | |
Topological domaini | 178 – 183 | Cytoplasmic1 Publication | 6 | |
Transmembranei | 184 – 211 | Helical; Name=41 PublicationAdd BLAST | 28 | |
Topological domaini | 212 – 235 | Extracellular1 PublicationAdd BLAST | 24 | |
Transmembranei | 236 – 269 | Helical; Name=51 PublicationAdd BLAST | 34 | |
Topological domaini | 270 – 277 | Cytoplasmic1 Publication | 8 | |
Transmembranei | 278 – 317 | Helical; Name=61 PublicationAdd BLAST | 40 | |
Topological domaini | 318 – 323 | Extracellular1 Publication | 6 | |
Transmembranei | 324 – 347 | Helical; Name=71 PublicationAdd BLAST | 24 | |
Topological domaini | 348 – 397 | Cytoplasmic1 PublicationAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 30 | N → A: Decreases cell surface expression; when associate with A-222. 1 Publication | 1 | |
Mutagenesisi | 30 | N → A: Increase of sensitivity towards tryptase. 1 Publication | 1 | |
Mutagenesisi | 135 | H → Y: Slight reduction in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 154 | F → A: Severe reduction in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 157 | G → C or M: Severe reduction in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 210 | Y → L: No defect in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 222 | N → A: Decreases cell surface expression; when associated with A-30. Loss of sensitivity towards all tested proteases. 1 Publication | 1 | |
Mutagenesisi | 222 | N → Q: No defect in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 227 | H → A: No defect in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 227 | H → Q: Slight reduction in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 228 | D → A or N: Severe reduction in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 327 | I → L: Slight reduction in ligand-mediated receptor activation. 1 Publication | 1 | |
Mutagenesisi | 355 – 363 | Missing : Abolishes signaling through accumulation of intracellular calcium and phosphoinositide; no effect in signaling through MAPK. 1 Publication | 9 | |
Mutagenesisi | 361 | C → A: Loss of palmitoylation; increases surface expression and internalization following trypsin activation, decreases sensitivity and intracellular calcium signaling, increases ERK activation through G(i) subunit alpha. | 1 | |
Mutagenesisi | 363 | S → A: Reduces receptor desensitization and internalization, activates ERK1/2; when associated with A-366. 1 Publication | 1 | |
Mutagenesisi | 366 | T → A: Reduces receptor desensitization and internalization, activates ERK1/2; when associated with A-363. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2150 |
PharmGKBi | PA27947 |
Miscellaneous databases
Pharosi | P55085, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5963 |
GuidetoPHARMACOLOGYi | 348 |
Polymorphism and mutation databases
BioMutai | F2RL1 |
DMDMi | 1709580 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
PropeptideiPRO_0000012750 | 26 – 36 | Removed for receptor activationAdd BLAST | 11 | |
ChainiPRO_0000412954 | 37 – 397 | Proteinase-activated receptor 2Add BLAST | 361 | |
ChainiPRO_0000412956 | 38 – 397 | Proteinase-activated receptor 2, alternate cleaved 1Add BLAST | 360 | |
ChainiPRO_0000012751 | 39 – 397 | Proteinase-activated receptor 2, alternate cleaved 2Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 30 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 148 ↔ 226 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 222 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Lipidationi | 361 | S-palmitoyl cysteine1 Publication | 1 |
Post-translational modificationi
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888). Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and membrane-type serine protease 1/ST14 (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888, PubMed:23202369). Subsequent cleavage by serine proteases, including neutrophil elastase and cathepsin G, leads to receptor deactivation (PubMed:12594060). At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference (PubMed:12171601). In addition to conventional trypsin-like proteases activated by other proteases and glycosidases derived from bacteria, fungi and insects (PubMed:11447194, PubMed:11441110, PubMed:17404307, PubMed:18474671, PubMed:19864598). Activated by serine protease allergens such as dust mite Der p3 and Der p9 and mold Pen c13 (PubMed:11441110, PubMed:17404307). Activated by P.gingivalis arginine-specific (trypsin-like) cysteine proteinases called gingipains (PubMed:11447194). Activated by S.griseus exogenous chitinase (PubMed:18474671). Activated by A.alternata aspartate protease; the cleavage generates non-conventional processed forms (PubMed:19864598).12 Publications
N-glycosylated and sialylated.1 Publication
Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.1 Publication
Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 36 – 37 | Cleavage; by trypsin | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P55085 |
MassIVEi | P55085 |
MaxQBi | P55085 |
PaxDbi | P55085 |
PeptideAtlasi | P55085 |
PRIDEi | P55085 |
ProteomicsDBi | 56787 |
PTM databases
GlyGeni | P55085, 2 sites |
iPTMneti | P55085 |
PhosphoSitePlusi | P55085 |
SwissPalmi | P55085 |
Expressioni
Tissue specificityi
Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon (PubMed:7556175, PubMed:8615752). Moderate expression is detected in many organs, but none in brain or skeletal muscle (PubMed:7556175, PubMed:8615752). Expressed in endothelial cells (PubMed:23202369).3 Publications
Gene expression databases
Bgeei | ENSG00000164251, Expressed in colonic mucosa and 188 other tissues |
ExpressionAtlasi | P55085, baseline and differential |
Genevisiblei | P55085, HS |
Organism-specific databases
HPAi | ENSG00000164251, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Interacts with TLR4, COPS5 and TMED2.
Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14 (By similarity).
By similarityBinary interactionsi
Hide detailsP55085
GO - Molecular functioni
- G-protein alpha-subunit binding Source: UniProtKB
- G-protein beta-subunit binding Source: UniProtKB
- signaling receptor binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 108449, 15 interactors |
DIPi | DIP-42044N |
IntActi | P55085, 77 interactors |
MINTi | P55085 |
STRINGi | 9606.ENSP00000296677 |
Chemistry databases
BindingDBi | P55085 |
Miscellaneous databases
RNActi | P55085, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P55085 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 383 – 390 | Poly-Ser | 8 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QR8S, Eukaryota |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | P55085 |
OrthoDBi | 892946at2759 |
PhylomeDBi | P55085 |
TreeFami | TF330775 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002281, Pro_rcpt_2 IPR003912, Protea_act_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01428, PROTEASEAR PR01152, PROTEASEAR2 |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P55085-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG
60 70 80 90 100
KGVTVETVFS VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF
110 120 130 140 150
LFRTKKKHPA VIYMANLALA DLLSVIWFPL KIAYHIHGNN WIYGEALCNV
160 170 180 190 200
LIGFFYGNMY CSILFMTCLS VQRYWVIVNP MGHSRKKANI AIGISLAIWL
210 220 230 240 250
LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF NYFLSLAIGV
260 270 280 290 300
FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF
310 320 330 340 350
TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD
360 370 380 390
FRDHAKNALL CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RJH3 | D6RJH3_HUMAN | Proteinase-activated receptor 2 | F2RL1 | 112 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 138 | G → A in AAB47871 (PubMed:8615752).Curated | 1 | |
Sequence conflicti | 291 | T → S in AAH18130 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012846 | 21 | S → F1 PublicationCorresponds to variant dbSNP:rs2243072Ensembl. | 1 | |
Natural variantiVAR_049435 | 30 | N → S. Corresponds to variant dbSNP:rs616235Ensembl. | 1 | |
Natural variantiVAR_012847 | 270 | R → Q1 PublicationCorresponds to variant dbSNP:rs2243062Ensembl. | 1 | |
Natural variantiVAR_012848 | 291 | T → A1 PublicationCorresponds to variant dbSNP:rs2243083Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49993, Z49994 Genomic DNA Translation: CAA90290.1 U34038 mRNA Translation: AAB47871.1 AY336105 mRNA Translation: AAP97012.1 AF400075 Genomic DNA Translation: AAK77914.1 BT009856 mRNA Translation: AAP88858.1 CH471084 Genomic DNA Translation: EAW95782.1 BC012453 mRNA Translation: AAH12453.1 BC018130 mRNA Translation: AAH18130.1 U36753 Genomic DNA Translation: AAA90957.1 |
CCDSi | CCDS4033.1 |
PIRi | S66518 |
RefSeqi | NP_005233.3, NM_005242.5 |
Genome annotation databases
Ensembli | ENST00000296677; ENSP00000296677; ENSG00000164251 |
GeneIDi | 2150 |
KEGGi | hsa:2150 |
UCSCi | uc003keo.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Protease-activated receptor entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49993, Z49994 Genomic DNA Translation: CAA90290.1 U34038 mRNA Translation: AAB47871.1 AY336105 mRNA Translation: AAP97012.1 AF400075 Genomic DNA Translation: AAK77914.1 BT009856 mRNA Translation: AAP88858.1 CH471084 Genomic DNA Translation: EAW95782.1 BC012453 mRNA Translation: AAH12453.1 BC018130 mRNA Translation: AAH18130.1 U36753 Genomic DNA Translation: AAA90957.1 |
CCDSi | CCDS4033.1 |
PIRi | S66518 |
RefSeqi | NP_005233.3, NM_005242.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5NDD | X-ray | 2.80 | A | 59-269 | [»] | |
A | 276-377 | [»] | ||||
5NDZ | X-ray | 3.60 | A | 59-269 | [»] | |
A | 276-377 | [»] | ||||
5NJ6 | X-ray | 4.00 | A | 55-269 | [»] | |
A | 276-377 | [»] | ||||
SMRi | P55085 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108449, 15 interactors |
DIPi | DIP-42044N |
IntActi | P55085, 77 interactors |
MINTi | P55085 |
STRINGi | 9606.ENSP00000296677 |
Chemistry databases
BindingDBi | P55085 |
ChEMBLi | CHEMBL5963 |
GuidetoPHARMACOLOGYi | 348 |
Protein family/group databases
TCDBi | 9.A.14.13.12, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P55085, 2 sites |
iPTMneti | P55085 |
PhosphoSitePlusi | P55085 |
SwissPalmi | P55085 |
Polymorphism and mutation databases
BioMutai | F2RL1 |
DMDMi | 1709580 |
Proteomic databases
jPOSTi | P55085 |
MassIVEi | P55085 |
MaxQBi | P55085 |
PaxDbi | P55085 |
PeptideAtlasi | P55085 |
PRIDEi | P55085 |
ProteomicsDBi | 56787 |
Protocols and materials databases
ABCDi | P55085, 81 sequenced antibodies |
Antibodypediai | 4569, 307 antibodies |
DNASUi | 2150 |
Genome annotation databases
Ensembli | ENST00000296677; ENSP00000296677; ENSG00000164251 |
GeneIDi | 2150 |
KEGGi | hsa:2150 |
UCSCi | uc003keo.4, human |
Organism-specific databases
CTDi | 2150 |
DisGeNETi | 2150 |
EuPathDBi | HostDB:ENSG00000164251.4 |
GeneCardsi | F2RL1 |
HGNCi | HGNC:3538, F2RL1 |
HPAi | ENSG00000164251, Tissue enhanced (intestine) |
MIMi | 600933, gene |
neXtProti | NX_P55085 |
PharmGKBi | PA27947 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR8S, Eukaryota |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | P55085 |
OrthoDBi | 892946at2759 |
PhylomeDBi | P55085 |
TreeFami | TF330775 |
Enzyme and pathway databases
PathwayCommonsi | P55085 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P55085 |
Miscellaneous databases
BioGRID-ORCSi | 2150, 5 hits in 854 CRISPR screens |
ChiTaRSi | F2RL1, human |
GeneWikii | Protease_activated_receptor_2 |
GenomeRNAii | 2150 |
Pharosi | P55085, Tchem |
PROi | PR:P55085 |
RNActi | P55085, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164251, Expressed in colonic mucosa and 188 other tissues |
ExpressionAtlasi | P55085, baseline and differential |
Genevisiblei | P55085, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002281, Pro_rcpt_2 IPR003912, Protea_act_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01428, PROTEASEAR PR01152, PROTEASEAR2 |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAR2_HUMAN | |
Accessioni | P55085Primary (citable) accession number: P55085 Secondary accession number(s): Q13317, Q13346, Q53XJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries