UniProtKB - P55082 (MFAP3_HUMAN)
Protein
Microfibril-associated glycoprotein 3
Gene
MFAP3
Organism
Homo sapiens (Human)
Status
Functioni
Component of the elastin-associated microfibrils.
Enzyme and pathway databases
PathwayCommonsi | P55082 |
Reactomei | R-HSA-2129379, Molecules associated with elastic fibres |
Names & Taxonomyi
Protein namesi | Recommended name: Microfibril-associated glycoprotein 3 |
Gene namesi | Name:MFAP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000037749.11 |
HGNCi | HGNC:7034, MFAP3 |
MIMi | 600491, gene |
neXtProti | NX_P55082 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Extracellular region or secreted
- extracellular region Source: Reactome
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 147 | ExtracellularSequence analysisAdd BLAST | 129 | |
Transmembranei | 148 – 170 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 171 – 362 | CytoplasmicSequence analysisAdd BLAST | 192 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4238 |
OpenTargetsi | ENSG00000037749 |
PharmGKBi | PA30770 |
Miscellaneous databases
Pharosi | P55082, Tdark |
Polymorphism and mutation databases
BioMutai | MFAP3 |
DMDMi | 1709013 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000014865 | 19 – 362 | Microfibril-associated glycoprotein 3Add BLAST | 344 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 73 ↔ 124 | PROSITE-ProRule annotation | ||
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.Curated
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P55082 |
MassIVEi | P55082 |
MaxQBi | P55082 |
PaxDbi | P55082 |
PeptideAtlasi | P55082 |
PRIDEi | P55082 |
ProteomicsDBi | 56783 [P55082-1] 56784 [P55082-2] |
PTM databases
GlyGeni | P55082, 3 sites |
iPTMneti | P55082 |
PhosphoSitePlusi | P55082 |
Expressioni
Gene expression databases
Bgeei | ENSG00000037749, Expressed in kidney and 208 other tissues |
ExpressionAtlasi | P55082, baseline and differential |
Genevisiblei | P55082, HS |
Organism-specific databases
HPAi | ENSG00000037749, Low tissue specificity |
Interactioni
Binary interactionsi
P55082
With | #Exp. | IntAct |
---|---|---|
GRIP1 - isoform 3 [Q9Y3R0-3] | 3 | EBI-11287173,EBI-12193965 |
Protein-protein interaction databases
BioGRIDi | 110396, 45 interactors |
IntActi | P55082, 35 interactors |
STRINGi | 9606.ENSP00000322956 |
Miscellaneous databases
RNActi | P55082, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 137 | Ig-like C2-typeAdd BLAST | 93 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW9J, Eukaryota |
GeneTreei | ENSGT00390000011576 |
HOGENOMi | CLU_1277263_0_0_1 |
InParanoidi | P55082 |
OMAi | KPHCCLF |
OrthoDBi | 1154642at2759 |
PhylomeDBi | P55082 |
TreeFami | TF333205 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR039696, MFAP3-like |
PANTHERi | PTHR14340, PTHR14340, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P55082-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLHCCLFTL VASIIVPAAF VLEDVDFDQM VSLEANRSSY NASFPSSFEL
60 70 80 90 100
SASSHSDDDV IIAKEGTSVS IECLLTASHY EDVHWHNSKG QQLDGRSRGG
110 120 130 140 150
KWLVSDNFLN ITNVAFDDRG LYTCFVTSPI RASYSVTLRV IFTSGDMSVY
160 170 180 190 200
YMIVCLIAFT ITLILNVTRL CMMSSHLRKT EKAINEFFRT EGAEKLQKAF
210 220 230 240 250
EIAKRIPIIT SAKTLELAKV TQFKTMEFAR YIEELARSVP LPPLILNCRA
260 270 280 290 300
FVEEMFEAVR VDDPDDLGER IKERPALNAQ GGIYVINPEM GRSNSPGGDS
310 320 330 340 350
DDGSLNEQGQ EIAVQVSVHL QSETKSIDTE SQGSSHFSPP DDIGSAESNC
360
NYKDGAYENC QL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RHQ6 | E5RHQ6_HUMAN | Microfibril-associated glycoprotein... | MFAP3 | 123 | Annotation score: | ||
E5RJ59 | E5RJ59_HUMAN | Microfibril-associated glycoprotein... | MFAP3 | 109 | Annotation score: | ||
E5RH26 | E5RH26_HUMAN | Microfibril-associated glycoprotein... | MFAP3 | 16 | Annotation score: |
Sequence cautioni
The sequence BAA91108 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069386 | 53 | S → G1 PublicationCorresponds to variant dbSNP:rs748271641Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042948 | 1 – 146 | Missing in isoform 2. 1 PublicationAdd BLAST | 146 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35251 Genomic DNA Translation: AAC41753.1 AK000358 mRNA Translation: BAA91108.1 Frameshift. AK296468 mRNA Translation: BAG59113.1 AK315573 mRNA Translation: BAG37947.1 AC008672 Genomic DNA No translation available. AC010232 Genomic DNA No translation available. AC010295 Genomic DNA No translation available. AC022088 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61645.1 BC026244 mRNA Translation: AAH26244.1 |
CCDSi | CCDS4324.1 [P55082-1] CCDS47319.1 [P55082-2] |
PIRi | A56745 |
RefSeqi | NP_001128509.1, NM_001135037.1 [P55082-2] NP_001229265.1, NM_001242336.1 [P55082-1] NP_005918.1, NM_005927.4 [P55082-1] |
Genome annotation databases
Ensembli | ENST00000322602; ENSP00000322956; ENSG00000037749 [P55082-1] ENST00000439768; ENSP00000414219; ENSG00000037749 [P55082-2] |
GeneIDi | 4238 |
KEGGi | hsa:4238 |
UCSCi | uc003lvf.3, human [P55082-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35251 Genomic DNA Translation: AAC41753.1 AK000358 mRNA Translation: BAA91108.1 Frameshift. AK296468 mRNA Translation: BAG59113.1 AK315573 mRNA Translation: BAG37947.1 AC008672 Genomic DNA No translation available. AC010232 Genomic DNA No translation available. AC010295 Genomic DNA No translation available. AC022088 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61645.1 BC026244 mRNA Translation: AAH26244.1 |
CCDSi | CCDS4324.1 [P55082-1] CCDS47319.1 [P55082-2] |
PIRi | A56745 |
RefSeqi | NP_001128509.1, NM_001135037.1 [P55082-2] NP_001229265.1, NM_001242336.1 [P55082-1] NP_005918.1, NM_005927.4 [P55082-1] |
3D structure databases
SMRi | P55082 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110396, 45 interactors |
IntActi | P55082, 35 interactors |
STRINGi | 9606.ENSP00000322956 |
PTM databases
GlyGeni | P55082, 3 sites |
iPTMneti | P55082 |
PhosphoSitePlusi | P55082 |
Polymorphism and mutation databases
BioMutai | MFAP3 |
DMDMi | 1709013 |
Proteomic databases
jPOSTi | P55082 |
MassIVEi | P55082 |
MaxQBi | P55082 |
PaxDbi | P55082 |
PeptideAtlasi | P55082 |
PRIDEi | P55082 |
ProteomicsDBi | 56783 [P55082-1] 56784 [P55082-2] |
Protocols and materials databases
Antibodypediai | 2980, 142 antibodies |
DNASUi | 4238 |
Genome annotation databases
Ensembli | ENST00000322602; ENSP00000322956; ENSG00000037749 [P55082-1] ENST00000439768; ENSP00000414219; ENSG00000037749 [P55082-2] |
GeneIDi | 4238 |
KEGGi | hsa:4238 |
UCSCi | uc003lvf.3, human [P55082-1] |
Organism-specific databases
CTDi | 4238 |
DisGeNETi | 4238 |
EuPathDBi | HostDB:ENSG00000037749.11 |
GeneCardsi | MFAP3 |
HGNCi | HGNC:7034, MFAP3 |
HPAi | ENSG00000037749, Low tissue specificity |
MIMi | 600491, gene |
neXtProti | NX_P55082 |
OpenTargetsi | ENSG00000037749 |
PharmGKBi | PA30770 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW9J, Eukaryota |
GeneTreei | ENSGT00390000011576 |
HOGENOMi | CLU_1277263_0_0_1 |
InParanoidi | P55082 |
OMAi | KPHCCLF |
OrthoDBi | 1154642at2759 |
PhylomeDBi | P55082 |
TreeFami | TF333205 |
Enzyme and pathway databases
PathwayCommonsi | P55082 |
Reactomei | R-HSA-2129379, Molecules associated with elastic fibres |
Miscellaneous databases
BioGRID-ORCSi | 4238, 5 hits in 838 CRISPR screens |
ChiTaRSi | MFAP3, human |
GenomeRNAii | 4238 |
Pharosi | P55082, Tdark |
PROi | PR:P55082 |
RNActi | P55082, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000037749, Expressed in kidney and 208 other tissues |
ExpressionAtlasi | P55082, baseline and differential |
Genevisiblei | P55082, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR039696, MFAP3-like |
PANTHERi | PTHR14340, PTHR14340, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFAP3_HUMAN | |
Accessioni | P55082Primary (citable) accession number: P55082 Secondary accession number(s): B2RDK0, B4DKA1, Q9NXA7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations