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Protein

Microfibrillar-associated protein 1

Gene

MFAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as a component of the spliceosome.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 1Imported
Alternative name(s):
Spliceosome B complex protein MFAP11 Publication
Gene namesi
Name:MFAP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140259.6
HGNCiHGNC:7032 MFAP1
MIMi600215 gene
neXtProtiNX_P55081

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi4236
OpenTargetsiENSG00000140259
PharmGKBiPA30768

Polymorphism and mutation databases

BioMutaiMFAP1
DMDMi205831094

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000964582 – 439Microfibrillar-associated protein 1Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei94PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei267PhosphothreonineCombined sources1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei361PhosphoserineCombined sources1
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki415Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki418Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei432PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP55081
MaxQBiP55081
PaxDbiP55081
PeptideAtlasiP55081
PRIDEiP55081
ProteomicsDBi56782
TopDownProteomicsiP55081

PTM databases

iPTMnetiP55081
PhosphoSitePlusiP55081

Expressioni

Gene expression databases

BgeeiENSG00000140259 Expressed in 231 organ(s), highest expression level in secondary oocyte
CleanExiHS_MFAP1
GenevisibleiP55081 HS

Organism-specific databases

HPAiHPA042370

Interactioni

Subunit structurei

Component of the spliceosome B complex (PubMed:28781166). Interacts with PRPF38A (via N-terminal interaction domain) (PubMed:26673105, PubMed:27773687).3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi110394, 108 interactors
CORUMiP55081
IntActiP55081, 100 interactors
MINTiP55081
STRINGi9606.ENSP00000267812

Structurei

Secondary structure

1439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55081
SMRiP55081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 318Glu-richPROSITE-ProRule annotationAdd BLAST268

Sequence similaritiesi

Belongs to the MFAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1425 Eukaryota
ENOG410Y1JB LUCA
GeneTreeiENSGT00690000102225
HOGENOMiHOG000231845
HOVERGENiHBG052462
InParanoidiP55081
KOiK13110
OMAiDSAWAQE
OrthoDBiEOG091G0DXV
PhylomeDBiP55081
TreeFamiTF314398

Family and domain databases

InterProiView protein in InterPro
IPR033194 MFAP1
IPR009730 MFAP1_C
PANTHERiPTHR15327:SF0 PTHR15327:SF0, 1 hit
PfamiView protein in Pfam
PF06991 MFAP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55081-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVPSALMKQ PPIQSTAGAV PVRNEKGEIS MEKVKVKRYV SGKRPDYAPM
60 70 80 90 100
ESSDEEDEEF QFIKKAKEQE AEPEEQEEDS SSDPRLRRLQ NRISEDVEER
110 120 130 140 150
LARHRKIVEP EVVGESDSEV EGDAWRMERE DSSEEEEEEI DDEEIERRRG
160 170 180 190 200
MMRQRAQERK NEEMEVMEVE DEGRSGEESE SESEYEEYTD SEDEMEPRLK
210 220 230 240 250
PVFIRKKDRV TVQEREAEAL KQKELEQEAK RMAEERRKYT LKIVEEETKK
260 270 280 290 300
ELEENKRSLA ALDALNTDDE NDEEEYEAWK VRELKRIKRD REDREALEKE
310 320 330 340 350
KAEIERMRNL TEEERRAELR ANGKVITNKA VKGKYKFLQK YYHRGAFFMD
360 370 380 390 400
EDEEVYKRDF SAPTLEDHFN KTILPKVMQV KNFGRSGRTK YTHLVDQDTT
410 420 430
SFDSAWGQES AQNTKFFKQK AAGVRDVFER PSAKKRKTT
Length:439
Mass (Da):51,958
Last modified:July 22, 2008 - v2
Checksum:i0EF6F4F091C05A88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238K → Q in AAA92786 (PubMed:7835894).Curated1
Sequence conflicti242K → Q in AAA92786 (PubMed:7835894).Curated1
Sequence conflicti245E → G in AAA92786 (PubMed:7835894).Curated1
Sequence conflicti249K → P in AAA92786 (PubMed:7835894).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04209 mRNA Translation: AAA92786.1
AK312867 mRNA Translation: BAG35719.1
AC018512 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77247.1
BC023557 mRNA Translation: AAH23557.1
BC050742 mRNA Translation: AAH50742.1
CCDSiCCDS10105.1
PIRiA55565
RefSeqiNP_005917.2, NM_005926.2
UniGeneiHs.61418

Genome annotation databases

EnsembliENST00000267812; ENSP00000267812; ENSG00000140259
GeneIDi4236
KEGGihsa:4236
UCSCiuc001zth.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04209 mRNA Translation: AAA92786.1
AK312867 mRNA Translation: BAG35719.1
AC018512 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77247.1
BC023557 mRNA Translation: AAH23557.1
BC050742 mRNA Translation: AAH50742.1
CCDSiCCDS10105.1
PIRiA55565
RefSeqiNP_005917.2, NM_005926.2
UniGeneiHs.61418

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F5SX-ray2.40B267-344[»]
5O9Zelectron microscopy4.50K1-439[»]
ProteinModelPortaliP55081
SMRiP55081
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110394, 108 interactors
CORUMiP55081
IntActiP55081, 100 interactors
MINTiP55081
STRINGi9606.ENSP00000267812

PTM databases

iPTMnetiP55081
PhosphoSitePlusiP55081

Polymorphism and mutation databases

BioMutaiMFAP1
DMDMi205831094

Proteomic databases

EPDiP55081
MaxQBiP55081
PaxDbiP55081
PeptideAtlasiP55081
PRIDEiP55081
ProteomicsDBi56782
TopDownProteomicsiP55081

Protocols and materials databases

DNASUi4236
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267812; ENSP00000267812; ENSG00000140259
GeneIDi4236
KEGGihsa:4236
UCSCiuc001zth.2 human

Organism-specific databases

CTDi4236
DisGeNETi4236
EuPathDBiHostDB:ENSG00000140259.6
GeneCardsiMFAP1
H-InvDBiHIX0026808
HGNCiHGNC:7032 MFAP1
HPAiHPA042370
MIMi600215 gene
neXtProtiNX_P55081
OpenTargetsiENSG00000140259
PharmGKBiPA30768
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1425 Eukaryota
ENOG410Y1JB LUCA
GeneTreeiENSGT00690000102225
HOGENOMiHOG000231845
HOVERGENiHBG052462
InParanoidiP55081
KOiK13110
OMAiDSAWAQE
OrthoDBiEOG091G0DXV
PhylomeDBiP55081
TreeFamiTF314398

Enzyme and pathway databases

ReactomeiR-HSA-2129379 Molecules associated with elastic fibres

Miscellaneous databases

ChiTaRSiMFAP1 human
GeneWikiiMFAP1
GenomeRNAii4236
PROiPR:P55081
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140259 Expressed in 231 organ(s), highest expression level in secondary oocyte
CleanExiHS_MFAP1
GenevisibleiP55081 HS

Family and domain databases

InterProiView protein in InterPro
IPR033194 MFAP1
IPR009730 MFAP1_C
PANTHERiPTHR15327:SF0 PTHR15327:SF0, 1 hit
PfamiView protein in Pfam
PF06991 MFAP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMFAP1_HUMAN
AccessioniPrimary (citable) accession number: P55081
Secondary accession number(s): Q86TG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 22, 2008
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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