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Protein

Fibroblast growth factor 8

Gene

FGF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190371 FGFR3b ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkiP55075
SIGNORiP55075

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 8
Short name:
FGF-8
Alternative name(s):
Androgen-induced growth factor
Short name:
AIGF
Heparin-binding growth factor 8
Short name:
HBGF-8
Gene namesi
Name:FGF8
Synonyms:AIGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107831.12
HGNCiHGNC:3686 FGF8
MIMi600483 gene
neXtProtiNX_P55075

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)2 Publications
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in FGF8 as well as in other HH-associated genes including FGFR1 (PubMed:23643382).1 Publication
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
See also OMIM:612702
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05796214H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852659EnsemblClinVar.1
Natural variantiVAR_05796326P → L in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852660EnsemblClinVar.1
Natural variantiVAR_05796440F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852661EnsemblClinVar.1
Natural variantiVAR_05796589K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852662Ensembl.1
Natural variantiVAR_057966116R → G in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852663Ensembl.1
Natural variantiVAR_057967218T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852664Ensembl.1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

DisGeNETi2253
GeneReviewsiFGF8
MalaCardsiFGF8
MIMi612702 phenotype
OpenTargetsiENSG00000107831
Orphaneti93925 Alobar holoprosencephaly
478 Kallmann syndrome
93924 Lobar holoprosencephaly
280200 Microform holoprosencephaly
93926 Midline interhemispheric variant of holoprosencephaly
432 Normosmic congenital hypogonadotropic hypogonadism
220386 Semilobar holoprosencephaly
280195 Septopreoptic holoprosencephaly
PharmGKBiPA28125

Polymorphism and mutation databases

BioMutaiFGF8
DMDMi1706791

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000897023 – 233Fibroblast growth factor 8Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55075
PeptideAtlasiP55075
PRIDEiP55075
ProteomicsDBi56778
56779 [P55075-2]
56780 [P55075-3]
56781 [P55075-4]

PTM databases

iPTMnetiP55075
PhosphoSitePlusiP55075

Expressioni

Developmental stagei

In adults expression is restricted to the gonads.

Gene expression databases

BgeeiENSG00000107831 Expressed in 49 organ(s), highest expression level in frontal cortex
CleanExiHS_FGF8
ExpressionAtlasiP55075 baseline and differential
GenevisibleiP55075 HS

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108544, 124 interactors
DIPiDIP-59630N
IntActiP55075, 3 interactors
STRINGi9606.ENSP00000321797

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55075
SMRiP55075
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55075

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110785
HOGENOMiHOG000115986
HOVERGENiHBG005659
InParanoidiP55075
KOiK04358
OMAiLPKGHHT
OrthoDBiEOG091G0NQH
PhylomeDBiP55075
TreeFamiTF331233

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028249 FGF8
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF3 PTHR11486:SF3, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform FGF-8E (identifier: P55075-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS
60 70 80 90 100
QQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP
110 120 130 140 150
FAKLIVETDT FGSRVRVRGA ETGLYICMNK KGKLIAKSNG KGKDCVFTEI
160 170 180 190 200
VLENNYTALQ NAKYEGWYMA FTRKGRPRKG SKTRQHQREV HFMKRLPRGH
210 220 230
HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR
Length:233
Mass (Da):26,525
Last modified:October 1, 1996 - v1
Checksum:i4C1EAF932A3A211D
GO
Isoform FGF-8A (identifier: P55075-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-52: Missing.

Show »
Length:204
Mass (Da):23,522
Checksum:i9A4CAB7686A2B190
GO
Isoform FGF-8B (identifier: P55075-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-51: EGPGRGPALGRELASLFRAGREPQGVSQ → VTVQSSPNFT

Show »
Length:215
Mass (Da):24,711
Checksum:iA39424271EF7CBFF
GO
Isoform FGF-8F (identifier: P55075-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → QVTVQSSPNFTQ

Show »
Length:244
Mass (Da):27,715
Checksum:i73DA5874CA918E6A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1S5A0A087X1S5_HUMAN
Fibroblast growth factor
FGF8 hCG_25633
140Annotation score:
R4GMQ3R4GMQ3_HUMAN
Fibroblast growth factor 8
FGF8
37Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05796214H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852659EnsemblClinVar.1
Natural variantiVAR_05796326P → L in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852660EnsemblClinVar.1
Natural variantiVAR_05796440F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852661EnsemblClinVar.1
Natural variantiVAR_05796589K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852662Ensembl.1
Natural variantiVAR_057966116R → G in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852663Ensembl.1
Natural variantiVAR_057967218T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852664Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00152524 – 52Missing in isoform FGF-8A. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_00152424 – 51EGPGR…QGVSQ → VTVQSSPNFT in isoform FGF-8B. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_00152652Q → QVTVQSSPNFTQ in isoform FGF-8F. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78466
, S78462, S78463, S78464, S78465 Genomic DNA Translation: AAB34255.1
D38752 Genomic DNA Translation: BAA22527.1
U46213 mRNA Translation: AAB40955.1
U46212 mRNA Translation: AAB40954.1
U46211 mRNA Translation: AAB40953.1
U47011, U47009, U47010 Genomic DNA Translation: AAC50784.1
U47011, U47009, U47010 Genomic DNA Translation: AAC50785.1
U47011, U47009, U47010 Genomic DNA Translation: AAC50782.1
U36223 mRNA Translation: AAB17893.1
U36228
, U36225, U36226, U36227 Genomic DNA Translation: AAB17894.1
U47011, U47009, U47010 Genomic DNA Translation: AAC50783.1
U56978 mRNA Translation: AAB03787.1
AB014615 mRNA Translation: BAA28605.1
AF520763 Genomic DNA Translation: AAM55238.1
CH471066 Genomic DNA Translation: EAW49746.1
BC128235 mRNA Translation: AAI28236.1
CCDSiCCDS7515.1 [P55075-3]
CCDS7516.1 [P55075-4]
CCDS7517.1 [P55075-1]
CCDS7518.1 [P55075-2]
RefSeqiNP_006110.1, NM_006119.4 [P55075-3]
NP_149353.1, NM_033163.3 [P55075-4]
NP_149354.1, NM_033164.3 [P55075-1]
NP_149355.1, NM_033165.3 [P55075-2]
UniGeneiHs.57710

Genome annotation databases

EnsembliENST00000320185; ENSP00000321797; ENSG00000107831 [P55075-4]
ENST00000344255; ENSP00000340039; ENSG00000107831 [P55075-1]
ENST00000346714; ENSP00000344306; ENSG00000107831 [P55075-2]
ENST00000347978; ENSP00000321945; ENSG00000107831 [P55075-3]
GeneIDi2253
KEGGihsa:2253
UCSCiuc001ktp.3 human [P55075-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78466
, S78462, S78463, S78464, S78465 Genomic DNA Translation: AAB34255.1
D38752 Genomic DNA Translation: BAA22527.1
U46213 mRNA Translation: AAB40955.1
U46212 mRNA Translation: AAB40954.1
U46211 mRNA Translation: AAB40953.1
U47011, U47009, U47010 Genomic DNA Translation: AAC50784.1
U47011, U47009, U47010 Genomic DNA Translation: AAC50785.1
U47011, U47009, U47010 Genomic DNA Translation: AAC50782.1
U36223 mRNA Translation: AAB17893.1
U36228
, U36225, U36226, U36227 Genomic DNA Translation: AAB17894.1
U47011, U47009, U47010 Genomic DNA Translation: AAC50783.1
U56978 mRNA Translation: AAB03787.1
AB014615 mRNA Translation: BAA28605.1
AF520763 Genomic DNA Translation: AAM55238.1
CH471066 Genomic DNA Translation: EAW49746.1
BC128235 mRNA Translation: AAI28236.1
CCDSiCCDS7515.1 [P55075-3]
CCDS7516.1 [P55075-4]
CCDS7517.1 [P55075-1]
CCDS7518.1 [P55075-2]
RefSeqiNP_006110.1, NM_006119.4 [P55075-3]
NP_149353.1, NM_033163.3 [P55075-4]
NP_149354.1, NM_033164.3 [P55075-1]
NP_149355.1, NM_033165.3 [P55075-2]
UniGeneiHs.57710

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FDBX-ray2.28M/N52-204[»]
ProteinModelPortaliP55075
SMRiP55075
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108544, 124 interactors
DIPiDIP-59630N
IntActiP55075, 3 interactors
STRINGi9606.ENSP00000321797

PTM databases

iPTMnetiP55075
PhosphoSitePlusiP55075

Polymorphism and mutation databases

BioMutaiFGF8
DMDMi1706791

Proteomic databases

PaxDbiP55075
PeptideAtlasiP55075
PRIDEiP55075
ProteomicsDBi56778
56779 [P55075-2]
56780 [P55075-3]
56781 [P55075-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320185; ENSP00000321797; ENSG00000107831 [P55075-4]
ENST00000344255; ENSP00000340039; ENSG00000107831 [P55075-1]
ENST00000346714; ENSP00000344306; ENSG00000107831 [P55075-2]
ENST00000347978; ENSP00000321945; ENSG00000107831 [P55075-3]
GeneIDi2253
KEGGihsa:2253
UCSCiuc001ktp.3 human [P55075-1]

Organism-specific databases

CTDi2253
DisGeNETi2253
EuPathDBiHostDB:ENSG00000107831.12
GeneCardsiFGF8
GeneReviewsiFGF8
HGNCiHGNC:3686 FGF8
MalaCardsiFGF8
MIMi600483 gene
612702 phenotype
neXtProtiNX_P55075
OpenTargetsiENSG00000107831
Orphaneti93925 Alobar holoprosencephaly
478 Kallmann syndrome
93924 Lobar holoprosencephaly
280200 Microform holoprosencephaly
93926 Midline interhemispheric variant of holoprosencephaly
432 Normosmic congenital hypogonadotropic hypogonadism
220386 Semilobar holoprosencephaly
280195 Septopreoptic holoprosencephaly
PharmGKBiPA28125
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110785
HOGENOMiHOG000115986
HOVERGENiHBG005659
InParanoidiP55075
KOiK04358
OMAiLPKGHHT
OrthoDBiEOG091G0NQH
PhylomeDBiP55075
TreeFamiTF331233

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190371 FGFR3b ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkiP55075
SIGNORiP55075

Miscellaneous databases

EvolutionaryTraceiP55075
GeneWikiiFGF8
GenomeRNAii2253
PROiPR:P55075
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107831 Expressed in 49 organ(s), highest expression level in frontal cortex
CleanExiHS_FGF8
ExpressionAtlasiP55075 baseline and differential
GenevisibleiP55075 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028249 FGF8
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF3 PTHR11486:SF3, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF8_HUMAN
AccessioniPrimary (citable) accession number: P55075
Secondary accession number(s): A1A514, Q14915, Q15766
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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