UniProtKB - P55075 (FGF8_HUMAN)
Fibroblast growth factor 8
FGF8
Functioni
GO - Molecular functioni
- chemoattractant activity Source: Ensembl
- fibroblast growth factor receptor binding Source: InterPro
- growth factor activity Source: UniProtKB
- type 1 fibroblast growth factor receptor binding Source: UniProtKB
- type 2 fibroblast growth factor receptor binding Source: UniProtKB
GO - Biological processi
- anatomical structure morphogenesis Source: UniProtKB
- aorta morphogenesis Source: Ensembl
- blood vessel remodeling Source: Ensembl
- bone development Source: UniProtKB
- branching involved in blood vessel morphogenesis Source: Ensembl
- branching involved in salivary gland morphogenesis Source: Ensembl
- branching involved in ureteric bud morphogenesis Source: Ensembl
- cell fate commitment Source: Ensembl
- cell migration involved in mesendoderm migration Source: Ensembl
- cell proliferation in forebrain Source: Ensembl
- corticotropin hormone secreting cell differentiation Source: Ensembl
- dopaminergic neuron differentiation Source: UniProtKB
- dorsal/ventral axon guidance Source: Ensembl
- embryonic hindlimb morphogenesis Source: Ensembl
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- fibroblast growth factor receptor signaling pathway Source: MGI
- forebrain dorsal/ventral pattern formation Source: Ensembl
- forebrain morphogenesis Source: Ensembl
- forebrain neuron development Source: Ensembl
- gastrulation Source: UniProtKB
- gonad development Source: UniProtKB
- heart looping Source: Ensembl
- lung morphogenesis Source: Ensembl
- male genitalia development Source: Ensembl
- MAPK cascade Source: Reactome
- mesodermal cell migration Source: Ensembl
- mesonephros development Source: UniProtKB
- metanephros development Source: UniProtKB
- midbrain-hindbrain boundary development Source: Ensembl
- motor neuron axon guidance Source: Ensembl
- negative regulation of cardiac muscle tissue development Source: BHF-UCL
- negative regulation of neuron apoptotic process Source: Ensembl
- neural plate morphogenesis Source: Ensembl
- neuroepithelial cell differentiation Source: UniProtKB
- odontogenesis Source: UniProtKB
- organ induction Source: Ensembl
- otic vesicle formation Source: Ensembl
- outflow tract septum morphogenesis Source: UniProtKB
- pallium development Source: Ensembl
- pharyngeal system development Source: Ensembl
- positive regulation of cell differentiation Source: ParkinsonsUK-UCL
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of gene expression Source: ParkinsonsUK-UCL
- positive regulation of G protein-coupled receptor signaling pathway Source: Ensembl
- positive regulation of mitotic nuclear division Source: Ensembl
- positive regulation of organ growth Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- positive regulation of protein kinase B signaling Source: Reactome
- regulation of odontogenesis of dentin-containing tooth Source: Ensembl
- response to drug Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- response to oxidative stress Source: Ensembl
- signal transduction involved in regulation of gene expression Source: Ensembl
- subpallium development Source: Ensembl
- thyroid gland development Source: Ensembl
- thyroid-stimulating hormone-secreting cell differentiation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Growth factor, Mitogen |
Biological process | Differentiation |
Enzyme and pathway databases
Reactomei | R-HSA-109704 PI3K Cascade [P55075-1] R-HSA-1257604 PIP3 activates AKT signaling [P55075-1] R-HSA-1839122 Signaling by activated point mutants of FGFR1 [P55075-1] R-HSA-1839130 Signaling by activated point mutants of FGFR3 [P55075-1] R-HSA-190322 FGFR4 ligand binding and activation [P55075-1] R-HSA-190371 FGFR3b ligand binding and activation [P55075-1] R-HSA-190372 FGFR3c ligand binding and activation [P55075-1] R-HSA-190373 FGFR1c ligand binding and activation [P55075-1] R-HSA-190375 FGFR2c ligand binding and activation [P55075-1] R-HSA-2033514 FGFR3 mutant receptor activation [P55075-1] R-HSA-2033519 Activated point mutants of FGFR2 [P55075-1] R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer [P55075-1] R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 [P55075-1] R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 [P55075-1] R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3 [P55075-1] R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4 [P55075-1] R-HSA-5654687 Downstream signaling of activated FGFR1 [P55075-1] R-HSA-5654688 SHC-mediated cascade:FGFR1 [P55075-1] R-HSA-5654689 PI-3K cascade:FGFR1 [P55075-1] R-HSA-5654693 FRS-mediated FGFR1 signaling [P55075-1] R-HSA-5654695 PI-3K cascade:FGFR2 [P55075-1] R-HSA-5654699 SHC-mediated cascade:FGFR2 [P55075-1] R-HSA-5654700 FRS-mediated FGFR2 signaling [P55075-1] R-HSA-5654704 SHC-mediated cascade:FGFR3 [P55075-1] R-HSA-5654706 FRS-mediated FGFR3 signaling [P55075-1] R-HSA-5654710 PI-3K cascade:FGFR3 [P55075-1] R-HSA-5654712 FRS-mediated FGFR4 signaling [P55075-1] R-HSA-5654719 SHC-mediated cascade:FGFR4 [P55075-1] R-HSA-5654720 PI-3K cascade:FGFR4 [P55075-1] R-HSA-5654726 Negative regulation of FGFR1 signaling [P55075-1] R-HSA-5654727 Negative regulation of FGFR2 signaling [P55075-1] R-HSA-5654732 Negative regulation of FGFR3 signaling [P55075-1] R-HSA-5654733 Negative regulation of FGFR4 signaling [P55075-1] R-HSA-5655253 Signaling by FGFR2 in disease [P55075-1] R-HSA-5655302 Signaling by FGFR1 in disease [P55075-1] R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling [P55075-1] R-HSA-5673001 RAF/MAP kinase cascade [P55075-1] R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [P55075-1] R-HSA-8853338 Signaling by FGFR3 point mutants in cancer [P55075-1] |
SignaLinki | P55075 |
SIGNORi | P55075 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor 8Short name: FGF-8 Alternative name(s): Androgen-induced growth factor Short name: AIGF Heparin-binding growth factor 8 Short name: HBGF-8 |
Gene namesi | Name:FGF8 Synonyms:AIGF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3686 FGF8 |
MIMi | 600483 gene |
neXtProti | NX_P55075 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057962 | 14 | H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852659EnsemblClinVar. | 1 | |
Natural variantiVAR_057963 | 26 | P → L in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852660EnsemblClinVar. | 1 | |
Natural variantiVAR_057964 | 40 | F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852661EnsemblClinVar. | 1 | |
Natural variantiVAR_057965 | 89 | K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852662EnsemblClinVar. | 1 | |
Natural variantiVAR_057966 | 116 | R → G in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852663EnsemblClinVar. | 1 | |
Natural variantiVAR_057967 | 218 | T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852664EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndromeOrganism-specific databases
DisGeNETi | 2253 |
GeneReviewsi | FGF8 |
MalaCardsi | FGF8 |
MIMi | 612702 phenotype |
OpenTargetsi | ENSG00000107831 |
Orphaneti | 93925 Alobar holoprosencephaly 478 Kallmann syndrome 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 432 Normosmic congenital hypogonadotropic hypogonadism 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly |
PharmGKBi | PA28125 |
Miscellaneous databases
Pharosi | P55075 |
Polymorphism and mutation databases
BioMutai | FGF8 |
DMDMi | 1706791 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000008970 | 23 – 233 | Fibroblast growth factor 8Add BLAST | 211 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P55075 |
PeptideAtlasi | P55075 |
PRIDEi | P55075 |
ProteomicsDBi | 56778 [P55075-1] 56779 [P55075-2] 56780 [P55075-3] 56781 [P55075-4] |
PTM databases
iPTMneti | P55075 |
PhosphoSitePlusi | P55075 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSG00000107831 Expressed in 49 organ(s), highest expression level in frontal cortex |
ExpressionAtlasi | P55075 baseline and differential |
Genevisiblei | P55075 HS |
Interactioni
Subunit structurei
Monomer. Homodimer.
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
3 PublicationsGO - Molecular functioni
- chemoattractant activity Source: Ensembl
- fibroblast growth factor receptor binding Source: InterPro
- growth factor activity Source: UniProtKB
- type 1 fibroblast growth factor receptor binding Source: UniProtKB
- type 2 fibroblast growth factor receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 108544, 125 interactors |
DIPi | DIP-59630N |
IntActi | P55075, 99 interactors |
STRINGi | 9606.ENSP00000321797 |
Structurei
Secondary structure
3D structure databases
SMRi | P55075 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P55075 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3885 Eukaryota ENOG4111IPH LUCA |
GeneTreei | ENSGT00940000159518 |
HOGENOMi | HOG000115986 |
InParanoidi | P55075 |
KOi | K04358 |
OMAi | QHRPFDF |
OrthoDBi | 388324at2759 |
PhylomeDBi | P55075 |
TreeFami | TF331233 |
Family and domain databases
CDDi | cd00058 FGF, 1 hit |
InterProi | View protein in InterPro IPR028249 FGF8 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF |
PANTHERi | PTHR11486 PTHR11486, 1 hit PTHR11486:SF3 PTHR11486:SF3, 1 hit |
Pfami | View protein in Pfam PF00167 FGF, 1 hit |
SMARTi | View protein in SMART SM00442 FGF, 1 hit |
SUPFAMi | SSF50353 SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247 HBGF_FGF, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS
60 70 80 90 100
QQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP
110 120 130 140 150
FAKLIVETDT FGSRVRVRGA ETGLYICMNK KGKLIAKSNG KGKDCVFTEI
160 170 180 190 200
VLENNYTALQ NAKYEGWYMA FTRKGRPRKG SKTRQHQREV HFMKRLPRGH
210 220 230
HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR
The sequence of this isoform differs from the canonical sequence as follows:
24-52: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
24-51: EGPGRGPALGRELASLFRAGREPQGVSQ → VTVQSSPNFT
The sequence of this isoform differs from the canonical sequence as follows:
52-52: Q → QVTVQSSPNFTQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X1S5 | A0A087X1S5_HUMAN | Fibroblast growth factor | FGF8 hCG_25633 | 140 | Annotation score: | ||
R4GMQ3 | R4GMQ3_HUMAN | Fibroblast growth factor 8 | FGF8 | 37 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057962 | 14 | H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852659EnsemblClinVar. | 1 | |
Natural variantiVAR_057963 | 26 | P → L in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852660EnsemblClinVar. | 1 | |
Natural variantiVAR_057964 | 40 | F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852661EnsemblClinVar. | 1 | |
Natural variantiVAR_057965 | 89 | K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852662EnsemblClinVar. | 1 | |
Natural variantiVAR_057966 | 116 | R → G in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852663EnsemblClinVar. | 1 | |
Natural variantiVAR_057967 | 218 | T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852664EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001525 | 24 – 52 | Missing in isoform FGF-8A. 3 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_001524 | 24 – 51 | EGPGR…QGVSQ → VTVQSSPNFT in isoform FGF-8B. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_001526 | 52 | Q → QVTVQSSPNFTQ in isoform FGF-8F. 2 Publications | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000320185; ENSP00000321797; ENSG00000107831 [P55075-4] ENST00000344255; ENSP00000340039; ENSG00000107831 [P55075-1] ENST00000346714; ENSP00000344306; ENSG00000107831 [P55075-2] ENST00000347978; ENSP00000321945; ENSG00000107831 [P55075-3] |
GeneIDi | 2253 |
KEGGi | hsa:2253 |
UCSCi | uc001ktp.3 human [P55075-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FDB | X-ray | 2.28 | M/N | 52-204 | [»] | |
SMRi | P55075 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 108544, 125 interactors |
DIPi | DIP-59630N |
IntActi | P55075, 99 interactors |
STRINGi | 9606.ENSP00000321797 |
PTM databases
iPTMneti | P55075 |
PhosphoSitePlusi | P55075 |
Polymorphism and mutation databases
BioMutai | FGF8 |
DMDMi | 1706791 |
Proteomic databases
PaxDbi | P55075 |
PeptideAtlasi | P55075 |
PRIDEi | P55075 |
ProteomicsDBi | 56778 [P55075-1] 56779 [P55075-2] 56780 [P55075-3] 56781 [P55075-4] |
Genome annotation databases
Ensembli | ENST00000320185; ENSP00000321797; ENSG00000107831 [P55075-4] ENST00000344255; ENSP00000340039; ENSG00000107831 [P55075-1] ENST00000346714; ENSP00000344306; ENSG00000107831 [P55075-2] ENST00000347978; ENSP00000321945; ENSG00000107831 [P55075-3] |
GeneIDi | 2253 |
KEGGi | hsa:2253 |
UCSCi | uc001ktp.3 human [P55075-1] |
Organism-specific databases
CTDi | 2253 |
DisGeNETi | 2253 |
GeneCardsi | FGF8 |
GeneReviewsi | FGF8 |
HGNCi | HGNC:3686 FGF8 |
MalaCardsi | FGF8 |
MIMi | 600483 gene 612702 phenotype |
neXtProti | NX_P55075 |
OpenTargetsi | ENSG00000107831 |
Orphaneti | 93925 Alobar holoprosencephaly 478 Kallmann syndrome 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 432 Normosmic congenital hypogonadotropic hypogonadism 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly |
PharmGKBi | PA28125 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3885 Eukaryota ENOG4111IPH LUCA |
GeneTreei | ENSGT00940000159518 |
HOGENOMi | HOG000115986 |
InParanoidi | P55075 |
KOi | K04358 |
OMAi | QHRPFDF |
OrthoDBi | 388324at2759 |
PhylomeDBi | P55075 |
TreeFami | TF331233 |
Enzyme and pathway databases
Reactomei | R-HSA-109704 PI3K Cascade [P55075-1] R-HSA-1257604 PIP3 activates AKT signaling [P55075-1] R-HSA-1839122 Signaling by activated point mutants of FGFR1 [P55075-1] R-HSA-1839130 Signaling by activated point mutants of FGFR3 [P55075-1] R-HSA-190322 FGFR4 ligand binding and activation [P55075-1] R-HSA-190371 FGFR3b ligand binding and activation [P55075-1] R-HSA-190372 FGFR3c ligand binding and activation [P55075-1] R-HSA-190373 FGFR1c ligand binding and activation [P55075-1] R-HSA-190375 FGFR2c ligand binding and activation [P55075-1] R-HSA-2033514 FGFR3 mutant receptor activation [P55075-1] R-HSA-2033519 Activated point mutants of FGFR2 [P55075-1] R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer [P55075-1] R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 [P55075-1] R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 [P55075-1] R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3 [P55075-1] R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4 [P55075-1] R-HSA-5654687 Downstream signaling of activated FGFR1 [P55075-1] R-HSA-5654688 SHC-mediated cascade:FGFR1 [P55075-1] R-HSA-5654689 PI-3K cascade:FGFR1 [P55075-1] R-HSA-5654693 FRS-mediated FGFR1 signaling [P55075-1] R-HSA-5654695 PI-3K cascade:FGFR2 [P55075-1] R-HSA-5654699 SHC-mediated cascade:FGFR2 [P55075-1] R-HSA-5654700 FRS-mediated FGFR2 signaling [P55075-1] R-HSA-5654704 SHC-mediated cascade:FGFR3 [P55075-1] R-HSA-5654706 FRS-mediated FGFR3 signaling [P55075-1] R-HSA-5654710 PI-3K cascade:FGFR3 [P55075-1] R-HSA-5654712 FRS-mediated FGFR4 signaling [P55075-1] R-HSA-5654719 SHC-mediated cascade:FGFR4 [P55075-1] R-HSA-5654720 PI-3K cascade:FGFR4 [P55075-1] R-HSA-5654726 Negative regulation of FGFR1 signaling [P55075-1] R-HSA-5654727 Negative regulation of FGFR2 signaling [P55075-1] R-HSA-5654732 Negative regulation of FGFR3 signaling [P55075-1] R-HSA-5654733 Negative regulation of FGFR4 signaling [P55075-1] R-HSA-5655253 Signaling by FGFR2 in disease [P55075-1] R-HSA-5655302 Signaling by FGFR1 in disease [P55075-1] R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling [P55075-1] R-HSA-5673001 RAF/MAP kinase cascade [P55075-1] R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [P55075-1] R-HSA-8853338 Signaling by FGFR3 point mutants in cancer [P55075-1] |
SignaLinki | P55075 |
SIGNORi | P55075 |
Miscellaneous databases
EvolutionaryTracei | P55075 |
GeneWikii | FGF8 |
GenomeRNAii | 2253 |
Pharosi | P55075 |
PROi | PR:P55075 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107831 Expressed in 49 organ(s), highest expression level in frontal cortex |
ExpressionAtlasi | P55075 baseline and differential |
Genevisiblei | P55075 HS |
Family and domain databases
CDDi | cd00058 FGF, 1 hit |
InterProi | View protein in InterPro IPR028249 FGF8 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF |
PANTHERi | PTHR11486 PTHR11486, 1 hit PTHR11486:SF3 PTHR11486:SF3, 1 hit |
Pfami | View protein in Pfam PF00167 FGF, 1 hit |
SMARTi | View protein in SMART SM00442 FGF, 1 hit |
SUPFAMi | SSF50353 SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247 HBGF_FGF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGF8_HUMAN | |
Accessioni | P55075Primary (citable) accession number: P55075 Secondary accession number(s): A1A514, Q14915, Q15766 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | October 16, 2019 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references