FGF8

Functionⁱ

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).4 Publications

GO - Molecular functionⁱ

1-phosphatidylinositol-3-kinase activity Source: Reactome
chemoattractant activity Source: Ensembl
fibroblast growth factor receptor binding Source: InterPro
growth factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8891346
- 17265164
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
protein tyrosine kinase activity Source: Reactome
Ras guanyl-nucleotide exchange factor activity Source: Reactome
type 1 fibroblast growth factor receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16384934
type 2 fibroblast growth factor receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16384934

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: UniProtKB
Non-traceable author statementⁱ
- 8595889
aorta morphogenesis Source: Ensembl
apoptotic process Source: Ensembl
blood vessel remodeling Source: Ensembl
BMP signaling pathway Source: Ensembl
bone development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18596921
branching involved in blood vessel morphogenesis Source: Ensembl
branching involved in salivary gland morphogenesis Source: Ensembl
branching involved in ureteric bud morphogenesis Source: Ensembl
canonical Wnt signaling pathway Source: Ensembl
cell fate commitment Source: Ensembl
cell migration involved in mesendoderm migration Source: Ensembl
cell proliferation in forebrain Source: Ensembl
corticotropin hormone secreting cell differentiation Source: Ensembl
dopaminergic neuron differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 15193767
dorsal/ventral axon guidance Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
fibroblast growth factor receptor signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 8663044
forebrain dorsal/ventral pattern formation Source: Ensembl
forebrain morphogenesis Source: Ensembl
forebrain neuron development Source: Ensembl
gastrulation
Source: UniProtKB
Non-traceable author statementⁱ
- 8700553
gonad development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18596921
heart looping Source: Ensembl
lung morphogenesis Source: Ensembl
male genitalia development Source: Ensembl
MAPK cascade Source: Reactome
mesodermal cell migration Source: Ensembl
mesonephros development
Source: UniProtKB
Inferred from expression patternⁱ
- 18437684
metanephros development
Source: UniProtKB
Inferred from expression patternⁱ
- 18437684
midbrain-hindbrain boundary development Source: Ensembl
motor neuron axon guidance Source: Ensembl
negative regulation of cardiac muscle tissue development
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20702560
negative regulation of neuron apoptotic process Source: Ensembl
neural plate morphogenesis Source: Ensembl
neuroepithelial cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 17309880
odontogenesis
Source: UniProtKB
Inferred from expression patternⁱ
- 17394220
organ induction Source: Ensembl
otic vesicle formation Source: Ensembl
outflow tract septum morphogenesis Source: UniProtKB
pallium development Source: Ensembl
pharyngeal system development Source: Ensembl
positive regulation of cell differentiation
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22235191
positive regulation of cell division Source: UniProtKB-KW
positive regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 17265164
positive regulation of ERK1 and ERK2 cascade Source: Ensembl
positive regulation of gene expression
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302
positive regulation of mitotic nuclear division Source: Ensembl
positive regulation of organ growth Source: Ensembl
positive regulation of protein kinase B signaling Source: Reactome
regulation of odontogenesis of dentin-containing tooth Source: Ensembl
response to drug Source: Ensembl
response to organic cyclic compound Source: Ensembl
response to oxidative stress Source: Ensembl
signal transduction involved in regulation of gene expression Source: Ensembl
subpallium development Source: Ensembl
thyroid gland development Source: Ensembl
thyroid-stimulating hormone-secreting cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Growth factor, Mitogen
Biological process	Differentiation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1839122 Signaling by activated point mutants of FGFR1 R-HSA-1839130 Signaling by activated point mutants of FGFR3 R-HSA-190322 FGFR4 ligand binding and activation R-HSA-190371 FGFR3b ligand binding and activation R-HSA-190372 FGFR3c ligand binding and activation R-HSA-190373 FGFR1c ligand binding and activation R-HSA-190375 FGFR2c ligand binding and activation R-HSA-2033514 FGFR3 mutant receptor activation R-HSA-2033519 Activated point mutants of FGFR2 R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654688 SHC-mediated cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654699 SHC-mediated cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654704 SHC-mediated cascade:FGFR3 R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654719 SHC-mediated cascade:FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkⁱ	P55075
SIGNORⁱ	P55075

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fibroblast growth factor 8 Short name: FGF-8 Alternative name(s): Androgen-induced growth factor Short name: AIGF Heparin-binding growth factor 8 Short name: HBGF-8
Gene namesⁱ	Name:FGF8 Synonyms:AIGF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107831.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3686 FGF8
MIMⁱ	600483 gene
neXtProtⁱ	NX_P55075

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)2 Publications

The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in FGF8 as well as in other HH-associated genes including FGFR1 (PubMed:23643382).1 Publication

Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).

Keywords - Diseaseⁱ

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2253
GeneReviewsⁱ	FGF8
MalaCards human disease database More...MalaCardsⁱ	FGF8
MIMⁱ	612702 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000107831
Orphanetⁱ	93925 Alobar holoprosencephaly 478 Kallmann syndrome 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 432 Normosmic congenital hypogonadotropic hypogonadism 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly
PharmGKBⁱ	PA28125

Polymorphism and mutation databases

BioMutaⁱ	FGF8
DMDMⁱ	1706791

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000008970	23 – 233	Fibroblast growth factor 8Add BLAST		211

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	155	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	P55075
PeptideAtlas More...PeptideAtlasⁱ	P55075
PRIDEⁱ	P55075
ProteomicsDBⁱ	56778 56779 [P55075-2] 56780 [P55075-3] 56781 [P55075-4]

PTM databases

iPTMnetⁱ	P55075
PhosphoSitePlusⁱ	P55075

Expressionⁱ

Developmental stageⁱ

In adults expression is restricted to the gonads.

Gene expression databases

Bgeeⁱ	ENSG00000107831 Expressed in 49 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_FGF8
ExpressionAtlasⁱ	P55075 baseline and differential
Genevisibleⁱ	P55075 HS

Interactionⁱ

Subunit structureⁱ

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

GO - Molecular functionⁱ

chemoattractant activity Source: Ensembl
fibroblast growth factor receptor binding Source: InterPro
growth factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8891346
- 17265164
Ras guanyl-nucleotide exchange factor activity Source: Reactome
type 1 fibroblast growth factor receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16384934
type 2 fibroblast growth factor receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16384934

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108544, 124 interactors
Database of interacting proteins More...DIPⁱ	DIP-59630N
IntActⁱ	P55075, 3 interactors
STRINGⁱ	9606.ENSP00000321797

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	52 – 57	Combined sources	6
Beta strandⁱ	63 – 65	Combined sources	3
Beta strandⁱ	69 – 76	Combined sources	8
Turnⁱ	77 – 79	Combined sources	3
Beta strandⁱ	80 – 85	Combined sources	6
Beta strandⁱ	91 – 95	Combined sources	5
Helixⁱ	100 – 102	Combined sources	3
Beta strandⁱ	104 – 110	Combined sources	7
Turnⁱ	111 – 113	Combined sources	3
Beta strandⁱ	114 – 119	Combined sources	6
Turnⁱ	120 – 122	Combined sources	3
Beta strandⁱ	125 – 128	Combined sources	4
Beta strandⁱ	134 – 138	Combined sources	5
Helixⁱ	143 – 145	Combined sources	3
Beta strandⁱ	146 – 151	Combined sources	6
Beta strandⁱ	157 – 164	Combined sources	8
Helixⁱ	180 – 182	Combined sources	3
Helixⁱ	188 – 190	Combined sources	3
Beta strandⁱ	192 – 195	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P55075
SMRⁱ	P55075
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P55075

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heparin-binding growth factors family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3885 Eukaryota ENOG4111IPH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110785
HOGENOMⁱ	HOG000115986
HOVERGENⁱ	HBG005659
InParanoidⁱ	P55075
KEGG Orthology (KO) More...KOⁱ	K04358
OMAⁱ	LPKGHHT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NQH
PhylomeDBⁱ	P55075
TreeFamⁱ	TF331233

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00058 FGF, 1 hit
InterProⁱ	View protein in InterPro IPR028249 FGF8 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF
PANTHERⁱ	PTHR11486 PTHR11486, 1 hit PTHR11486:SF3 PTHR11486:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00167 FGF, 1 hit
SMARTⁱ	View protein in SMART SM00442 FGF, 1 hit
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00247 HBGF_FGF, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform FGF-8E (identifier: P55075-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS 
        60         70         80         90        100
QQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP 
       110        120        130        140        150
FAKLIVETDT FGSRVRVRGA ETGLYICMNK KGKLIAKSNG KGKDCVFTEI 
       160        170        180        190        200
VLENNYTALQ NAKYEGWYMA FTRKGRPRKG SKTRQHQREV HFMKRLPRGH 
       210        220        230 
HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR

Length:233

Mass (Da):26,525

Last modified:October 1, 1996 - v1

Checksum:ⁱ4C1EAF932A3A211D

GO

Isoform FGF-8A (identifier: P55075-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
24-52: Missing.

« Hide

        10         20         30         40         50
MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS 
        60         70         80         90        100
GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN 
       110        120        130        140        150
KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK 
       160        170        180        190        200
GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA 

PEPR

Show »

Length:204

Mass (Da):23,522

Checksum:ⁱ9A4CAB7686A2B190

GO

Isoform FGF-8B (identifier: P55075-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
24-51: EGPGRGPALGRELASLFRAGREPQGVSQ → VTVQSSPNFT

« Hide

        10         20         30         40         50
MGSPRSALSC LLLHLLVLCL QAQVTVQSSP NFTQHVREQS LVTDQLSRRL 
        60         70         80         90        100
IRTYQLYSRT SGKHVQVLAN KRINAMAEDG DPFAKLIVET DTFGSRVRVR 
       110        120        130        140        150
GAETGLYICM NKKGKLIAKS NGKGKDCVFT EIVLENNYTA LQNAKYEGWY 
       160        170        180        190        200
MAFTRKGRPR KGSKTRQHQR EVHFMKRLPR GHHTTEQSLR FEFLNYPPFT 
       210 
RSLRGSQRTW APEPR

Show »

Length:215

Mass (Da):24,711

Checksum:ⁱA39424271EF7CBFF

GO

Isoform FGF-8F (identifier: P55075-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
52-52: Q → QVTVQSSPNFTQ

« Hide

        10         20         30         40         50
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS 
        60         70         80         90        100
QQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK 
       110        120        130        140        150
RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN 
       160        170        180        190        200
GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE 
       210        220        230        240 
VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR

Show »

Length:244

Mass (Da):27,715

Checksum:ⁱ73DA5874CA918E6A

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	A0A087X1S5	A0A087X1S5_HUMAN		Fibroblast growth factor Fibroblast growth factor, FGF	FGF8 hCG_25633	140	Annotation score:
	R4GMQ3	R4GMQ3_HUMAN		Fibroblast growth factor 8 Fibroblast growth factor 8	FGF8	37	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057962	14	H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852659EnsemblClinVar.	1
Natural variantⁱVAR_057963	26	P → L in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852660EnsemblClinVar.	1
Natural variantⁱVAR_057964	40	F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852661EnsemblClinVar.	1
Natural variantⁱVAR_057965	89	K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 PublicationsCorresponds to variant dbSNP:rs137852662Ensembl.	1
Natural variantⁱVAR_057966	116	R → G in HH6; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs137852663Ensembl.	1
Natural variantⁱVAR_057967	218	T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs137852664Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_001525	24 – 52	Missing in isoform FGF-8A. 3 PublicationsAdd BLAST	29
Alternative sequenceⁱVSP_001524	24 – 51	EGPGR…QGVSQ → VTVQSSPNFT in isoform FGF-8B. 1 PublicationAdd BLAST	28
Alternative sequenceⁱVSP_001526	52	Q → QVTVQSSPNFTQ in isoform FGF-8F. 2 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S78466 , S78462, S78463, S78464, S78465 Genomic DNA Translation: AAB34255.1 D38752 Genomic DNA Translation: BAA22527.1 U46213 mRNA Translation: AAB40955.1 U46212 mRNA Translation: AAB40954.1 U46211 mRNA Translation: AAB40953.1 U47011, U47009, U47010 Genomic DNA Translation: AAC50784.1 U47011, U47009, U47010 Genomic DNA Translation: AAC50785.1 U47011, U47009, U47010 Genomic DNA Translation: AAC50782.1 U36223 mRNA Translation: AAB17893.1 U36228 , U36225, U36226, U36227 Genomic DNA Translation: AAB17894.1 U47011, U47009, U47010 Genomic DNA Translation: AAC50783.1 U56978 mRNA Translation: AAB03787.1 AB014615 mRNA Translation: BAA28605.1 AF520763 Genomic DNA Translation: AAM55238.1 CH471066 Genomic DNA Translation: EAW49746.1 BC128235 mRNA Translation: AAI28236.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7515.1 [P55075-3] CCDS7516.1 [P55075-4] CCDS7517.1 [P55075-1] CCDS7518.1 [P55075-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_006110.1, NM_006119.4 [P55075-3] NP_149353.1, NM_033163.3 [P55075-4] NP_149354.1, NM_033164.3 [P55075-1] NP_149355.1, NM_033165.3 [P55075-2]
UniGeneⁱ	Hs.57710

Genome annotation databases

Ensemblⁱ	ENST00000320185; ENSP00000321797; ENSG00000107831 [P55075-4] ENST00000344255; ENSP00000340039; ENSG00000107831 [P55075-1] ENST00000346714; ENSP00000344306; ENSG00000107831 [P55075-2] ENST00000347978; ENSP00000321945; ENSG00000107831 [P55075-3]
GeneIDⁱ	2253
KEGGⁱ	hsa:2253
UCSC genome browser More...UCSCⁱ	uc001ktp.3 human [P55075-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P55075	Fibroblast growth factor		PANTR		233	UniRef100_P55075
Fibroblast growth factor		PANPA		210
P55075-2	Fibroblast growth factor		PANTR		204	UniRef100_P55075-2
Fibroblast growth factor		ODORO		204
fibroblast growth factor 8 isoform X4		DELLE		204
fibroblast growth factor 8 isoform X4		Enhydra lutris kenyoni		204
fibroblast growth factor 8 isoform X4		PHYCD		204
+3
P55075-3	Fibroblast growth factor		MOUSE		215	UniRef100_P55075-3
Fibroblast growth factor		PANTR		215
Fibroblast growth factor		PROCO		215
Fibroblast growth factor		MACMU		215
Fibroblast growth factor		ODORO		215
+14
P55075-4	Fibroblast growth factor		PANTR		244	UniRef100_P55075-4
Fibroblast growth factor		GORGO		244

Protein	Similar proteins		Species	Score	Length	Source
P55075	Fibroblast growth factor		PANTR		233	UniRef90_P55075
Fibroblast growth factor		PANPA		210
Fibroblast growth factor		AILME		248
Fibroblast growth factor		MUSPF		247
fibroblast growth factor 8 isoform X1		Enhydra lutris kenyoni		247
+35
P55075-2	Fibroblast growth factor		PANTR		204	UniRef90_P55075-2
Fibroblast growth factor		ODORO		204
fibroblast growth factor 8 isoform X4		DELLE		204
fibroblast growth factor 8 isoform X4		Enhydra lutris kenyoni		204
fibroblast growth factor 8 isoform X4		PHYCD		204
+29
P55075-3	Fibroblast growth factor		MOUSE		215	UniRef90_P55075-3
Fibroblast growth factor		PANTR		215
Fibroblast growth factor		PROCO		215
Fibroblast growth factor		MACMU		215
Fibroblast growth factor		ODORO		215
+27
P55075-4	Fibroblast growth factor		PANTR		244	UniRef90_P55075-4
Fibroblast growth factor		GORGO		244
Fibroblast growth factor		PROCO		244
Fibroblast growth factor		PONAB		244
Fibroblast growth factor		MESAU		244
+24

Protein	Similar proteins		Species	Score	Length	Source
P55075	Fibroblast growth factor		PANTR		233	UniRef50_P55075
Fibroblast growth factor		PANPA		210
Fibroblast growth factor		AILME		248
fibroblast growth factor 8 isoform X1		Enhydra lutris kenyoni		247
Fibroblast growth factor		MUSPF		247
+75
P55075-2	Fibroblast growth factor 8		MOUSE		268	UniRef50_P37237
Fibroblast growth factor 17		RAT		216
Fibroblast growth factor 17		HUMAN		216
Fibroblast growth factor 8		CHICK		214
Fibroblast growth factor		MESAU		268
+336
P55075-3	Fibroblast growth factor 8		MOUSE		268	UniRef50_P37237
Fibroblast growth factor 17		RAT		216
Fibroblast growth factor 17		HUMAN		216
Fibroblast growth factor 8		CHICK		214
Fibroblast growth factor		MESAU		268
+336

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S78466 , S78462, S78463, S78464, S78465 Genomic DNA Translation: AAB34255.1 D38752 Genomic DNA Translation: BAA22527.1 U46213 mRNA Translation: AAB40955.1 U46212 mRNA Translation: AAB40954.1 U46211 mRNA Translation: AAB40953.1 U47011, U47009, U47010 Genomic DNA Translation: AAC50784.1 U47011, U47009, U47010 Genomic DNA Translation: AAC50785.1 U47011, U47009, U47010 Genomic DNA Translation: AAC50782.1 U36223 mRNA Translation: AAB17893.1 U36228 , U36225, U36226, U36227 Genomic DNA Translation: AAB17894.1 U47011, U47009, U47010 Genomic DNA Translation: AAC50783.1 U56978 mRNA Translation: AAB03787.1 AB014615 mRNA Translation: BAA28605.1 AF520763 Genomic DNA Translation: AAM55238.1 CH471066 Genomic DNA Translation: EAW49746.1 BC128235 mRNA Translation: AAI28236.1
CCDSⁱ	CCDS7515.1 [P55075-3] CCDS7516.1 [P55075-4] CCDS7517.1 [P55075-1] CCDS7518.1 [P55075-2]
RefSeqⁱ	NP_006110.1, NM_006119.4 [P55075-3] NP_149353.1, NM_033163.3 [P55075-4] NP_149354.1, NM_033164.3 [P55075-1] NP_149355.1, NM_033165.3 [P55075-2]
UniGeneⁱ	Hs.57710

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2FDB	X-ray	2.28	M/N	52-204	[»]
ProteinModelPortalⁱ	P55075
SMRⁱ	P55075
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108544, 124 interactors
DIPⁱ	DIP-59630N
IntActⁱ	P55075, 3 interactors
STRINGⁱ	9606.ENSP00000321797

PTM databases

iPTMnetⁱ	P55075
PhosphoSitePlusⁱ	P55075

Polymorphism and mutation databases

BioMutaⁱ	FGF8
DMDMⁱ	1706791

Proteomic databases

PaxDbⁱ	P55075
PeptideAtlasⁱ	P55075
PRIDEⁱ	P55075
ProteomicsDBⁱ	56778 56779 [P55075-2] 56780 [P55075-3] 56781 [P55075-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000320185; ENSP00000321797; ENSG00000107831 [P55075-4] ENST00000344255; ENSP00000340039; ENSG00000107831 [P55075-1] ENST00000346714; ENSP00000344306; ENSG00000107831 [P55075-2] ENST00000347978; ENSP00000321945; ENSG00000107831 [P55075-3]
GeneIDⁱ	2253
KEGGⁱ	hsa:2253
UCSCⁱ	uc001ktp.3 human [P55075-1]

Organism-specific databases

CTDⁱ	2253
DisGeNETⁱ	2253
EuPathDBⁱ	HostDB:ENSG00000107831.12
GeneCardsⁱ	FGF8
GeneReviewsⁱ	FGF8
HGNCⁱ	HGNC:3686 FGF8
MalaCardsⁱ	FGF8
MIMⁱ	600483 gene 612702 phenotype
neXtProtⁱ	NX_P55075
OpenTargetsⁱ	ENSG00000107831
Orphanetⁱ	93925 Alobar holoprosencephaly 478 Kallmann syndrome 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 432 Normosmic congenital hypogonadotropic hypogonadism 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly
PharmGKBⁱ	PA28125
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3885 Eukaryota ENOG4111IPH LUCA
GeneTreeⁱ	ENSGT00730000110785
HOGENOMⁱ	HOG000115986
HOVERGENⁱ	HBG005659
InParanoidⁱ	P55075
KOⁱ	K04358
OMAⁱ	LPKGHHT
OrthoDBⁱ	EOG091G0NQH
PhylomeDBⁱ	P55075
TreeFamⁱ	TF331233

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1839122 Signaling by activated point mutants of FGFR1 R-HSA-1839130 Signaling by activated point mutants of FGFR3 R-HSA-190322 FGFR4 ligand binding and activation R-HSA-190371 FGFR3b ligand binding and activation R-HSA-190372 FGFR3c ligand binding and activation R-HSA-190373 FGFR1c ligand binding and activation R-HSA-190375 FGFR2c ligand binding and activation R-HSA-2033514 FGFR3 mutant receptor activation R-HSA-2033519 Activated point mutants of FGFR2 R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654688 SHC-mediated cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654699 SHC-mediated cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654704 SHC-mediated cascade:FGFR3 R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654719 SHC-mediated cascade:FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkⁱ	P55075
SIGNORⁱ	P55075

Miscellaneous databases

EvolutionaryTraceⁱ	P55075
GeneWikiⁱ	FGF8
GenomeRNAiⁱ	2253
Protein Ontology More...PROⁱ	PR:P55075
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107831 Expressed in 49 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_FGF8
ExpressionAtlasⁱ	P55075 baseline and differential
Genevisibleⁱ	P55075 HS

Family and domain databases

CDDⁱ	cd00058 FGF, 1 hit
InterProⁱ	View protein in InterPro IPR028249 FGF8 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF
PANTHERⁱ	PTHR11486 PTHR11486, 1 hit PTHR11486:SF3 PTHR11486:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00167 FGF, 1 hit
SMARTⁱ	View protein in SMART SM00442 FGF, 1 hit
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00247 HBGF_FGF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FGF8_HUMAN
Accessionⁱ	P55075Primary (citable) accession number: P55075 Secondary accession number(s): A1A514, Q14915, Q15766
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - P55075 (FGF8_HUMAN)

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Fibroblast growth factor 8

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ