UniProtKB - P55061 (BI1_HUMAN)
Protein
Bax inhibitor 1
Gene
TMBIM6
Organism
Homo sapiens (Human)
Status
Functioni
Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).By similarity2 Publications
GO - Molecular functioni
- endoribonuclease inhibitor activity Source: ParkinsonsUK-UCL
- enzyme binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- autophagy Source: UniProtKB-KW
- cellular response to unfolded protein Source: ParkinsonsUK-UCL
- endoplasmic reticulum calcium ion homeostasis Source: Ensembl
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
- negative regulation of apoptotic process Source: ParkinsonsUK-UCL
- negative regulation of apoptotic signaling pathway Source: ParkinsonsUK-UCL
- negative regulation of calcium ion transport into cytosol Source: MGI
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
- negative regulation of endoribonuclease activity Source: ParkinsonsUK-UCL
- negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
- negative regulation of immunoglobulin secretion Source: Ensembl
- negative regulation of protein binding Source: ParkinsonsUK-UCL
- negative regulation of RNA splicing Source: ParkinsonsUK-UCL
- negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: Ensembl
- response to L-glutamate Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Apoptosis, Autophagy, Unfolded protein response |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | P55061 |
Protein family/group databases
TCDBi | 1.A.14.1.1, the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Bax inhibitor 1Short name: BI-1 Alternative name(s): Testis-enhanced gene transcript protein Transmembrane BAX inhibitor motif-containing protein 6 |
Gene namesi | Name:TMBIM6 Synonyms:BI1, TEGT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11723, TMBIM6 |
MIMi | 600748, gene |
neXtProti | NX_P55061 |
VEuPathDBi | HostDB:ENSG00000139644.12 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 2 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: ParkinsonsUK-UCL
- endoplasmic reticulum membrane Source: ParkinsonsUK-UCL
Mitochondrion
- mitochondrial membrane Source: ParkinsonsUK-UCL
Nucleus
- nucleus Source: ProtInc
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Other locations
- cytoplasm Source: ParkinsonsUK-UCL
- integral component of membrane Source: ParkinsonsUK-UCL
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 50 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 51 – 52 | LumenalSequence analysis | 2 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 86 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 112 | LumenalSequence analysis | 5 | |
Transmembranei | 113 – 133 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 139 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 166 | LumenalSequence analysis | 6 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 206 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Intramembranei | 207 – 227 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 228 – 237 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 209 | D → A: Abolishes calcium flux properties. 1 Publication | 1 | |
Mutagenesisi | 213 | D → A: Abolishes calcium flux properties. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7009 |
OpenTargetsi | ENSG00000139644 |
PharmGKBi | PA36440 |
Miscellaneous databases
Pharosi | P55061, Tbio |
Genetic variation databases
BioMutai | TMBIM6 |
DMDMi | 20981681 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000179078 | 1 – 237 | Bax inhibitor 1Add BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 7 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P55061 |
jPOSTi | P55061 |
MassIVEi | P55061 |
MaxQBi | P55061 |
PaxDbi | P55061 |
PeptideAtlasi | P55061 |
PRIDEi | P55061 |
ProteomicsDBi | 29424 56774 [P55061-1] |
TopDownProteomicsi | P55061-1 [P55061-1] |
PTM databases
iPTMneti | P55061 |
PhosphoSitePlusi | P55061 |
SwissPalmi | P55061 |
Expressioni
Tissue specificityi
Highly abundant in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000139644, Expressed in adult mammalian kidney and 249 other tissues |
ExpressionAtlasi | P55061, baseline and differential |
Genevisiblei | P55061, HS |
Organism-specific databases
HPAi | ENSG00000139644, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with BCL2 and BCL2L1.
1 PublicationBinary interactionsi
P55061
GO - Molecular functioni
- enzyme binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 112868, 93 interactors |
IntActi | P55061, 87 interactors |
MINTi | P55061 |
STRINGi | 9606.ENSP00000389277 |
Miscellaneous databases
RNActi | P55061, protein |
Family & Domainsi
Domaini
The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.1 Publication
Sequence similaritiesi
Belongs to the BI1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1629, Eukaryota |
GeneTreei | ENSGT01010000222482 |
InParanoidi | P55061 |
OMAi | PVRQHLK |
OrthoDBi | 1275249at2759 |
PhylomeDBi | P55061 |
TreeFami | TF323395 |
Family and domain databases
InterProi | View protein in InterPro IPR006213, Bax_inhbtr1_CS IPR006214, Bax_inhibitor_1-related |
PANTHERi | PTHR23291, PTHR23291, 1 hit |
Pfami | View protein in Pfam PF01027, Bax1-I, 1 hit |
PROSITEi | View protein in PROSITE PS01243, BI1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P55061-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHMV
60 70 80 90 100
THFIQAGLLS ALGSLILMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG
110 120 130 140 150
PALEFCIAVN PSILPTAFMG TAMIFTCFTL SALYARRRSY LFLGGILMSA
160 170 180 190 200
LSLLLLSSLG NVFFGSIWLF QANLYVGLVV MCGFVLFDTQ LIIEKAEHGD
210 220 230
QDYIWHCIDL FLDFITVFRK LMMILAMNEK DKKKEKK
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VQQ5 | F8VQQ5_HUMAN | Bax inhibitor 1 | TMBIM6 | 130 | Annotation score: | ||
F8VSI7 | F8VSI7_HUMAN | Bax inhibitor 1 | TMBIM6 | 138 | Annotation score: | ||
F8VVJ4 | F8VVJ4_HUMAN | Bax inhibitor 1 | TMBIM6 | 145 | Annotation score: | ||
F8W1V3 | F8W1V3_HUMAN | Bax inhibitor 1 | TMBIM6 | 200 | Annotation score: | ||
F8W086 | F8W086_HUMAN | Bax inhibitor 1 | TMBIM6 | 108 | Annotation score: | ||
F8VPI1 | F8VPI1_HUMAN | Bax inhibitor 1 | TMBIM6 | 89 | Annotation score: | ||
F8VR05 | F8VR05_HUMAN | Bax inhibitor 1 | TMBIM6 | 113 | Annotation score: | ||
F8W201 | F8W201_HUMAN | Bax inhibitor 1 | TMBIM6 | 95 | Annotation score: | ||
F8VX73 | F8VX73_HUMAN | Bax inhibitor 1 | TMBIM6 | 44 | Annotation score: | ||
F8VQW0 | F8VQW0_HUMAN | Bax inhibitor 1 | TMBIM6 | 41 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | F → L in AAU29521 (Ref. 2) Curated | 1 | |
Sequence conflicti | 169 | L → P in CAA53472 (PubMed:8530040).Curated | 1 | |
Sequence conflicti | 187 | F → V in CAA53472 (PubMed:8530040).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055119 | 1 | M → MSHSSVTREAPQLLSQRQRR EVRGVWGWGCLPGPRGGPAL FGLVTFGQSGDCCTDSGTM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75861 mRNA Translation: CAA53472.1 AF033095 mRNA Translation: AAB87479.1 AY736129 mRNA Translation: AAU29521.1 AK312238 mRNA Translation: BAG35171.1 AC020612 Genomic DNA No translation available. AC084037 Genomic DNA No translation available. AC131157 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58089.1 BC000916 mRNA Translation: AAH00916.1 BC036203 mRNA Translation: AAH36203.2 |
CCDSi | CCDS31797.1 [P55061-1] CCDS44875.1 [P55061-2] |
PIRi | I38334 |
RefSeqi | NP_001092046.1, NM_001098576.1 [P55061-2] NP_003208.2, NM_003217.2 [P55061-1] XP_005269183.1, XM_005269126.3 [P55061-2] |
Genome annotation databases
Ensembli | ENST00000267115; ENSP00000267115; ENSG00000139644 [P55061-1] ENST00000395006; ENSP00000378454; ENSG00000139644 [P55061-1] ENST00000423828; ENSP00000389277; ENSG00000139644 [P55061-2] ENST00000549385; ENSP00000448036; ENSG00000139644 [P55061-1] ENST00000552370; ENSP00000450158; ENSG00000139644 [P55061-1] ENST00000552699; ENSP00000446734; ENSG00000139644 [P55061-2] |
GeneIDi | 7009 |
KEGGi | hsa:7009 |
UCSCi | uc001rux.3, human [P55061-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75861 mRNA Translation: CAA53472.1 AF033095 mRNA Translation: AAB87479.1 AY736129 mRNA Translation: AAU29521.1 AK312238 mRNA Translation: BAG35171.1 AC020612 Genomic DNA No translation available. AC084037 Genomic DNA No translation available. AC131157 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58089.1 BC000916 mRNA Translation: AAH00916.1 BC036203 mRNA Translation: AAH36203.2 |
CCDSi | CCDS31797.1 [P55061-1] CCDS44875.1 [P55061-2] |
PIRi | I38334 |
RefSeqi | NP_001092046.1, NM_001098576.1 [P55061-2] NP_003208.2, NM_003217.2 [P55061-1] XP_005269183.1, XM_005269126.3 [P55061-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112868, 93 interactors |
IntActi | P55061, 87 interactors |
MINTi | P55061 |
STRINGi | 9606.ENSP00000389277 |
Protein family/group databases
TCDBi | 1.A.14.1.1, the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family |
PTM databases
iPTMneti | P55061 |
PhosphoSitePlusi | P55061 |
SwissPalmi | P55061 |
Genetic variation databases
BioMutai | TMBIM6 |
DMDMi | 20981681 |
Proteomic databases
EPDi | P55061 |
jPOSTi | P55061 |
MassIVEi | P55061 |
MaxQBi | P55061 |
PaxDbi | P55061 |
PeptideAtlasi | P55061 |
PRIDEi | P55061 |
ProteomicsDBi | 29424 56774 [P55061-1] |
TopDownProteomicsi | P55061-1 [P55061-1] |
Protocols and materials databases
Antibodypediai | 26071, 216 antibodies |
Genome annotation databases
Ensembli | ENST00000267115; ENSP00000267115; ENSG00000139644 [P55061-1] ENST00000395006; ENSP00000378454; ENSG00000139644 [P55061-1] ENST00000423828; ENSP00000389277; ENSG00000139644 [P55061-2] ENST00000549385; ENSP00000448036; ENSG00000139644 [P55061-1] ENST00000552370; ENSP00000450158; ENSG00000139644 [P55061-1] ENST00000552699; ENSP00000446734; ENSG00000139644 [P55061-2] |
GeneIDi | 7009 |
KEGGi | hsa:7009 |
UCSCi | uc001rux.3, human [P55061-1] |
Organism-specific databases
CTDi | 7009 |
DisGeNETi | 7009 |
GeneCardsi | TMBIM6 |
HGNCi | HGNC:11723, TMBIM6 |
HPAi | ENSG00000139644, Low tissue specificity |
MIMi | 600748, gene |
neXtProti | NX_P55061 |
OpenTargetsi | ENSG00000139644 |
PharmGKBi | PA36440 |
VEuPathDBi | HostDB:ENSG00000139644.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1629, Eukaryota |
GeneTreei | ENSGT01010000222482 |
InParanoidi | P55061 |
OMAi | PVRQHLK |
OrthoDBi | 1275249at2759 |
PhylomeDBi | P55061 |
TreeFami | TF323395 |
Enzyme and pathway databases
PathwayCommonsi | P55061 |
Miscellaneous databases
BioGRID-ORCSi | 7009, 4 hits in 875 CRISPR screens |
ChiTaRSi | TMBIM6, human |
GeneWikii | TEGT |
GenomeRNAii | 7009 |
Pharosi | P55061, Tbio |
PROi | PR:P55061 |
RNActi | P55061, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139644, Expressed in adult mammalian kidney and 249 other tissues |
ExpressionAtlasi | P55061, baseline and differential |
Genevisiblei | P55061, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006213, Bax_inhbtr1_CS IPR006214, Bax_inhibitor_1-related |
PANTHERi | PTHR23291, PTHR23291, 1 hit |
Pfami | View protein in Pfam PF01027, Bax1-I, 1 hit |
PROSITEi | View protein in PROSITE PS01243, BI1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BI1_HUMAN | |
Accessioni | P55061Primary (citable) accession number: P55061 Secondary accession number(s): B2R5M4 Q96J50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | May 15, 2002 | |
Last modified: | February 10, 2021 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries