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Entry version 187 (16 Oct 2019)
Sequence version 3 (29 Mar 2005)
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Protein

Exportin-2

Gene

CSE1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-2
Short name:
Exp2
Alternative name(s):
Cellular apoptosis susceptibility protein1 Publication
Chromosome segregation 1-like protein
Importin-alpha re-exporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSE1L
Synonyms:CAS1 Publication, XPO2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2431 CSE1L

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601342 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55060

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1434

Open Targets

More...
OpenTargetsi
ENSG00000124207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26933

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P55060

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSE1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62297557

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001172871 – 971Exportin-2Add BLAST971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei112PhosphoserineCombined sources1
Modified residuei574N6-acetyllysineCombined sources1
Modified residuei824N6-acetyllysineCombined sources1
Modified residuei931PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P55060

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P55060

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P55060

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P55060

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55060

PeptideAtlas

More...
PeptideAtlasi
P55060

PRoteomics IDEntifications database

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PRIDEi
P55060

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
30232
56771 [P55060-1]
56772 [P55060-2]
56773 [P55060-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55060

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55060

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P55060

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:7479798,PubMed:10331944).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124207 Expressed in 238 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55060 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55060 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002140
HPA038059
HPA038060

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with CSE1L/XPO2, Ran and KPNA2 (PubMed:9323134, PubMed:9786944). Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1 (PubMed:9323134).

Interacts with CFTR (PubMed:20933420).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107821, 154 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P55060

Database of interacting proteins

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DIPi
DIP-32573N

Protein interaction database and analysis system

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IntActi
P55060, 51 interactors

Molecular INTeraction database

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MINTi
P55060

STRING: functional protein association networks

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STRINGi
9606.ENSP00000262982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55060

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 102Importin N-terminalPROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPO2/CSE1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1992 Eukaryota
COG5657 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00550000074884

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55060

KEGG Orthology (KO)

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KOi
K18423

Identification of Orthologs from Complete Genome Data

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OMAi
MPYVFQM

Database of Orthologous Groups

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OrthoDBi
1248958at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P55060

TreeFam database of animal gene trees

More...
TreeFami
TF300473

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
IPR005043 XPO2_C
IPR013713 XPO2_central

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03378 CAS_CSE1, 1 hit
PF08506 Cse1, 1 hit
PF03810 IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00913 IBN_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P55060-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL
60 70 80 90 100
EKSQDNVIKV CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM
110 120 130 140 150
LSSPEQIQKQ LSDAISIIGR EDFPQKWPDL LTEMVNRFQS GDFHVINGVL
160 170 180 190 200
RTAHSLFKRY RHEFKSNELW TEIKLVLDAF ALPLTNLFKA TIELCSTHAN
210 220 230 240 250
DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN NFHTLLTLDN
260 270 280 290 300
KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL
310 320 330 340 350
LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP
360 370 380 390 400
NMEFRAADEE AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP
410 420 430 440 450
VTGIFSGYVN SMLQEYAKNP SVNWKHKDAA IYLVTSLASK AQTQKHGITQ
460 470 480 490 500
ANELVNLTEF FVNHILPDLK SANVNEFPVL KADGIKYIMI FRNQVPKEHL
510 520 530 540 550
LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL FTAAEIAPFV
560 570 580 590 600
EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ
610 620 630 640 650
KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE
660 670 680 690 700
ILQNDVQEFI PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN
710 720 730 740 750
IPALVRLLQA FLERGSNTIA SAAADKIPGL LGVFQKLIAS KANDHQGFYL
760 770 780 790 800
LNSIIEHMPP ESVDQYRKQI FILLFQRLQN SKTTKFIKSF LVFINLYCIK
810 820 830 840 850
YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK ICAVGITKLL
860 870 880 890 900
TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ
910 920 930 940 950
TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS
960 970
LNAEALQYLQ GYLQAASVTL L
Length:971
Mass (Da):110,417
Last modified:March 29, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08E837AB5008EBFD
GO
Isoform 2 (identifier: P55060-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-195: ATIELC → VWNASW
     196-971: Missing.

Show »
Length:195
Mass (Da):22,670
Checksum:i94798963277F26F5
GO
Isoform 3 (identifier: P55060-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     943-945: VPS → TYF
     946-971: Missing.

Show »
Length:945
Mass (Da):107,778
Checksum:i6E2D39436F2ABDD9
GO
Isoform 4 (identifier: P55060-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-312: Missing.

Note: No experimental confirmation available.
Show »
Length:915
Mass (Da):103,879
Checksum:i6EDE8048022CF7D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231 – 233FED → WEG in AAC50367 (PubMed:7479798).Curated3
Sequence conflicti231 – 233FED → WEG in AAC35008 (PubMed:10331944).Curated3
Sequence conflicti514E → G in AAC50367 (PubMed:7479798).Curated1
Sequence conflicti514E → G in AAC35008 (PubMed:10331944).Curated1
Sequence conflicti538A → T in ABO15009 (PubMed:11703094).Curated1
Sequence conflicti848K → N in AAC50367 (PubMed:7479798).Curated1
Sequence conflicti934K → M in AAC50367 (PubMed:7479798).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029327754I → V. Corresponds to variant dbSNP:rs2229042Ensembl.1
Natural variantiVAR_036558842C → F in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_048836968V → L. Corresponds to variant dbSNP:rs3505Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001222190 – 195ATIELC → VWNASW in isoform 2. 1 Publication6
Alternative sequenceiVSP_001223196 – 971Missing in isoform 2. 1 PublicationAdd BLAST776
Alternative sequenceiVSP_047203257 – 312Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_001224943 – 945VPS → TYF in isoform 3. 1 Publication3
Alternative sequenceiVSP_001225946 – 971Missing in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33286 mRNA Translation: AAC50367.1
AF053640 mRNA Translation: AAC35007.1
AF053641 mRNA Translation: AAC35008.1
AF053642 mRNA Translation: AAC35009.1
AF053651
, AF053644, AF053645, AF053646, AF053647, AF053648, AF053649, AF053650 Genomic DNA Translation: AAC35297.1
EF426455 mRNA Translation: ABO15009.1
AK312306 mRNA Translation: BAG35231.1
AL121903 Genomic DNA No translation available.
AL133174 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75676.1
CH471077 Genomic DNA Translation: EAW75677.1
BC108309 mRNA Translation: AAI08310.1
BC109313 mRNA Translation: AAI09314.1
BC109314 mRNA Translation: AAI09315.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13412.1 [P55060-1]
CCDS58773.1 [P55060-4]

Protein sequence database of the Protein Information Resource

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PIRi
I39166

NCBI Reference Sequences

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RefSeqi
NP_001243064.1, NM_001256135.1 [P55060-4]
NP_001307.2, NM_001316.3 [P55060-1]
XP_011526901.1, XM_011528599.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262982; ENSP00000262982; ENSG00000124207 [P55060-1]
ENST00000396192; ENSP00000379495; ENSG00000124207 [P55060-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1434

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1434

UCSC genome browser

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UCSCi
uc002xty.5 human [P55060-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33286 mRNA Translation: AAC50367.1
AF053640 mRNA Translation: AAC35007.1
AF053641 mRNA Translation: AAC35008.1
AF053642 mRNA Translation: AAC35009.1
AF053651
, AF053644, AF053645, AF053646, AF053647, AF053648, AF053649, AF053650 Genomic DNA Translation: AAC35297.1
EF426455 mRNA Translation: ABO15009.1
AK312306 mRNA Translation: BAG35231.1
AL121903 Genomic DNA No translation available.
AL133174 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75676.1
CH471077 Genomic DNA Translation: EAW75677.1
BC108309 mRNA Translation: AAI08310.1
BC109313 mRNA Translation: AAI09314.1
BC109314 mRNA Translation: AAI09315.1
CCDSiCCDS13412.1 [P55060-1]
CCDS58773.1 [P55060-4]
PIRiI39166
RefSeqiNP_001243064.1, NM_001256135.1 [P55060-4]
NP_001307.2, NM_001316.3 [P55060-1]
XP_011526901.1, XM_011528599.2

3D structure databases

SMRiP55060
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107821, 154 interactors
CORUMiP55060
DIPiDIP-32573N
IntActiP55060, 51 interactors
MINTiP55060
STRINGi9606.ENSP00000262982

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiP55060
PhosphoSitePlusiP55060
SwissPalmiP55060

Polymorphism and mutation databases

BioMutaiCSE1L
DMDMi62297557

Proteomic databases

EPDiP55060
jPOSTiP55060
MassIVEiP55060
MaxQBiP55060
PaxDbiP55060
PeptideAtlasiP55060
PRIDEiP55060
ProteomicsDBi30232
56771 [P55060-1]
56772 [P55060-2]
56773 [P55060-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1434

Genome annotation databases

EnsembliENST00000262982; ENSP00000262982; ENSG00000124207 [P55060-1]
ENST00000396192; ENSP00000379495; ENSG00000124207 [P55060-4]
GeneIDi1434
KEGGihsa:1434
UCSCiuc002xty.5 human [P55060-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1434
DisGeNETi1434

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CSE1L
HGNCiHGNC:2431 CSE1L
HPAiCAB002140
HPA038059
HPA038060
MIMi601342 gene
neXtProtiNX_P55060
OpenTargetsiENSG00000124207
PharmGKBiPA26933

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1992 Eukaryota
COG5657 LUCA
GeneTreeiENSGT00550000074884
InParanoidiP55060
KOiK18423
OMAiMPYVFQM
OrthoDBi1248958at2759
PhylomeDBiP55060
TreeFamiTF300473

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSE1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1434
PharosiP55060

Protein Ontology

More...
PROi
PR:P55060

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124207 Expressed in 238 organ(s), highest expression level in substantia nigra
ExpressionAtlasiP55060 baseline and differential
GenevisibleiP55060 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
IPR005043 XPO2_C
IPR013713 XPO2_central
PfamiView protein in Pfam
PF03378 CAS_CSE1, 1 hit
PF08506 Cse1, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55060
Secondary accession number(s): A3RLL6
, B2R5T4, E1P5Y0, F8W904, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 29, 2005
Last modified: October 16, 2019
This is version 187 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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