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Protein

Apolipoprotein C-IV

Gene

APOC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in lipoprotein metabolism.

GO - Molecular functioni

  • lipid transporter activity Source: ProtInc

GO - Biological processi

  • lipid metabolic process Source: ProtInc
  • positive regulation of sequestering of triglyceride Source: BHF-UCL
  • triglyceride homeostasis Source: BHF-UCL
  • very-low-density lipoprotein particle assembly Source: Reactome
  • very-low-density lipoprotein particle clearance Source: Reactome

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-8866423 VLDL assembly
R-HSA-8964046 VLDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-IV
Short name:
Apo-CIV
Short name:
ApoC-IV
Alternative name(s):
Apolipoprotein C4
Gene namesi
Name:APOC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000267467.3
HGNCiHGNC:611 APOC4
MIMi600745 gene
neXtProtiNX_P55056

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi346
OpenTargetsiENSG00000224916
ENSG00000267467
PharmGKBiPA54

Polymorphism and mutation databases

BioMutaiAPOC4
DMDMi1703333

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000203630 – 127Apolipoprotein C-IVAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55056
PeptideAtlasiP55056
PRIDEiP55056
ProteomicsDBi56768

PTM databases

iPTMnetiP55056
PhosphoSitePlusiP55056

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSG00000267467
CleanExiHS_APOC4
ExpressionAtlasiP55056 baseline and differential
GenevisibleiP55056 HS

Organism-specific databases

HPAiHPA062671

Interactioni

Protein-protein interaction databases

BioGridi106843, 3 interactors
IntActiP55056, 12 interactors
STRINGi9606.ENSP00000468236

Structurei

3D structure databases

ProteinModelPortaliP55056
SMRiP55056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C4 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JGNY Eukaryota
ENOG41118WT LUCA
GeneTreeiENSGT00390000015914
HOGENOMiHOG000034003
HOVERGENiHBG050550
InParanoidiP55056
OMAiKTHSLCP
OrthoDBiEOG091G12IF
PhylomeDBiP55056
TreeFamiTF336879

Family and domain databases

InterProiView protein in InterPro
IPR028120 APOC4
PANTHERiPTHR32288 PTHR32288, 1 hit
PfamiView protein in Pfam
PF15119 APOC4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV
60 70 80 90 100
RGRMKELLET VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW
110 120
FLESKDSLLK KTHSLCPRLV CGDKDQG
Length:127
Mass (Da):14,553
Last modified:October 1, 1996 - v1
Checksum:iD7C7F6F2CD922775
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01208136L → P2 PublicationsCorresponds to variant dbSNP:rs1132899Ensembl.1
Natural variantiVAR_01208252G → D1 PublicationCorresponds to variant dbSNP:rs12691089Ensembl.1
Natural variantiVAR_03654075P → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_01206896L → R1 PublicationCorresponds to variant dbSNP:rs5167Ensembl.1
Natural variantiVAR_012069126Q → L. Corresponds to variant dbSNP:rs5168Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32576 Genomic DNA Translation: AAA91653.1
AY422953 Genomic DNA Translation: AAQ91812.1
AK126257 mRNA Translation: BAG54298.1
CH471126 Genomic DNA Translation: EAW57310.1
BC020723 mRNA Translation: AAH20723.1
CCDSiCCDS12649.1
RefSeqiNP_001637.1, NM_001646.2
UniGeneiHs.731599

Genome annotation databases

EnsembliENST00000592954; ENSP00000468236; ENSG00000267467
GeneIDi346
KEGGihsa:346
UCSCiuc060zuq.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPOC4_HUMAN
AccessioniPrimary (citable) accession number: P55056
Secondary accession number(s): B3KWY6, Q53YY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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