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Protein

Fatty acid-binding protein, intestinal

Gene

Fabp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83Fatty acidBy similarity1
Binding sitei107Fatty acidBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163560 Triglyceride catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, intestinal
Alternative name(s):
Fatty acid-binding protein 2
Intestinal-type fatty acid-binding protein
Short name:
I-FABP
Gene namesi
Name:Fabp2
Synonyms:Fabpi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95478 Fabp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673292 – 132Fatty acid-binding protein, intestinalAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP55050
PeptideAtlasiP55050
PRIDEiP55050

PTM databases

iPTMnetiP55050
PhosphoSitePlusiP55050

Expressioni

Tissue specificityi

Expressed in the small intestine. Highest expression levels in the proximal ileum.1 Publication

Gene expression databases

BgeeiENSMUSG00000023057 Expressed in 53 organ(s), highest expression level in small intestine
CleanExiMM_FABP2
ExpressionAtlasiP55050 baseline and differential
GenevisibleiP55050 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023820

Structurei

3D structure databases

ProteinModelPortaliP55050
SMRiP55050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00800000124172
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP55050
KOiK08751
OMAiQTYTYEG
OrthoDBiEOG091G0QSV
PhylomeDBiP55050
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031272 FABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF89 PTHR11955:SF89, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFDGTWKVD RNENYEKFME KMGINVMKRK LGAHDNLKLT ITQDGNKFTV
60 70 80 90 100
KESSNFRNID VVFELGVNFP YSLADGTELT GAWTIEGNKL IGKFTRVDNG
110 120 130
KELIAVREVS GNELIQTYTY EGVEAKRFFK KE
Length:132
Mass (Da):15,126
Last modified:January 23, 2007 - v2
Checksum:iE02001EE47267456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65034 mRNA Translation: AAA37589.1
AK007995 mRNA Translation: BAB25397.1
BC013457 mRNA Translation: AAH13457.1
CCDSiCCDS17813.1
RefSeqiNP_032006.1, NM_007980.3
UniGeneiMm.28398

Genome annotation databases

EnsembliENSMUST00000023820; ENSMUSP00000023820; ENSMUSG00000023057
GeneIDi14079
KEGGimmu:14079
UCSCiuc008rex.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65034 mRNA Translation: AAA37589.1
AK007995 mRNA Translation: BAB25397.1
BC013457 mRNA Translation: AAH13457.1
CCDSiCCDS17813.1
RefSeqiNP_032006.1, NM_007980.3
UniGeneiMm.28398

3D structure databases

ProteinModelPortaliP55050
SMRiP55050
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023820

PTM databases

iPTMnetiP55050
PhosphoSitePlusiP55050

Proteomic databases

PaxDbiP55050
PeptideAtlasiP55050
PRIDEiP55050

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023820; ENSMUSP00000023820; ENSMUSG00000023057
GeneIDi14079
KEGGimmu:14079
UCSCiuc008rex.2 mouse

Organism-specific databases

CTDi2169
MGIiMGI:95478 Fabp2

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00800000124172
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP55050
KOiK08751
OMAiQTYTYEG
OrthoDBiEOG091G0QSV
PhylomeDBiP55050
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-MMU-163560 Triglyceride catabolism

Miscellaneous databases

PROiPR:P55050
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023057 Expressed in 53 organ(s), highest expression level in small intestine
CleanExiMM_FABP2
ExpressionAtlasiP55050 baseline and differential
GenevisibleiP55050 MM

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031272 FABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF89 PTHR11955:SF89, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFABPI_MOUSE
AccessioniPrimary (citable) accession number: P55050
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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