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Protein

GTP-binding protein RAD

Gene

RRAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi98 – 105GTPBy similarity8
Nucleotide bindingi203 – 206GTPBy similarity4

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB-KW
  • GTPase activity Source: ProtInc
  • GTP binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP55042
SIGNORiP55042

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein RAD
Alternative name(s):
RAD1
Ras associated with diabetes
Gene namesi
Name:RRAD
Synonyms:RAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000166592.11
HGNCiHGNC:10446 RRAD
MIMi179503 gene
neXtProtiNX_P55042

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6236
OpenTargetsiENSG00000166592
PharmGKBiPA34860

Polymorphism and mutation databases

BioMutaiRRAD
DMDMi38258885

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224781 – 308GTP-binding protein RADAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Omega-N-methylarginineBy similarity1
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP55042
PaxDbiP55042
PeptideAtlasiP55042
PRIDEiP55042
ProteomicsDBi56766
TopDownProteomicsiP55042

PTM databases

iPTMnetiP55042
PhosphoSitePlusiP55042

Expressioni

Tissue specificityi

Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.1 Publication

Inductioni

Down-regulated in failing hearts.1 Publication

Gene expression databases

BgeeiENSG00000166592 Expressed in 168 organ(s), highest expression level in quadriceps femoris
CleanExiHS_RRAD
ExpressionAtlasiP55042 baseline and differential
GenevisibleiP55042 HS

Organism-specific databases

HPAiHPA041755

Interactioni

Subunit structurei

Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952735EBI-3911502,EBI-748961

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112150, 14 interactors
IntActiP55042, 3 interactors
STRINGi9606.ENSP00000299759

Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55042
SMRiP55042
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55042

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni278 – 297Calmodulin-bindingAdd BLAST20

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000246961
HOVERGENiHBG104899
InParanoidiP55042
KOiK07845
OMAiDRSIMVD
OrthoDBiEOG091G0OCN
PhylomeDBiP55042
TreeFamiTF314379

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR028869 RAD
IPR017358 RGK
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PTHR24070:SF74 PTHR24070:SF74, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PIRSFiPIRSF038017 GTP-binding_GEM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P55042-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLNGGGSGA GGSRGGGQER ERRRGSTPWG PAPPLHRRSM PVDERDLQAA
60 70 80 90 100
LTPGALTAAA AGTGTQGPRL DWPEDSEDSL SSGGSDSDES VYKVLLLGAP
110 120 130 140 150
GVGKSALARI FGGVEDGPEA EAAGHTYDRS IVVDGEEASL MVYDIWEQDG
160 170 180 190 200
GRWLPGHCMA MGDAYVIVYS VTDKGSFEKA SELRVQLRRA RQTDDVPIIL
210 220 230 240 250
VGNKSDLVRS REVSVDEGRA CAVVFDCKFI ETSAALHHNV QALFEGVVRQ
260 270 280 290 300
IRLRRDSKEA NARRQAGTRR RESLGKKAKR FLGRIVARNS RKMAFRAKSK

SCHDLSVL
Length:308
Mass (Da):33,245
Last modified:November 7, 2003 - v2
Checksum:iEF098960A371D2C4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KSM6J3KSM6_HUMAN
GTP-binding protein RAD
RRAD
162Annotation score:
J3KRG9J3KRG9_HUMAN
GTP-binding protein RAD
RRAD
136Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04949766Q → P. Corresponds to variant dbSNP:rs7198458Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24564 mRNA Translation: AAA36540.1
BC011645 mRNA Translation: AAH11645.1
BC057815 mRNA Translation: AAH57815.1
CCDSiCCDS10824.1
PIRiA49334
RefSeqiNP_001122322.1, NM_001128850.1
NP_004156.1, NM_004165.2
UniGeneiHs.1027

Genome annotation databases

EnsembliENST00000299759; ENSP00000299759; ENSG00000166592
ENST00000420652; ENSP00000388744; ENSG00000166592
GeneIDi6236
KEGGihsa:6236
UCSCiuc002eqn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24564 mRNA Translation: AAA36540.1
BC011645 mRNA Translation: AAH11645.1
BC057815 mRNA Translation: AAH57815.1
CCDSiCCDS10824.1
PIRiA49334
RefSeqiNP_001122322.1, NM_001128850.1
NP_004156.1, NM_004165.2
UniGeneiHs.1027

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DPXX-ray1.80A/B87-258[»]
2GJSX-ray1.90A/B87-260[»]
3Q72X-ray1.66A/B90-255[»]
3Q7PX-ray2.50A/B90-255[»]
3Q7QX-ray2.30A/B90-255[»]
ProteinModelPortaliP55042
SMRiP55042
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112150, 14 interactors
IntActiP55042, 3 interactors
STRINGi9606.ENSP00000299759

PTM databases

iPTMnetiP55042
PhosphoSitePlusiP55042

Polymorphism and mutation databases

BioMutaiRRAD
DMDMi38258885

Proteomic databases

MaxQBiP55042
PaxDbiP55042
PeptideAtlasiP55042
PRIDEiP55042
ProteomicsDBi56766
TopDownProteomicsiP55042

Protocols and materials databases

DNASUi6236
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299759; ENSP00000299759; ENSG00000166592
ENST00000420652; ENSP00000388744; ENSG00000166592
GeneIDi6236
KEGGihsa:6236
UCSCiuc002eqn.2 human

Organism-specific databases

CTDi6236
DisGeNETi6236
EuPathDBiHostDB:ENSG00000166592.11
GeneCardsiRRAD
HGNCiHGNC:10446 RRAD
HPAiHPA041755
MIMi179503 gene
neXtProtiNX_P55042
OpenTargetsiENSG00000166592
PharmGKBiPA34860
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000246961
HOVERGENiHBG104899
InParanoidiP55042
KOiK07845
OMAiDRSIMVD
OrthoDBiEOG091G0OCN
PhylomeDBiP55042
TreeFamiTF314379

Enzyme and pathway databases

SignaLinkiP55042
SIGNORiP55042

Miscellaneous databases

EvolutionaryTraceiP55042
GeneWikiiRRAD
GenomeRNAii6236
PROiPR:P55042
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166592 Expressed in 168 organ(s), highest expression level in quadriceps femoris
CleanExiHS_RRAD
ExpressionAtlasiP55042 baseline and differential
GenevisibleiP55042 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR028869 RAD
IPR017358 RGK
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PTHR24070:SF74 PTHR24070:SF74, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PIRSFiPIRSF038017 GTP-binding_GEM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAD_HUMAN
AccessioniPrimary (citable) accession number: P55042
Secondary accession number(s): Q96F39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 7, 2003
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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