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UniProtKB - P55040 (GEM_HUMAN)

Entry version 202 (23 Feb 2022)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

GTP-binding protein GEM

Gene

GEM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi82 – 89GTPBy similarity8
Nucleotide bindingi191 – 194GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P55040

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P55040

SIGNOR Signaling Network Open Resource

More...SIGNORi		P55040

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTP-binding protein GEM
Alternative name(s):
GTP-binding mitogen-induced T-cell protein
RAS-like protein KIR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GEM
Synonyms:KIR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4234, GEM

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600164, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P55040

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164949

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2669

Open Targets

More...OpenTargetsi		ENSG00000164949

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28645

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P55040, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GEM

Domain mapping of disease mutations (DMDM)

More...DMDMi		1707896

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001224751 – 296GTP-binding protein GEMAdd BLAST296

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P55040

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P55040

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P55040

MaxQB - The MaxQuant DataBase

More...MaxQBi		P55040

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P55040

PeptideAtlas

More...PeptideAtlasi		P55040

PRoteomics IDEntifications database

More...PRIDEi		P55040

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56765

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P55040

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P55040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By mitogens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164949, Expressed in pigmented layer of retina and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P55040, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P55040, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164949, Tissue enhanced (gallbladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with calmodulin in a Ca2+-dependent manner. Binds ROCK1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P55040
With#Exp.IntAct
AHCYL1 [O43865]8EBI-744104,EBI-2371423
ANKRD36B - isoform 4 [Q8N2N9-4]3EBI-744104,EBI-12170453
ASB15 [Q8WXK1]3EBI-744104,EBI-12809012
BEGAIN [Q9BUH8]5EBI-744104,EBI-742722
BHLHB9 [Q6PI77]3EBI-744104,EBI-11519926
BLOC1S2 [Q6QNY1]3EBI-744104,EBI-465872
BLZF1 [Q9H2G9]6EBI-744104,EBI-2548012
C1orf131 - isoform 3 [Q8NDD1-6]3EBI-744104,EBI-17761821
CACNB3 [P54284]8EBI-744104,EBI-1184651
CARD9 - isoform 2 [Q9H257-2]3EBI-744104,EBI-11530605
CCDC102B [Q68D86]3EBI-744104,EBI-10171570
CCDC125 [Q86Z20]3EBI-744104,EBI-11977221
CCDC88B [A6NC98]3EBI-744104,EBI-347573
CDR2 [Q01850]3EBI-744104,EBI-1181367
CEP70 [Q8NHQ1]3EBI-744104,EBI-739624
COG6 [Q9Y2V7]3EBI-744104,EBI-3866319
COG8 [Q96MW5]3EBI-744104,EBI-720875
CYSRT1 [A8MQ03]3EBI-744104,EBI-3867333
DBF4B - isoform 2 [Q8NFT6-2]3EBI-744104,EBI-12205861
DEUP1 [Q05D60]6EBI-744104,EBI-748597
DISC1 - isoform 2 [Q9NRI5-2]3EBI-744104,EBI-11988027
ECSIT [Q9BQ95]3EBI-744104,EBI-712452
EFHC2 [Q5JST6]3EBI-744104,EBI-2349927
EXOSC8 [Q96B26]3EBI-744104,EBI-371922
GADD45GIP1 [Q8TAE8]3EBI-744104,EBI-372506
GAS8 [O95995]3EBI-744104,EBI-1052570
GOLGA2 [Q08379]6EBI-744104,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-744104,EBI-5916454
GOPC - isoform 2 [Q9HD26-2]3EBI-744104,EBI-11102276
HOOK2 - isoform 2 [Q96ED9-2]3EBI-744104,EBI-10961706
HSF2BP [O75031]3EBI-744104,EBI-7116203
IHO1 [Q8IYA8]3EBI-744104,EBI-8638439
IKZF3 [Q9UKT9]8EBI-744104,EBI-747204
INCA1 [Q0VD86]3EBI-744104,EBI-6509505
INO80E [Q8NBZ0]6EBI-744104,EBI-769401
INSC [Q1MX18]3EBI-744104,EBI-12081118
ISCA2 [Q86U28]3EBI-744104,EBI-10258659
KATNBL1 [Q9H079]5EBI-744104,EBI-715394
KCTD9 [Q7L273]6EBI-744104,EBI-4397613
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-744104,EBI-14069005
KRT31 [Q15323]6EBI-744104,EBI-948001
KRT34 [O76011]3EBI-744104,EBI-1047093
KRT36 - isoform 2 [O76013-2]3EBI-744104,EBI-11958506
KRT40 [Q6A162]3EBI-744104,EBI-10171697
KRT6A [P02538]3EBI-744104,EBI-702198
KRT83 [P78385]3EBI-744104,EBI-10221390
KRTAP10-7 [P60409]6EBI-744104,EBI-10172290
KRTAP10-8 [P60410]3EBI-744104,EBI-10171774
LIMS1 - isoform 3 [P48059-3]3EBI-744104,EBI-12864460
LRP2BP [Q9P2M1]3EBI-744104,EBI-18273118
LZTS2 [Q9BRK4]6EBI-744104,EBI-741037
MCRS1 [Q96EZ8]3EBI-744104,EBI-348259
MESD [Q14696]3EBI-744104,EBI-6165891
MGLL [A0A0C4DFN3]3EBI-744104,EBI-12866138
MID2 - isoform 2 [Q9UJV3-2]4EBI-744104,EBI-10172526
MIPOL1 [Q8TD10]3EBI-744104,EBI-2548751
MKRN3 [Q13064]3EBI-744104,EBI-2340269
MORN3 [Q6PF18]3EBI-744104,EBI-9675802
MSS51 [Q4VC12]3EBI-744104,EBI-11599933
MTUS2 - isoform 2 [Q5JR59-3]6EBI-744104,EBI-11522433
MYOG [P15173]3EBI-744104,EBI-3906629
NDUFB7 [P17568]3EBI-744104,EBI-1246238
NOTCH2NLA [Q7Z3S9]3EBI-744104,EBI-945833
OIP5 [O43482]3EBI-744104,EBI-536879
PBX4 [Q9BYU1]3EBI-744104,EBI-10302990
PDLIM7 [Q9NR12]5EBI-744104,EBI-350517
PIH1D1 [Q9NWS0]3EBI-744104,EBI-357318
PLAGL2 [Q9UPG8]3EBI-744104,EBI-2876622
PLEKHF2 [Q9H8W4]3EBI-744104,EBI-742388
PNMA1 [Q8ND90]3EBI-744104,EBI-302345
POF1B - isoform 1 [Q8WVV4-1]3EBI-744104,EBI-11986735
PRDM14 [Q9GZV8]3EBI-744104,EBI-3957793
PRDM6 [Q9NQX0]3EBI-744104,EBI-11320284
RUNDC3A [Q59EK9]3EBI-744104,EBI-747225
SNAP91 - isoform 3 [O60641-3]3EBI-744104,EBI-12854506
SORBS3 [O60504]3EBI-744104,EBI-741237
SPAG5 [Q96R06]3EBI-744104,EBI-413317
SPATA6 - isoform 2 [Q9NWH7-2]3EBI-744104,EBI-17860101
SSX2IP [Q9Y2D8]3EBI-744104,EBI-2212028
TBC1D3G [Q6DHY5]3EBI-744104,EBI-13092532
TCF4 [P15884]3EBI-744104,EBI-533224
TFAP4 [Q01664]2EBI-744104,EBI-2514218
TFIP11 [Q9UBB9]7EBI-744104,EBI-1105213
TGM7 [Q96PF1]3EBI-744104,EBI-12029034
TLE5 - isoform 2 [Q08117-2]3EBI-744104,EBI-11741437
TP53BP2 [Q05BL1]3EBI-744104,EBI-11952721
TRAF1 [Q13077]6EBI-744104,EBI-359224
TRAF2 [Q12933]3EBI-744104,EBI-355744
TRIM10 - isoform Beta [Q9UDY6-2]3EBI-744104,EBI-11981577
TRIM23 [P36406]7EBI-744104,EBI-740098
TRIM27 [P14373]6EBI-744104,EBI-719493
TRIM32 [Q13049]3EBI-744104,EBI-742790
TRIM54 [Q9BYV2]3EBI-744104,EBI-2130429
TRIM69 - isoform 2 [Q86WT6-2]3EBI-744104,EBI-11525489
USH1G [Q495M9]3EBI-744104,EBI-8601749
USHBP1 [Q8N6Y0]3EBI-744104,EBI-739895
VIM [P08670]3EBI-744104,EBI-353844
VPS28 - isoform 2 [Q9UK41-2]3EBI-744104,EBI-12146727
VPS52 [Q8N1B4]3EBI-744104,EBI-2799833
WWOX - isoform 5 [Q9NZC7-5]3EBI-744104,EBI-12040603
YWHAB [P31946]4EBI-744104,EBI-359815
ZBTB42 [B2RXF5]3EBI-744104,EBI-12287587
ZC4H2 [Q9NQZ6]3EBI-744104,EBI-747993
ZMAT5 [Q9UDW3]3EBI-744104,EBI-7850213
ZNF20 [P17024]3EBI-744104,EBI-717634
ZNF552 [Q9H707]3EBI-744104,EBI-2555731
ZNF655 [Q8N720]3EBI-744104,EBI-625509
ZNF688 [P0C7X2]3EBI-744104,EBI-4395732
ZNF774 [Q6NX45]3EBI-744104,EBI-10251462
ZRANB1 [Q9UGI0]3EBI-744104,EBI-527853
ZSCAN9 [O15535]3EBI-744104,EBI-751531
CACNA1A [P27884] from Oryctolagus cuniculus.2EBI-744104,EBI-15685548
Cacnb3 [P54287] from Rattus norvegicus.2EBI-744104,EBI-8028596

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108937, 145 interactors

Database of interacting proteins

More...DIPi		DIP-41587N

Protein interaction database and analysis system

More...IntActi		P55040, 148 interactors

Molecular INTeraction database

More...MINTi		P55040

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000297596

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P55040, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P55040

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P55040

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni37 – 68DisorderedSequence analysisAdd BLAST32
Regioni266 – 285Calmodulin-bindingBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 59Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0395, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157830

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041217_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P55040

Identification of Orthologs from Complete Genome Data

More...OMAi		LDTWDAE

Database of Orthologous Groups

More...OrthoDBi		679855at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P55040

TreeFam database of animal gene trees

More...TreeFami		TF314379

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR017358, RGK
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00071, Ras, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038017, GTP-binding_GEM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00174, RHO, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51421, RAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P55040-1 [UniParc]FASTAAdd to basket
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MTLNNVTMRQ GTVGMQPQQQ RWSIPADGRH LMVQKEPHQY SHRNRHSATP 
        60         70         80         90        100
EDHCRRSWSS DSTDSVISSE SGNTYYRVVL IGEQGVGKST LANIFAGVHD 
       110        120        130        140        150
SMDSDCEVLG EDTYERTLMV DGESATIILL DMWENKGENE WLHDHCMQVG 
       160        170        180        190        200
DAYLIVYSIT DRASFEKASE LRIQLRRARQ TEDIPIILVG NKSDLVRCRE 
       210        220        230        240        250
VSVSEGRACA VVFDCKFIET SAAVQHNVKE LFEGIVRQVR LRRDSKEKNE 
       260        270        280        290 
RRLAYQKRKE SMPRKARRFW GKIVAKNNKN MAFKLKSKSC HDLSVL
Length:296
Mass (Da):33,949
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7BB3F2CA96D338F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJF9E5RJF9_HUMAN
GTP-binding protein GEM
GEM
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159I → V in AAC50067 (PubMed:7809057).Curated1
Sequence conflicti174 – 175QL → HV in AAC50067 (PubMed:7809057).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02009743R → G. Corresponds to variant dbSNP:rs2170363Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U10550 mRNA Translation: AAA64911.1
U13052 mRNA Translation: AAC50067.1
AK314017 mRNA Translation: BAG36728.1
CH471060 Genomic DNA Translation: EAW91709.1
BC022010 mRNA Translation: AAH22010.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6261.1

Protein sequence database of the Protein Information Resource

More...PIRi		A54575
I38745

NCBI Reference Sequences

More...RefSeqi		NP_005252.1, NM_005261.3
NP_859053.1, NM_181702.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297596; ENSP00000297596; ENSG00000164949
ENST00000396194; ENSP00000379497; ENSG00000164949

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2669

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2669

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000297596.3; ENSP00000297596.2; NM_005261.4; NP_005252.1

UCSC genome browser

More...UCSCi		uc003ygi.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10550 mRNA Translation: AAA64911.1
U13052 mRNA Translation: AAC50067.1
AK314017 mRNA Translation: BAG36728.1
CH471060 Genomic DNA Translation: EAW91709.1
BC022010 mRNA Translation: AAH22010.1
CCDSiCCDS6261.1
PIRiA54575
I38745
RefSeqiNP_005252.1, NM_005261.3
NP_859053.1, NM_181702.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CJWX-ray2.10A/B74-261[»]
2G3YX-ray2.40A62-249[»]
2HT6X-ray2.40A/B71-243[»]
SMRiP55040
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108937, 145 interactors
DIPiDIP-41587N
IntActiP55040, 148 interactors
MINTiP55040
STRINGi9606.ENSP00000297596

PTM databases

iPTMnetiP55040
PhosphoSitePlusiP55040

Genetic variation databases

BioMutaiGEM
DMDMi1707896

Proteomic databases

EPDiP55040
jPOSTiP55040
MassIVEiP55040
MaxQBiP55040
PaxDbiP55040
PeptideAtlasiP55040
PRIDEiP55040
ProteomicsDBi56765

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12852, 176 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		2669

Genome annotation databases

EnsembliENST00000297596; ENSP00000297596; ENSG00000164949
ENST00000396194; ENSP00000379497; ENSG00000164949
GeneIDi2669
KEGGihsa:2669
MANE-SelectiENST00000297596.3; ENSP00000297596.2; NM_005261.4; NP_005252.1
UCSCiuc003ygi.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2669
DisGeNETi2669

GeneCards: human genes, protein and diseases

More...GeneCardsi		GEM
HGNCiHGNC:4234, GEM
HPAiENSG00000164949, Tissue enhanced (gallbladder)
MIMi600164, gene
neXtProtiNX_P55040
OpenTargetsiENSG00000164949
PharmGKBiPA28645
VEuPathDBiHostDB:ENSG00000164949

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0395, Eukaryota
GeneTreeiENSGT00940000157830
HOGENOMiCLU_041217_3_2_1
InParanoidiP55040
OMAiLDTWDAE
OrthoDBi679855at2759
PhylomeDBiP55040
TreeFamiTF314379

Enzyme and pathway databases

PathwayCommonsiP55040
SignaLinkiP55040
SIGNORiP55040

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2669, 7 hits in 1043 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GEM, human
EvolutionaryTraceiP55040

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GEM_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2669
PharosiP55040, Tbio

Protein Ontology

More...PROi		PR:P55040
RNActiP55040, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164949, Expressed in pigmented layer of retina and 223 other tissues
ExpressionAtlasiP55040, baseline and differential
GenevisibleiP55040, HS

Family and domain databases

Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR017358, RGK
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
PfamiView protein in Pfam
PF00071, Ras, 1 hit
PIRSFiPIRSF038017, GTP-binding_GEM, 1 hit
SMARTiView protein in SMART
SM00174, RHO, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421, RAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGEM_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55040
Secondary accession number(s): B2RA31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 202 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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