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Entry version 194 (17 Jun 2020)
Sequence version 1 (01 Oct 1996)
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Protein

GTP-binding protein GEM

Gene

GEM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi82 – 89GTPBy similarity8
Nucleotide bindingi191 – 194GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTP-binding protein GEM
Alternative name(s):
GTP-binding mitogen-induced T-cell protein
RAS-like protein KIR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GEM
Synonyms:KIR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000164949.7

Human Gene Nomenclature Database

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HGNCi
HGNC:4234 GEM

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600164 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2669

Open Targets

More...
OpenTargetsi
ENSG00000164949

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28645

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P55040 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GEM

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1707896

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001224751 – 296GTP-binding protein GEMAdd BLAST296

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P55040

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P55040

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P55040

MaxQB - The MaxQuant DataBase

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MaxQBi
P55040

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P55040

PeptideAtlas

More...
PeptideAtlasi
P55040

PRoteomics IDEntifications database

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PRIDEi
P55040

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56765

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P55040

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By mitogens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164949 Expressed in pigmented layer of retina and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55040 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55040 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164949 Tissue enhanced (gallbladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with calmodulin in a Ca2+-dependent manner. Binds ROCK1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P55040
With#Exp.IntAct
AHCYL1 [O43865]8EBI-744104,EBI-2371423
ANKRD36B - isoform 4 [Q8N2N9-4]3EBI-744104,EBI-12170453
ASB15 [Q8WXK1]3EBI-744104,EBI-12809012
BEGAIN [Q9BUH8]5EBI-744104,EBI-742722
BHLHB9 [Q6PI77]3EBI-744104,EBI-11519926
BLOC1S2 [Q6QNY1]3EBI-744104,EBI-465872
BLZF1 [Q9H2G9]6EBI-744104,EBI-2548012
C1orf131 - isoform 3 [Q8NDD1-6]3EBI-744104,EBI-17761821
CACNB3 [P54284]8EBI-744104,EBI-1184651
CARD9 - isoform 2 [Q9H257-2]3EBI-744104,EBI-11530605
CCDC102B [Q68D86]3EBI-744104,EBI-10171570
CCDC125 [Q86Z20]3EBI-744104,EBI-11977221
CCDC36 [Q8IYA8]3EBI-744104,EBI-8638439
CCDC88B [A6NC98]3EBI-744104,EBI-347573
CDR2 [Q01850]3EBI-744104,EBI-1181367
CEP70 [Q8NHQ1]3EBI-744104,EBI-739624
COG6 [Q9Y2V7]3EBI-744104,EBI-3866319
COG8 [Q96MW5]3EBI-744104,EBI-720875
CYSRT1 [A8MQ03]3EBI-744104,EBI-3867333
DBF4B - isoform 2 [Q8NFT6-2]3EBI-744104,EBI-12205861
DEUP1 [Q05D60]6EBI-744104,EBI-748597
DISC1 - isoform 2 [Q9NRI5-2]3EBI-744104,EBI-11988027
ECSIT [Q9BQ95]3EBI-744104,EBI-712452
EFHC2 [Q5JST6]3EBI-744104,EBI-2349927
EXOSC8 [Q96B26]3EBI-744104,EBI-371922
GADD45GIP1 [Q8TAE8]3EBI-744104,EBI-372506
GAS8 [O95995]3EBI-744104,EBI-1052570
GOLGA2 [Q08379]6EBI-744104,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-744104,EBI-5916454
GOPC - isoform 2 [Q9HD26-2]3EBI-744104,EBI-11102276
HOOK2 - isoform 2 [Q96ED9-2]3EBI-744104,EBI-10961706
HSF2BP [O75031]3EBI-744104,EBI-7116203
IKZF3 [Q9UKT9]8EBI-744104,EBI-747204
INCA1 [Q0VD86]3EBI-744104,EBI-6509505
INO80E [Q8NBZ0]6EBI-744104,EBI-769401
INSC [Q1MX18]3EBI-744104,EBI-12081118
ISCA2 [Q86U28]3EBI-744104,EBI-10258659
KATNBL1 [Q9H079]5EBI-744104,EBI-715394
KCTD9 [Q7L273]6EBI-744104,EBI-4397613
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-744104,EBI-14069005
KRT31 [Q15323]6EBI-744104,EBI-948001
KRT34 [O76011]3EBI-744104,EBI-1047093
KRT36 - isoform 2 [O76013-2]3EBI-744104,EBI-11958506
KRT40 [Q6A162]3EBI-744104,EBI-10171697
KRT6A [P02538]3EBI-744104,EBI-702198
KRT83 [P78385]3EBI-744104,EBI-10221390
KRTAP10-7 [P60409]6EBI-744104,EBI-10172290
KRTAP10-8 [P60410]3EBI-744104,EBI-10171774
LIMS1 - isoform 3 [P48059-3]3EBI-744104,EBI-12864460
LRP2BP [Q9P2M1]3EBI-744104,EBI-18273118
LZTS2 [Q9BRK4]6EBI-744104,EBI-741037
MCRS1 [Q96EZ8]3EBI-744104,EBI-348259
MESD [Q14696]3EBI-744104,EBI-6165891
MGLL [A0A0C4DFN3]3EBI-744104,EBI-12866138
MID2 - isoform 2 [Q9UJV3-2]4EBI-744104,EBI-10172526
MIPOL1 [Q8TD10]3EBI-744104,EBI-2548751
MKRN3 [Q13064]3EBI-744104,EBI-2340269
MORN3 [Q6PF18]3EBI-744104,EBI-9675802
MSS51 [Q4VC12]3EBI-744104,EBI-11599933
MTUS2 - isoform 2 [Q5JR59-3]6EBI-744104,EBI-11522433
MYOG [P15173]3EBI-744104,EBI-3906629
NDUFB7 [P17568]3EBI-744104,EBI-1246238
NOTCH2NLA [Q7Z3S9]3EBI-744104,EBI-945833
OIP5 [O43482]3EBI-744104,EBI-536879
PBX4 [Q9BYU1]3EBI-744104,EBI-10302990
PDLIM7 [Q9NR12]5EBI-744104,EBI-350517
PIH1D1 [Q9NWS0]3EBI-744104,EBI-357318
PLAGL2 [Q9UPG8]3EBI-744104,EBI-2876622
PLEKHF2 [Q9H8W4]3EBI-744104,EBI-742388
PNMA1 [Q8ND90]3EBI-744104,EBI-302345
POF1B - isoform 1 [Q8WVV4-1]3EBI-744104,EBI-11986735
PRDM14 [Q9GZV8]3EBI-744104,EBI-3957793
PRDM6 [Q9NQX0]3EBI-744104,EBI-11320284
RUNDC3A [Q59EK9]3EBI-744104,EBI-747225
SNAP91 - isoform 3 [O60641-3]3EBI-744104,EBI-12854506
SORBS3 [O60504]3EBI-744104,EBI-741237
SPAG5 [Q96R06]3EBI-744104,EBI-413317
SPATA6 - isoform 2 [Q9NWH7-2]3EBI-744104,EBI-17860101
SSX2IP [Q9Y2D8]3EBI-744104,EBI-2212028
TBC1D3G [Q6DHY5]3EBI-744104,EBI-13092532
TCF4 [P15884]3EBI-744104,EBI-533224
TFAP4 [Q01664]2EBI-744104,EBI-2514218
TFIP11 [Q9UBB9]7EBI-744104,EBI-1105213
TGM7 [Q96PF1]3EBI-744104,EBI-12029034
TLE5 - isoform 2 [Q08117-2]3EBI-744104,EBI-11741437
TP53BP2 [Q05BL1]3EBI-744104,EBI-11952721
TRAF1 [Q13077]6EBI-744104,EBI-359224
TRAF2 [Q12933]3EBI-744104,EBI-355744
TRIM10 - isoform Beta [Q9UDY6-2]3EBI-744104,EBI-11981577
TRIM23 [P36406]7EBI-744104,EBI-740098
TRIM27 [P14373]6EBI-744104,EBI-719493
TRIM32 [Q13049]3EBI-744104,EBI-742790
TRIM54 [Q9BYV2]3EBI-744104,EBI-2130429
TRIM69 - isoform 2 [Q86WT6-2]3EBI-744104,EBI-11525489
USH1G [Q495M9]3EBI-744104,EBI-8601749
USHBP1 [Q8N6Y0]3EBI-744104,EBI-739895
VIM [P08670]3EBI-744104,EBI-353844
VPS28 - isoform 2 [Q9UK41-2]3EBI-744104,EBI-12146727
VPS52 [Q8N1B4]3EBI-744104,EBI-2799833
WWOX - isoform 5 [Q9NZC7-5]3EBI-744104,EBI-12040603
YWHAB [P31946]4EBI-744104,EBI-359815
ZBTB42 [B2RXF5]3EBI-744104,EBI-12287587
ZC4H2 [Q9NQZ6]3EBI-744104,EBI-747993
ZMAT5 [Q9UDW3]3EBI-744104,EBI-7850213
ZNF20 [P17024]3EBI-744104,EBI-717634
ZNF552 [Q9H707]3EBI-744104,EBI-2555731
ZNF655 [Q8N720]3EBI-744104,EBI-625509
ZNF688 [P0C7X2]3EBI-744104,EBI-4395732
ZNF774 [Q6NX45]3EBI-744104,EBI-10251462
ZRANB1 [Q9UGI0]3EBI-744104,EBI-527853
ZSCAN9 [O15535]3EBI-744104,EBI-751531
CACNA1A [P27884] from Oryctolagus cuniculus.2EBI-744104,EBI-15685548
Cacnb3 [P54287] from Rattus norvegicus.2EBI-744104,EBI-8028596

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
108937, 57 interactors

Database of interacting proteins

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DIPi
DIP-41587N

Protein interaction database and analysis system

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IntActi
P55040, 148 interactors

Molecular INTeraction database

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MINTi
P55040

STRING: functional protein association networks

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STRINGi
9606.ENSP00000297596

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P55040 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55040

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P55040

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 285Calmodulin-bindingBy similarityAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0395 Eukaryota
COG1100 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157830

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_041217_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55040

KEGG Orthology (KO)

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KOi
K07846

Identification of Orthologs from Complete Genome Data

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OMAi
QTELHRW

Database of Orthologous Groups

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OrthoDBi
679855at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P55040

TreeFam database of animal gene trees

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TreeFami
TF314379

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR017358 RGK
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type

Pfam protein domain database

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Pfami
View protein in Pfam
PF00071 Ras, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF038017 GTP-binding_GEM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00231 small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51421 RAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P55040-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLNNVTMRQ GTVGMQPQQQ RWSIPADGRH LMVQKEPHQY SHRNRHSATP
60 70 80 90 100
EDHCRRSWSS DSTDSVISSE SGNTYYRVVL IGEQGVGKST LANIFAGVHD
110 120 130 140 150
SMDSDCEVLG EDTYERTLMV DGESATIILL DMWENKGENE WLHDHCMQVG
160 170 180 190 200
DAYLIVYSIT DRASFEKASE LRIQLRRARQ TEDIPIILVG NKSDLVRCRE
210 220 230 240 250
VSVSEGRACA VVFDCKFIET SAAVQHNVKE LFEGIVRQVR LRRDSKEKNE
260 270 280 290
RRLAYQKRKE SMPRKARRFW GKIVAKNNKN MAFKLKSKSC HDLSVL
Length:296
Mass (Da):33,949
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7BB3F2CA96D338F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJF9E5RJF9_HUMAN
GTP-binding protein GEM
GEM
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159I → V in AAC50067 (PubMed:7809057).Curated1
Sequence conflicti174 – 175QL → HV in AAC50067 (PubMed:7809057).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02009743R → G. Corresponds to variant dbSNP:rs2170363Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U10550 mRNA Translation: AAA64911.1
U13052 mRNA Translation: AAC50067.1
AK314017 mRNA Translation: BAG36728.1
CH471060 Genomic DNA Translation: EAW91709.1
BC022010 mRNA Translation: AAH22010.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6261.1

Protein sequence database of the Protein Information Resource

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PIRi
A54575
I38745

NCBI Reference Sequences

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RefSeqi
NP_005252.1, NM_005261.3
NP_859053.1, NM_181702.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000297596; ENSP00000297596; ENSG00000164949
ENST00000396194; ENSP00000379497; ENSG00000164949

Database of genes from NCBI RefSeq genomes

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GeneIDi
2669

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2669

UCSC genome browser

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UCSCi
uc003ygi.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10550 mRNA Translation: AAA64911.1
U13052 mRNA Translation: AAC50067.1
AK314017 mRNA Translation: BAG36728.1
CH471060 Genomic DNA Translation: EAW91709.1
BC022010 mRNA Translation: AAH22010.1
CCDSiCCDS6261.1
PIRiA54575
I38745
RefSeqiNP_005252.1, NM_005261.3
NP_859053.1, NM_181702.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CJWX-ray2.10A/B74-261[»]
2G3YX-ray2.40A62-249[»]
2HT6X-ray2.40A/B71-243[»]
SMRiP55040
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108937, 57 interactors
DIPiDIP-41587N
IntActiP55040, 148 interactors
MINTiP55040
STRINGi9606.ENSP00000297596

PTM databases

iPTMnetiP55040
PhosphoSitePlusiP55040

Polymorphism and mutation databases

BioMutaiGEM
DMDMi1707896

Proteomic databases

EPDiP55040
jPOSTiP55040
MassIVEiP55040
MaxQBiP55040
PaxDbiP55040
PeptideAtlasiP55040
PRIDEiP55040
ProteomicsDBi56765

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
12852 166 antibodies

The DNASU plasmid repository

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DNASUi
2669

Genome annotation databases

EnsembliENST00000297596; ENSP00000297596; ENSG00000164949
ENST00000396194; ENSP00000379497; ENSG00000164949
GeneIDi2669
KEGGihsa:2669
UCSCiuc003ygi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2669
DisGeNETi2669
EuPathDBiHostDB:ENSG00000164949.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GEM
HGNCiHGNC:4234 GEM
HPAiENSG00000164949 Tissue enhanced (gallbladder)
MIMi600164 gene
neXtProtiNX_P55040
OpenTargetsiENSG00000164949
PharmGKBiPA28645

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00940000157830
HOGENOMiCLU_041217_3_2_1
InParanoidiP55040
KOiK07846
OMAiQTELHRW
OrthoDBi679855at2759
PhylomeDBiP55040
TreeFamiTF314379

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
2669 1 hit in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GEM human
EvolutionaryTraceiP55040

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GEM_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2669
PharosiP55040 Tbio

Protein Ontology

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PROi
PR:P55040
RNActiP55040 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164949 Expressed in pigmented layer of retina and 213 other tissues
ExpressionAtlasiP55040 baseline and differential
GenevisibleiP55040 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR017358 RGK
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PIRSFiPIRSF038017 GTP-binding_GEM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGEM_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55040
Secondary accession number(s): B2RA31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 17, 2020
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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