Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Developmentally-regulated GTP-binding protein 2

Gene

DRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell proliferation, differentiation and death.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 76GTPPROSITE-ProRule annotation8
Nucleotide bindingi115 – 119GTPPROSITE-ProRule annotation5
Nucleotide bindingi246 – 249GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GTP binding Source: ProtInc

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 2
Short name:
DRG-2
Gene namesi
Name:DRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108591.9
HGNCiHGNC:3030 DRG2
MIMi602986 gene
neXtProtiNX_P55039

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108591
PharmGKBiPA27484

Polymorphism and mutation databases

BioMutaiDRG2
DMDMi1706518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002054271 – 364Developmentally-regulated GTP-binding protein 2Add BLAST364

Post-translational modificationi

Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiP55039
MaxQBiP55039
PaxDbiP55039
PeptideAtlasiP55039
PRIDEiP55039
ProteomicsDBi56764

PTM databases

iPTMnetiP55039
PhosphoSitePlusiP55039

Expressioni

Tissue specificityi

Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.

Gene expression databases

BgeeiENSG00000108591 Expressed in 195 organ(s), highest expression level in right lobe of liver
CleanExiHS_DRG2
ExpressionAtlasiP55039 baseline and differential
GenevisibleiP55039 HS

Organism-specific databases

HPAiHPA007716

Interactioni

Subunit structurei

Interacts with RWDD1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RWDD1Q9H4466EBI-750565,EBI-748952

Protein-protein interaction databases

BioGridi108153, 14 interactors
IntActiP55039, 11 interactors
STRINGi9606.ENSP00000225729

Structurei

3D structure databases

ProteinModelPortaliP55039
SMRiP55039
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 288OBG-type GPROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1486 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075059
HOGENOMiHOG000112078
HOVERGENiHBG000948
InParanoidiP55039
KOiK06944
OMAiMIREDIT
OrthoDBiEOG091G0A12
PhylomeDBiP55039
TreeFamiTF105706

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P55039-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS
60 70 80 90 100
KGEGFDVMKS GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI
110 120 130 140 150
PGVIEYKGAN IQLLDLPGII EGAAQGKGRG RQVIAVARTA DVIIMMLDAT
160 170 180 190 200
KGEVQRSLLE KELESVGIRL NKHKPNIYFK PKKGGGISFN STVTLTQCSE
210 220 230 240 250
KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP CLYVYNKIDQ
260 270 280 290 300
ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR
310 320 330 340 350
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT
360
HTMEHEDVIQ IVKK
Length:364
Mass (Da):40,746
Last modified:October 1, 1996 - v1
Checksum:iD1754BEB02671F85
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MZF9A8MZF9_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
343Annotation score:
J3QKW7J3QKW7_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
244Annotation score:
J3QRI9J3QRI9_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
172Annotation score:
J3QL90J3QL90_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
112Annotation score:
J3QR71J3QR71_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
158Annotation score:
J3QKV7J3QKV7_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
161Annotation score:
J3KRL5J3KRL5_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
113Annotation score:
J3QLF3J3QLF3_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
90Annotation score:
J3QQI1J3QQI1_HUMAN
Developmentally-regulated GTP-bindi...
DRG2
22Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067452194T → M2 PublicationsCorresponds to variant dbSNP:rs17855350Ensembl.1
Natural variantiVAR_067453224S → T. Corresponds to variant dbSNP:rs61256737Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80754 mRNA Translation: CAA56730.1
BT006976 mRNA Translation: AAP35622.1
AK313362 mRNA Translation: BAG36162.1
CH471196 Genomic DNA Translation: EAW55669.1
BC000493 mRNA Translation: AAH00493.1
CCDSiCCDS11191.1
PIRiA55014
RefSeqiNP_001379.1, NM_001388.4
UniGeneiHs.78582

Genome annotation databases

EnsembliENST00000225729; ENSP00000225729; ENSG00000108591
GeneIDi1819
KEGGihsa:1819
UCSCiuc002gsh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80754 mRNA Translation: CAA56730.1
BT006976 mRNA Translation: AAP35622.1
AK313362 mRNA Translation: BAG36162.1
CH471196 Genomic DNA Translation: EAW55669.1
BC000493 mRNA Translation: AAH00493.1
CCDSiCCDS11191.1
PIRiA55014
RefSeqiNP_001379.1, NM_001388.4
UniGeneiHs.78582

3D structure databases

ProteinModelPortaliP55039
SMRiP55039
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108153, 14 interactors
IntActiP55039, 11 interactors
STRINGi9606.ENSP00000225729

PTM databases

iPTMnetiP55039
PhosphoSitePlusiP55039

Polymorphism and mutation databases

BioMutaiDRG2
DMDMi1706518

Proteomic databases

EPDiP55039
MaxQBiP55039
PaxDbiP55039
PeptideAtlasiP55039
PRIDEiP55039
ProteomicsDBi56764

Protocols and materials databases

DNASUi1819
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225729; ENSP00000225729; ENSG00000108591
GeneIDi1819
KEGGihsa:1819
UCSCiuc002gsh.3 human

Organism-specific databases

CTDi1819
EuPathDBiHostDB:ENSG00000108591.9
GeneCardsiDRG2
HGNCiHGNC:3030 DRG2
HPAiHPA007716
MIMi602986 gene
neXtProtiNX_P55039
OpenTargetsiENSG00000108591
PharmGKBiPA27484
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1486 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075059
HOGENOMiHOG000112078
HOVERGENiHBG000948
InParanoidiP55039
KOiK06944
OMAiMIREDIT
OrthoDBiEOG091G0A12
PhylomeDBiP55039
TreeFamiTF105706

Miscellaneous databases

GeneWikiiDRG2
GenomeRNAii1819
PROiPR:P55039
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108591 Expressed in 195 organ(s), highest expression level in right lobe of liver
CleanExiHS_DRG2
ExpressionAtlasiP55039 baseline and differential
GenevisibleiP55039 HS

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRG2_HUMAN
AccessioniPrimary (citable) accession number: P55039
Secondary accession number(s): B2R8G5, Q53Y50, Q9BWB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again