Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 160 (18 Sep 2019)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Solute carrier family 12 member 2

Gene

Slc12a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by WNK3.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Symport, Transport
LigandChloride, Potassium, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-426117 Cation-coupled Chloride cotransporters

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 12 member 2
Alternative name(s):
Basolateral Na-K-Cl symporter
Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc12a2
Synonyms:Nkcc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:101924 Slc12a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 278CytoplasmicSequence analysisAdd BLAST278
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 302ExtracellularSequence analysis3
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 359CytoplasmicSequence analysisAdd BLAST36
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 403ExtracellularSequence analysisAdd BLAST23
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 428CytoplasmicSequence analysis4
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 479ExtracellularSequence analysisAdd BLAST30
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Topological domaini501 – 513CytoplasmicSequence analysisAdd BLAST13
Transmembranei514 – 534HelicalSequence analysisAdd BLAST21
Topological domaini535 – 584ExtracellularSequence analysisAdd BLAST50
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 644CytoplasmicSequence analysisAdd BLAST39
Transmembranei645 – 667HelicalSequence analysisAdd BLAST23
Topological domaini668 – 673ExtracellularSequence analysis6
Transmembranei674 – 691HelicalSequence analysisAdd BLAST18
Topological domaini692 – 709CytoplasmicSequence analysisAdd BLAST18
Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Topological domaini731 – 892ExtracellularSequence analysisAdd BLAST162
Transmembranei893 – 913HelicalSequence analysisAdd BLAST21
Topological domaini914 – 1205CytoplasmicSequence analysisAdd BLAST292

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001780241 – 1205Solute carrier family 12 member 2Add BLAST1205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei205PhosphothreonineBy similarity1
Modified residuei210PhosphothreonineBy similarity1
Modified residuei223PhosphothreonineBy similarity1
Modified residuei235PhosphoserineBy similarity1
Modified residuei259PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi546N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi555N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei933PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P55012

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P55012

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P55012

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55012

PeptideAtlas

More...
PeptideAtlasi
P55012

PRoteomics IDEntifications database

More...
PRIDEi
P55012

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55012

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P55012

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P55012

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203277, 1 interactor

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P55012

Protein interaction database and analysis system

More...
IntActi
P55012, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000111023

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 117Ala-richAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2083 Eukaryota
COG0531 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000062855

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55012

KEGG Orthology (KO)

More...
KOi
K10951

Database of Orthologous Groups

More...
OrthoDBi
254933at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR013612 AA_permease_N
IPR002444 NKCC1
IPR018491 SLC12_C
IPR002443 SLC12A1/SLC12A2
IPR004842 SLC12A_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11827:SF58 PTHR11827:SF58, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit
PF08403 AA_permease_N, 1 hit
PF03522 SLC12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01207 NAKCLTRNSPRT
PR01208 NAKCLTRSPRT1

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P55012-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGPARPRL APAARPGWGR AAGCRRRGGP ARHGRASGQE DATTAGRQAG
60 70 80 90 100
GGVRGEGTPA AGDGLGRPLG PTPSQSRFQV DPVSENAGRA AAAAAAAAAA
110 120 130 140 150
AAAAGAAGKE TPAAGKAGGE SGVAKGSEEA KGRFRVNFVD PAASSSADDS
160 170 180 190 200
LSDAAGVGGD GPNVSFQNGG DTVLSEGSSL HSGGGSGHHQ QYYYDTHTNT
210 220 230 240 250
YYLRTFGHNT MDAVPRIDHY RHTAAQLGEK LLRPSLAELH DELEKEPFED
260 270 280 290 300
GFANGEESTP TRDAVVAYTA ESKGVVKFGW IKGVLVRCML NIWGVMLFIR
310 320 330 340 350
LSWIVGQAGI GLSVVVIAMA TVVTTITGLS TSAIATNGFV RGGGAYYLIS
360 370 380 390 400
RSLGPEFGGA IGLIFAFANA VAVAMYVVGF AETVVELLKE HSILMIDEIN
410 420 430 440 450
DIRIIGAITV VILLGISVAG MEWEAKAQIV LLVILLLAIA DFVIGTFISL
460 470 480 490 500
ESKKPKGFFG YKSEIFNENF GPDFREEETF FSVFAIFFPA ATGILAGANI
510 520 530 540 550
SGDLADPQSA IPKGTLLAIL ITTVVYIGIA VSVGSCVVRD ATGNVNDTIT
560 570 580 590 600
TELTNCTSAA CKLNFDFSYC ESNTCSYGLM NNFQVMSMVS GFAPLISAGI
610 620 630 640 650
FSATLSSALA SLVSAPKIFQ ALCKDNIYPA FQMFAKGYGK NNEPLRGYIL
660 670 680 690 700
TFLIALGFIL IAELNVIAPI ISNFFLASYA LINFSVFHAS LAKSPGWRPA
710 720 730 740 750
FKYYNMWISL IGAILCCIVM FVINWWAALL TYVIVLGLYI YVTYKKPDVN
760 770 780 790 800
WGSSTQALTY LSALQHSIRL SGVEDHVKNF RPQCLVMTGS PNSRPALLHL
810 820 830 840 850
VHDFTKNVGL MICGHVHMGP RRQAMKEMSI DQARYQRWLI KNKMKAFYAP
860 870 880 890 900
VHADDLREGA QYLMQAAGLG RMKPNTLVLG FKKDWLQADM RDVDMYINLF
910 920 930 940 950
HDAFDIQFGV VVIRLKEGLD ISHLQGQEEL LSSQEKSPGT KDVVVNVDYS
960 970 980 990 1000
KKSDQDTCKS SGEKSITQKD EEEDGKTPTQ PLLKKESKGP IVPLNVADQK
1010 1020 1030 1040 1050
LLEASTQFQK KQGKNTIDVW WLFDDGGLTL LIPYLLTTKK KWKDCKIRVF
1060 1070 1080 1090 1100
IGGKINRIDH DRRAMATLLS KFRIDFSDIM VLGDINTKPK KENIIAFDDM
1110 1120 1130 1140 1150
IEPYRLHEDD KEQDIADKMK EDEPWRITDN ELELYKTKTY RQIRLNELLK
1160 1170 1180 1190 1200
EHSSTANIIV MSLPVARKGA VSSALYMAWL EALSKDLPPV LLVRGNHQSV

LTFYS
Length:1,205
Mass (Da):131,034
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DE24CC8070D42F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QM38E9QM38_MOUSE
Solute carrier family 12 member 2
Slc12a2
1,206Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7R → G in AAC77832 (PubMed:7929272).Curated1
Sequence conflicti1097F → Y in AAC77832 (PubMed:7929272).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U13174 mRNA Translation: AAC77832.1
AC127678 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
A55015

NCBI Reference Sequences

More...
RefSeqi
NP_033220.2, NM_009194.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20496

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20496

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13174 mRNA Translation: AAC77832.1
AC127678 Genomic DNA No translation available.
PIRiA55015
RefSeqiNP_033220.2, NM_009194.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi203277, 1 interactor
ELMiP55012
IntActiP55012, 3 interactors
STRINGi10090.ENSMUSP00000111023

PTM databases

iPTMnetiP55012
PhosphoSitePlusiP55012
SwissPalmiP55012

Proteomic databases

EPDiP55012
jPOSTiP55012
MaxQBiP55012
PaxDbiP55012
PeptideAtlasiP55012
PRIDEiP55012

Genome annotation databases

GeneIDi20496
KEGGimmu:20496

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6558
MGIiMGI:101924 Slc12a2

Phylogenomic databases

eggNOGiKOG2083 Eukaryota
COG0531 LUCA
HOGENOMiHOG000062855
InParanoidiP55012
KOiK10951
OrthoDBi254933at2759

Enzyme and pathway databases

ReactomeiR-MMU-426117 Cation-coupled Chloride cotransporters

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Slc12a2 mouse

Protein Ontology

More...
PROi
PR:P55012

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR013612 AA_permease_N
IPR002444 NKCC1
IPR018491 SLC12_C
IPR002443 SLC12A1/SLC12A2
IPR004842 SLC12A_fam
PANTHERiPTHR11827:SF58 PTHR11827:SF58, 1 hit
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF08403 AA_permease_N, 1 hit
PF03522 SLC12, 1 hit
PRINTSiPR01207 NAKCLTRNSPRT
PR01208 NAKCLTRSPRT1
TIGRFAMsiTIGR00930 2a30, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS12A2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55012
Secondary accession number(s): E9PYU3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: September 18, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again