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Entry version 188 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Solute carrier family 12 member 2

Gene

SLC12A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by bumetanide (PubMed:7629105, PubMed:32081947). Activated by WNK3 (PubMed:21613606).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Symport, Transport
LigandChloride, Potassium, Sodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P55011

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-426117, Cation-coupled Chloride cotransporters

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P55011

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P55011

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.30.1.4, the cation-chloride cotransporter (ccc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 12 member 2
Alternative name(s):
Basolateral Na-K-Cl symporter
Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC12A2
Synonyms:NKCC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10911, SLC12A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600840, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55011

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000064651.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 286CytoplasmicCuratedAdd BLAST286
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei287 – 313Discontinuously helicalSequence analysisAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei287 – 299Helical1 PublicationAdd BLAST13
Intramembranei300 – 3071 Publication8
Intramembranei308 – 313Helical1 Publication6
Topological domaini314 – 321ExtracellularCurated8
Transmembranei322 – 343HelicalSequence analysisAdd BLAST22
Topological domaini344 – 361CytoplasmicCuratedAdd BLAST18
Transmembranei362 – 397HelicalSequence analysisAdd BLAST36
Topological domaini398 – 406ExtracellularCurated9
Transmembranei407 – 424HelicalSequence analysisAdd BLAST18
Topological domaini425 – 429CytoplasmicCurated5
Transmembranei430 – 454HelicalSequence analysisAdd BLAST25
Topological domaini455 – 486ExtracellularCuratedAdd BLAST32
Transmembranei487 – 507Discontinuously helicalSequence analysisAdd BLAST21
Intramembranei487 – 498Helical1 PublicationAdd BLAST12
Intramembranei499 – 5001 Publication2
Intramembranei501 – 507Helical1 Publication7
Topological domaini508 – 514CytoplasmicCurated7
Transmembranei515 – 542HelicalSequence analysisAdd BLAST28
Topological domaini543 – 599ExtracellularCuratedAdd BLAST57
Transmembranei600 – 632HelicalSequence analysisAdd BLAST33
Topological domaini633 – 653CytoplasmicCuratedAdd BLAST21
Transmembranei654 – 668HelicalSequence analysisAdd BLAST15
Topological domaini669 – 670ExtracellularCurated2
Transmembranei671 – 697HelicalSequence analysisAdd BLAST27
Topological domaini698 – 711CytoplasmicCuratedAdd BLAST14
Transmembranei712 – 730HelicalSequence analysisAdd BLAST19
Topological domaini731ExtracellularCurated1
Transmembranei732 – 751HelicalSequence analysisAdd BLAST20
Topological domaini752 – 1212CytoplasmicCuratedAdd BLAST461

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi294R → A: Severely impairs transporter activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6558

Open Targets

More...
OpenTargetsi
ENSG00000064651

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35806

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P55011, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1615383

Drug and drug target database

More...
DrugBanki
DB00887, Bumetanide
DB11098, Potassium bicarbonate
DB00761, Potassium chloride
DB01325, Quinethazone
DB00214, Torasemide

DrugCentral

More...
DrugCentrali
P55011

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
969

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC12A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1709292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001780231 – 1212Solute carrier family 12 member 2Add BLAST1212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei212PhosphothreonineBy similarity1
Modified residuei217PhosphothreonineCombined sources1
Modified residuei230PhosphothreonineBy similarity1
Modified residuei242PhosphoserineBy similarity1
Modified residuei266PhosphothreonineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi563 ↔ 568Combined sources1 Publication
Disulfide bondi577 ↔ 582Combined sources1 Publication
Modified residuei940PhosphoserineCombined sources1
Modified residuei944PhosphoserineBy similarity1
Modified residuei994PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P55011

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P55011

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P55011

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55011

PeptideAtlas

More...
PeptideAtlasi
P55011

PRoteomics IDEntifications database

More...
PRIDEi
P55011

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56757 [P55011-1]
56758 [P55011-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1761, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P55011, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55011

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P55011

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064651, Expressed in corpus callosum and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P55011, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55011, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000064651, Tissue enhanced (gallbladder, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112447, 74 interactors

Database of interacting proteins

More...
DIPi
DIP-43979N

Protein interaction database and analysis system

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IntActi
P55011, 31 interactors

Molecular INTeraction database

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MINTi
P55011

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262461

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P55011

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P55011, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55011

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi90 – 122Ala-richAdd BLAST33
Compositional biasi188 – 194Poly-Gly7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2083, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001883_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55011

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERAANWF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55011

TreeFam database of animal gene trees

More...
TreeFami
TF313191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR013612, AA_permease_N
IPR002444, NKCC1
IPR018491, SLC12_C
IPR002443, SLC12A1/SLC12A2
IPR004842, SLC12A_fam

The PANTHER Classification System

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PANTHERi
PTHR11827:SF58, PTHR11827:SF58, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00324, AA_permease, 1 hit
PF08403, AA_permease_N, 1 hit
PF03522, SLC12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01207, NAKCLTRNSPRT
PR01208, NAKCLTRSPRT1

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930, 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P55011-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVP SVPEDAAPAS
60 70 80 90 100
RDGGGVRDEG PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA
110 120 130 140 150
AAAAAAAGAG AGAKQTPADG EASGESEPAK GSEEAKGRFR VNFVDPAASS
160 170 180 190 200
SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS EGSSLHSGGG GGSGHHQHYY
210 220 230 240 250
YDTHTNTYYL RTFGHNTMDA VPRIDHYRHT AAQLGEKLLR PSLAELHDEL
260 270 280 290 300
EKEPFEDGFA NGEESTPTRD AVVTYTAESK GVVKFGWIKG VLVRCMLNIW
310 320 330 340 350
GVMLFIRLSW IVGQAGIGLS VLVIMMATVV TTITGLSTSA IATNGFVRGG
360 370 380 390 400
GAYYLISRSL GPEFGGAIGL IFAFANAVAV AMYVVGFAET VVELLKEHSI
410 420 430 440 450
LMIDEINDIR IIGAITVVIL LGISVAGMEW EAKAQIVLLV ILLLAIGDFV
460 470 480 490 500
IGTFIPLESK KPKGFFGYKS EIFNENFGPD FREEETFFSV FAIFFPAATG
510 520 530 540 550
ILAGANISGD LADPQSAIPK GTLLAILITT LVYVGIAVSV GSCVVRDATG
560 570 580 590 600
NVNDTIVTEL TNCTSAACKL NFDFSSCESS PCSYGLMNNF QVMSMVSGFT
610 620 630 640 650
PLISAGIFSA TLSSALASLV SAPKIFQALC KDNIYPAFQM FAKGYGKNNE
660 670 680 690 700
PLRGYILTFL IALGFILIAE LNVIAPIISN FFLASYALIN FSVFHASLAK
710 720 730 740 750
SPGWRPAFKY YNMWISLLGA ILCCIVMFVI NWWAALLTYV IVLGLYIYVT
760 770 780 790 800
YKKPDVNWGS STQALTYLNA LQHSIRLSGV EDHVKNFRPQ CLVMTGAPNS
810 820 830 840 850
RPALLHLVHD FTKNVGLMIC GHVHMGPRRQ AMKEMSIDQA KYQRWLIKNK
860 870 880 890 900
MKAFYAPVHA DDLREGAQYL MQAAGLGRMK PNTLVLGFKK DWLQADMRDV
910 920 930 940 950
DMYINLFHDA FDIQYGVVVI RLKEGLDISH LQGQEELLSS QEKSPGTKDV
960 970 980 990 1000
VVSVEYSKKS DLDTSKPLSE KPITHKVEEE DGKTATQPLL KKESKGPIVP
1010 1020 1030 1040 1050
LNVADQKLLE ASTQFQKKQG KNTIDVWWLF DDGGLTLLIP YLLTTKKKWK
1060 1070 1080 1090 1100
DCKIRVFIGG KINRIDHDRR AMATLLSKFR IDFSDIMVLG DINTKPKKEN
1110 1120 1130 1140 1150
IIAFEEIIEP YRLHEDDKEQ DIADKMKEDE PWRITDNELE LYKTKTYRQI
1160 1170 1180 1190 1200
RLNELLKEHS STANIIVMSL PVARKGAVSS ALYMAWLEAL SKDLPPILLV
1210
RGNHQSVLTF YS
Length:1,212
Mass (Da):131,447
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6BF174ACCDA2EC1
GO
Isoform 2 (identifier: P55011-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     976-991: Missing.

Show »
Length:1,196
Mass (Da):129,679
Checksum:i651AF731842344AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAL9G3XAL9_HUMAN
Solute carrier family 12 (Sodium/po...
SLC12A2 hCG_27034
1,150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006105976 – 991Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U30246 mRNA Translation: AAC50561.1
AF439152 mRNA Translation: AAL32454.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4144.1 [P55011-1]
CCDS58965.1 [P55011-3]

Protein sequence database of the Protein Information Resource

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PIRi
A57187

NCBI Reference Sequences

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RefSeqi
NP_001037.1, NM_001046.2 [P55011-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262461; ENSP00000262461; ENSG00000064651 [P55011-1]
ENST00000343225; ENSP00000340878; ENSG00000064651 [P55011-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6558

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6558

UCSC genome browser

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UCSCi
uc010jdg.4, human [P55011-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30246 mRNA Translation: AAC50561.1
AF439152 mRNA Translation: AAL32454.1
CCDSiCCDS4144.1 [P55011-1]
CCDS58965.1 [P55011-3]
PIRiA57187
RefSeqiNP_001037.1, NM_001046.2 [P55011-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6PZTelectron microscopy3.46A/B1-1212[»]
SMRiP55011
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112447, 74 interactors
DIPiDIP-43979N
IntActiP55011, 31 interactors
MINTiP55011
STRINGi9606.ENSP00000262461

Chemistry databases

BindingDBiP55011
ChEMBLiCHEMBL1615383
DrugBankiDB00887, Bumetanide
DB11098, Potassium bicarbonate
DB00761, Potassium chloride
DB01325, Quinethazone
DB00214, Torasemide
DrugCentraliP55011
GuidetoPHARMACOLOGYi969

Protein family/group databases

TCDBi2.A.30.1.4, the cation-chloride cotransporter (ccc) family

PTM databases

GlyConnecti1761, 3 N-Linked glycans (1 site)
GlyGeniP55011, 3 sites
iPTMnetiP55011
PhosphoSitePlusiP55011

Genetic variation databases

BioMutaiSLC12A2
DMDMi1709292

Proteomic databases

EPDiP55011
jPOSTiP55011
MassIVEiP55011
PaxDbiP55011
PeptideAtlasiP55011
PRIDEiP55011
ProteomicsDBi56757 [P55011-1]
56758 [P55011-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
14071, 364 antibodies

Genome annotation databases

EnsembliENST00000262461; ENSP00000262461; ENSG00000064651 [P55011-1]
ENST00000343225; ENSP00000340878; ENSG00000064651 [P55011-3]
GeneIDi6558
KEGGihsa:6558
UCSCiuc010jdg.4, human [P55011-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6558
DisGeNETi6558

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC12A2
HGNCiHGNC:10911, SLC12A2
HPAiENSG00000064651, Tissue enhanced (gallbladder, salivary gland)
MIMi600840, gene
neXtProtiNX_P55011
OpenTargetsiENSG00000064651
PharmGKBiPA35806
VEuPathDBiHostDB:ENSG00000064651.13

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2083, Eukaryota
GeneTreeiENSGT00940000155742
HOGENOMiCLU_001883_0_0_1
InParanoidiP55011
OMAiERAANWF
PhylomeDBiP55011
TreeFamiTF313191

Enzyme and pathway databases

PathwayCommonsiP55011
ReactomeiR-HSA-426117, Cation-coupled Chloride cotransporters
SignaLinkiP55011
SIGNORiP55011

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6558, 11 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC12A2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6558
PharosiP55011, Tclin

Protein Ontology

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PROi
PR:P55011
RNActiP55011, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000064651, Expressed in corpus callosum and 236 other tissues
ExpressionAtlasiP55011, baseline and differential
GenevisibleiP55011, HS

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR013612, AA_permease_N
IPR002444, NKCC1
IPR018491, SLC12_C
IPR002443, SLC12A1/SLC12A2
IPR004842, SLC12A_fam
PANTHERiPTHR11827:SF58, PTHR11827:SF58, 1 hit
PfamiView protein in Pfam
PF00324, AA_permease, 1 hit
PF08403, AA_permease_N, 1 hit
PF03522, SLC12, 1 hit
PRINTSiPR01207, NAKCLTRNSPRT
PR01208, NAKCLTRSPRT1
TIGRFAMsiTIGR00930, 2a30, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS12A2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55011
Secondary accession number(s): Q8N713, Q8WWH7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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