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Protein

Allograft inflammatory factor 1

Gene

AIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi58 – 691PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 1052PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Allograft inflammatory factor 1
Short name:
AIF-1
Alternative name(s):
Ionized calcium-binding adapter molecule 1
Protein G1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AIF1
Synonyms:G1, IBA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204472.12

Human Gene Nomenclature Database

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HGNCi
HGNC:352 AIF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601833 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55008

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
199

Open Targets

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OpenTargetsi
ENSG00000204472

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24646

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AIF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1703217

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000738652 – 147Allograft inflammatory factor 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei11N6-acetyllysineCombined sources1
Modified residuei39PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P55008

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P55008

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P55008

PeptideAtlas

More...
PeptideAtlasi
P55008

PRoteomics IDEntifications database

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PRIDEi
P55008

ProteomicsDB human proteome resource

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ProteomicsDBi
56753
56754 [P55008-2]
56755 [P55008-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P55008-1 [P55008-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55008

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55008

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in T-lymphocytes and peripheral blood mononuclear cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204472 Expressed in 214 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

More...
CleanExi
HS_AIF1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55008 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P55008 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049234
HPA062949

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Potential). Monomer. Interacts with LCP1.Curated2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106702, 1 interactor

Protein interaction database and analysis system

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IntActi
P55008, 2 interactors

Molecular INTeraction database

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MINTi
P55008

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365227

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D58X-ray1.90A17-123[»]
2G2BNMR-A2-147[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P55008

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55008

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P55008

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 80EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 115EF-hand 2; degeneratePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INJA Eukaryota
ENOG411206J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231928

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004002

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P55008

KEGG Orthology (KO)

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KOi
K18617

Database of Orthologous Groups

More...
OrthoDBi
1557466at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55008

TreeFam database of animal gene trees

More...
TreeFami
TF320736

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P55008-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF
60 70 80 90 100
KEKYMEFDLN GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET
110 120 130 140
FSYPDFLRMM LGKRSAILKM ILMYEEKARE KEKPTGPPAK KAISELP
Length:147
Mass (Da):16,703
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0104CCF092074E8F
GO
Isoform 2 (identifier: P55008-2) [UniParc]FASTAAdd to basket
Also known as: G1

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:93
Mass (Da):10,455
Checksum:i4365FCB38F2B7329
GO
Isoform 3 (identifier: P55008-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: MSQTRDLQGG...EFDLNGNGDI → MEFDLNGNGD...PSPHPHPLPP
     121-147: Missing.

Show »
Length:132
Mass (Da):14,617
Checksum:iFC69F38ECC92A697
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5STX8Q5STX8_HUMAN
Allograft inflammatory factor 1
AIF1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33D → H in AAA92457 (PubMed:8081366).Curated1
Sequence conflicti131 – 147KEKPT…ISELP → RKTNTPPSQESPI in AAA92457 (PubMed:8081366).CuratedAdd BLAST17

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04866514G → R2 PublicationsCorresponds to variant dbSNP:rs2736182Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0438371 – 65MSQTR…GNGDI → MEFDLNGNGDIGEKRVICGG RVVCRPKKTEVSPTCSIPHD LGGGPPTTVGGRRMGMRKWE RRERVSPPSPHPHPLPP in isoform 3. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_0438381 – 54Missing in isoform 2. 3 PublicationsAdd BLAST54
Alternative sequenceiVSP_043839121 – 147Missing in isoform 3. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U49392 mRNA Translation: AAA92457.1
U95213 mRNA Translation: AAC24422.1
U19713 mRNA Translation: AAB05003.1
Y14768 Genomic DNA Translation: CAA75060.1
Y14768 Genomic DNA Translation: CAA75061.1
Y14768 Genomic DNA Translation: CAA75062.1
D86438 mRNA Translation: BAA13088.1
AF299327 mRNA Translation: AAG39110.1
EF070982 mRNA Translation: ABK35646.1
AK290771 mRNA Translation: BAF83460.1
CR542153 mRNA Translation: CAG46950.1
AF129756 Genomic DNA Translation: AAD18087.1
BA000025 Genomic DNA Translation: BAB63392.1
AL662801 Genomic DNA No translation available.
AL662847 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX248305 Genomic DNA No translation available.
CR753892 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03442.1
CH471081 Genomic DNA Translation: EAX03446.1
BC009474 mRNA Translation: AAH09474.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34398.1 [P55008-2]
CCDS4706.1 [P55008-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC5246

NCBI Reference Sequences

More...
RefSeqi
NP_001305899.1, NM_001318970.1 [P55008-2]
NP_001614.3, NM_001623.4 [P55008-1]
NP_116573.1, NM_032955.2 [P55008-2]
XP_016865821.1, XM_017010332.1 [P55008-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.76364

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376049; ENSP00000365217; ENSG00000204472 [P55008-2]
ENST00000376059; ENSP00000365227; ENSG00000204472 [P55008-1]
ENST00000383473; ENSP00000372965; ENSG00000206428 [P55008-2]
ENST00000383474; ENSP00000372966; ENSG00000206428 [P55008-1]
ENST00000413349; ENSP00000416061; ENSG00000235985 [P55008-1]
ENST00000414149; ENSP00000391720; ENSG00000237727 [P55008-1]
ENST00000415830; ENSP00000413709; ENSG00000235985 [P55008-2]
ENST00000416422; ENSP00000399901; ENSG00000234836 [P55008-2]
ENST00000419376; ENSP00000401433; ENSG00000237727 [P55008-2]
ENST00000424944; ENSP00000399621; ENSG00000235588 [P55008-2]
ENST00000425748; ENSP00000398013; ENSG00000234836 [P55008-1]
ENST00000440907; ENSP00000397842; ENSG00000235588 [P55008-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
199

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:199

UCSC genome browser

More...
UCSCi
uc003nva.4 human [P55008-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49392 mRNA Translation: AAA92457.1
U95213 mRNA Translation: AAC24422.1
U19713 mRNA Translation: AAB05003.1
Y14768 Genomic DNA Translation: CAA75060.1
Y14768 Genomic DNA Translation: CAA75061.1
Y14768 Genomic DNA Translation: CAA75062.1
D86438 mRNA Translation: BAA13088.1
AF299327 mRNA Translation: AAG39110.1
EF070982 mRNA Translation: ABK35646.1
AK290771 mRNA Translation: BAF83460.1
CR542153 mRNA Translation: CAG46950.1
AF129756 Genomic DNA Translation: AAD18087.1
BA000025 Genomic DNA Translation: BAB63392.1
AL662801 Genomic DNA No translation available.
AL662847 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX248305 Genomic DNA No translation available.
CR753892 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03442.1
CH471081 Genomic DNA Translation: EAX03446.1
BC009474 mRNA Translation: AAH09474.1
CCDSiCCDS34398.1 [P55008-2]
CCDS4706.1 [P55008-1]
PIRiJC5246
RefSeqiNP_001305899.1, NM_001318970.1 [P55008-2]
NP_001614.3, NM_001623.4 [P55008-1]
NP_116573.1, NM_032955.2 [P55008-2]
XP_016865821.1, XM_017010332.1 [P55008-3]
UniGeneiHs.76364

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D58X-ray1.90A17-123[»]
2G2BNMR-A2-147[»]
ProteinModelPortaliP55008
SMRiP55008
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106702, 1 interactor
IntActiP55008, 2 interactors
MINTiP55008
STRINGi9606.ENSP00000365227

PTM databases

iPTMnetiP55008
PhosphoSitePlusiP55008

Polymorphism and mutation databases

BioMutaiAIF1
DMDMi1703217

Proteomic databases

EPDiP55008
jPOSTiP55008
PaxDbiP55008
PeptideAtlasiP55008
PRIDEiP55008
ProteomicsDBi56753
56754 [P55008-2]
56755 [P55008-3]
TopDownProteomicsiP55008-1 [P55008-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
199
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376049; ENSP00000365217; ENSG00000204472 [P55008-2]
ENST00000376059; ENSP00000365227; ENSG00000204472 [P55008-1]
ENST00000383473; ENSP00000372965; ENSG00000206428 [P55008-2]
ENST00000383474; ENSP00000372966; ENSG00000206428 [P55008-1]
ENST00000413349; ENSP00000416061; ENSG00000235985 [P55008-1]
ENST00000414149; ENSP00000391720; ENSG00000237727 [P55008-1]
ENST00000415830; ENSP00000413709; ENSG00000235985 [P55008-2]
ENST00000416422; ENSP00000399901; ENSG00000234836 [P55008-2]
ENST00000419376; ENSP00000401433; ENSG00000237727 [P55008-2]
ENST00000424944; ENSP00000399621; ENSG00000235588 [P55008-2]
ENST00000425748; ENSP00000398013; ENSG00000234836 [P55008-1]
ENST00000440907; ENSP00000397842; ENSG00000235588 [P55008-1]
GeneIDi199
KEGGihsa:199
UCSCiuc003nva.4 human [P55008-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
199
DisGeNETi199
EuPathDBiHostDB:ENSG00000204472.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AIF1
HGNCiHGNC:352 AIF1
HPAiHPA049234
HPA062949
MIMi601833 gene
neXtProtiNX_P55008
OpenTargetsiENSG00000204472
PharmGKBiPA24646

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INJA Eukaryota
ENOG411206J LUCA
GeneTreeiENSGT00390000013846
HOGENOMiHOG000231928
HOVERGENiHBG004002
InParanoidiP55008
KOiK18617
OrthoDBi1557466at2759
PhylomeDBiP55008
TreeFamiTF320736

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AIF1 human
EvolutionaryTraceiP55008

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AIF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
199

Protein Ontology

More...
PROi
PR:P55008

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204472 Expressed in 214 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_AIF1
ExpressionAtlasiP55008 baseline and differential
GenevisibleiP55008 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAIF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55008
Secondary accession number(s): A8K406
, O43904, Q9UIV4, Q9UKS9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 16, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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