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UniProtKB - P55006 (RDH7_RAT)
Protein
Retinol dehydrogenase 7
Gene
Rdh7
Organism
Rattus norvegicus (Rat)
Status
Functioni
Acts on retinol bound on cellular retinol-binding protein (CRBP).
Catalytic activityi
- all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADHEC:1.1.1.105
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 164 | SubstrateBy similarity | 1 | |
Active sitei | 176 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 57 | NADPBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- NAD-retinol dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- retinol metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD, NADP |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinol dehydrogenase 7 (EC:1.1.1.105)Alternative name(s): Retinol dehydrogenase 3Imported Retinol dehydrogenase type III Short name: RODH III |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 631370, Rdh7 |
Subcellular locationi
Endoplasmic reticulum
- Microsome
- Endoplasmic reticulum Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054762 | 1 – 317 | Retinol dehydrogenase 7Add BLAST | 317 |
Proteomic databases
PaxDbi | P55006 |
PTM databases
iPTMneti | P55006 |
PhosphoSitePlusi | P55006 |
Interactioni
Protein-protein interaction databases
IntActi | P55006, 2 interactors |
STRINGi | 10116.ENSRNOP00000005875 |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | KOG1610, Eukaryota |
OMAi | DRKGFQV |
OrthoDBi | 942985at2759 |
PhylomeDBi | P55006 |
TreeFami | TF325617 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
P55006-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNRGLWGLV NNAGISVPMG PNEWMRKKDF ASVLDVNLLG VIEVTLNMLP
160 170 180 190 200
LVRKARGRVV NIASTMGRMS LLGGGYCISK YGVEAFSDSL RRELTYFGVK
210 220 230 240 250
VAIIEPGGFK TNVTNMERLS DNLKKLWDQA TEEVKEIYGE KFRDSYMKAM
260 270 280 290 300
ESLVNMCSGD LSLVTDCMEH ALTSCHPRTR YSAGWDAKFF YLPMSYLPTF
310
LSDAVIYWGS VKPARAL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 119 | M → V in AAB07997 (PubMed:7876135).Curated | 1 | |
Sequence conflicti | 172 | L → V in AAB07997 (PubMed:7876135).Curated | 1 | |
Sequence conflicti | 230 | A → T in AAB07997 (PubMed:7876135).Curated | 1 | |
Sequence conflicti | 243 | R → Q in AAB07997 (PubMed:7876135).Curated | 1 | |
Sequence conflicti | 256 | M → T in AAB07997 (PubMed:7876135).Curated | 1 | |
Sequence conflicti | 283 | A → P in AAB07997 (PubMed:7876135).Curated | 1 | |
Sequence conflicti | 307 | Y → H in AAB07997 (PubMed:7876135).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18762 mRNA Translation: AAB07997.1 U33501 mRNA Translation: AAB07995.1 BC088090 mRNA Translation: AAH88090.1 BC098650 mRNA Translation: AAH98650.1 |
PIRi | A55884 |
RefSeqi | NP_598227.3, NM_133543.3 |
Genome annotation databases
GeneIDi | 360420 |
KEGGi | rno:360420 |
UCSCi | RGD:631370, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18762 mRNA Translation: AAB07997.1 U33501 mRNA Translation: AAB07995.1 BC088090 mRNA Translation: AAH88090.1 BC098650 mRNA Translation: AAH98650.1 |
PIRi | A55884 |
RefSeqi | NP_598227.3, NM_133543.3 |
3D structure databases
SMRi | P55006 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P55006, 2 interactors |
STRINGi | 10116.ENSRNOP00000005875 |
PTM databases
iPTMneti | P55006 |
PhosphoSitePlusi | P55006 |
Proteomic databases
PaxDbi | P55006 |
Genome annotation databases
GeneIDi | 360420 |
KEGGi | rno:360420 |
UCSCi | RGD:631370, rat |
Organism-specific databases
CTDi | 54150 |
RGDi | 631370, Rdh7 |
Phylogenomic databases
eggNOGi | KOG1610, Eukaryota |
OMAi | DRKGFQV |
OrthoDBi | 942985at2759 |
PhylomeDBi | P55006 |
TreeFami | TF325617 |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
Miscellaneous databases
PROi | PR:P55006 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDH7_RAT | |
Accessioni | P55006Primary (citable) accession number: P55006 Secondary accession number(s): P50169, Q4KMB6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families