Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Microfibrillar-associated protein 2

Gene

Mfap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the elastin-associated microfibrils.

GO - Molecular functioni

  • extracellular matrix structural constituent Source: BHF-UCL
  • fibrinogen binding Source: MGI
  • fibronectin binding Source: MGI

GO - Biological processi

  • platelet formation Source: MGI
  • positive regulation of cold-induced thermogenesis Source: YuBioLab

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 2
Short name:
MFAP-2
Alternative name(s):
Microfibril-associated glycoprotein 1
Short name:
MAGP
Short name:
MAGP-1
Gene namesi
Name:Mfap2
Synonyms:Magp, Magp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99559 Mfap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Or 18Sequence analysisAdd BLAST16
ChainiPRO_000001868317 – 183Microfibrillar-associated protein 2Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Pyrrolidone carboxylic acidBy similarity1
Modified residuei46SulfotyrosineBy similarity1
Modified residuei47SulfotyrosineBy similarity1
Modified residuei49SulfotyrosineBy similarity1
Disulfide bondi153 ↔ 183PROSITE-ProRule annotation
Disulfide bondi160 ↔ 176PROSITE-ProRule annotation
Disulfide bondi169 ↔ 180PROSITE-ProRule annotation

Post-translational modificationi

Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.
O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

MaxQBiP55002
PaxDbiP55002
PeptideAtlasiP55002
PRIDEiP55002

PTM databases

iPTMnetiP55002
PhosphoSitePlusiP55002

Expressioni

Gene expression databases

CleanExiMM_MFAP2

Interactioni

Subunit structurei

Forms a ternary complex with BGN and ELN. Interacts with FBN1 (via N-terminal domain) and FBN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071868

Structurei

3D structure databases

SMRiP55002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 183ShKTPROSITE-ProRule annotationAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 70Gln/Glu-richAdd BLAST13

Sequence similaritiesi

Belongs to the MFAP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFBN Eukaryota
ENOG410YIKT LUCA
HOGENOMiHOG000231186
HOVERGENiHBG060871
InParanoidiP55002

Family and domain databases

InterProiView protein in InterPro
IPR008673 MAGP
IPR003582 ShKT_dom
PANTHERiPTHR16485 PTHR16485, 1 hit
PfamiView protein in Pfam
PF05507 MAGP, 1 hit
PROSITEiView protein in PROSITE
PS51670 SHKT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P55002-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAACLFLLF MPGLLAQGQY DLDPLPPFPD HVQYNHYGDQ IDNADYYDYQ
60 70 80 90 100
EVSPRTPEEQ FQSQQQVQQE VIPAPTPEPA AAGDLETEPT EPGPLDCREE
110 120 130 140 150
QYPCTRLYSI HKPCKQCLNE VCFYSLRRVY VVNKEICVRT VCAHEELLRA
160 170 180
DLCRDKFSKC GVMAVSGLCQ SVAASCARSC GGC
Length:183
Mass (Da):20,578
Last modified:October 1, 1996 - v1
Checksum:i1F193F2BE2EF1D05
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q99PM0Q99PM0_MOUSE
Microfibril-associated glycoprotein...
Mfap2 Magp1
185Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23769 mRNA Translation: AAA16448.1
BC035490 mRNA Translation: AAH35490.1
PIRiA49313
UniGeneiMm.7386

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23769 mRNA Translation: AAA16448.1
BC035490 mRNA Translation: AAH35490.1
PIRiA49313
UniGeneiMm.7386

3D structure databases

SMRiP55002
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071868

PTM databases

iPTMnetiP55002
PhosphoSitePlusiP55002

Proteomic databases

MaxQBiP55002
PaxDbiP55002
PeptideAtlasiP55002
PRIDEiP55002

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:99559 Mfap2

Phylogenomic databases

eggNOGiENOG410IFBN Eukaryota
ENOG410YIKT LUCA
HOGENOMiHOG000231186
HOVERGENiHBG060871
InParanoidiP55002

Miscellaneous databases

ChiTaRSiMfap2 mouse
PROiPR:P55002
SOURCEiSearch...

Gene expression databases

CleanExiMM_MFAP2

Family and domain databases

InterProiView protein in InterPro
IPR008673 MAGP
IPR003582 ShKT_dom
PANTHERiPTHR16485 PTHR16485, 1 hit
PfamiView protein in Pfam
PF05507 MAGP, 1 hit
PROSITEiView protein in PROSITE
PS51670 SHKT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMFAP2_MOUSE
AccessioniPrimary (citable) accession number: P55002
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again