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Protein

Microfibrillar-associated protein 2

Gene

MFAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the elastin-associated microfibrils.

GO - Molecular functioni

GO - Biological processi

  • embryonic eye morphogenesis Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • positive regulation of cold-induced thermogenesis Source: YuBioLab
  • post-embryonic eye morphogenesis Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-1566948 Elastic fibre formation
R-HSA-2129379 Molecules associated with elastic fibres
SignaLinkiP55001

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 2
Short name:
MFAP-2
Alternative name(s):
Microfibril-associated glycoprotein 1
Short name:
MAGP
Short name:
MAGP-1
Gene namesi
Name:MFAP2
Synonyms:MAGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117122.13
HGNCiHGNC:7033 MFAP2
MIMi156790 gene
neXtProtiNX_P55001

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4237
OpenTargetsiENSG00000117122
PharmGKBiPA30769

Polymorphism and mutation databases

BioMutaiMFAP2
DMDMi1708914

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Or 19Sequence analysisAdd BLAST17
ChainiPRO_000001868218 – 183Microfibrillar-associated protein 2Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Pyrrolidone carboxylic acidBy similarity1
Modified residuei47SulfotyrosineBy similarity1
Modified residuei48SulfotyrosineBy similarity1
Modified residuei50SulfotyrosineBy similarity1
Disulfide bondi153 ↔ 183PROSITE-ProRule annotation
Disulfide bondi160 ↔ 176PROSITE-ProRule annotation
Disulfide bondi169 ↔ 180PROSITE-ProRule annotation

Post-translational modificationi

Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.
O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

EPDiP55001
MaxQBiP55001
PaxDbiP55001
PeptideAtlasiP55001
PRIDEiP55001
ProteomicsDBi56750
56751 [P55001-2]
56752 [P55001-3]

PTM databases

iPTMnetiP55001
PhosphoSitePlusiP55001

Expressioni

Gene expression databases

BgeeiENSG00000117122 Expressed in 93 organ(s), highest expression level in endocervix
CleanExiHS_MFAP2
ExpressionAtlasiP55001 baseline and differential
GenevisibleiP55001 HS

Organism-specific databases

HPAiHPA007354

Interactioni

Subunit structurei

Forms a ternary complex with BGN and ELN. Interacts with FBN1 (via N-terminal domain) and FBN2.By similarity

Protein-protein interaction databases

BioGridi110395, 4 interactors
IntActiP55001, 1 interactor
STRINGi9606.ENSP00000364685

Structurei

3D structure databases

ProteinModelPortaliP55001
SMRiP55001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 183ShKTPROSITE-ProRule annotationAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 73Gln/Glu-richAdd BLAST15

Sequence similaritiesi

Belongs to the MFAP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFBN Eukaryota
ENOG410YIKT LUCA
GeneTreeiENSGT00390000017736
HOGENOMiHOG000231186
HOVERGENiHBG060871
InParanoidiP55001
OMAiHYNDQID
OrthoDBiEOG091G0UQX
PhylomeDBiP55001
TreeFamiTF333418

Family and domain databases

InterProiView protein in InterPro
IPR008673 MAGP
IPR003582 ShKT_dom
PANTHERiPTHR16485 PTHR16485, 1 hit
PfamiView protein in Pfam
PF05507 MAGP, 1 hit
PF01549 ShK, 1 hit
PROSITEiView protein in PROSITE
PS51670 SHKT, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: P55001-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAAYLFLLF LPAGLLAQGQ YDLDPLPPFP DHVQYTHYSD QIDNPDYYDY
60 70 80 90 100
QEVTPRPSEE QFQFQSQQQV QQEVIPAPTP EPGNAELEPT EPGPLDCREE
110 120 130 140 150
QYPCTRLYSI HRPCKQCLNE VCFYSLRRVY VINKEICVRT VCAHEELLRA
160 170 180
DLCRDKFSKC GVMASSGLCQ SVAASCARSC GSC
Length:183
Mass (Da):20,826
Last modified:October 1, 1996 - v1
Checksum:iA75BE15DC9629B26
GO
Isoform A' (identifier: P55001-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-13: Missing.

Show »
Length:182
Mass (Da):20,754
Checksum:iF8179D36FF49C25B
GO
Isoform B (identifier: P55001-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-42: Missing.

Show »
Length:153
Mass (Da):17,444
Checksum:i949A4852012F645A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04277913 – 42Missing in isoform B. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_04278013Missing in isoform A'. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19718 mRNA Translation: AAA79920.1
CR407678 mRNA Translation: CAG28606.1
AK222751 mRNA Translation: BAD96471.1
AL049569 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94821.1
BC015039 mRNA Translation: AAH15039.1
H27217 mRNA No translation available.
CCDSiCCDS174.1 [P55001-1]
CCDS44071.1 [P55001-2]
PIRiI38923
RefSeqiNP_001128719.1, NM_001135247.1 [P55001-2]
NP_001128720.1, NM_001135248.1 [P55001-2]
NP_002394.1, NM_002403.3 [P55001-1]
NP_059453.1, NM_017459.2 [P55001-1]
XP_011539778.1, XM_011541476.2
UniGeneiHs.389137

Genome annotation databases

EnsembliENST00000375534; ENSP00000364684; ENSG00000117122 [P55001-2]
ENST00000375535; ENSP00000364685; ENSG00000117122 [P55001-1]
GeneIDi4237
KEGGihsa:4237
UCSCiuc001azw.4 human [P55001-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19718 mRNA Translation: AAA79920.1
CR407678 mRNA Translation: CAG28606.1
AK222751 mRNA Translation: BAD96471.1
AL049569 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94821.1
BC015039 mRNA Translation: AAH15039.1
H27217 mRNA No translation available.
CCDSiCCDS174.1 [P55001-1]
CCDS44071.1 [P55001-2]
PIRiI38923
RefSeqiNP_001128719.1, NM_001135247.1 [P55001-2]
NP_001128720.1, NM_001135248.1 [P55001-2]
NP_002394.1, NM_002403.3 [P55001-1]
NP_059453.1, NM_017459.2 [P55001-1]
XP_011539778.1, XM_011541476.2
UniGeneiHs.389137

3D structure databases

ProteinModelPortaliP55001
SMRiP55001
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110395, 4 interactors
IntActiP55001, 1 interactor
STRINGi9606.ENSP00000364685

PTM databases

iPTMnetiP55001
PhosphoSitePlusiP55001

Polymorphism and mutation databases

BioMutaiMFAP2
DMDMi1708914

Proteomic databases

EPDiP55001
MaxQBiP55001
PaxDbiP55001
PeptideAtlasiP55001
PRIDEiP55001
ProteomicsDBi56750
56751 [P55001-2]
56752 [P55001-3]

Protocols and materials databases

DNASUi4237
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375534; ENSP00000364684; ENSG00000117122 [P55001-2]
ENST00000375535; ENSP00000364685; ENSG00000117122 [P55001-1]
GeneIDi4237
KEGGihsa:4237
UCSCiuc001azw.4 human [P55001-1]

Organism-specific databases

CTDi4237
DisGeNETi4237
EuPathDBiHostDB:ENSG00000117122.13
GeneCardsiMFAP2
HGNCiHGNC:7033 MFAP2
HPAiHPA007354
MIMi156790 gene
neXtProtiNX_P55001
OpenTargetsiENSG00000117122
PharmGKBiPA30769
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFBN Eukaryota
ENOG410YIKT LUCA
GeneTreeiENSGT00390000017736
HOGENOMiHOG000231186
HOVERGENiHBG060871
InParanoidiP55001
OMAiHYNDQID
OrthoDBiEOG091G0UQX
PhylomeDBiP55001
TreeFamiTF333418

Enzyme and pathway databases

ReactomeiR-HSA-1566948 Elastic fibre formation
R-HSA-2129379 Molecules associated with elastic fibres
SignaLinkiP55001

Miscellaneous databases

GeneWikiiMFAP2
GenomeRNAii4237
PROiPR:P55001
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117122 Expressed in 93 organ(s), highest expression level in endocervix
CleanExiHS_MFAP2
ExpressionAtlasiP55001 baseline and differential
GenevisibleiP55001 HS

Family and domain databases

InterProiView protein in InterPro
IPR008673 MAGP
IPR003582 ShKT_dom
PANTHERiPTHR16485 PTHR16485, 1 hit
PfamiView protein in Pfam
PF05507 MAGP, 1 hit
PF01549 ShK, 1 hit
PROSITEiView protein in PROSITE
PS51670 SHKT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMFAP2_HUMAN
AccessioniPrimary (citable) accession number: P55001
Secondary accession number(s): Q53X60, Q5JXY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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