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Entry version 172 (02 Dec 2020)
Sequence version 2 (15 Jul 1998)
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Protein

Secreted Ly-6/uPAR-related protein 1

Gene

SLURP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca2+ signaling (PubMed:17286989). Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).By similarity2 Publications4 Publications

Caution

It is not certain that ARS and ANUP are identical proteins.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acetylcholine receptor activator activity Source: UniProtKB
  • cytokine activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P55000

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.31.1.3, the ly-6 neurotoxin-like protein1 precursor (lynx1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secreted Ly-6/uPAR-related protein 1
Short name:
SLURP-1
Alternative name(s):
ARS component B
ARS(component B)-81/S
Anti-neoplastic urinary protein
Short name:
ANUP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLURP1
Synonyms:ARS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000126233.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18746, SLURP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606119, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mal de Meleda (MDM)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03287115W → R in MDM; no expression of the protein. 4 PublicationsCorresponds to variant dbSNP:rs121908318EnsemblClinVar.1
Natural variantiVAR_03287271R → H in MDM; reduced expression of the protein; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs1448017161Ensembl.1
Natural variantiVAR_07730771R → P in MDM; decreased secretion. 2 Publications1
Natural variantiVAR_03287377C → R in MDM; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs121908319EnsemblClinVar.1
Natural variantiVAR_07730882P → S in MDM; unknown pathological significance; no effect on secretion. 2 PublicationsCorresponds to variant dbSNP:rs1181208026Ensembl.1
Natural variantiVAR_03287486G → R in MDM; reduced expression of the protein. 2 PublicationsCorresponds to variant dbSNP:rs28937888EnsemblClinVar.1
Natural variantiVAR_07730994C → S in MDM; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs772388665Ensembl.1
Natural variantiVAR_07731098L → P in MDM; decreased secretion. 2 Publications1
Natural variantiVAR_03287599C → Y in MDM. 1 PublicationCorresponds to variant dbSNP:rs121908320EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
57152

MalaCards human disease database

More...
MalaCardsi
SLURP1
MIMi248300, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000126233

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
86923, Hereditary palmoplantar keratoderma, Gamborg-Nielsen type
87503, Mal de Meleda

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134936818

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P55000, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLURP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3287957

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003616723 – 103Secreted Ly-6/uPAR-related protein 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 50Sequence analysisBy similarity1 Publication
Disulfide bondi28 ↔ 37Sequence analysisBy similarity1 Publication
Disulfide bondi43 ↔ 73Sequence analysisBy similarity1 Publication
Disulfide bondi77 ↔ 93Sequence analysisBy similarity1 Publication
Disulfide bondi94 ↔ 99Sequence analysisBy similarity1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P55000

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P55000

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55000

PeptideAtlas

More...
PeptideAtlasi
P55000

PRoteomics IDEntifications database

More...
PRIDEi
P55000

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56749

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55000

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P55000

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Regulated by retinoic acid, EGF and IFNG/IFN-gamma (PubMed:14721776). Down-regulated by IL-13 in cultured human bronchial epithelial cells (related to asthmatic condition) (PubMed:20621062).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126233, Expressed in lower esophagus mucosa and 109 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P55000, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000126233, Group enriched (esophagus, lymphoid tissue, skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with PLAU (PubMed:25168896).

Interacts with CHRNA7 (PubMed:26905431).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121409, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P55000, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000246515

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P55000, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55000

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 73UPAR/Ly6Add BLAST50

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TDUY, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162933

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_141358_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55000

Identification of Orthologs from Complete Genome Data

More...
OMAi
GEAFRCY

Database of Orthologous Groups

More...
OrthoDBi
1592016at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55000

TreeFam database of animal gene trees

More...
TreeFami
TF336080

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00117, LU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016054, LY6_UPA_recep-like
IPR027103, SLURP1

The PANTHER Classification System

More...
PANTHERi
PTHR10036:SF9, PTHR10036:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00021, UPAR_LY6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P55000-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC
60 70 80 90 100
MTTLVTVEAE YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN

SEL
Length:103
Mass (Da):11,186
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07AAF6BCA8031282
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17M → V in AAT01436 (PubMed:16354194).Curated1
Sequence conflicti22A → Q AA sequence (PubMed:8742060).Curated1
Sequence conflicti36S → A AA sequence (PubMed:8742060).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03287115W → R in MDM; no expression of the protein. 4 PublicationsCorresponds to variant dbSNP:rs121908318EnsemblClinVar.1
Natural variantiVAR_03287271R → H in MDM; reduced expression of the protein; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs1448017161Ensembl.1
Natural variantiVAR_07730771R → P in MDM; decreased secretion. 2 Publications1
Natural variantiVAR_03287377C → R in MDM; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs121908319EnsemblClinVar.1
Natural variantiVAR_07730882P → S in MDM; unknown pathological significance; no effect on secretion. 2 PublicationsCorresponds to variant dbSNP:rs1181208026Ensembl.1
Natural variantiVAR_03287486G → R in MDM; reduced expression of the protein. 2 PublicationsCorresponds to variant dbSNP:rs28937888EnsemblClinVar.1
Natural variantiVAR_07730994C → S in MDM; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs772388665Ensembl.1
Natural variantiVAR_07731098L → P in MDM; decreased secretion. 2 Publications1
Natural variantiVAR_03287599C → Y in MDM. 1 PublicationCorresponds to variant dbSNP:rs121908320EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X99977 Genomic DNA Translation: CAA68237.1
AY579079 mRNA Translation: AAT01436.1
AY579080 mRNA Translation: AAT01437.1
BC069292 mRNA Translation: AAH69292.1
BC105133 mRNA Translation: AAI05134.1
BC105135 mRNA Translation: AAI05136.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6387.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A59031

NCBI Reference Sequences

More...
RefSeqi
NP_065160.1, NM_020427.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000246515; ENSP00000246515; ENSG00000126233

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57152

UCSC genome browser

More...
UCSCi
uc003ywy.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99977 Genomic DNA Translation: CAA68237.1
AY579079 mRNA Translation: AAT01436.1
AY579080 mRNA Translation: AAT01437.1
BC069292 mRNA Translation: AAH69292.1
BC105133 mRNA Translation: AAI05134.1
BC105135 mRNA Translation: AAI05136.1
CCDSiCCDS6387.1
PIRiA59031
RefSeqiNP_065160.1, NM_020427.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MUONMR-A23-103[»]
2MUPNMR-A23-103[»]
SMRiP55000
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121409, 1 interactor
IntActiP55000, 3 interactors
STRINGi9606.ENSP00000246515

Protein family/group databases

TCDBi8.A.31.1.3, the ly-6 neurotoxin-like protein1 precursor (lynx1) family

PTM databases

iPTMnetiP55000
PhosphoSitePlusiP55000

Polymorphism and mutation databases

BioMutaiSLURP1
DMDMi3287957

Proteomic databases

jPOSTiP55000
MassIVEiP55000
PaxDbiP55000
PeptideAtlasiP55000
PRIDEiP55000
ProteomicsDBi56749

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27784, 150 antibodies

Genome annotation databases

EnsembliENST00000246515; ENSP00000246515; ENSG00000126233
GeneIDi57152
KEGGihsa:57152
UCSCiuc003ywy.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57152
DisGeNETi57152
EuPathDBiHostDB:ENSG00000126233.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLURP1
HGNCiHGNC:18746, SLURP1
HPAiENSG00000126233, Group enriched (esophagus, lymphoid tissue, skin, tongue)
MalaCardsiSLURP1
MIMi248300, phenotype
606119, gene
neXtProtiNX_P55000
OpenTargetsiENSG00000126233
Orphaneti86923, Hereditary palmoplantar keratoderma, Gamborg-Nielsen type
87503, Mal de Meleda
PharmGKBiPA134936818

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502TDUY, Eukaryota
GeneTreeiENSGT00940000162933
HOGENOMiCLU_141358_2_1_1
InParanoidiP55000
OMAiGEAFRCY
OrthoDBi1592016at2759
PhylomeDBiP55000
TreeFamiTF336080

Enzyme and pathway databases

PathwayCommonsiP55000

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57152, 7 hits in 838 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLURP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57152
PharosiP55000, Tbio

Protein Ontology

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PROi
PR:P55000
RNActiP55000, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000126233, Expressed in lower esophagus mucosa and 109 other tissues
GenevisibleiP55000, HS

Family and domain databases

CDDicd00117, LU, 1 hit
InterProiView protein in InterPro
IPR016054, LY6_UPA_recep-like
IPR027103, SLURP1
PANTHERiPTHR10036:SF9, PTHR10036:SF9, 1 hit
PfamiView protein in Pfam
PF00021, UPAR_LY6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLUR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55000
Secondary accession number(s): Q53YJ6, Q6PUA6, Q92483
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: December 2, 2020
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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