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Entry version 80 (07 Oct 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Phytoene dehydrogenase

Gene

crtI

Organism
Streptomyces griseus
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme converts phytoene into zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADCurated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: lycopene biosynthesis

This protein is involved in the pathway lycopene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway lycopene biosynthesis and in Carotenoid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi12 – 45FADSequence analysisAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processCarotenoid biosynthesis
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:MONOMER-20342

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00803

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phytoene dehydrogenase (EC:1.3.99.-)
Alternative name(s):
Phytoene desaturase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:crtI
Synonyms:crtE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces griseus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1911 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000676921 – 507Phytoene dehydrogenaseAdd BLAST507

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P54981

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54981

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002937, Amino_oxidase
IPR014105, Carotenoid/retinoid_OxRdtase
IPR036188, FAD/NAD-bd_sf
IPR008150, Phytoene_DH_bac_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01593, Amino_oxidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905, SSF51905, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02734, crtI_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00982, PHYTOENE_DH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P54981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITVKGPVDH VVVVGAGLAG LAAALHLLGA GRRVTVVERE DVPGGRAGLL
60 70 80 90 100
ESGGFRIDTG PTVLTMPDLV EDAFAAVGER MADRLELIRL APAYRARFAD
110 120 130 140 150
GSQLDVHTDG AAMEAAVEEF AGARQAVGYR RLRIWLERLY RVQMRRFIDT
160 170 180 190 200
NFDSPLQLAH PDLARLAALG GFGRLDARIG HFVSDERLRR VFSFQALYAG
210 220 230 240 250
VPPARALAAY AVIAYMDTVA GVYFPRGGMH ALPRAMADAA SDAGAVLRYG
260 270 280 290 300
QRVTRLERSG DRVTAVVTDQ EHIPCDAVVL TPDLPVSYRL LGRTPHRPLP
310 320 330 340 350
LRHSPSAVIL HTGTDRTWPD LAHHTISFGA AWKNTFHELT RTGRLMSDPS
360 370 380 390 400
LLITRPTATD PSLAPPGKHL HYVLAPCPNT EVGPGVREWR ELGPRYRDEL
410 420 430 440 450
LAELERREMP GLGAAIEEEG LVTPVDWTAQ GHAAGTPFSV AHTFPQTGPF
460 470 480 490 500
RPRNLVRGTV NAVLAGCGTT PGVGVPTVLI SGKLAAERIT GPRIARAPRS

APGGSSA
Length:507
Mass (Da):54,509
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBB97F7FE696B2AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33R → S in BAA09537 (Ref. 1) Curated1
Sequence conflicti39 – 41RED → QEG in BAA09537 (Ref. 1) Curated3
Sequence conflicti52 – 53SG → TD in BAA09537 (Ref. 1) Curated2
Sequence conflicti57I → V in BAA09537 (Ref. 1) Curated1
Sequence conflicti72D → E in BAA09537 (Ref. 1) Curated1
Sequence conflicti80R → P in BAA09537 (Ref. 1) Curated1
Sequence conflicti91A → D in BAA09537 (Ref. 1) Curated1
Sequence conflicti119E → Q in BAA09537 (Ref. 1) Curated1
Sequence conflicti150T → A in BAA09537 (Ref. 1) Curated1
Sequence conflicti156L → F in BAA09537 (Ref. 1) Curated1
Sequence conflicti159A → V in BAA09537 (Ref. 1) Curated1
Sequence conflicti241S → A in BAA09537 (Ref. 1) Curated1
Sequence conflicti246 – 247VL → SF in BAA09537 (Ref. 1) Curated2
Sequence conflicti252R → S in BAA09537 (Ref. 1) Curated1
Sequence conflicti272 – 274HIP → RIA in BAA09537 (Ref. 1) Curated3
Sequence conflicti294T → S in BAA09537 (Ref. 1) Curated1
Sequence conflicti312T → A in BAA09537 (Ref. 1) Curated1
Sequence conflicti320D → N in BAA09537 (Ref. 1) Curated1
Sequence conflicti334N → S in BAA09537 (Ref. 1) Curated1
Sequence conflicti344R → E in BAA09537 (Ref. 1) Curated1
Sequence conflicti359T → S in BAA09537 (Ref. 1) Curated1
Sequence conflicti367G → S in BAA09537 (Ref. 1) Curated1
Sequence conflicti414A → S in BAA09537 (Ref. 1) Curated1
Sequence conflicti418E → V in BAA09537 (Ref. 1) Curated1
Sequence conflicti453R → G in BAA09537 (Ref. 1) Curated1
Sequence conflicti487E → Q in BAA09537 (Ref. 1) Curated1
Sequence conflicti493 – 507RIARA…GGSSA → PPFRDPAREVLSHDRP in BAA09537 (Ref. 1) CuratedAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D55723 Genomic DNA Translation: BAA09537.1
L37405 Genomic DNA Translation: AAA91950.1
X95596 Genomic DNA Translation: CAA64850.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55723 Genomic DNA Translation: BAA09537.1
L37405 Genomic DNA Translation: AAA91950.1
X95596 Genomic DNA Translation: CAA64850.1

3D structure databases

SMRiP54981
ModBaseiSearch...

Proteomic databases

PRIDEiP54981

Enzyme and pathway databases

UniPathwayiUPA00803
BioCyciMetaCyc:MONOMER-20342

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR002937, Amino_oxidase
IPR014105, Carotenoid/retinoid_OxRdtase
IPR036188, FAD/NAD-bd_sf
IPR008150, Phytoene_DH_bac_CS
PfamiView protein in Pfam
PF01593, Amino_oxidase, 1 hit
SUPFAMiSSF51905, SSF51905, 1 hit
TIGRFAMsiTIGR02734, crtI_fam, 1 hit
PROSITEiView protein in PROSITE
PS00982, PHYTOENE_DH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRTI_STRGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54981
Secondary accession number(s): P54971, P72447
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 7, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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