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Protein

Oligoribonuclease, mitochondrial

Gene

REX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

3'-to-5' exoribonuclease specific for small oligoribonucleotides.By similarity

Miscellaneous

Present with 1730 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184Sequence analysis1

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: SGD
  • 3'-5'-exoribonuclease activity Source: SGD
  • nucleic acid binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciYEAST:G3O-32213-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Oligoribonuclease, mitochondrial (EC:3.1.-.-)
Gene namesi
Name:REX2
Synonyms:YNT20
Ordered Locus Names:YLR059C
ORF Names:L2159
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR059C
SGDiS000004049 REX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020274? – 269Oligoribonuclease, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP54964
PaxDbiP54964
PRIDEiP54964

PTM databases

iPTMnetiP54964

Interactioni

Protein-protein interaction databases

BioGridi31334, 98 interactors
DIPiDIP-5084N
IntActiP54964, 5 interactors
STRINGi4932.YLR059C

Structurei

3D structure databases

ProteinModelPortaliP54964
SMRiP54964
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 227ExonucleaseAdd BLAST173

Sequence similaritiesi

Belongs to the oligoribonuclease family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000009255
HOGENOMiHOG000246596
InParanoidiP54964
KOiK13288
OrthoDBiEOG092C4ZN4

Family and domain databases

CDDicd06135 Orn, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR022894 Oligoribonuclease
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54964-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWLLFPARI VARTRPNLFS LYRRSVSQYL RPRTIQNLQS MAQTPELKTK
60 70 80 90 100
LFKPLVWIDC EMTGLDHVND RIIEICCIIT DGHLAPVKAA DGQGDSHYES
110 120 130 140 150
VIHYGPEVMN KMNEWCIEHH GNSGLTAKVL ASEKTLAQVE DELLEYIQRY
160 170 180 190 200
IPDKNVGVLA GNSVHMDRLF MVREFPKVID HLFYRIVDVS SIMEVARRHN
210 220 230 240 250
PALQARNPKK EAAHTAYSDI KESIAQLQWY MDNYLKPPQE TESVESIGSE
260
QPESPSSSTS SLKRQRTDF
Length:269
Mass (Da):30,870
Last modified:October 1, 1996 - v1
Checksum:iC942C823691E9815
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100S → T in AAA98633 (Ref. 1) Curated1
Sequence conflicti124 – 127GLTA → ESHP in AAA98633 (Ref. 1) Curated4
Sequence conflicti181H → R in AAT93024 (PubMed:17322287).Curated1
Sequence conflicti223 – 269SIAQL…QRTDF → HSSIAMVHGQLLEATTGNRV GRVNRI (Ref. 1) CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47977 Genomic DNA Translation: AAA98633.1
X94607 Genomic DNA Translation: CAA64306.1
Z73231 Genomic DNA Translation: CAA97590.1
AY693005 Genomic DNA Translation: AAT93024.1
BK006945 Genomic DNA Translation: DAA09377.1
PIRiS61633
RefSeqiNP_013160.1, NM_001181946.1

Genome annotation databases

EnsemblFungiiYLR059C; YLR059C; YLR059C
GeneIDi850748
KEGGisce:YLR059C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47977 Genomic DNA Translation: AAA98633.1
X94607 Genomic DNA Translation: CAA64306.1
Z73231 Genomic DNA Translation: CAA97590.1
AY693005 Genomic DNA Translation: AAT93024.1
BK006945 Genomic DNA Translation: DAA09377.1
PIRiS61633
RefSeqiNP_013160.1, NM_001181946.1

3D structure databases

ProteinModelPortaliP54964
SMRiP54964
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31334, 98 interactors
DIPiDIP-5084N
IntActiP54964, 5 interactors
STRINGi4932.YLR059C

PTM databases

iPTMnetiP54964

Proteomic databases

MaxQBiP54964
PaxDbiP54964
PRIDEiP54964

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR059C; YLR059C; YLR059C
GeneIDi850748
KEGGisce:YLR059C

Organism-specific databases

EuPathDBiFungiDB:YLR059C
SGDiS000004049 REX2

Phylogenomic databases

GeneTreeiENSGT00390000009255
HOGENOMiHOG000246596
InParanoidiP54964
KOiK13288
OrthoDBiEOG092C4ZN4

Enzyme and pathway databases

BioCyciYEAST:G3O-32213-MONOMER

Miscellaneous databases

PROiPR:P54964

Family and domain databases

CDDicd06135 Orn, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR022894 Oligoribonuclease
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiORN_YEAST
AccessioniPrimary (citable) accession number: P54964
Secondary accession number(s): D6VY61, E9P909
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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