UniProtKB - P54958 (ASP2_BLAGE)
Protein
Aspartic protease Bla g 2
Gene
N/A
Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Functioni
Functions as a digestive enzyme in the cockroach.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 55 | By similarity | 1 | |
Metal bindingi | 178 | Zinc | 1 | |
Metal bindingi | 186 | Zinc | 1 | |
Active sitei | 239 | By similarity | 1 | |
Metal bindingi | 326 | Zinc | 1 | |
Metal bindingi | 330 | Zinc | 1 |
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Aspartyl protease, Hydrolase, Protease |
Ligand | Metal-binding, Zinc |
Protein family/group databases
MEROPSi | A01.950 |
Names & Taxonomyi
Protein namesi | Recommended name: Aspartic protease Bla g 2 (EC:3.4.23.-)Alternative name(s): Allergen Bla g II Allergen: Bla g 2 |
Organismi | Blattella germanica (German cockroach) (Blatta germanica) |
Taxonomic identifieri | 6973 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Polyneoptera › Dictyoptera › Blattodea › Blaberoidea › Ectobiidae › Blattellinae › Blattella |
Pathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human. Binds to IgE.
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 141, Bla g 2 3140, Bla g 2.0101 4012, Bla g 2.0201 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
PropeptideiPRO_0000025935 | 20 – 24 | Removed in mature form | 5 | |
ChainiPRO_0000025936 | 25 – 352 | Aspartic protease Bla g 2Add BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 59 ↔ 151 | |||
Disulfide bondi | 68 ↔ 73 | |||
Disulfide bondi | 75 ↔ 136 | |||
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 261 ↔ 272 | |||
Disulfide bondi | 276 ↔ 309 | |||
Glycosylationi | 295 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 340 | N-linked (GlcNAc...) asparagine2 Publications | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenPTM databases
iPTMneti | P54958 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P54958 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P54958 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 346 | Peptidase A1PROSITE-ProRule annotationAdd BLAST | 308 |
Sequence similaritiesi
Belongs to the peptidase A1 family.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd05471, pepsin_like, 1 hit |
Gene3Di | 2.40.70.10, 2 hits |
InterProi | View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR034164, Pepsin-like_dom IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf |
PANTHERi | PTHR13683, PTHR13683, 1 hit |
Pfami | View protein in Pfam PF00026, Asp, 1 hit |
PRINTSi | PR00792, PEPSIN |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS51767, PEPTIDASE_A1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P54958-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIGLKLVTVL FAVATITHAA ELQRVPLYKL VHVFINTQYA GITKIGNQNF
60 70 80 90 100
LTVFDSTSCN VVVASQECVG GACVCPNLQK YEKLKPKYIS DGNVQVKFFD
110 120 130 140 150
TGSAVGRGIE DSLTISNLTT SQQDIVLADE LSQEVCILSA DVVVGIAAPG
160 170 180 190 200
CPNALKGKTV LENFVEENLI APVFSIHHAR FQDGEHFGEI IFGGSDWKYV
210 220 230 240 250
DGEFTYVPLV GDDSWKFRLD GVKIGDTTVA PAGTQAIIDT SKAIIVGPKA
260 270 280 290 300
YVNPINEAIG CVVEKTTTRR ICKLDCSKIP SLPDVTFVIN GRNFNISSQY
310 320 330 340 350
YIQQNGNLCY SGFQPCGHSD HFFIGDFFVD HYYSEFNWEN KTMGFGRSVE
SV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | L → I in ABP35603 (Ref. 2) Curated | 1 | |
Sequence conflicti | 87 | K → R in ABP35603 (Ref. 2) Curated | 1 | |
Sequence conflicti | 116 | S → F in ABP35603 (Ref. 2) Curated | 1 | |
Sequence conflicti | 142 | V → G in ABP35603 (Ref. 2) Curated | 1 | |
Sequence conflicti | 342 | T → A in ABP35603 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28863 mRNA Translation: AAA86744.1 EF203068 mRNA Translation: ABP35603.1 |
PIRi | A57164 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28863 mRNA Translation: AAA86744.1 EF203068 mRNA Translation: ABP35603.1 |
PIRi | A57164 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YG9 | X-ray | 1.30 | A | 25-348 | [»] | |
2NR6 | X-ray | 2.81 | A/B | 25-343 | [»] | |
3LIZ | X-ray | 1.80 | A | 25-352 | [»] | |
4RLD | X-ray | 2.90 | A/B/C/D | 25-350 | [»] | |
SMRi | P54958 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
Allergomei | 141, Bla g 2 3140, Bla g 2.0101 4012, Bla g 2.0201 |
MEROPSi | A01.950 |
PTM databases
iPTMneti | P54958 |
Protocols and materials databases
ABCDi | P54958, 2 sequenced antibodies |
Miscellaneous databases
EvolutionaryTracei | P54958 |
Family and domain databases
CDDi | cd05471, pepsin_like, 1 hit |
Gene3Di | 2.40.70.10, 2 hits |
InterProi | View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR034164, Pepsin-like_dom IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf |
PANTHERi | PTHR13683, PTHR13683, 1 hit |
Pfami | View protein in Pfam PF00026, Asp, 1 hit |
PRINTSi | PR00792, PEPSIN |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS51767, PEPTIDASE_A1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ASP2_BLAGE | |
Accessioni | P54958Primary (citable) accession number: P54958 Secondary accession number(s): B0L0M0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | June 17, 2020 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Allergens
Nomenclature of allergens and list of entries - Peptidase families
Classification of peptidase families and list of entries