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UniProtKB - P54939 (TLN1_CHICK)

Protein

Talin-1

Gene

TLN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Talin-1
Gene namesi
Name:TLN1
Synonyms:TLN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194301 – 2541Talin-1Add BLAST2541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_0001551486O-linked (GlcNAc) threonine1 Publication1
GlycosylationiCAR_0001561889O-linked (GlcNAc) threonine1 Publication1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP54939
PRIDEiP54939

PTM databases

GlyConnecti584
UniCarbKBiP54939

Interactioni

Subunit structurei

Interacts with PIP5K1C and NRAP (By similarity). Binds with high affinity to vinculin VCL and with low affinity to integrins (PubMed:14702644, PubMed:12535520, PubMed:8937989, PubMed:20610383). Interacts with APBB1IP; this inhibits VCL binding (By similarity). Interacts with F-actin (PubMed:8937989). Interacts with LAYN (PubMed:9786953).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB3P051062EBI-1035421,EBI-702847From Homo sapiens.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

DIPiDIP-35571N
ELMiP54939
IntActiP54939, 4 interactors
STRINGi9031.ENSGALP00000038501

Structurei

Secondary structure

12541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP54939
SMRiP54939
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54939

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 403FERMPROSITE-ProRule annotationAdd BLAST318
Domaini2292 – 2531I/LWEQPROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni280 – 435Interaction with LAYN1 PublicationAdd BLAST156
Regioni1358 – 1658Interaction with VCL and F-actinBy similarityAdd BLAST301

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi672 – 681Poly-Ala10
Compositional biasi1335 – 1340Poly-Ala6

Phylogenomic databases

eggNOGiKOG4261 Eukaryota
ENOG410XQ0V LUCA
HOVERGENiHBG023870
InParanoidiP54939
KOiK06271
PhylomeDBiP54939

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd12150 talin-RS, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR032425 FERM_f0
IPR018979 FERM_N
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR011993 PH-like_dom_sf
IPR037438 Talin1/2-RS
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR029071 Ubiquitin-like_domsf
IPR015009 Vinculin-bd_dom
PfamiView protein in Pfam
PF16511 FERM_f0, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF01608 I_LWEQ, 1 hit
PF09141 Talin_middle, 1 hit
PF08913 VBS, 2 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011820 ILWEQ, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00307 ILWEQ, 1 hit
SUPFAMiSSF109880 SSF109880, 1 hit
SSF109885 SSF109885, 4 hits
SSF47031 SSF47031, 1 hit
SSF47220 SSF47220, 5 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50945 I_LWEQ, 1 hit

Sequencei

Sequence statusi: Complete.

P54939-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVALSLKISI GNVVKTMQFE PSTMVYDACR MIRERVPEAQ MGQPNDFGLF 
        60         70         80         90        100
LSDEDPKKGI WLEAGKALDY YMLRNGDTME YKKKQRPLKI RMLDGTVKTV 
       110        120        130        140        150
MVDDSKTVTD MLTTICARIG ITNYDEYSLV REIMEEKKEE VTGTLKKDKT 
       160        170        180        190        200
LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL REQGIDDNET LLLRRKFFYS 
       210        220        230        240        250
DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG YQCQIQFGPH 
       260        270        280        290        300
NEQKHKPGFL ELKDFLPKEY IKQKGERKIF MAHKNCGNMS EIEAKVRYVK 
       310        320        330        340        350
LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE 
       360        370        380        390        400
WSLTNIKRWA ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL 
       410        420        430        440        450
KKKKSKDHFG LEGDEESTML EDSVSPKKST VLQQQFNRVG KAELGSVALP 
       460        470        480        490        500
AIMRTGAGGP ENFQVGTMPQ AQMQITSGQM HRGHMPPLTS AQQALTGTIN 
       510        520        530        540        550
SSMQAVNAAQ ATLDDFETLP PLGQDAASKA WRKNKMDESK HEIHSQADAI 
       560        570        580        590        600
TAGTASVVNL TAGDPADTDY TAVGCAVTTI SSNLTEMSKG VKLLAALMED 
       610        620        630        640        650
EGGNGRQLLQ AAKNLASAVS DLLKTAQPAS AEPRQNLLQA AGLVGQTSGE 
       660        670        680        690        700
LLQQIGESDT DPRFQDMLMQ LAKAVASAAA ALVLKAKNVA QKTEDSALQT 
       710        720        730        740        750
QVIAAATQCA LSTSQLVACT KVVAPTISSP VCQEQLIEAG KLVAKSAEGC 
       760        770        780        790        800
VEASKAATND DQLLKQVGVA ATAVTQALND LLQHIKQHAT GGQPIGRYDQ 
       810        820        830        840        850
ATDTILNVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI KADAEGETDL 
       860        870        880        890        900
ENSRKLLSAA KILADATAKM VEAAKGAAAH PDSEEQQQRL REAAEGLRMA 
       910        920        930        940        950
TNAAAQNAIK KKLVHKLEHA AKQAAASATQ TIAAAQHAAA SNKNPAAQQQ 
       960        970        980        990       1000
LVQSCKVVAD QIPMLVQGVR GSQSQPDSPS AQLALIAASQ NFLQPGGKMV 
      1010       1020       1030       1040       1050
AAAKATVPTI TDQASAMQLS QCAKNLAAAL AELRTAAQKA QEACGPLEID 
      1060       1070       1080       1090       1100
SALGLVQSLE RDLKEAKAAA RDGKLKPLPG ETMEKCAQDL GNSTKAVTSA 
      1110       1120       1130       1140       1150
IAHLLGEVAQ GNENYTGIAA REVAQALRSL SQAARGVAAN SSDPQAQNAM 
      1160       1170       1180       1190       1200
LECASDVMDK ANNLIEEARK AVAKPGDPDS QQRLVQVAKA VSQALNRCVN 
      1210       1220       1230       1240       1250
CLPGQRDVDA AIRMVGEASK RLLSDSFPPS NKTFQEAQSQ LNRAAAGLNQ 
      1260       1270       1280       1290       1300
SANELVQASR GTPQDLAKSS GKFGQDFNEF LQAGVEMASL SPTKEDQAQV 
      1310       1320       1330       1340       1350
VSNLKSISMS SSKLLLAAKA LSADPTSPNL KSQLAAAARA VTDSINQLIT 
      1360       1370       1380       1390       1400
MCTQQAPGQK ECDNALRELE TVKELLENPT QTVNDMSYFS CLDSVMENSK 
      1410       1420       1430       1440       1450
VLGESMAGIS QNAKNSKLPE FGESISAASK ALCGLTEAAA QAAYLVGVSD 
      1460       1470       1480       1490       1500
PNSQAGQQGL VDPTQFARAN QAIQMACQNL VDPACTQSQV LSAATIVAKH 
      1510       1520       1530       1540       1550
TSALCNTCRL ASSRTANPVA KRQFVQPAKE VANSTANLVK TIKALDGAFN 
      1560       1570       1580       1590       1600
EENRERCRAA TAPLIEAVDN LTAFASNPEF ATVPAQISPE GRRAMEPIVT 
      1610       1620       1630       1640       1650
SAKTMLESSA GLIQTARSLA VNPKDPPQWS VLAGHSRTVS DSIKKLITNM 
      1660       1670       1680       1690       1700
RDKAPGQREC DEAIDVLNRC MREVDQASLA AISQQLAPRE GISQEALHNQ 
      1710       1720       1730       1740       1750
MITAVQEINN LIEPVASAAR AEASQLGHKV SQMAQYFEPL ILAAIGAASK 
      1760       1770       1780       1790       1800
TPNHQQQMNL LDQTKTLAES ALQMLYTAKE AGGNPKQAAH TQEALEEAVQ 
      1810       1820       1830       1840       1850
MMKEAVEDLT TTLNEAASAA GVVGGMVDSI TQAINQLDEG PMGEPEGTFV 
      1860       1870       1880       1890       1900
DYQTTMVKTA KAIAVTVQEM VTKSTTNPDE LGILANQLTN DYGQLAQQAK 
      1910       1920       1930       1940       1950
PAALTAENEE IGSHIKRRVQ ELGHGCAALV TKAGALQCSP SDAYTKKELI 
      1960       1970       1980       1990       2000
ESARKVSEKV SHVLAALQAG NRGTQACITA ASAVSGIIAD LDTTIMFATA 
      2010       2020       2030       2040       2050
GTLNRENSET FADHREGILK TAKALVEDTK VLVQNATASQ EKLAQAAQSS 
      2060       2070       2080       2090       2100
VSTITRLAEV VKLGAASLGS EDPETQVVLI NAVKDVAKAL GDLIGATKAA 
      2110       2120       2130       2140       2150
AGKAGDDPAV YQLKNSAKVM VTNVTSLLKT VKAVEDEATK GTRALEATIE 
      2160       2170       2180       2190       2200
HIRQELAVFS SPVPPAQVST PEDFIRMTKG ITMATAKAVA AGNSCRQEDV 
      2210       2220       2230       2240       2250
IATANLSRRA IADMLRACKE AAYHPEVSAD VRQRALRFGK ECADGYLELL 
      2260       2270       2280       2290       2300
EHVLVILQKP THELKQQLAG YSKRVASSVT ELIQAAEAMK GTEWVDPEDP 
      2310       2320       2330       2340       2350
TVIAENELLG AAAAIEAAAK KLEQLKPRAK PKQADESLDF EEQILEAAKS 
      2360       2370       2380       2390       2400
IAAATSALVK AASAAQRELV AQGKVGVIPA NAVDDGQWSQ GLISAARMVA 
      2410       2420       2430       2440       2450
AATNNLCEAA NAAVQGHASE EKLISSAKQV AASTAQLLVA CKVKADHDSE 
      2460       2470       2480       2490       2500
AMKRLQAAGN AVKRASDNLV KAAQKAAAFQ DHDETVVVKE KMVGGIAQII 
      2510       2520       2530       2540 
AAQEEMLRKE RELEEARKKL AMIRQQQYKF LPTELRDEEQ N
Length:2,541
Mass (Da):271,842
Last modified:November 8, 2005 - v2
Checksum:i5A94C290C624699E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150847 mRNA Translation: AAN75275.1
PIRiB42965
D42965
RefSeqiNP_989854.1, NM_204523.1
UniGeneiGga.4319

Genome annotation databases

GeneIDi395194
KEGGigga:395194

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150847 mRNA Translation: AAN75275.1
PIRiB42965
D42965
RefSeqiNP_989854.1, NM_204523.1
UniGeneiGga.4319

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MIXX-ray1.75A196-400[»]
1MIZX-ray1.90B200-400[»]
1MK7X-ray2.20B/D209-400[»]
1MK9X-ray2.80B/D/F/H209-400[»]
1RKCX-ray2.70B1944-1969[»]
1U6HX-ray2.38B849-879[»]
1XWJX-ray2.60B1944-1969[»]
1ZVZX-ray1.80B820-844[»]
1ZW2X-ray2.10B2344-2368[»]
2H7DNMR-A309-405[»]
2H7ENMR-A309-405[»]
2HRJNMR-A189-309[»]
2K00NMR-A309-400[»]
ProteinModelPortaliP54939
SMRiP54939
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35571N
ELMiP54939
IntActiP54939, 4 interactors
STRINGi9031.ENSGALP00000038501

PTM databases

GlyConnecti584
UniCarbKBiP54939

Proteomic databases

PaxDbiP54939
PRIDEiP54939

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395194
KEGGigga:395194

Organism-specific databases

CTDi7094

Phylogenomic databases

eggNOGiKOG4261 Eukaryota
ENOG410XQ0V LUCA
HOVERGENiHBG023870
InParanoidiP54939
KOiK06271
PhylomeDBiP54939

Miscellaneous databases

EvolutionaryTraceiP54939
PROiPR:P54939

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd12150 talin-RS, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR032425 FERM_f0
IPR018979 FERM_N
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR011993 PH-like_dom_sf
IPR037438 Talin1/2-RS
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR029071 Ubiquitin-like_domsf
IPR015009 Vinculin-bd_dom
PfamiView protein in Pfam
PF16511 FERM_f0, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF01608 I_LWEQ, 1 hit
PF09141 Talin_middle, 1 hit
PF08913 VBS, 2 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011820 ILWEQ, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00307 ILWEQ, 1 hit
SUPFAMiSSF109880 SSF109880, 1 hit
SSF109885 SSF109885, 4 hits
SSF47031 SSF47031, 1 hit
SSF47220 SSF47220, 5 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50945 I_LWEQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLN1_CHICK
AccessioniPrimary (citable) accession number: P54939
Secondary accession number(s): Q8AWI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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