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Entry version 127 (13 Nov 2019)
Sequence version 2 (08 Nov 2005)
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Protein

Talin-1

Gene

TLN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Talin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLN1
Synonyms:TLN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194301 – 2541Talin-1Add BLAST2541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_0001551486O-linked (GlcNAc) threonine1 Publication1
GlycosylationiCAR_0001561889O-linked (GlcNAc) threonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54939

PRoteomics IDEntifications database

More...
PRIDEi
P54939

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
584

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P54939

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PIP5K1C and NRAP (By similarity). Binds with high affinity to vinculin VCL and with low affinity to integrins (PubMed:14702644, PubMed:12535520, PubMed:8937989, PubMed:20610383).

Interacts with APBB1IP; this inhibits VCL binding (By similarity).

Interacts with F-actin (PubMed:8937989).

Interacts with LAYN (PubMed:9786953).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P051062EBI-1035421,EBI-702847From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-35571N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P54939

Protein interaction database and analysis system

More...
IntActi
P54939, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000004013

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P54939

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P54939

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 403FERMPROSITE-ProRule annotationAdd BLAST318
Domaini2292 – 2531I/LWEQPROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni280 – 435Interaction with LAYN1 PublicationAdd BLAST156
Regioni1358 – 1658Interaction with VCL and F-actinBy similarityAdd BLAST301

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi672 – 681Poly-Ala10
Compositional biasi1335 – 1340Poly-Ala6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4261 Eukaryota
ENOG410XQ0V LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54939

KEGG Orthology (KO)

More...
KOi
K06271

Database of Orthologous Groups

More...
OrthoDBi
9839at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54939

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit
cd12150 talin-RS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR032425 FERM_f0
IPR018979 FERM_N
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR011993 PH-like_dom_sf
IPR030224 Sla2_fam
IPR037438 Talin1/2-RS
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR029071 Ubiquitin-like_domsf
IPR015009 Vinculin-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10407 PTHR10407, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16511 FERM_f0, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF01608 I_LWEQ, 1 hit
PF09141 Talin_middle, 1 hit
PF08913 VBS, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM00307 ILWEQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109880 SSF109880, 1 hit
SSF109885 SSF109885, 4 hits
SSF47031 SSF47031, 1 hit
SSF47220 SSF47220, 5 hits
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50945 I_LWEQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P54939-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVALSLKISI GNVVKTMQFE PSTMVYDACR MIRERVPEAQ MGQPNDFGLF
60 70 80 90 100
LSDEDPKKGI WLEAGKALDY YMLRNGDTME YKKKQRPLKI RMLDGTVKTV
110 120 130 140 150
MVDDSKTVTD MLTTICARIG ITNYDEYSLV REIMEEKKEE VTGTLKKDKT
160 170 180 190 200
LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL REQGIDDNET LLLRRKFFYS
210 220 230 240 250
DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG YQCQIQFGPH
260 270 280 290 300
NEQKHKPGFL ELKDFLPKEY IKQKGERKIF MAHKNCGNMS EIEAKVRYVK
310 320 330 340 350
LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE
360 370 380 390 400
WSLTNIKRWA ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL
410 420 430 440 450
KKKKSKDHFG LEGDEESTML EDSVSPKKST VLQQQFNRVG KAELGSVALP
460 470 480 490 500
AIMRTGAGGP ENFQVGTMPQ AQMQITSGQM HRGHMPPLTS AQQALTGTIN
510 520 530 540 550
SSMQAVNAAQ ATLDDFETLP PLGQDAASKA WRKNKMDESK HEIHSQADAI
560 570 580 590 600
TAGTASVVNL TAGDPADTDY TAVGCAVTTI SSNLTEMSKG VKLLAALMED
610 620 630 640 650
EGGNGRQLLQ AAKNLASAVS DLLKTAQPAS AEPRQNLLQA AGLVGQTSGE
660 670 680 690 700
LLQQIGESDT DPRFQDMLMQ LAKAVASAAA ALVLKAKNVA QKTEDSALQT
710 720 730 740 750
QVIAAATQCA LSTSQLVACT KVVAPTISSP VCQEQLIEAG KLVAKSAEGC
760 770 780 790 800
VEASKAATND DQLLKQVGVA ATAVTQALND LLQHIKQHAT GGQPIGRYDQ
810 820 830 840 850
ATDTILNVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI KADAEGETDL
860 870 880 890 900
ENSRKLLSAA KILADATAKM VEAAKGAAAH PDSEEQQQRL REAAEGLRMA
910 920 930 940 950
TNAAAQNAIK KKLVHKLEHA AKQAAASATQ TIAAAQHAAA SNKNPAAQQQ
960 970 980 990 1000
LVQSCKVVAD QIPMLVQGVR GSQSQPDSPS AQLALIAASQ NFLQPGGKMV
1010 1020 1030 1040 1050
AAAKATVPTI TDQASAMQLS QCAKNLAAAL AELRTAAQKA QEACGPLEID
1060 1070 1080 1090 1100
SALGLVQSLE RDLKEAKAAA RDGKLKPLPG ETMEKCAQDL GNSTKAVTSA
1110 1120 1130 1140 1150
IAHLLGEVAQ GNENYTGIAA REVAQALRSL SQAARGVAAN SSDPQAQNAM
1160 1170 1180 1190 1200
LECASDVMDK ANNLIEEARK AVAKPGDPDS QQRLVQVAKA VSQALNRCVN
1210 1220 1230 1240 1250
CLPGQRDVDA AIRMVGEASK RLLSDSFPPS NKTFQEAQSQ LNRAAAGLNQ
1260 1270 1280 1290 1300
SANELVQASR GTPQDLAKSS GKFGQDFNEF LQAGVEMASL SPTKEDQAQV
1310 1320 1330 1340 1350
VSNLKSISMS SSKLLLAAKA LSADPTSPNL KSQLAAAARA VTDSINQLIT
1360 1370 1380 1390 1400
MCTQQAPGQK ECDNALRELE TVKELLENPT QTVNDMSYFS CLDSVMENSK
1410 1420 1430 1440 1450
VLGESMAGIS QNAKNSKLPE FGESISAASK ALCGLTEAAA QAAYLVGVSD
1460 1470 1480 1490 1500
PNSQAGQQGL VDPTQFARAN QAIQMACQNL VDPACTQSQV LSAATIVAKH
1510 1520 1530 1540 1550
TSALCNTCRL ASSRTANPVA KRQFVQPAKE VANSTANLVK TIKALDGAFN
1560 1570 1580 1590 1600
EENRERCRAA TAPLIEAVDN LTAFASNPEF ATVPAQISPE GRRAMEPIVT
1610 1620 1630 1640 1650
SAKTMLESSA GLIQTARSLA VNPKDPPQWS VLAGHSRTVS DSIKKLITNM
1660 1670 1680 1690 1700
RDKAPGQREC DEAIDVLNRC MREVDQASLA AISQQLAPRE GISQEALHNQ
1710 1720 1730 1740 1750
MITAVQEINN LIEPVASAAR AEASQLGHKV SQMAQYFEPL ILAAIGAASK
1760 1770 1780 1790 1800
TPNHQQQMNL LDQTKTLAES ALQMLYTAKE AGGNPKQAAH TQEALEEAVQ
1810 1820 1830 1840 1850
MMKEAVEDLT TTLNEAASAA GVVGGMVDSI TQAINQLDEG PMGEPEGTFV
1860 1870 1880 1890 1900
DYQTTMVKTA KAIAVTVQEM VTKSTTNPDE LGILANQLTN DYGQLAQQAK
1910 1920 1930 1940 1950
PAALTAENEE IGSHIKRRVQ ELGHGCAALV TKAGALQCSP SDAYTKKELI
1960 1970 1980 1990 2000
ESARKVSEKV SHVLAALQAG NRGTQACITA ASAVSGIIAD LDTTIMFATA
2010 2020 2030 2040 2050
GTLNRENSET FADHREGILK TAKALVEDTK VLVQNATASQ EKLAQAAQSS
2060 2070 2080 2090 2100
VSTITRLAEV VKLGAASLGS EDPETQVVLI NAVKDVAKAL GDLIGATKAA
2110 2120 2130 2140 2150
AGKAGDDPAV YQLKNSAKVM VTNVTSLLKT VKAVEDEATK GTRALEATIE
2160 2170 2180 2190 2200
HIRQELAVFS SPVPPAQVST PEDFIRMTKG ITMATAKAVA AGNSCRQEDV
2210 2220 2230 2240 2250
IATANLSRRA IADMLRACKE AAYHPEVSAD VRQRALRFGK ECADGYLELL
2260 2270 2280 2290 2300
EHVLVILQKP THELKQQLAG YSKRVASSVT ELIQAAEAMK GTEWVDPEDP
2310 2320 2330 2340 2350
TVIAENELLG AAAAIEAAAK KLEQLKPRAK PKQADESLDF EEQILEAAKS
2360 2370 2380 2390 2400
IAAATSALVK AASAAQRELV AQGKVGVIPA NAVDDGQWSQ GLISAARMVA
2410 2420 2430 2440 2450
AATNNLCEAA NAAVQGHASE EKLISSAKQV AASTAQLLVA CKVKADHDSE
2460 2470 2480 2490 2500
AMKRLQAAGN AVKRASDNLV KAAQKAAAFQ DHDETVVVKE KMVGGIAQII
2510 2520 2530 2540
AAQEEMLRKE RELEEARKKL AMIRQQQYKF LPTELRDEEQ N
Length:2,541
Mass (Da):271,842
Last modified:November 8, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A94C290C624699E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY150847 mRNA Translation: AAN75275.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B42965
D42965

NCBI Reference Sequences

More...
RefSeqi
NP_989854.1, NM_204523.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395194

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150847 mRNA Translation: AAN75275.1
PIRiB42965
D42965
RefSeqiNP_989854.1, NM_204523.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MIXX-ray1.75A196-400[»]
1MIZX-ray1.90B200-400[»]
1MK7X-ray2.20B/D209-400[»]
1MK9X-ray2.80B/D/F/H209-400[»]
1RKCX-ray2.70B1944-1969[»]
1U6HX-ray2.38B849-879[»]
1XWJX-ray2.60B1944-1969[»]
1ZVZX-ray1.80B820-844[»]
1ZW2X-ray2.10B2344-2368[»]
2H7DNMR-A309-405[»]
2H7ENMR-A309-405[»]
2HRJNMR-A189-309[»]
2K00NMR-A309-400[»]
SMRiP54939
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-35571N
ELMiP54939
IntActiP54939, 4 interactors
STRINGi9031.ENSGALP00000004013

PTM databases

GlyConnecti584
UniCarbKBiP54939

Proteomic databases

PaxDbiP54939
PRIDEiP54939

Genome annotation databases

GeneIDi395194
KEGGigga:395194

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7094

Phylogenomic databases

eggNOGiKOG4261 Eukaryota
ENOG410XQ0V LUCA
InParanoidiP54939
KOiK06271
OrthoDBi9839at2759
PhylomeDBiP54939

Miscellaneous databases

EvolutionaryTraceiP54939

Protein Ontology

More...
PROi
PR:P54939

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd12150 talin-RS, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR032425 FERM_f0
IPR018979 FERM_N
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR011993 PH-like_dom_sf
IPR030224 Sla2_fam
IPR037438 Talin1/2-RS
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR029071 Ubiquitin-like_domsf
IPR015009 Vinculin-bd_dom
PANTHERiPTHR10407 PTHR10407, 1 hit
PfamiView protein in Pfam
PF16511 FERM_f0, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF01608 I_LWEQ, 1 hit
PF09141 Talin_middle, 1 hit
PF08913 VBS, 2 hits
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00307 ILWEQ, 1 hit
SUPFAMiSSF109880 SSF109880, 1 hit
SSF109885 SSF109885, 4 hits
SSF47031 SSF47031, 1 hit
SSF47220 SSF47220, 5 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50945 I_LWEQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLN1_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54939
Secondary accession number(s): Q8AWI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 8, 2005
Last modified: November 13, 2019
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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