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UniProtKB - P54898 (ARG56_NEUCR)
Protein
Protein arg-6, mitochondrial
Gene
arg-6
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Functioni
Catalytic activityi
- N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = H+ + N-acetyl-L-glutamyl 5-phosphate + NADPHEC:1.2.1.38
- EC:2.7.2.8
: L-arginine biosynthesis Pathwayi
This protein is involved in step 2 and 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate. This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 689 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- acetyl-CoA:L-glutamate N-acetyltransferase activity Source: GO_Central
- arginine binding Source: GO_Central
- ATP binding Source: UniProtKB-KW
- kinase activity Source: UniProtKB-KW
- N-acetyl-gamma-glutamyl-phosphate reductase activity Source: GO_Central
- NAD binding Source: InterPro
GO - Biological processi
- arginine biosynthetic process Source: GO_Central
- regulation of transcription, DNA-templated Source: EnsemblFungi
Keywordsi
Molecular function | Kinase, Multifunctional enzyme, Oxidoreductase, Transferase |
Biological process | Amino-acid biosynthesis, Arginine biosynthesis |
Ligand | ATP-binding, NADP, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00107 UPA00068;UER00108 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein arg-6, mitochondrialCleaved into the following 2 chains: Alternative name(s): N-acetyl-glutamate semialdehyde dehydrogenase Short name: NAGSA dehydrogenase Alternative name(s): N-acetyl-L-glutamate 5-phosphotransferase NAG kinase Short name: AGK |
Gene namesi | Name:arg-6 Synonyms:orn-2 ORF Names:NCU00567 |
Organismi | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic identifieri | 367110 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:NCU00567 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 44 | Mitochondrion1 PublicationAdd BLAST | 44 | |
ChainiPRO_0000002069 | 45 – 531 | Acetylglutamate kinaseAdd BLAST | 487 | |
ChainiPRO_0000002070 | 532 – 871 | N-acetyl-gamma-glutamyl-phosphate reductaseAdd BLAST | 340 |
Post-translational modificationi
The protein precursor is cleaved into the two biologically active enzymes, the kinase and the reductase.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 336 – 488 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 153 |
Sequence similaritiesi
In the N-terminal section; belongs to the acetylglutamate kinase family.Curated
In the C-terminal section; belongs to the NAGSA dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
HOGENOMi | CLU_006384_4_0_1 |
InParanoidi | P54898 |
Family and domain databases
CDDi | cd04252, AAK_NAGK-fArgBP, 1 hit |
Gene3Di | 3.40.1160.10, 1 hit |
HAMAPi | MF_00150, ArgC_type1, 1 hit |
InterProi | View protein in InterPro IPR036393, AceGlu_kinase-like_sf IPR004662, AcgluKinase_fam IPR023013, AGPR_AS IPR000706, AGPR_type-1 IPR001048, Asp/Glu/Uridylate_kinase IPR036291, NAD(P)-bd_dom_sf IPR041734, NAGK-fArgBP IPR011241, NAGK/NAGSA IPR000534, Semialdehyde_DH_NAD-bd IPR006855, Vertebrate-like_GNAT_dom |
Pfami | View protein in Pfam PF00696, AA_kinase, 1 hit PF04768, NAT, 1 hit PF01118, Semialdhyde_dh, 1 hit |
PIRSFi | PIRSF036440, ARG5-6, 1 hit |
SMARTi | View protein in SMART SM00859, Semialdhyde_dh, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF53633, SSF53633, 1 hit |
TIGRFAMsi | TIGR00761, argB, 1 hit TIGR01850, argC, 1 hit |
PROSITEi | View protein in PROSITE PS01224, ARGC, 1 hit PS51731, GNAT_NAGS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P54898-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYSACAVALR AGARRVVRRV PKSARALPRA AAARRQISTT AARSTDLTTR
60 70 80 90 100
GMIVQTLSSV GSKREVQQYL SLFTSVSSQR FAVIKVGGAI LTDYLDELCA
110 120 130 140 150
ALKFLYTVGL YPVIVHGAGP QLNRLLEDAG VEPQFEEGIR VTDAKTLRVA
160 170 180 190 200
RDLFLQENLK LVNKLEEMGV HAQPLTTGMF RADYLNKEKW GLVGKVTGVN
210 220 230 240 250
KQAIETAISN GYLPILTSMA ETDDGQILNV NADVAAAELA RALEPLKVVY
260 270 280 290 300
LSEKGGLFDA GGQKISAINL DEEYEHLMSQ AWVKYGTRLK IKEIKELLDT
310 320 330 340 350
LPRTTSVAII HPEELQKELF TDSGAGTLIR RGSKLQASTS LSEFKDLEAL
360 370 380 390 400
KSVLIRDREG PDAKETVEKY LDFLKENPFK AYFDSSMNAL AIVLPASEGR
410 420 430 440 450
QATLATLTIT KSGWLTNIAD NIFTALKKEH PSLVWTVKED DENLGWFFDK
460 470 480 490 500
ADGSITRQGD VMFWYGIENG DEIVKLMKDF TENGRAMLGN SNLESRLRQA
510 520 530 540 550
ASKPAAQQVR GYSTLARRPA LPKFSISNRR GYLTQTNPNP PVGKQNASMD
560 570 580 590 600
RPARVALIGA RGYTGQELIR LIDSHPNMEL HHVSSRELAG KKLEGYNKQE
610 620 630 640 650
VIYENLSPED VRDMEKRGEI DCWVMALPNG VCKPFVEAVW EGRKASGHKS
660 670 680 690 700
VIIDLSADYR FDNKWTYGLP ELVQRSNIIQ ATQIANPGCY ATAAQLGISP
710 720 730 740 750
LVPHLGGMPH VFGVSGYSGA GTKPSPKNDV ENLTNNIIPY SLTGHIHERE
760 770 780 790 800
VSSQLGAEIA FMPHVAVWFR GIHHTISIPL NKSMTSRDIR QLYQDRYAGE
810 820 830 840 850
KLVKVVGEAP SVKNIGGKHG VEIGGFEVDK SGRRVVICAT IDNLLKGAAT
860 870
QCLQNMNLAL GYAEYEGIPT M
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | A → G in AAB05636 (PubMed:7907589).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L27746 Genomic DNA Translation: AAB05636.1 CM002236 Genomic DNA Translation: ESA44319.1 CM002236 Genomic DNA Translation: ESA44320.1 |
PIRi | A53429 |
RefSeqi | XP_011392782.1, XM_011394480.1 XP_011392783.1, XM_011394481.1 |
Genome annotation databases
EnsemblFungii | ESA44319; ESA44319; NCU00567 ESA44320; ESA44320; NCU00567 |
GeneIDi | 3880877 |
KEGGi | ncr:NCU00567 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L27746 Genomic DNA Translation: AAB05636.1 CM002236 Genomic DNA Translation: ESA44319.1 CM002236 Genomic DNA Translation: ESA44320.1 |
PIRi | A53429 |
RefSeqi | XP_011392782.1, XM_011394480.1 XP_011392783.1, XM_011394481.1 |
3D structure databases
SMRi | P54898 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5141.EFNCRP00000000910 |
Genome annotation databases
EnsemblFungii | ESA44319; ESA44319; NCU00567 ESA44320; ESA44320; NCU00567 |
GeneIDi | 3880877 |
KEGGi | ncr:NCU00567 |
Organism-specific databases
VEuPathDBi | FungiDB:NCU00567 |
Phylogenomic databases
HOGENOMi | CLU_006384_4_0_1 |
InParanoidi | P54898 |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00107 UPA00068;UER00108 |
Family and domain databases
CDDi | cd04252, AAK_NAGK-fArgBP, 1 hit |
Gene3Di | 3.40.1160.10, 1 hit |
HAMAPi | MF_00150, ArgC_type1, 1 hit |
InterProi | View protein in InterPro IPR036393, AceGlu_kinase-like_sf IPR004662, AcgluKinase_fam IPR023013, AGPR_AS IPR000706, AGPR_type-1 IPR001048, Asp/Glu/Uridylate_kinase IPR036291, NAD(P)-bd_dom_sf IPR041734, NAGK-fArgBP IPR011241, NAGK/NAGSA IPR000534, Semialdehyde_DH_NAD-bd IPR006855, Vertebrate-like_GNAT_dom |
Pfami | View protein in Pfam PF00696, AA_kinase, 1 hit PF04768, NAT, 1 hit PF01118, Semialdhyde_dh, 1 hit |
PIRSFi | PIRSF036440, ARG5-6, 1 hit |
SMARTi | View protein in SMART SM00859, Semialdhyde_dh, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF53633, SSF53633, 1 hit |
TIGRFAMsi | TIGR00761, argB, 1 hit TIGR01850, argC, 1 hit |
PROSITEi | View protein in PROSITE PS01224, ARGC, 1 hit PS51731, GNAT_NAGS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARG56_NEUCR | |
Accessioni | P54898Primary (citable) accession number: P54898 Secondary accession number(s): Q7RVL1, V5IRF5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | February 19, 2014 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families