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Entry version 156 (13 Feb 2019)
Sequence version 2 (15 Mar 2005)
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Protein

Hydroxymethylglutaryl-CoA synthase, mitochondrial

Gene

Hmgcs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=460 µM for acetyl-CoA1 Publication
  1. Vmax=59 nmol/min/mg enzyme with acetyl-CoA as a substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1), Hydroxymethylglutaryl-CoA synthase, cytoplasmic (Hmgcs1), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs2), Hydroxymethylglutaryl-CoA synthase, mitochondrial (Hmgcs2), 3-hydroxy-3-methylglutaryl coenzyme A synthase (Hmgcs1)
  3. 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei80SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei132Proton donor/acceptorPROSITE-ProRule annotation1
Active sitei166Acyl-thioester intermediatePROSITE-ProRule annotation1
Binding sitei204SubstrateBy similarity1
Binding sitei258SubstrateBy similarity1
Active sitei301Proton donor/acceptorPROSITE-ProRule annotation1
Binding sitei380SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.3.10 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-77111 Synthesis of Ketone Bodies

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P54869

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00058;UER00102

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthase, mitochondrial (EC:2.3.3.101 Publication)
Short name:
HMG-CoA synthase
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hmgcs2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:101939 Hmgcs2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi83K → E: Abolishes enzymatic activity. 1 Publication1
Mutagenesisi310K → E: Abolishes enzymatic activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 37MitochondrionCuratedAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001348438 – 508Hydroxymethylglutaryl-CoA synthase, mitochondrialAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52N6-succinyllysineCombined sources1
Modified residuei83N6-acetyllysine; alternateCombined sources1
Modified residuei83N6-succinyllysine; alternateCombined sources1 Publication1
Modified residuei118N6-acetyllysine; alternateCombined sources1
Modified residuei118N6-succinyllysine; alternateCombined sources1
Modified residuei221N6-succinyllysineCombined sources1
Modified residuei243N6-acetyllysineCombined sources1
Modified residuei256N6-acetyllysine; alternateCombined sources1
Modified residuei256N6-succinyllysine; alternateCombined sources1
Modified residuei306N6-acetyllysineCombined sources1
Modified residuei310N6-acetyllysine; alternateCombined sources1
Modified residuei310N6-succinyllysine; alternateCombined sources1 Publication1
Modified residuei327N6-acetyllysine; alternateCombined sources1
Modified residuei327N6-succinyllysine; alternateCombined sources1
Modified residuei333N6-succinyllysineCombined sources1
Modified residuei342N6-acetyllysine; alternateCombined sources1
Modified residuei342N6-succinyllysine; alternateCombined sources1
Modified residuei350N6-acetyllysine; alternateCombined sources1
Modified residuei350N6-succinyllysine; alternateCombined sources1
Modified residuei354N6-acetyllysine; alternateCombined sources1
Modified residuei354N6-succinyllysine; alternateCombined sources1 Publication1
Modified residuei358N6-acetyllysine; alternateCombined sources1
Modified residuei358N6-succinyllysine; alternateCombined sources1 Publication1
Modified residuei427N6-acetyllysineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei437N6-acetyllysineCombined sources1
Modified residuei440PhosphoserineBy similarity1
Modified residuei447N6-acetyllysine; alternateCombined sources1
Modified residuei447N6-succinyllysine; alternateCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei473N6-acetyllysine; alternateCombined sources1
Modified residuei473N6-succinyllysine; alternateCombined sources1
Modified residuei477PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation of Lys-427 is observed in liver mitochondria from fasted mice but not from fed mice.
Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P54869

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P54869

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54869

PeptideAtlas

More...
PeptideAtlasi
P54869

PRoteomics IDEntifications database

More...
PRIDEi
P54869

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
P54869

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P54869

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54869

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54869

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P54869

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027875 Expressed in 215 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P54869 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200339, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P54869, 1 interactor

Molecular INTeraction database

More...
MINTi
P54869

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000088249

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P54869

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54869

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HMG-CoA synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1393 Eukaryota
COG3425 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006096

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000012351

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051912

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P54869

KEGG Orthology (KO)

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KOi
K01641

Identification of Orthologs from Complete Genome Data

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OMAi
DLQFMIF

Database of Orthologous Groups

More...
OrthoDBi
495111at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P54869

TreeFam database of animal gene trees

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TreeFami
TF105361

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000590 HMG_CoA_synt_AS
IPR013746 HMG_CoA_synt_C_dom
IPR013528 HMG_CoA_synth_N
IPR010122 HMG_CoA_synthase_euk
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08540 HMG_CoA_synt_C, 1 hit
PF01154 HMG_CoA_synt_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53901 SSF53901, 2 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01833 HMG-CoA-S_euk, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01226 HMG_COA_SYNTHASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P54869-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRLLAPARR VLQVKRAMQE TSLTPAHLLS AAQQRFSTIP PAPLAKTDTW
60 70 80 90 100
PKDVGILALE VYFPAQYVDQ TDLEKFNNVE AGKYTVGLGQ TRMGFCSVQE
110 120 130 140 150
DINSLCLTVV QRLMERTKLP WDAVGRLEVG TETIIDKSKA VKTVLMELFQ
160 170 180 190 200
DSGNTDIEGI DTTNACYGGT ASLFNAANWM ESSYWDGRYA LVVCGDIAVY
210 220 230 240 250
PSGNARPTGG AGAVAMLIGP KAPLVLEQGL RGTHMENAYD FYKPNLASEY
260 270 280 290 300
PLVDGKLSIQ CYLRALDRCY AAYRKKIQNQ WKQAGNNQPF TLDDVQYMIF
310 320 330 340 350
HTPFCKMVQK SLARLMFNDF LSSSSDKQNN LYKGLEAFRG LKLEETYTNK
360 370 380 390 400
DVDKALLKAS LDMFNQKTKA SLYLSTNNGN MYTSSLYGCL ASLLSHHSAQ
410 420 430 440 450
ELAGSRIGAF SYGSGLAASF FSFRVSKDAS PGSPLEKLVS SVSDLPKRLD
460 470 480 490 500
SRRRMSPEEF TEIMNQREQF YHKVNFSPPG DTSNLFPGTW YLERVDEMHR

RKYARCPV
Length:508
Mass (Da):56,823
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A20ACE918FF4758
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29 – 31LSA → EFR in AAA92675 (PubMed:7851882).Curated3
Sequence conflicti394L → I in BAB23657 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK004865 mRNA Translation: BAB23626.1
AK004902 mRNA Translation: BAB23657.1
BC014714 mRNA Translation: AAH14714.1
BC024744 mRNA Translation: AAH24744.1
U12790 Genomic DNA Translation: AAA92675.1
U12791 Genomic DNA Translation: AAA92676.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17662.1

Protein sequence database of the Protein Information Resource

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PIRi
B55729

NCBI Reference Sequences

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RefSeqi
NP_032282.2, NM_008256.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.289131

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000090746; ENSMUSP00000088249; ENSMUSG00000027875
ENSMUST00000120541; ENSMUSP00000113296; ENSMUSG00000027875

Database of genes from NCBI RefSeq genomes

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GeneIDi
15360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:15360

UCSC genome browser

More...
UCSCi
uc008qpr.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004865 mRNA Translation: BAB23626.1
AK004902 mRNA Translation: BAB23657.1
BC014714 mRNA Translation: AAH14714.1
BC024744 mRNA Translation: AAH24744.1
U12790 Genomic DNA Translation: AAA92675.1
U12791 Genomic DNA Translation: AAA92676.1
CCDSiCCDS17662.1
PIRiB55729
RefSeqiNP_032282.2, NM_008256.4
UniGeneiMm.289131

3D structure databases

ProteinModelPortaliP54869
SMRiP54869
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200339, 1 interactor
IntActiP54869, 1 interactor
MINTiP54869
STRINGi10090.ENSMUSP00000088249

PTM databases

iPTMnetiP54869
PhosphoSitePlusiP54869
SwissPalmiP54869

2D gel databases

REPRODUCTION-2DPAGEiP54869
SWISS-2DPAGEiP54869

Proteomic databases

jPOSTiP54869
MaxQBiP54869
PaxDbiP54869
PeptideAtlasiP54869
PRIDEiP54869

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090746; ENSMUSP00000088249; ENSMUSG00000027875
ENSMUST00000120541; ENSMUSP00000113296; ENSMUSG00000027875
GeneIDi15360
KEGGimmu:15360
UCSCiuc008qpr.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3158
MGIiMGI:101939 Hmgcs2

Phylogenomic databases

eggNOGiKOG1393 Eukaryota
COG3425 LUCA
GeneTreeiENSGT00390000006096
HOGENOMiHOG000012351
HOVERGENiHBG051912
InParanoidiP54869
KOiK01641
OMAiDLQFMIF
OrthoDBi495111at2759
PhylomeDBiP54869
TreeFamiTF105361

Enzyme and pathway databases

UniPathwayi
UPA00058;UER00102

BRENDAi2.3.3.10 3474
ReactomeiR-MMU-77111 Synthesis of Ketone Bodies
SABIO-RKiP54869

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Hmgcs2 mouse

Protein Ontology

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PROi
PR:P54869

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000027875 Expressed in 215 organ(s), highest expression level in liver
GenevisibleiP54869 MM

Family and domain databases

Gene3Di3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR000590 HMG_CoA_synt_AS
IPR013746 HMG_CoA_synt_C_dom
IPR013528 HMG_CoA_synth_N
IPR010122 HMG_CoA_synthase_euk
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF08540 HMG_CoA_synt_C, 1 hit
PF01154 HMG_CoA_synt_N, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01833 HMG-CoA-S_euk, 1 hit
PROSITEiView protein in PROSITE
PS01226 HMG_COA_SYNTHASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMCS2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54869
Secondary accession number(s): Q64740, Q9DBK1, Q9DBM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 15, 2005
Last modified: February 13, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
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