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Protein

Epithelial membrane protein 3

Gene

EMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in cell proliferation and cell-cell interactions.

GO - Biological processi

  • bleb assembly Source: UniProtKB
  • cell death Source: UniProtKB
  • negative regulation of cell proliferation Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 3
Short name:
EMP-3
Alternative name(s):
Hematopoietic neural membrane protein 1
Short name:
HNMP-1
Protein YMP
Gene namesi
Name:EMP3
Synonyms:YMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142227.10
HGNCiHGNC:3335 EMP3
MIMi602335 gene
neXtProtiNX_P54852

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2014
OpenTargetsiENSG00000142227
PharmGKBiPA27772

Polymorphism and mutation databases

BioMutaiEMP3
DMDMi1706644

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646601 – 163Epithelial membrane protein 3Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP54852
MaxQBiP54852
PaxDbiP54852
PeptideAtlasiP54852
PRIDEiP54852
ProteomicsDBi56741
TopDownProteomicsiP54852

PTM databases

iPTMnetiP54852
PhosphoSitePlusiP54852
SwissPalmiP54852

Expressioni

Gene expression databases

BgeeiENSG00000142227 Expressed in 205 organ(s), highest expression level in leukocyte
CleanExiHS_EMP3
ExpressionAtlasiP54852 baseline and differential
GenevisibleiP54852 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDAQ928385EBI-3907816,EBI-529425

Protein-protein interaction databases

BioGridi108329, 5 interactors
IntActiP54852, 38 interactors
STRINGi9606.ENSP00000270221

Structurei

3D structure databases

ProteinModelPortaliP54852
SMRiP54852
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY40 Eukaryota
ENOG4111MF9 LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiP54852
OMAiMEKSWWV
OrthoDBiEOG091G0RF4
PhylomeDBiP54852
TreeFamiTF330414

Family and domain databases

InterProiView protein in InterPro
IPR003934 EMP_3
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF8 PTHR10671:SF8, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01456 EPMEMPROT3
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P54852-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNNDTK
60 70 80 90 100
TWACSNVSEN GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT
110 120 130 140 150
GLCQLCTSVA VFTGALIYAI HAEEILEKHP RGGSFGYCFA LAWVAFPLAL
160
VSGIIYIHLR KRE
Length:163
Mass (Da):18,429
Last modified:October 1, 1996 - v1
Checksum:i2B5DF55938825940
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXS0M0QXS0_HUMAN
Epithelial membrane protein 3
EMP3
94Annotation score:
M0QZ66M0QZ66_HUMAN
Epithelial membrane protein 3
EMP3
89Annotation score:
M0R1L9M0R1L9_HUMAN
Epithelial membrane protein 3
EMP3
56Annotation score:
M0R122M0R122_HUMAN
Epithelial membrane protein 3
EMP3
63Annotation score:
M0QXN1M0QXN1_HUMAN
Epithelial membrane protein 3
EMP3
161Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100 – 101TG → HR in CAA64394 (PubMed:8917086).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050609125I → V. Corresponds to variant dbSNP:rs4893Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52101 mRNA Translation: AAC50920.1
X94771 mRNA Translation: CAA64394.1
U87947 mRNA Translation: AAC51730.1
BT007124 mRNA Translation: AAP35788.1
CR541955 mRNA Translation: CAG46753.1
CH471177 Genomic DNA Translation: EAW52333.1
BC009718 mRNA Translation: AAH09718.1
CCDSiCCDS12715.1
PIRiJC5045
RefSeqiNP_001300834.1, NM_001313905.1
NP_001416.1, NM_001425.2
XP_011524907.1, XM_011526605.2
UniGeneiHs.9999

Genome annotation databases

EnsembliENST00000270221; ENSP00000270221; ENSG00000142227
ENST00000597279; ENSP00000469194; ENSG00000142227
GeneIDi2014
KEGGihsa:2014
UCSCiuc002piv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52101 mRNA Translation: AAC50920.1
X94771 mRNA Translation: CAA64394.1
U87947 mRNA Translation: AAC51730.1
BT007124 mRNA Translation: AAP35788.1
CR541955 mRNA Translation: CAG46753.1
CH471177 Genomic DNA Translation: EAW52333.1
BC009718 mRNA Translation: AAH09718.1
CCDSiCCDS12715.1
PIRiJC5045
RefSeqiNP_001300834.1, NM_001313905.1
NP_001416.1, NM_001425.2
XP_011524907.1, XM_011526605.2
UniGeneiHs.9999

3D structure databases

ProteinModelPortaliP54852
SMRiP54852
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108329, 5 interactors
IntActiP54852, 38 interactors
STRINGi9606.ENSP00000270221

PTM databases

iPTMnetiP54852
PhosphoSitePlusiP54852
SwissPalmiP54852

Polymorphism and mutation databases

BioMutaiEMP3
DMDMi1706644

Proteomic databases

EPDiP54852
MaxQBiP54852
PaxDbiP54852
PeptideAtlasiP54852
PRIDEiP54852
ProteomicsDBi56741
TopDownProteomicsiP54852

Protocols and materials databases

DNASUi2014
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270221; ENSP00000270221; ENSG00000142227
ENST00000597279; ENSP00000469194; ENSG00000142227
GeneIDi2014
KEGGihsa:2014
UCSCiuc002piv.3 human

Organism-specific databases

CTDi2014
DisGeNETi2014
EuPathDBiHostDB:ENSG00000142227.10
GeneCardsiEMP3
HGNCiHGNC:3335 EMP3
MIMi602335 gene
neXtProtiNX_P54852
OpenTargetsiENSG00000142227
PharmGKBiPA27772
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY40 Eukaryota
ENOG4111MF9 LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiP54852
OMAiMEKSWWV
OrthoDBiEOG091G0RF4
PhylomeDBiP54852
TreeFamiTF330414

Miscellaneous databases

GeneWikiiEMP3
GenomeRNAii2014
PROiPR:P54852
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142227 Expressed in 205 organ(s), highest expression level in leukocyte
CleanExiHS_EMP3
ExpressionAtlasiP54852 baseline and differential
GenevisibleiP54852 HS

Family and domain databases

InterProiView protein in InterPro
IPR003934 EMP_3
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF8 PTHR10671:SF8, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01456 EPMEMPROT3
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMP3_HUMAN
AccessioniPrimary (citable) accession number: P54852
Secondary accession number(s): Q6FH01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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