UniProtKB - P54849 (EMP1_HUMAN)
Protein
Epithelial membrane protein 1
Gene
EMP1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- bleb assembly Source: UniProtKB
- cell death Source: UniProtKB
- epidermis development Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | P54849 |
Names & Taxonomyi
Protein namesi | Recommended name: Epithelial membrane protein 1Short name: EMP-1 Alternative name(s): CL-20 Protein B4B Tumor-associated membrane protein |
Gene namesi | Name:EMP1 Synonyms:B4B, TMP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3333, EMP1 |
MIMi | 602333, gene |
neXtProti | NX_P54849 |
VEuPathDBi | HostDB:ENSG00000134531.9 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 95 – 115 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 134 – 154 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2012 |
OpenTargetsi | ENSG00000134531 |
PharmGKBi | PA27770 |
Miscellaneous databases
Pharosi | P54849, Tbio |
Genetic variation databases
BioMutai | EMP1 |
DMDMi | 3041684 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164653 | 1 – 157 | Epithelial membrane protein 1Add BLAST | 157 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | P54849 |
PaxDbi | P54849 |
PeptideAtlasi | P54849 |
PRIDEi | P54849 |
ProteomicsDBi | 4966 56739 [P54849-1] |
TopDownProteomicsi | P54849-1 [P54849-1] |
PTM databases
GlyGeni | P54849, 2 sites |
Expressioni
Gene expression databases
Bgeei | ENSG00000134531, Expressed in lower esophagus mucosa and 237 other tissues |
ExpressionAtlasi | P54849, baseline and differential |
Genevisiblei | P54849, HS |
Organism-specific databases
HPAi | ENSG00000134531, Tissue enhanced (esophagus, lymphoid tissue) |
Interactioni
Binary interactionsi
P54849
Protein-protein interaction databases
BioGRIDi | 108327, 61 interactors |
IntActi | P54849, 61 interactors |
STRINGi | 9606.ENSP00000256951 |
Miscellaneous databases
RNActi | P54849, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the PMP-22/EMP/MP20 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S028, Eukaryota |
GeneTreei | ENSGT00950000182696 |
HOGENOMi | CLU_138632_0_1_1 |
InParanoidi | P54849 |
OMAi | KSVQAFM |
OrthoDBi | 1218356at2759 |
PhylomeDBi | P54849 |
TreeFami | TF330414 |
Family and domain databases
InterProi | View protein in InterPro IPR003932, EMP_1 IPR004031, PMP22/EMP/MP20/Claudin IPR004032, PMP22_EMP_MP20 |
PANTHERi | PTHR10671:SF6, PTHR10671:SF6, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01453, EPMEMFAMILY PR01454, EPMEMPROT1 |
PROSITEi | View protein in PROSITE PS01221, PMP22_1, 1 hit PS01222, PMP22_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P54849-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS
60 70 80 90 100
DSLSYASEDA LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA
110 120 130 140 150
TTLVCWLCIL VGVSIYTSHY ANRDGTQYHH GYSYILGWIC FCFSFIIGVL
YLVLRKK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KQX4 | J3KQX4_HUMAN | Epithelial membrane protein 1 | EMP1 | 90 | Annotation score: | ||
F5H397 | F5H397_HUMAN | Epithelial membrane protein 1 | EMP1 | 69 | Annotation score: | ||
F5GYV0 | F5GYV0_HUMAN | Epithelial membrane protein 1 | EMP1 | 146 | Annotation score: | ||
F5H2P5 | F5H2P5_HUMAN | Epithelial membrane protein 1 | EMP1 | 94 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050608 | 57 | S → N. Corresponds to variant dbSNP:rs34412222Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056984 | 106 – 157 | WLCIL…VLRKK → FIMRIVMERSITTAIPTSWA GSASASASSSAFSIWS in isoform 2. 1 PublicationAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43916 mRNA Translation: AAC51783.1 U77085 mRNA Translation: AAC51207.1 Z50751 mRNA Translation: CAA90627.1 Y07909 mRNA Translation: CAA69217.1 AK299388 mRNA Translation: BAG61373.1 AK312246 mRNA Translation: BAG35178.1 AC022276 Genomic DNA No translation available. AC079628 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96304.1 BC047300 mRNA Translation: AAH47300.1 |
CCDSi | CCDS8660.1 [P54849-1] |
PIRi | G02355 |
RefSeqi | NP_001414.1, NM_001423.2 [P54849-1] |
Genome annotation databases
Ensembli | ENST00000256951; ENSP00000256951; ENSG00000134531 [P54849-1] ENST00000396301; ENSP00000379595; ENSG00000134531 [P54849-2] |
GeneIDi | 2012 |
KEGGi | hsa:2012 |
UCSCi | uc001rbr.4, human [P54849-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43916 mRNA Translation: AAC51783.1 U77085 mRNA Translation: AAC51207.1 Z50751 mRNA Translation: CAA90627.1 Y07909 mRNA Translation: CAA69217.1 AK299388 mRNA Translation: BAG61373.1 AK312246 mRNA Translation: BAG35178.1 AC022276 Genomic DNA No translation available. AC079628 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96304.1 BC047300 mRNA Translation: AAH47300.1 |
CCDSi | CCDS8660.1 [P54849-1] |
PIRi | G02355 |
RefSeqi | NP_001414.1, NM_001423.2 [P54849-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 108327, 61 interactors |
IntActi | P54849, 61 interactors |
STRINGi | 9606.ENSP00000256951 |
PTM databases
GlyGeni | P54849, 2 sites |
Genetic variation databases
BioMutai | EMP1 |
DMDMi | 3041684 |
Proteomic databases
MassIVEi | P54849 |
PaxDbi | P54849 |
PeptideAtlasi | P54849 |
PRIDEi | P54849 |
ProteomicsDBi | 4966 56739 [P54849-1] |
TopDownProteomicsi | P54849-1 [P54849-1] |
Protocols and materials databases
Antibodypediai | 23604, 108 antibodies |
DNASUi | 2012 |
Genome annotation databases
Ensembli | ENST00000256951; ENSP00000256951; ENSG00000134531 [P54849-1] ENST00000396301; ENSP00000379595; ENSG00000134531 [P54849-2] |
GeneIDi | 2012 |
KEGGi | hsa:2012 |
UCSCi | uc001rbr.4, human [P54849-1] |
Organism-specific databases
CTDi | 2012 |
DisGeNETi | 2012 |
GeneCardsi | EMP1 |
HGNCi | HGNC:3333, EMP1 |
HPAi | ENSG00000134531, Tissue enhanced (esophagus, lymphoid tissue) |
MIMi | 602333, gene |
neXtProti | NX_P54849 |
OpenTargetsi | ENSG00000134531 |
PharmGKBi | PA27770 |
VEuPathDBi | HostDB:ENSG00000134531.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S028, Eukaryota |
GeneTreei | ENSGT00950000182696 |
HOGENOMi | CLU_138632_0_1_1 |
InParanoidi | P54849 |
OMAi | KSVQAFM |
OrthoDBi | 1218356at2759 |
PhylomeDBi | P54849 |
TreeFami | TF330414 |
Enzyme and pathway databases
PathwayCommonsi | P54849 |
Miscellaneous databases
BioGRID-ORCSi | 2012, 7 hits in 875 CRISPR screens |
ChiTaRSi | EMP1, human |
GeneWikii | EMP1 |
GenomeRNAii | 2012 |
Pharosi | P54849, Tbio |
PROi | PR:P54849 |
RNActi | P54849, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134531, Expressed in lower esophagus mucosa and 237 other tissues |
ExpressionAtlasi | P54849, baseline and differential |
Genevisiblei | P54849, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003932, EMP_1 IPR004031, PMP22/EMP/MP20/Claudin IPR004032, PMP22_EMP_MP20 |
PANTHERi | PTHR10671:SF6, PTHR10671:SF6, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01453, EPMEMFAMILY PR01454, EPMEMPROT1 |
PROSITEi | View protein in PROSITE PS01221, PMP22_1, 1 hit PS01222, PMP22_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EMP1_HUMAN | |
Accessioni | P54849Primary (citable) accession number: P54849 Secondary accession number(s): B2R5N1 Q13834 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | July 15, 1998 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families