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UniProtKB - P54849 (EMP1_HUMAN)

Entry version 158 (12 Aug 2020)
Sequence version 3 (15 Jul 1998)
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Protein

Epithelial membrane protein 1

Gene

EMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P54849

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epithelial membrane protein 1
Short name:
EMP-1
Alternative name(s):
CL-20
Protein B4B
Tumor-associated membrane protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EMP1
Synonyms:B4B, TMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000134531.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:3333, EMP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602333, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P54849

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2012

Open Targets

More...OpenTargetsi		ENSG00000134531

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27770

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P54849, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EMP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		3041684

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001646531 – 157Epithelial membrane protein 1Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P54849

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P54849

PeptideAtlas

More...PeptideAtlasi		P54849

PRoteomics IDEntifications database

More...PRIDEi		P54849

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4966
56739 [P54849-1]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P54849-1 [P54849-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P54849, 2 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134531, Expressed in lower esophagus mucosa and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P54849, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P54849, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134531, Tissue enhanced (esophagus, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P54849
With#Exp.IntAct
ANK1 - isoform Mu17 [P16157-17]3EBI-4319440,EBI-941819
ANKS6 [Q68DC2]3EBI-4319440,EBI-7054139
APOL2 [Q9BQE5]3EBI-4319440,EBI-4290634
AQP6 [Q13520]3EBI-4319440,EBI-13059134
ARL13B [Q3SXY8]3EBI-4319440,EBI-11343438
ARL6IP1 [Q15041]3EBI-4319440,EBI-714543
ASGR2 - isoform 3 [P07307-3]3EBI-4319440,EBI-12808270
ATP6V0B [Q99437]3EBI-4319440,EBI-3904417
ATP6V0E1 [O15342]3EBI-4319440,EBI-12935759
BTN2A2 [Q8WVV5]3EBI-4319440,EBI-8648738
CCR5 [P51681]3EBI-4319440,EBI-489374
CD37 [P11049]3EBI-4319440,EBI-6139068
CD3G [P09693]3EBI-4319440,EBI-3862428
CD53 [P19397]3EBI-4319440,EBI-6657396
CD79A [P11912]3EBI-4319440,EBI-7797864
CEP70 [Q8NHQ1]3EBI-4319440,EBI-739624
CLDN9 [O95484]3EBI-4319440,EBI-18341636
CORIN [Q9Y5Q5]3EBI-4319440,EBI-17876114
CXCR2 [P25025]3EBI-4319440,EBI-2835281
EBP [Q15125]3EBI-4319440,EBI-3915253
EDA [Q92838]3EBI-4319440,EBI-529425
EHHADH [Q08426]3EBI-4319440,EBI-2339219
ERGIC3 [Q9Y282]3EBI-4319440,EBI-781551
FFAR2 [O15552]3EBI-4319440,EBI-2833872
GIMAP5 [Q96F15]3EBI-4319440,EBI-6166686
GPR42 [O15529]3EBI-4319440,EBI-18076404
GPRC5D [Q9NZD1]3EBI-4319440,EBI-13067820
HTR2C [P28335]3EBI-4319440,EBI-994141
ISLR2 [Q6UXK2]3EBI-4319440,EBI-1266923
JPH1 [Q9HDC5]3EBI-4319440,EBI-465137
KLRC1 [P26715]3EBI-4319440,EBI-9018187
LAPTM4B [Q86VI4]3EBI-4319440,EBI-3267258
LEPROTL1 [O95214]3EBI-4319440,EBI-750776
LHFPL5 [Q8TAF8]3EBI-4319440,EBI-2820517
LPAR6 [P43657]3EBI-4319440,EBI-2876949
LRRC3B [Q96PB8]3EBI-4319440,EBI-17775622
LSMEM2 [Q8N112]6EBI-4319440,EBI-10264855
MAL [P21145]3EBI-4319440,EBI-3932027
MALL [Q13021]3EBI-4319440,EBI-750078
MS4A7 [Q9GZW8]3EBI-4319440,EBI-721391
OPRM1 - isoform 10 [P35372-10]3EBI-4319440,EBI-12807478
PLEKHB2 [Q96CS7]3EBI-4319440,EBI-373552
PMP22 [Q01453]3EBI-4319440,EBI-2845982
RABAC1 [Q9UI14]3EBI-4319440,EBI-712367
RPRM [Q9NS64]3EBI-4319440,EBI-1052363
SERTM1 [A2A2V5]3EBI-4319440,EBI-17284533
SMIM3 [Q9BZL3]6EBI-4319440,EBI-741850
SPACA1 [Q9HBV2]3EBI-4319440,EBI-17498703
STOM [P27105]3EBI-4319440,EBI-1211440
SYNE4 [Q8N205]3EBI-4319440,EBI-7131783
TBXA2R [Q0VAB0]3EBI-4319440,EBI-18271435
TEX264 [Q9Y6I9]3EBI-4319440,EBI-10329860
TLCD4 [Q96MV1]3EBI-4319440,EBI-12947623
TMEM114 [B3SHH9]3EBI-4319440,EBI-19132172
TMEM160 [Q9NX00]3EBI-4319440,EBI-2514588
TMEM218 [A2RU14]3EBI-4319440,EBI-10173151
TMEM239 - isoform 2 [Q8WW34-2]3EBI-4319440,EBI-11528917
TMEM262 [E9PQX1]3EBI-4319440,EBI-17180389
TMEM9 [Q9P0T7]3EBI-4319440,EBI-723976
TSPO2 [Q5TGU0]3EBI-4319440,EBI-12195249

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108327, 3 interactors

Protein interaction database and analysis system

More...IntActi		P54849, 61 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256951

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P54849, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S028, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182696

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_138632_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P54849

Identification of Orthologs from Complete Genome Data

More...OMAi		KSVQAFM

Database of Orthologous Groups

More...OrthoDBi		1218356at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P54849

TreeFam database of animal gene trees

More...TreeFami		TF330414

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003932, EMP_1
IPR004031, PMP22/EMP/MP20/Claudin
IPR004032, PMP22_EMP_MP20

The PANTHER Classification System

More...PANTHERi		PTHR10671:SF6, PTHR10671:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00822, PMP22_Claudin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01453, EPMEMFAMILY
PR01454, EPMEMPROT1

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01221, PMP22_1, 1 hit
PS01222, PMP22_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P54849-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS 
        60         70         80         90        100
DSLSYASEDA LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA 
       110        120        130        140        150
TTLVCWLCIL VGVSIYTSHY ANRDGTQYHH GYSYILGWIC FCFSFIIGVL 

YLVLRKK
Length:157
Mass (Da):17,563
Last modified:July 15, 1998 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB470B4ADC5C16821
GO
Isoform 2 (identifier: P54849-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-157: WLCILVGVSI...GVLYLVLRKK → FIMRIVMERS...ASSSAFSIWS

Show »
Length:141
Mass (Da):15,252
Checksum:iFBA7A4754382838C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQX4J3KQX4_HUMAN
Epithelial membrane protein 1
EMP1
90Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H397F5H397_HUMAN
Epithelial membrane protein 1
EMP1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYV0F5GYV0_HUMAN
Epithelial membrane protein 1
EMP1
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2P5F5H2P5_HUMAN
Epithelial membrane protein 1
EMP1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05060857S → N. Corresponds to variant dbSNP:rs34412222Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056984106 – 157WLCIL…VLRKK → FIMRIVMERSITTAIPTSWA GSASASASSSAFSIWS in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U43916 mRNA Translation: AAC51783.1
U77085 mRNA Translation: AAC51207.1
Z50751 mRNA Translation: CAA90627.1
Y07909 mRNA Translation: CAA69217.1
AK299388 mRNA Translation: BAG61373.1
AK312246 mRNA Translation: BAG35178.1
AC022276 Genomic DNA No translation available.
AC079628 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96304.1
BC047300 mRNA Translation: AAH47300.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8660.1 [P54849-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G02355

NCBI Reference Sequences

More...RefSeqi		NP_001414.1, NM_001423.2 [P54849-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256951; ENSP00000256951; ENSG00000134531 [P54849-1]
ENST00000396301; ENSP00000379595; ENSG00000134531 [P54849-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2012

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2012

UCSC genome browser

More...UCSCi		uc001rbr.4, human [P54849-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43916 mRNA Translation: AAC51783.1
U77085 mRNA Translation: AAC51207.1
Z50751 mRNA Translation: CAA90627.1
Y07909 mRNA Translation: CAA69217.1
AK299388 mRNA Translation: BAG61373.1
AK312246 mRNA Translation: BAG35178.1
AC022276 Genomic DNA No translation available.
AC079628 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96304.1
BC047300 mRNA Translation: AAH47300.1
CCDSiCCDS8660.1 [P54849-1]
PIRiG02355
RefSeqiNP_001414.1, NM_001423.2 [P54849-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi108327, 3 interactors
IntActiP54849, 61 interactors
STRINGi9606.ENSP00000256951

PTM databases

GlyGeniP54849, 2 sites

Polymorphism and mutation databases

BioMutaiEMP1
DMDMi3041684

Proteomic databases

MassIVEiP54849
PaxDbiP54849
PeptideAtlasiP54849
PRIDEiP54849
ProteomicsDBi4966
56739 [P54849-1]
TopDownProteomicsiP54849-1 [P54849-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23604, 108 antibodies

The DNASU plasmid repository

More...DNASUi		2012

Genome annotation databases

EnsembliENST00000256951; ENSP00000256951; ENSG00000134531 [P54849-1]
ENST00000396301; ENSP00000379595; ENSG00000134531 [P54849-2]
GeneIDi2012
KEGGihsa:2012
UCSCiuc001rbr.4, human [P54849-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2012
DisGeNETi2012
EuPathDBiHostDB:ENSG00000134531.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		EMP1
HGNCiHGNC:3333, EMP1
HPAiENSG00000134531, Tissue enhanced (esophagus, lymphoid tissue)
MIMi602333, gene
neXtProtiNX_P54849
OpenTargetsiENSG00000134531
PharmGKBiPA27770

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S028, Eukaryota
GeneTreeiENSGT00950000182696
HOGENOMiCLU_138632_0_1_1
InParanoidiP54849
OMAiKSVQAFM
OrthoDBi1218356at2759
PhylomeDBiP54849
TreeFamiTF330414

Enzyme and pathway databases

PathwayCommonsiP54849

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2012, 6 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EMP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		EMP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2012
PharosiP54849, Tbio

Protein Ontology

More...PROi		PR:P54849
RNActiP54849, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134531, Expressed in lower esophagus mucosa and 237 other tissues
ExpressionAtlasiP54849, baseline and differential
GenevisibleiP54849, HS

Family and domain databases

InterProiView protein in InterPro
IPR003932, EMP_1
IPR004031, PMP22/EMP/MP20/Claudin
IPR004032, PMP22_EMP_MP20
PANTHERiPTHR10671:SF6, PTHR10671:SF6, 1 hit
PfamiView protein in Pfam
PF00822, PMP22_Claudin, 1 hit
PRINTSiPR01453, EPMEMFAMILY
PR01454, EPMEMPROT1
PROSITEiView protein in PROSITE
PS01221, PMP22_1, 1 hit
PS01222, PMP22_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54849
Secondary accession number(s): B2R5N1
, B4DRR1, O00681, Q13481, Q13834
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: August 12, 2020
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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