EMP1

Functionⁱ

GO - Biological processⁱ

bleb assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 12107182
cell death
Source: UniProtKB
Inferred from direct assayⁱ
- 12107182
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8996089
epidermis development
Source: ProtInc
Traceable author statementⁱ
- 7499420
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 8996089

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Epithelial membrane protein 1 Short name: EMP-1 Alternative name(s): CL-20 Protein B4B Tumor-associated membrane protein
Gene namesⁱ	Name:EMP1 Synonyms:B4B, TMP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134531.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3333 EMP1
MIMⁱ	602333 gene
neXtProtⁱ	NX_P54849

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	1 – 21	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	67 – 87	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	95 – 115	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	134 – 154	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2012
Open Targets More...OpenTargetsⁱ	ENSG00000134531
PharmGKBⁱ	PA27770

Polymorphism and mutation databases

BioMutaⁱ	EMP1
DMDMⁱ	3041684

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000164653	1 – 157	Epithelial membrane protein 1Add BLAST		157

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	43	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	46	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	P54849
PeptideAtlas More...PeptideAtlasⁱ	P54849
PRIDEⁱ	P54849
ProteomicsDBⁱ	56739
TopDownProteomicsⁱ	P54849-1 [P54849-1]

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134531 Expressed in 226 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_EMP1
ExpressionAtlasⁱ	P54849 baseline and differential
Genevisibleⁱ	P54849 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051931 HPA056250

HPAⁱ

HPA051931
HPA056250

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CD53	P19397	4	EBI-4319440,EBI-6657396
CEP70	Q8NHQ1	3	EBI-4319440,EBI-739624
LSMEM2	Q8N112	4	EBI-4319440,EBI-10264855
SMIM3	Q9BZL3	5	EBI-4319440,EBI-741850
SYNE4	Q8N205	3	EBI-4319440,EBI-7131783

Protein-protein interaction databases

BioGridⁱ	108327, 3 interactors
IntActⁱ	P54849, 55 interactors
STRINGⁱ	9606.ENSP00000256951

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P54849
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IW7W Eukaryota ENOG410Z5WT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046328
HOGENOMⁱ	HOG000059542
HOVERGENⁱ	HBG001690
InParanoidⁱ	P54849
OMAⁱ	WICFCFS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RF4
PhylomeDBⁱ	P54849
TreeFamⁱ	TF330414

Family and domain databases

InterProⁱ	View protein in InterPro IPR003932 EMP_1 IPR004031 PMP22/EMP/MP20/Claudin IPR004032 PMP22_EMP_MP20
PANTHERⁱ	PTHR10671:SF6 PTHR10671:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01453 EPMEMFAMILY PR01454 EPMEMPROT1
PROSITEⁱ	View protein in PROSITE PS01221 PMP22_1, 1 hit PS01222 PMP22_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P54849-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS 
        60         70         80         90        100
DSLSYASEDA LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA 
       110        120        130        140        150
TTLVCWLCIL VGVSIYTSHY ANRDGTQYHH GYSYILGWIC FCFSFIIGVL 

YLVLRKK

Length:157

Mass (Da):17,563

Last modified:July 15, 1998 - v3

Checksum:ⁱB470B4ADC5C16821

GO

Isoform 2 (identifier: P54849-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
106-157: WLCILVGVSI...GVLYLVLRKK → FIMRIVMERS...ASSSAFSIWS

« Hide

        10         20         30         40         50
MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS 
        60         70         80         90        100
DSLSYASEDA LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA 
       110        120        130        140 
TTLVCFIMRI VMERSITTAI PTSWAGSASA SASSSAFSIW S

Note: No experimental confirmation available.

Show »

Length:141

Mass (Da):15,252

Checksum:ⁱFBA7A4754382838C

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KQX4	J3KQX4_HUMAN	Epithelial membrane protein 1 Epithelial membrane protein 1	EMP1	90	Annotation score:
F5GYV0	F5GYV0_HUMAN	Epithelial membrane protein 1 Epithelial membrane protein 1	EMP1	146	Annotation score:
F5H397	F5H397_HUMAN	Epithelial membrane protein 1 Epithelial membrane protein 1	EMP1	69	Annotation score:
F5H2P5	F5H2P5_HUMAN	Epithelial membrane protein 1 Epithelial membrane protein 1	EMP1	94	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050608	57	S → N. Corresponds to variant dbSNP:rs34412222Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056984	106 – 157	WLCIL…VLRKK → FIMRIVMERSITTAIPTSWA GSASASASSSAFSIWS in isoform 2. 1 PublicationAdd BLAST		52

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U43916 mRNA Translation: AAC51783.1 U77085 mRNA Translation: AAC51207.1 Z50751 mRNA Translation: CAA90627.1 Y07909 mRNA Translation: CAA69217.1 AK299388 mRNA Translation: BAG61373.1 AK312246 mRNA Translation: BAG35178.1 AC022276 Genomic DNA No translation available. AC079628 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96304.1 BC047300 mRNA Translation: AAH47300.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8660.1 [P54849-1]
PIRⁱ	G02355
NCBI Reference Sequences More...RefSeqⁱ	NP_001414.1, NM_001423.2 [P54849-1]
UniGeneⁱ	Hs.719042

Genome annotation databases

Ensemblⁱ	ENST00000256951; ENSP00000256951; ENSG00000134531 [P54849-1] ENST00000396301; ENSP00000379595; ENSG00000134531 [P54849-2]
GeneIDⁱ	2012
KEGGⁱ	hsa:2012
UCSC genome browser More...UCSCⁱ	uc001rbr.4 human [P54849-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P54849	Epithelial membrane protein 1		PONAB		157	UniRef100_P54849
Epithelial membrane protein 1		HUMAN		157

Protein	Similar proteins		Species	Score	Length	Source
P54849	Epithelial membrane protein 1		PONAB		157	UniRef90_P54849
Epithelial membrane protein 1		HUMAN		157
Epithelial membrane protein 1		PANTR		157
Epithelial membrane protein 1		GORGO		157
Epithelial membrane protein 1		PANPA		157
+2
P54849-2	EMP1 isoform 7		PANTR		141	UniRef90_P54849-2

Protein	Similar proteins		Species	Score	Length	Source
P54849	Epithelial membrane protein 1		PONAB		157	UniRef50_P54849
Epithelial membrane protein 1		RAT		160
Epithelial membrane protein 1		MOUSE		160
Epithelial membrane protein 1		RABIT		160
Epithelial membrane protein 1		HUMAN		157
+135
P54849-2	EMP1 isoform 7		PANTR		141	UniRef50_P54849-2
Epithelial membrane protein 1		Patagioenas fasciata monilis		141
Epithelial membrane protein 1		COLLI		158
Epithelial membrane protein 1		MYOBR		146
Epithelial membrane protein 1		DRYPU		161
+88

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U43916 mRNA Translation: AAC51783.1 U77085 mRNA Translation: AAC51207.1 Z50751 mRNA Translation: CAA90627.1 Y07909 mRNA Translation: CAA69217.1 AK299388 mRNA Translation: BAG61373.1 AK312246 mRNA Translation: BAG35178.1 AC022276 Genomic DNA No translation available. AC079628 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96304.1 BC047300 mRNA Translation: AAH47300.1
CCDSⁱ	CCDS8660.1 [P54849-1]
PIRⁱ	G02355
RefSeqⁱ	NP_001414.1, NM_001423.2 [P54849-1]
UniGeneⁱ	Hs.719042

3D structure databases

ProteinModelPortalⁱ	P54849
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108327, 3 interactors
IntActⁱ	P54849, 55 interactors
STRINGⁱ	9606.ENSP00000256951

Polymorphism and mutation databases

BioMutaⁱ	EMP1
DMDMⁱ	3041684

Proteomic databases

PaxDbⁱ	P54849
PeptideAtlasⁱ	P54849
PRIDEⁱ	P54849
ProteomicsDBⁱ	56739
TopDownProteomicsⁱ	P54849-1 [P54849-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2012
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000256951; ENSP00000256951; ENSG00000134531 [P54849-1] ENST00000396301; ENSP00000379595; ENSG00000134531 [P54849-2]
GeneIDⁱ	2012
KEGGⁱ	hsa:2012
UCSCⁱ	uc001rbr.4 human [P54849-1]

Organism-specific databases

CTDⁱ	2012
DisGeNETⁱ	2012
EuPathDBⁱ	HostDB:ENSG00000134531.9
GeneCardsⁱ	EMP1
HGNCⁱ	HGNC:3333 EMP1
HPAⁱ	HPA051931 HPA056250
MIMⁱ	602333 gene
neXtProtⁱ	NX_P54849
OpenTargetsⁱ	ENSG00000134531
PharmGKBⁱ	PA27770
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IW7W Eukaryota ENOG410Z5WT LUCA
GeneTreeⁱ	ENSGT00510000046328
HOGENOMⁱ	HOG000059542
HOVERGENⁱ	HBG001690
InParanoidⁱ	P54849
OMAⁱ	WICFCFS
OrthoDBⁱ	EOG091G0RF4
PhylomeDBⁱ	P54849
TreeFamⁱ	TF330414

Miscellaneous databases

ChiTaRSⁱ	EMP1 human
GeneWikiⁱ	EMP1
GenomeRNAiⁱ	2012
Protein Ontology More...PROⁱ	PR:P54849
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134531 Expressed in 226 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_EMP1
ExpressionAtlasⁱ	P54849 baseline and differential
Genevisibleⁱ	P54849 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003932 EMP_1 IPR004031 PMP22/EMP/MP20/Claudin IPR004032 PMP22_EMP_MP20
PANTHERⁱ	PTHR10671:SF6 PTHR10671:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01453 EPMEMFAMILY PR01454 EPMEMPROT1
PROSITEⁱ	View protein in PROSITE PS01221 PMP22_1, 1 hit PS01222 PMP22_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EMP1_HUMAN
Accessionⁱ	P54849Primary (citable) accession number: P54849 Secondary accession number(s): B2R5N1 , B4DRR1, O00681, Q13481, Q13834
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	July 15, 1998
	Last modified:	September 12, 2018
	This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P54849 (EMP1_HUMAN)

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Epithelial membrane protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ