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Protein

Epithelial membrane protein 1

Gene

EMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • bleb assembly Source: UniProtKB
  • cell death Source: UniProtKB
  • cell proliferation Source: ProtInc
  • epidermis development Source: ProtInc
  • multicellular organism development Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 1
Short name:
EMP-1
Alternative name(s):
CL-20
Protein B4B
Tumor-associated membrane protein
Gene namesi
Name:EMP1
Synonyms:B4B, TMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000134531.9
HGNCiHGNC:3333 EMP1
MIMi602333 gene
neXtProtiNX_P54849

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2012
OpenTargetsiENSG00000134531
PharmGKBiPA27770

Polymorphism and mutation databases

BioMutaiEMP1
DMDMi3041684

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646531 – 157Epithelial membrane protein 1Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP54849
PeptideAtlasiP54849
PRIDEiP54849
ProteomicsDBi56739
TopDownProteomicsiP54849-1 [P54849-1]

Expressioni

Gene expression databases

BgeeiENSG00000134531 Expressed in 226 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_EMP1
ExpressionAtlasiP54849 baseline and differential
GenevisibleiP54849 HS

Organism-specific databases

HPAiHPA051931
HPA056250

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi108327, 3 interactors
IntActiP54849, 55 interactors
STRINGi9606.ENSP00000256951

Structurei

3D structure databases

ProteinModelPortaliP54849
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW7W Eukaryota
ENOG410Z5WT LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiP54849
OMAiWICFCFS
OrthoDBiEOG091G0RF4
PhylomeDBiP54849
TreeFamiTF330414

Family and domain databases

InterProiView protein in InterPro
IPR003932 EMP_1
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF6 PTHR10671:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01454 EPMEMPROT1
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P54849-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS
60 70 80 90 100
DSLSYASEDA LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA
110 120 130 140 150
TTLVCWLCIL VGVSIYTSHY ANRDGTQYHH GYSYILGWIC FCFSFIIGVL

YLVLRKK
Length:157
Mass (Da):17,563
Last modified:July 15, 1998 - v3
Checksum:iB470B4ADC5C16821
GO
Isoform 2 (identifier: P54849-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-157: WLCILVGVSI...GVLYLVLRKK → FIMRIVMERS...ASSSAFSIWS

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):15,252
Checksum:iFBA7A4754382838C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQX4J3KQX4_HUMAN
Epithelial membrane protein 1
EMP1
90Annotation score:
F5GYV0F5GYV0_HUMAN
Epithelial membrane protein 1
EMP1
146Annotation score:
F5H397F5H397_HUMAN
Epithelial membrane protein 1
EMP1
69Annotation score:
F5H2P5F5H2P5_HUMAN
Epithelial membrane protein 1
EMP1
94Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05060857S → N. Corresponds to variant dbSNP:rs34412222Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056984106 – 157WLCIL…VLRKK → FIMRIVMERSITTAIPTSWA GSASASASSSAFSIWS in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43916 mRNA Translation: AAC51783.1
U77085 mRNA Translation: AAC51207.1
Z50751 mRNA Translation: CAA90627.1
Y07909 mRNA Translation: CAA69217.1
AK299388 mRNA Translation: BAG61373.1
AK312246 mRNA Translation: BAG35178.1
AC022276 Genomic DNA No translation available.
AC079628 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96304.1
BC047300 mRNA Translation: AAH47300.1
CCDSiCCDS8660.1 [P54849-1]
PIRiG02355
RefSeqiNP_001414.1, NM_001423.2 [P54849-1]
UniGeneiHs.719042

Genome annotation databases

EnsembliENST00000256951; ENSP00000256951; ENSG00000134531 [P54849-1]
ENST00000396301; ENSP00000379595; ENSG00000134531 [P54849-2]
GeneIDi2012
KEGGihsa:2012
UCSCiuc001rbr.4 human [P54849-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43916 mRNA Translation: AAC51783.1
U77085 mRNA Translation: AAC51207.1
Z50751 mRNA Translation: CAA90627.1
Y07909 mRNA Translation: CAA69217.1
AK299388 mRNA Translation: BAG61373.1
AK312246 mRNA Translation: BAG35178.1
AC022276 Genomic DNA No translation available.
AC079628 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96304.1
BC047300 mRNA Translation: AAH47300.1
CCDSiCCDS8660.1 [P54849-1]
PIRiG02355
RefSeqiNP_001414.1, NM_001423.2 [P54849-1]
UniGeneiHs.719042

3D structure databases

ProteinModelPortaliP54849
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108327, 3 interactors
IntActiP54849, 55 interactors
STRINGi9606.ENSP00000256951

Polymorphism and mutation databases

BioMutaiEMP1
DMDMi3041684

Proteomic databases

PaxDbiP54849
PeptideAtlasiP54849
PRIDEiP54849
ProteomicsDBi56739
TopDownProteomicsiP54849-1 [P54849-1]

Protocols and materials databases

DNASUi2012
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256951; ENSP00000256951; ENSG00000134531 [P54849-1]
ENST00000396301; ENSP00000379595; ENSG00000134531 [P54849-2]
GeneIDi2012
KEGGihsa:2012
UCSCiuc001rbr.4 human [P54849-1]

Organism-specific databases

CTDi2012
DisGeNETi2012
EuPathDBiHostDB:ENSG00000134531.9
GeneCardsiEMP1
HGNCiHGNC:3333 EMP1
HPAiHPA051931
HPA056250
MIMi602333 gene
neXtProtiNX_P54849
OpenTargetsiENSG00000134531
PharmGKBiPA27770
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW7W Eukaryota
ENOG410Z5WT LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiP54849
OMAiWICFCFS
OrthoDBiEOG091G0RF4
PhylomeDBiP54849
TreeFamiTF330414

Miscellaneous databases

ChiTaRSiEMP1 human
GeneWikiiEMP1
GenomeRNAii2012
PROiPR:P54849
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134531 Expressed in 226 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_EMP1
ExpressionAtlasiP54849 baseline and differential
GenevisibleiP54849 HS

Family and domain databases

InterProiView protein in InterPro
IPR003932 EMP_1
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF6 PTHR10671:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01454 EPMEMPROT1
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMP1_HUMAN
AccessioniPrimary (citable) accession number: P54849
Secondary accession number(s): B2R5N1
, B4DRR1, O00681, Q13481, Q13834
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: September 12, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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