UniProtKB - P54848 (EMP1_RAT)
Protein
Epithelial membrane protein 1
Gene
Emp1
Organism
Rattus norvegicus (Rat)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Epithelial membrane protein 1Short name: EMP-1 Alternative name(s): Tumor-associated membrane protein |
Gene namesi | Name:Emp1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2552, Emp1 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- integral component of membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 95 – 115 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 137 – 157 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164657 | 1 – 160 | Epithelial membrane protein 1Add BLAST | 160 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P54848 |
PTM databases
GlyGeni | P54848, 1 site |
Expressioni
Tissue specificityi
Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver.
Gene expression databases
Bgeei | ENSRNOG00000008676, Expressed in esophagus and 20 other tissues |
Genevisiblei | P54848, RN |
Family & Domainsi
Sequence similaritiesi
Belongs to the PMP-22/EMP/MP20 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S028, Eukaryota |
GeneTreei | ENSGT00950000182696 |
HOGENOMi | CLU_138632_0_1_1 |
InParanoidi | P54848 |
OMAi | KSVQAFM |
OrthoDBi | 1218356at2759 |
PhylomeDBi | P54848 |
TreeFami | TF330414 |
Family and domain databases
InterProi | View protein in InterPro IPR003932, EMP_1 IPR004031, PMP22/EMP/MP20/Claudin IPR004032, PMP22_EMP_MP20 |
PANTHERi | PTHR10671:SF6, PTHR10671:SF6, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01453, EPMEMFAMILY PR01454, EPMEMPROT1 |
PROSITEi | View protein in PROSITE PS01221, PMP22_1, 1 hit PS01222, PMP22_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P54848-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVLLAGLFV VHIATAIMLF VSTIANVWMV ADGIDSSIGL WKNCTSGSCD
60 70 80 90 100
GSLSYGNDDA IKAVQAFMIL SIIFSIISLV VFVFQLFTME KGNRFFLSGS
110 120 130 140 150
TMLVCWLCIL IGVSIYTHHY AHSEGNFFPS SHQGYCFILT WICFCFSFII
160
GILYMVLRKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z54212 mRNA Translation: CAA90939.1 BC087031 mRNA Translation: AAH87031.1 |
RefSeqi | NP_036975.1, NM_012843.2 XP_008761591.1, XM_008763369.2 |
Genome annotation databases
Ensembli | ENSRNOT00000011580; ENSRNOP00000011580; ENSRNOG00000008676 ENSRNOT00000079785; ENSRNOP00000070837; ENSRNOG00000008676 |
GeneIDi | 25314 |
KEGGi | rno:25314 |
UCSCi | RGD:2552, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z54212 mRNA Translation: CAA90939.1 BC087031 mRNA Translation: AAH87031.1 |
RefSeqi | NP_036975.1, NM_012843.2 XP_008761591.1, XM_008763369.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011580 |
PTM databases
GlyGeni | P54848, 1 site |
Proteomic databases
PaxDbi | P54848 |
Genome annotation databases
Ensembli | ENSRNOT00000011580; ENSRNOP00000011580; ENSRNOG00000008676 ENSRNOT00000079785; ENSRNOP00000070837; ENSRNOG00000008676 |
GeneIDi | 25314 |
KEGGi | rno:25314 |
UCSCi | RGD:2552, rat |
Organism-specific databases
CTDi | 2012 |
RGDi | 2552, Emp1 |
Phylogenomic databases
eggNOGi | ENOG502S028, Eukaryota |
GeneTreei | ENSGT00950000182696 |
HOGENOMi | CLU_138632_0_1_1 |
InParanoidi | P54848 |
OMAi | KSVQAFM |
OrthoDBi | 1218356at2759 |
PhylomeDBi | P54848 |
TreeFami | TF330414 |
Miscellaneous databases
PROi | PR:P54848 |
Gene expression databases
Bgeei | ENSRNOG00000008676, Expressed in esophagus and 20 other tissues |
Genevisiblei | P54848, RN |
Family and domain databases
InterProi | View protein in InterPro IPR003932, EMP_1 IPR004031, PMP22/EMP/MP20/Claudin IPR004032, PMP22_EMP_MP20 |
PANTHERi | PTHR10671:SF6, PTHR10671:SF6, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01453, EPMEMFAMILY PR01454, EPMEMPROT1 |
PROSITEi | View protein in PROSITE PS01221, PMP22_1, 1 hit PS01222, PMP22_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EMP1_RAT | |
Accessioni | P54848Primary (citable) accession number: P54848 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | August 12, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families