Maf

Functionⁱ

Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding.By similarity12 Publications

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 12381733
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: MGI
Inferred from direct assayⁱ
- 19414009
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 12835653
DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
double-stranded DNA binding Source: MGI
protein heterodimerization activity Source: MGI
protein homodimerization activity Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 10603348

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10603348
cytokine production
Source: MGI
Inferred from direct assayⁱ
- 15790681
inner ear development
Source: MGI
Inferred from direct assayⁱ
- 21795542
lens development in camera-type eye
Source: MGI
Inferred from mutant phenotypeⁱ
lens fiber cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10383433
- 12835653
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from mutant phenotypeⁱ
- 19623612
positive regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 21460847
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 12381733
- 12835653
regulation of chondrocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 14512017
regulation of transcription, DNA-templated
Source: MGI
Inferred from mutant phenotypeⁱ
- 10403649

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor Maf Alternative name(s): Proto-oncogene c-Maf V-maf musculoaponeurotic fibrosarcoma oncogene homolog
Gene namesⁱ	Name:Maf Synonyms:Maf2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:96909 Maf

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Knockout mice lacking this gene exhibit small eyes or microphthalmia with an absence of normal lens structures, an abnormal chondrocyte development, with terminal differentiation of hypertrophic chondrocytes initially delayed, followed by a subsequent expansion of the hypertrophic chondrocyte domain in the growth plates of embryonic and postnatal long bones. They also show a lack of IL4 production.5 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	15	S → A: Inhibition on transcriptional activation on CD13 proximal promoter in endothelial cells. 1 Publication	1
Mutagenesisⁱ	70	S → A: No effect on transcriptional activation on CD13 proximal promoter. Increases liver specific transactivation on the IL-4 promoter. 1 Publication	1
Mutagenesisⁱ	334	L → P: Abolishes interaction with USF2. 1 Publication	1

Keywords - Diseaseⁱ

Proto-oncogene, Tumor suppressor

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076492	1 – 370	Transcription factor MafAdd BLAST		370

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	29	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	33	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	328	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids (By similarity).By similarity

Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (By similarity). The phosphorylation status can serve to either stimulate or inhibit transcription.By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P54843
PaxDbⁱ	P54843
PRIDEⁱ	P54843

PTM databases

iPTMnetⁱ	P54843
PhosphoSitePlusⁱ	P54843

Expressionⁱ

Tissue specificityⁱ

Expressed in tubules of the renal cortex and hepatocytes. Expressed in the lens (at protein level). Expressed in pancreatic islets and endothelial cells.3 Publications

Developmental stageⁱ

Expressed in the floor of the diencephalon at 10 dpc (at protein level). Expressed in the midline of the forebrain and in the eye region at 9 dpc. Expressed in the head ectoderm destined to become the lens vesicle at 9 and 10 dpc. Expressed in the lens placode at 10.5 dpc. Expressed in the lens vesicle in both epithelial and fiber cells at 11 dpc. Expressed in secondary fiber cells at the equatorial region that divides the lens into anterior and posterior hemispheres between 11 and 14 dpc. Expressed in the neural tube and in primary fiber cells of the lens at 11.5 dpc. Expressed in proximal tubules of the cortex in the kidney at 16 and 17 dpc. Expressed in hypertrophic chondrocytes at 14.5 to 18.5 dpc. Expressed in the pancreas at 12.5 dpc until the adult stage.5 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000055435 Expressed in 266 organ(s), highest expression level in lens of camera-type eye
Genevisibleⁱ	P54843 MM

Interactionⁱ

Subunit structureⁱ

Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or as a heterodimer. Heterotetramer of two MAF and two USF2. Interacts with PAX6; the interaction is direct. Interacts with MYB; interaction takes place weakly in normal T-cells and increases in T-cells following stimulation through the TCR engagement. Interacts with MYB; the ternary complex formed with MYB and the CD13 promoter is regulated in response to differentiating signals. Interacts with USF2; the interaction inhibits its DNA-binding activity on the L7 promoter. Interacts with CREBBP, EP300 and ETS1 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Smarca5	Q91ZW3	2	EBI-3842521,EBI-927547

With

Entry

#Exp.

IntAct

Notes

Smarca5

Q91ZW3

2

EBI-3842521,EBI-927547

GO - Molecular functionⁱ

protein heterodimerization activity Source: MGI
protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201281, 2 interactors
IntActⁱ	P54843, 2 interactors
Molecular INTeraction database More...MINTⁱ	P54843
STRINGⁱ	10090.ENSMUSP00000104732

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P54843
SMRⁱ	P54843
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	285 – 348	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	126 – 370	Represses ARE-mediated transcriptionBy similarityAdd BLAST	245
Regionⁱ	285 – 310	Basic motifPROSITE-ProRule annotationAdd BLAST	26
Regionⁱ	313 – 334	Leucine-zipperPROSITE-ProRule annotationAdd BLAST	22

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	126 – 251	Gly-richAdd BLAST	126
Compositional biasⁱ	132 – 224	Ala-richAdd BLAST	93
Compositional biasⁱ	180 – 194	His-richAdd BLAST	15

Sequence similaritiesⁱ

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG4196 Eukaryota ENOG41102C7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074549
HOGENOMⁱ	HOG000261683
HOVERGENⁱ	HBG000313
InParanoidⁱ	P54843
KEGG Orthology (KO) More...KOⁱ	K09035
OMAⁱ	DRSINQC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H46
PhylomeDBⁱ	P54843
TreeFamⁱ	TF325689

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR004826 bZIP_Maf IPR028573 Maf/V-MAF IPR013592 Maf_TF_N IPR008917 TF_DNA-bd_sf IPR024874 Transciption_factor_Maf_fam
PANTHERⁱ	PTHR10129 PTHR10129, 1 hit PTHR10129:SF9 PTHR10129:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03131 bZIP_Maf, 1 hit PF08383 Maf_N, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P54843-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASELAMNNS DLPTSPLAME YVNDFDLMKF EVKKEPVETD RIISQCGRLI 
        60         70         80         90        100
AGGSLSSTPM STPCSSVPPS PSFSAPSPGS GSEQKAHLED YYWMTGYPQQ 
       110        120        130        140        150
LNPEALGFSP EDAVEALISN SHQLQGGFDG YARGAQQLAA AAGAGAGASL 
       160        170        180        190        200
GGSGEEMGPA AAVVSAVIAA AAAQSGAAPH YHHHHHHAAG HHHHPTAGAP 
       210        220        230        240        250
GAAGGASASA SGAGGAGGGG PASAGGGGGG GGGGGTAGAG GALHPHHAAG 
       260        270        280        290        300
GLHFDDRFSD EQLVTMSVRE LNRQLRGVSK EEVIRLKQKR RTLKNRGYAQ 
       310        320        330        340        350
SCRFKRVQQR HVLESEKNQL LQQVDHLKQE ISRLVRERDA YKEKYEKLVS 
       360        370
NGFRENGSSS DNPSSPEFFM

Length:370

Mass (Da):38,435

Last modified:February 10, 2009 - v2

Checksum:ⁱ1E8722C8287AAAC9

GO

Isoform 2 (identifier: P54843-2) [UniParc]FASTA Add to basket

Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
370-370: M → MCVCVCALFIL

« Hide

        10         20         30         40         50
MASELAMNNS DLPTSPLAME YVNDFDLMKF EVKKEPVETD RIISQCGRLI 
        60         70         80         90        100
AGGSLSSTPM STPCSSVPPS PSFSAPSPGS GSEQKAHLED YYWMTGYPQQ 
       110        120        130        140        150
LNPEALGFSP EDAVEALISN SHQLQGGFDG YARGAQQLAA AAGAGAGASL 
       160        170        180        190        200
GGSGEEMGPA AAVVSAVIAA AAAQSGAAPH YHHHHHHAAG HHHHPTAGAP 
       210        220        230        240        250
GAAGGASASA SGAGGAGGGG PASAGGGGGG GGGGGTAGAG GALHPHHAAG 
       260        270        280        290        300
GLHFDDRFSD EQLVTMSVRE LNRQLRGVSK EEVIRLKQKR RTLKNRGYAQ 
       310        320        330        340        350
SCRFKRVQQR HVLESEKNQL LQQVDHLKQE ISRLVRERDA YKEKYEKLVS 
       360        370        380
NGFRENGSSS DNPSSPEFFM CVCVCALFIL

Note: No experimental confirmation available.

Show »

Length:380

Mass (Da):39,501

Checksum:ⁱ8A86683B08071901

GO

Isoform 3 (identifier: P54843-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
370-370: M → MYPRDSSTSVM

« Hide

        10         20         30         40         50
MASELAMNNS DLPTSPLAME YVNDFDLMKF EVKKEPVETD RIISQCGRLI 
        60         70         80         90        100
AGGSLSSTPM STPCSSVPPS PSFSAPSPGS GSEQKAHLED YYWMTGYPQQ 
       110        120        130        140        150
LNPEALGFSP EDAVEALISN SHQLQGGFDG YARGAQQLAA AAGAGAGASL 
       160        170        180        190        200
GGSGEEMGPA AAVVSAVIAA AAAQSGAAPH YHHHHHHAAG HHHHPTAGAP 
       210        220        230        240        250
GAAGGASASA SGAGGAGGGG PASAGGGGGG GGGGGTAGAG GALHPHHAAG 
       260        270        280        290        300
GLHFDDRFSD EQLVTMSVRE LNRQLRGVSK EEVIRLKQKR RTLKNRGYAQ 
       310        320        330        340        350
SCRFKRVQQR HVLESEKNQL LQQVDHLKQE ISRLVRERDA YKEKYEKLVS 
       360        370        380
NGFRENGSSS DNPSSPEFFM YPRDSSTSVM

Note: No experimental confirmation available.

Show »

Length:380

Mass (Da):39,560

Checksum:ⁱ79A6165D907C017B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	202	A → T in AAB32820 (PubMed:7799931).Curated	1
Sequence conflictⁱ	208 – 211	ASAS → SSSN in AAB32820 (PubMed:7799931).Curated	4
Sequence conflictⁱ	223 – 224	SA → NT in AAB32820 (PubMed:7799931).Curated	2
Sequence conflictⁱ	231	G → D in AAB32820 (PubMed:7799931).Curated	1
Sequence conflictⁱ	248	A → S in AAB32820 (PubMed:7799931).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_036408	370	M → MCVCVCALFIL in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_036409	370	M → MYPRDSSTSVM in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S74567 mRNA Translation: AAB32820.1 AY560005 mRNA Translation: AAY81957.1 AK132165 mRNA Translation: BAE21007.1 AC113301 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40486.1 [P54843-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001020748.2, NM_001025577.2 [P54843-1]
UniGeneⁱ	Mm.275549 Mm.439772 Mm.488377

Genome annotation databases

Ensemblⁱ	ENSMUST00000069009; ENSMUSP00000067704; ENSMUSG00000055435 [P54843-3] ENSMUST00000109104; ENSMUSP00000104732; ENSMUSG00000055435 [P54843-1]
GeneIDⁱ	17132
KEGGⁱ	mmu:17132
UCSC genome browser More...UCSCⁱ	uc009noe.2 mouse [P54843-3] uc009nof.1 mouse [P54843-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P54843	Transcription factor Maf		BOVIN		377	UniRef90_P54843
Transcription factor Maf		HUMAN		373
Transcription factor Maf		RAT		369
Isoform 2 of Transcription factor Maf		MOUSE		380
transcription factor Maf isoform X1		PHYCD		432
+63

Protein	Similar proteins		Species	Score	Length	Source
P54843	Transcription factor Maf		BOVIN		377	UniRef50_P54843
Transcription factor Maf		HUMAN		373
Transcription factor Maf		RAT		369
Transcription factor Maf		XENTR		352
Transcription factor Maf		CHICK		359
+185

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S74567 mRNA Translation: AAB32820.1 AY560005 mRNA Translation: AAY81957.1 AK132165 mRNA Translation: BAE21007.1 AC113301 Genomic DNA No translation available.
CCDSⁱ	CCDS40486.1 [P54843-1]
RefSeqⁱ	NP_001020748.2, NM_001025577.2 [P54843-1]
UniGeneⁱ	Mm.275549 Mm.439772 Mm.488377

3D structure databases

ProteinModelPortalⁱ	P54843
SMRⁱ	P54843
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201281, 2 interactors
IntActⁱ	P54843, 2 interactors
MINTⁱ	P54843
STRINGⁱ	10090.ENSMUSP00000104732

PTM databases

iPTMnetⁱ	P54843
PhosphoSitePlusⁱ	P54843

Proteomic databases

MaxQBⁱ	P54843
PaxDbⁱ	P54843
PRIDEⁱ	P54843

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000069009; ENSMUSP00000067704; ENSMUSG00000055435 [P54843-3] ENSMUST00000109104; ENSMUSP00000104732; ENSMUSG00000055435 [P54843-1]
GeneIDⁱ	17132
KEGGⁱ	mmu:17132
UCSCⁱ	uc009noe.2 mouse [P54843-3] uc009nof.1 mouse [P54843-1]

Organism-specific databases

CTDⁱ	4094
MGIⁱ	MGI:96909 Maf

Phylogenomic databases

eggNOGⁱ	KOG4196 Eukaryota ENOG41102C7 LUCA
GeneTreeⁱ	ENSGT00550000074549
HOGENOMⁱ	HOG000261683
HOVERGENⁱ	HBG000313
InParanoidⁱ	P54843
KOⁱ	K09035
OMAⁱ	DRSINQC
OrthoDBⁱ	EOG091G0H46
PhylomeDBⁱ	P54843
TreeFamⁱ	TF325689

Miscellaneous databases

ChiTaRSⁱ	Maf mouse
Protein Ontology More...PROⁱ	PR:P54843
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000055435 Expressed in 266 organ(s), highest expression level in lens of camera-type eye
Genevisibleⁱ	P54843 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR004826 bZIP_Maf IPR028573 Maf/V-MAF IPR013592 Maf_TF_N IPR008917 TF_DNA-bd_sf IPR024874 Transciption_factor_Maf_fam
PANTHERⁱ	PTHR10129 PTHR10129, 1 hit PTHR10129:SF9 PTHR10129:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF03131 bZIP_Maf, 1 hit PF08383 Maf_N, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MAF_MOUSE
Accessionⁱ	P54843Primary (citable) accession number: P54843 Secondary accession number(s): Q3V1Z2, Q4QY62
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	February 10, 2009
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P54843 (MAF_MOUSE)

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Transcription factor Maf

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ