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Protein

Glycogen [starch] synthase, liver

Gene

GYS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei40UDP-glucoseBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glycogen (starch) synthase activity Source: UniProtKB
  • glycogen synthase activity, transferring glucose-1-phosphate Source: Reactome
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
Biological processGlycogen biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3322077 Glycogen synthesis
R-HSA-3785653 Myoclonic epilepsy of Lafora
R-HSA-3858516 Glycogen storage disease type 0 (liver GYS2)
R-HSA-3878781 Glycogen storage disease type IV (GBE1)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00164

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT3 Glycosyltransferase Family 3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycogen [starch] synthase, liver (EC:2.4.1.11)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GYS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111713.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4707 GYS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138571 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54840

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glycogen storage disease 0 (GSD0)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood, high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia.
See also OMIM:240600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00786039N → S in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918423EnsemblClinVar.1
Natural variantiVAR_007861339A → P in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918421EnsemblClinVar.1
Natural variantiVAR_007862446H → D in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918425EnsemblClinVar.1
Natural variantiVAR_007863479P → Q in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918420EnsemblClinVar.1
Natural variantiVAR_007864483S → P in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918424EnsemblClinVar.1
Natural variantiVAR_007865491M → R in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918422EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
2998

MalaCards human disease database

More...
MalaCardsi
GYS2
MIMi240600 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000111713

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2089 Glycogen storage disease due to hepatic glycogen synthase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29085

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GYS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
288558811

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001947681 – 703Glycogen [starch] synthase, liverAdd BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8Phosphoserine; by PKABy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei627PhosphoserineCombined sources1
Modified residuei641Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity1
Modified residuei645Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity1
Modified residuei649Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity1
Modified residuei653Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity1
Modified residuei657Phosphoserine; by CK2By similarity1
Modified residuei683PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity). Phosphorylation at Ser-8 is not required for interaction with GYG1 (By similarity). Interaction with GYG1 does not regulate the phosphorylation at Ser-8 and Ser-641 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P54840

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P54840

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P54840

PeptideAtlas

More...
PeptideAtlasi
P54840

PRoteomics IDEntifications database

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PRIDEi
P54840

ProteomicsDB human proteome resource

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ProteomicsDBi
56737

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54840

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54840

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111713 Expressed in 65 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
HS_GYS2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P54840 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039482

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GYG1 (via C-terminus); required for GYS2-mediated glycogen synthesis.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109253, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P54840, 4 interactors

Molecular INTeraction database

More...
MINTi
P54840

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P54840

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54840

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3742 Eukaryota
COG0438 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000018612

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000160890

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001960

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P54840

KEGG Orthology (KO)

More...
KOi
K00693

Identification of Orthologs from Complete Genome Data

More...
OMAi
TADEWGD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0304

Database for complete collections of gene phylogenies

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PhylomeDBi
P54840

TreeFam database of animal gene trees

More...
TreeFami
TF300306

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03793 GT1_Glycogen_synthase_GSY2_lik, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008631 Glycogen_synth

The PANTHER Classification System

More...
PANTHERi
PTHR10176 PTHR10176, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05693 Glycogen_syn, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P54840-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRGRSLSVT SLGGLPQWEV EELPVEELLL FEVAWEVTNK VGGIYTVIQT
60 70 80 90 100
KAKTTADEWG ENYFLIGPYF EHNMKTQVEQ CEPVNDAVRR AVDAMNKHGC
110 120 130 140 150
QVHFGRWLIE GSPYVVLFDI GYSAWNLDRW KGDLWEACSV GIPYHDREAN
160 170 180 190 200
DMLIFGSLTA WFLKEVTDHA DGKYVVAQFH EWQAGIGLIL SRARKLPIAT
210 220 230 240 250
IFTTHATLLG RYLCAANIDF YNHLDKFNID KEAGERQIYH RYCMERASVH
260 270 280 290 300
CAHVFTTVSE ITAIEAEHML KRKPDVVTPN GLNVKKFSAV HEFQNLHAMY
310 320 330 340 350
KARIQDFVRG HFYGHLDFDL EKTLFLFIAG RYEFSNKGAD IFLESLSRLN
360 370 380 390 400
FLLRMHKSDI TVMVFFIMPA KTNNFNVETL KGQAVRKQLW DVAHSVKEKF
410 420 430 440 450
GKKLYDALLR GEIPDLNDIL DRDDLTIMKR AIFSTQRQSL PPVTTHNMID
460 470 480 490 500
DSTDPILSTI RRIGLFNNRT DRVKVILHPE FLSSTSPLLP MDYEEFVRGC
510 520 530 540 550
HLGVFPSYYE PWGYTPAECT VMGIPSVTTN LSGFGCFMQE HVADPTAYGI
560 570 580 590 600
YIVDRRFRSP DDSCNQLTKF LYGFCKQSRR QRIIQRNRTE RLSDLLDWRY
610 620 630 640 650
LGRYYQHARH LTLSRAFPDK FHVELTSPPT TEGFKYPRPS SVPPSPSGSQ
660 670 680 690 700
ASSPQSSDVE DEVEDERYDE EEEAERDRLN IKSPFSLSHV PHGKKKLHGE

YKN
Length:703
Mass (Da):80,989
Last modified:February 9, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i718F000D6D00CA4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti97K → M in BAA06154 (Ref. 3) Curated1
Sequence conflicti178Q → R in BAA06154 (Ref. 3) Curated1
Sequence conflicti186I → V in BAA06154 (Ref. 3) Curated1
Sequence conflicti335 – 336SN → FKT in BAA06154 (Ref. 3) Curated2
Sequence conflicti344E → D in BAA06154 (Ref. 3) Curated1
Sequence conflicti441P → A in BAA06154 (Ref. 3) Curated1
Sequence conflicti576 – 577KQ → NM in BAA06154 (Ref. 3) Curated2
Sequence conflicti583I → F in BAA06154 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00786039N → S in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918423EnsemblClinVar.1
Natural variantiVAR_055885193A → T. Corresponds to variant dbSNP:rs16924038EnsemblClinVar.1
Natural variantiVAR_007861339A → P in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918421EnsemblClinVar.1
Natural variantiVAR_058848363M → V4 PublicationsCorresponds to variant dbSNP:rs2306180EnsemblClinVar.1
Natural variantiVAR_055886415D → E. Corresponds to variant dbSNP:rs16924002EnsemblClinVar.1
Natural variantiVAR_007862446H → D in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918425EnsemblClinVar.1
Natural variantiVAR_007863479P → Q in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918420EnsemblClinVar.1
Natural variantiVAR_007864483S → P in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918424EnsemblClinVar.1
Natural variantiVAR_007865491M → R in GSD0. 1 PublicationCorresponds to variant dbSNP:rs121918422EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S70004 mRNA Translation: AAB30886.1
AJ003087
, AJ003088, AJ003089, AJ003090, AJ003091, AJ003092, AJ003093, AJ003094, AJ003095, AJ003096, AJ003097, AJ003098, AJ003099, AJ003100, AJ003101, AJ003102 Genomic DNA Translation: CAA05859.1
D29685 mRNA Translation: BAA06154.1
AC006559 Genomic DNA No translation available.
AC010197 Genomic DNA No translation available.
AC022072 Genomic DNA No translation available.
BC126310 mRNA Translation: AAI26311.1
BC126312 mRNA Translation: AAI26313.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8690.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45686

NCBI Reference Sequences

More...
RefSeqi
NP_068776.2, NM_021957.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.82614

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261195; ENSP00000261195; ENSG00000111713

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2998

UCSC genome browser

More...
UCSCi
uc001rfb.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70004 mRNA Translation: AAB30886.1
AJ003087
, AJ003088, AJ003089, AJ003090, AJ003091, AJ003092, AJ003093, AJ003094, AJ003095, AJ003096, AJ003097, AJ003098, AJ003099, AJ003100, AJ003101, AJ003102 Genomic DNA Translation: CAA05859.1
D29685 mRNA Translation: BAA06154.1
AC006559 Genomic DNA No translation available.
AC010197 Genomic DNA No translation available.
AC022072 Genomic DNA No translation available.
BC126310 mRNA Translation: AAI26311.1
BC126312 mRNA Translation: AAI26313.1
CCDSiCCDS8690.1
PIRiS45686
RefSeqiNP_068776.2, NM_021957.3
UniGeneiHs.82614

3D structure databases

ProteinModelPortaliP54840
SMRiP54840
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109253, 6 interactors
IntActiP54840, 4 interactors
MINTiP54840
STRINGi9606.ENSP00000261195

Protein family/group databases

CAZyiGT3 Glycosyltransferase Family 3

PTM databases

iPTMnetiP54840
PhosphoSitePlusiP54840

Polymorphism and mutation databases

BioMutaiGYS2
DMDMi288558811

Proteomic databases

EPDiP54840
MaxQBiP54840
PaxDbiP54840
PeptideAtlasiP54840
PRIDEiP54840
ProteomicsDBi56737

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2998
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261195; ENSP00000261195; ENSG00000111713
GeneIDi2998
KEGGihsa:2998
UCSCiuc001rfb.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2998
DisGeNETi2998
EuPathDBiHostDB:ENSG00000111713.2

GeneCards: human genes, protein and diseases

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GeneCardsi
GYS2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0036868
HGNCiHGNC:4707 GYS2
HPAiHPA039482
MalaCardsiGYS2
MIMi138571 gene
240600 phenotype
neXtProtiNX_P54840
OpenTargetsiENSG00000111713
Orphaneti2089 Glycogen storage disease due to hepatic glycogen synthase deficiency
PharmGKBiPA29085

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3742 Eukaryota
COG0438 LUCA
GeneTreeiENSGT00390000018612
HOGENOMiHOG000160890
HOVERGENiHBG001960
InParanoidiP54840
KOiK00693
OMAiTADEWGD
OrthoDBiEOG091G0304
PhylomeDBiP54840
TreeFamiTF300306

Enzyme and pathway databases

UniPathwayi
UPA00164

ReactomeiR-HSA-3322077 Glycogen synthesis
R-HSA-3785653 Myoclonic epilepsy of Lafora
R-HSA-3858516 Glycogen storage disease type 0 (liver GYS2)
R-HSA-3878781 Glycogen storage disease type IV (GBE1)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GYS2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2998

Protein Ontology

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PROi
PR:P54840

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000111713 Expressed in 65 organ(s), highest expression level in liver
CleanExiHS_GYS2
GenevisibleiP54840 HS

Family and domain databases

CDDicd03793 GT1_Glycogen_synthase_GSY2_lik, 1 hit
InterProiView protein in InterPro
IPR008631 Glycogen_synth
PANTHERiPTHR10176 PTHR10176, 1 hit
PfamiView protein in Pfam
PF05693 Glycogen_syn, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGYS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54840
Secondary accession number(s): A0AVD8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 9, 2010
Last modified: December 5, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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