UniProtKB - P54832 (PON2_CANLF)
Protein
Serum paraoxonase/arylesterase 2
Gene
PON2
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters.By similarity
Catalytic activityi
Cofactori
Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 54 | Calcium 2By similarity | 1 | |
Active sitei | 114 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 116 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 167 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 168 | Calcium 2By similarity | 1 | |
Metal bindingi | 223 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 268 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 269 | Calcium 1; catalyticBy similarity | 1 |
GO - Molecular functioni
- acyl-L-homoserine-lactone lactonohydrolase activity Source: UniProtKB-EC
- arylesterase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PON2 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Extracellular region or secreted
- extracellular region Source: InterPro
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223286 | 1 – 354 | Serum paraoxonase/arylesterase 2Add BLAST | 354 | |
Signal peptidei | 1 – ? | Not cleavedSequence analysis |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 352 | By similarity | ||
Glycosylationi | 254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 323 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
The signal sequence is not cleaved.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P54832 |
Interactioni
Subunit structurei
Homotrimer.
By similarityProtein-protein interaction databases
STRINGi | 9612.ENSCAFP00000003109 |
Family & Domainsi
Sequence similaritiesi
Belongs to the paraoxonase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUCT, Eukaryota |
InParanoidi | P54832 |
Family and domain databases
Gene3Di | 2.120.10.30, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR002640, Arylesterase IPR008364, Paraoxonase2 |
Pfami | View protein in Pfam PF01731, Arylesterase, 1 hit |
PRINTSi | PR01785, PARAOXONASE PR01787, PARAOXONASE2 |
i Sequence
Sequence statusi: Complete.
P54832-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRLLGVGLL GDRWRSWGER LLALRNRLKA SREVESVDLP NCHLIKGIEA
60 70 80 90 100
GADDIDILPN GLAFFSVGLK CPGLHSFSPD KPGGILMMDL KKENPRALEL
110 120 130 140 150
RISRGFNLAS FNPHGISTFI DSDDTVYLFV VNHPEFKNTV EIFKFEEEEN
160 170 180 190 200
SLLHLKTIKH ELLPSVNDII AVGPAHFYAT NDHYFSDPFL KYLETYLNLH
210 220 230 240 250
WANVVYYSPD EVKVVAEGFD AANGINISPD KKYIYVADIL AHEIHVLEKH
260 270 280 290 300
PNMNLTQLKV LKLDTLVDNL SIDPSSGDIL VGCHPNGQKL FIYDPNNPPS
310 320 330 340 350
SEVLRIQNIL CEKPTVTTVY ANNGSVLQGS SVASVYDRKL LIGTLYHRAL
YCEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L48515 mRNA Translation: AAC41635.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L48515 mRNA Translation: AAC41635.1 |
3D structure databases
SMRi | P54832 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000003109 |
Proteomic databases
PaxDbi | P54832 |
Phylogenomic databases
eggNOGi | ENOG502QUCT, Eukaryota |
InParanoidi | P54832 |
Family and domain databases
Gene3Di | 2.120.10.30, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR002640, Arylesterase IPR008364, Paraoxonase2 |
Pfami | View protein in Pfam PF01731, Arylesterase, 1 hit |
PRINTSi | PR01785, PARAOXONASE PR01787, PARAOXONASE2 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PON2_CANLF | |
Accessioni | P54832Primary (citable) accession number: P54832 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families